Robert C. Rostomily, MD

  • Phone713.441.3800
  • 3111 Citations
  • 31 h-Index
1983 …2020

Research output per year

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Research Output

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Article
2020

A microfluidic platform for functional testing of cancer drugs on intact tumor slices

Rodriguez, A. D., Horowitz, L. F., Castro, K., Kenerson, H., Bhattacharjee, N., Gandhe, G., Raman, A., Monnat, R. J., Yeung, R., Rostomily, R. C. & Folch, A., May 7 2020, In : Lab on a Chip. 20, 9, p. 1658-1675 18 p.

Research output: Contribution to journalArticle

2 Scopus citations

Patterns of management and outcomes of unifocal versus multifocal glioblastoma

Haque, W., Thong, Y., Verma, V., Rostomily, R., Butler, E. B. & Teh, B. S., Apr 2020, In : Journal of Clinical Neuroscience. 74, p. 155-159 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Phosphoproteomic and kinomic signature of clinically aggressive grade I (1.5) meningiomas reveals Rb1 signaling as a novel mediator and biomarker a C

Parada, C. A., Osbun, J. W., Busald, T., Karasozen, Y., Kaur, S., Shi, M., Barber, J., Adidharma, W., Cimino, P. J., Pan, C., Gonzalez-Cuyar, L. F., Rostomily, R. C., Born, D. E., Zhang, J. & Ferreira, M., Jan 1 2020, In : Clinical Cancer Research. 26, 1, p. 193-205 13 p.

Research output: Contribution to journalArticle

2019
1 Scopus citations

Prognostic gene discovery in glioblastoma patients using deep learning

Wong, K. K., Rostomily, R. & Wong, S. T. C., Jan 1 2019, In : Cancers. 11, 1, 53.

Research output: Contribution to journalArticle

11 Scopus citations

TWIST1 heterodimerization with e12 requires coordinated protein phosphorylation to regulate periostin expression

Mikheeva, S. A., Camp, N. D., Huang, L., Jain, A., Jung, S. Y., Avci, N. G., Tokita, M., Wolf-Yadlin, A., Zhang, J., Tapscott, S. J., Rostomily, R. C. & Mikheev, A. M., Sep 2019, In : Cancers. 11, 9, 1392.

Research output: Contribution to journalArticle

2018

An anatomic transcriptional atlas of human glioblastoma

Puchalski, R. B., Shah, N., Miller, J., Dalley, R., Nomura, S. R., Yoon, J. G., Smith, K. A., Lankerovich, M., Bertagnolli, D., Bickley, K., Boe, A. F., Brouner, K., Butler, S., Caldejon, S., Chapin, M., Datta, S., Dee, N., Desta, T., Dolbeare, T., Dotson, N. & 60 others, Ebbert, A., Feng, D., Feng, X., Fisher, M., Gee, G., Goldy, J., Gourley, L., Gregor, B. W., Gu, G., Hejazinia, N., Hohmann, J., Hothi, P., Howard, R., Joines, K., Kriedberg, A., Kuan, L., Lau, C., Lee, F., Lee, H., Lemon, T., Long, F., Mastan, N., Mott, E., Murthy, C., Ngo, K., Olson, E., Reding, M., Riley, Z., Rosen, D., Sandman, D., Shapovalova, N., Slaughterbeck, C. R., Sodt, A., Stockdale, G., Szafer, A., Wakeman, W., Wohnoutka, P. E., White, S. J., Marsh, D., Rostomily, R. C., Ng, L., Dang, C., Jones, A., Keogh, B., Gittleman, H. R., Barnholtz-Sloan, J. S., Cimino, P. J., Uppin, M. S., Dirk Keene, C., Farrokhi, F. R., Lathia, J. D., Berens, M. E., Iavarone, A., Bernard, A., Lein, E., Phillips, J. W., Rostad, S. W., Cobbs, C., Hawrylycz, M. J. & Foltz, G. D., May 11 2018, In : Science. 360, 6389, p. 660-663 4 p.

Research output: Contribution to journalArticle

67 Scopus citations

Cranial chordoma: A new preoperative grading system

Da Silva, H. B., Straus, D., Barber, J. K., Rostomily, R. C., Ferreira, M. & Sekhar, L. N., 2018, In : Clinical neurosurgery. 83, 3, p. 403-415 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression

Parada, C. A., Osbun, J., Kaur, S., Yakkioui, Y., Shi, M., Pan, C., Busald, T., Karasozen, Y., Gonzalez-Cuyar, L. F., Rostomily, R., Zhang, J. & Ferreira, M., Dec 1 2018, In : Scientific Reports. 8, 1, 2098.

Research output: Contribution to journalArticle

7 Scopus citations

Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma

Mikheev, A. M., Mikheeva, S. A., Severs, L. J., Funk, C. C., Huang, L., McFaline-Figueroa, J. L., Schwensen, J., Trapnell, C., Price, N. D., Wong, S. & Rostomily, R. C., Jun 2018, In : Molecular Oncology. 12, 7, p. 1188-1202 15 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy

Pollak, J., Rai, K. G., Funk, C. C., Arora, S., Lee, E., Zhu, J., Price, N. D., Paddison, P. J., Ramirez, J-M. & Rostomily, R. C., 2017, In : PLoS ONE. 12, 3, p. e0172884

Research output: Contribution to journalArticle

10 Scopus citations

Twist1 mediated regulation of glioma tumorigenicity is dependent on mode of mouse neural progenitor transformation

Mikheev, A. M., Mikheeva, S. A., Tokita, M., Severs, L. J. & Rostomily, R. C., 2017, In : Oncotarget. 8, 64, p. 107716-107729 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Fragment Length of Circulating Tumor DNA

Underhill, H. R., Kitzman, J. O., Hellwig, S., Welker, N. C., Daza, R., Baker, D. N., Gligorich, K. M., Rostomily, R. C., Bronner, M. P. & Shendure, J., Jul 2016, In : PLoS Genetics. 12, 7, p. e1006162

Research output: Contribution to journalArticle

225 Scopus citations
2015

Multivalent display of pendant pro-apoptotic peptides increases cytotoxic activity

Chu, D. S. H., Bocek, M. J., Shi, J., Ta, A., Ngambenjawong, C., Rostomily, R. C. & Pun, S. H., May 10 2015, In : Journal of Controlled Release. 205, p. 155-61 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

O(6)-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma

Bobola, M. S., Alnoor, M., Chen, J. Y-S., Kolstoe, D. D., Silbergeld, D. L., Rostomily, R. C., Blank, A., Chamberlain, M. C. & Silber, J. R., Jun 1 2015, In : Aging. 3, p. 1-10 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Outcomes in Reoperated Low-Grade Gliomas

Ramakrishna, R., Hebb, A., Barber, J., Rostomily, R. & Silbergeld, D., Aug 20 2015, In : Neurosurgery. 77, 2, p. 175-184 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Periostin is a novel therapeutic target that predicts and regulates glioma malignancy

Mikheev, A. M., Mikheeva, S. A., Trister, A. D., Tokita, M. J., Emerson, S. N., Parada, C. A., Born, D. E., Carnemolla, B., Frankel, S., Kim, D. H., Oxford, R. G., Kosai, Y., Tozer-Fink, K. R., Manning, T. C., Silber, J. R. & Rostomily, R. C., 2015, In : Neuro-oncology. 17, 3, p. 372-382 11 p.

Research output: Contribution to journalArticle

40 Scopus citations
2014

Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes

Kumar, A., Boyle, E. A., Tokita, M., Mikheev, A. M., Sanger, M. C., Girard, E., Silber, J. R., Gonzalez-Cuyar, L. F., Hiatt, J. B., Adey, A., Lee, C., Kitzman, J. O., Born, D. E., Silbergeld, D. L., Olson, J. M., Rostomily, R. C. & Shendure, J., Dec 3 2014, In : Genome Biology. 15, 12, p. 530

Research output: Contribution to journalArticle

32 Scopus citations

Parallel microfluidic chemosensitivity testing on individual slice cultures

Chang, T. C., Mikheev, A. M., Huynh, W., Monnat, R. J., Rostomily, R. C. & Folch, A., Dec 7 2014, In : Lab on a Chip. 14, 23, p. 4540-4551 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Patient-specific metrics of invasiveness reveal significant prognostic benefit of resection in a predictable subset of gliomas

Baldock, A. L., Ahn, S., Rockne, R., Johnston, S., Neal, M., Corwin, D., Clark-Swanson, K., Sterin, G., Trister, A. D., Malone, H., Ebiana, V., Sonabend, A. M., Mrugala, M., Rockhill, J. K., Silbergeld, D. L., Lai, A., Cloughesy, T., McKhann, G. M., Bruce, J. N., Rostomily, R. C. & 2 others, Canoll, P. & Swanson, K. R., Oct 28 2014, In : PLoS ONE. 9, 10, e99057.

Research output: Contribution to journalArticle

43 Scopus citations
2013

A rare case of gamma knife-induced smoking cessation in a patient with a vestibular schwannoma

Ramakrishna, R., Rostomily, R. C. & Rockhill, J., Apr 1 2013, In : British Journal of Neurosurgery. 27, 2, p. 251-252 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Seed, soil, and beyond: The basic biology of brain metastasis

Ramakrishna, R. & Rostomily, R., Oct 1 2013, In : Surgical Neurology International. 4, SUPPL4, p. S256-S264

Research output: Contribution to journalArticle

32 Scopus citations
2012

Current surgical outcomes for cranial base chordomas: Cohort study of 95 patients

Di Maio, S., Rostomily, R. C. & Sekhar, L. N., Jun 1 2012, In : Neurosurgery. 70, 6, p. 1355-1360 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy

Mikheev, A. M., Ramakrishna, R., Stoll, E. A., Mikheeva, S. A., Beyer, R. P., Plotnik, D. A., Schwartz, J. L., Rockhill, J. K., Silber, J. R., Born, D. E., Kosai, Y., Horner, P. J. & Rostomily, R. C., Dec 2012, In : Aging Cell. 11, 6, p. 1027-1035 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Radiation associated tumors following therapeutic cranial radiation

Chowdhary, A., Spence, A. M., Sales, L., Rostomily, R. C., Rockhill, J. K. & Silbergeld, D. L., Jan 1 2012, In : Surgical Neurology International. 3, 1, 96068.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism

Stoll, E. A., Cheung, W., Mikheev, A. M., Sweet, I. R., Bielas, J. H., Zhang, J., Rostomily, R. C. & Horner, P. J., Nov 4 2011, In : Journal of Biological Chemistry. 286, 44, p. 38592-38601 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Fast bound pool fraction imaging of the in vivo rat brain: Association with myelin content and validation in the C6 glioma model

Underhill, H. R., Rostomily, R. C., Mikheev, A. M., Yuan, C. & Yarnykh, V. L., Feb 1 2011, In : NeuroImage. 54, 3, p. 2052-2065 14 p.

Research output: Contribution to journalArticle

70 Scopus citations

Glioblastoma: the importance of not being ageist.

Ramakrishna, R., Kim, L. & Rostomily, R. C., Jan 1 2011, In : World neurosurgery. 76, 5, p. 369-370 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

HIF induces human embryonic stem cell markers in cancer cells

Mathieu, J., Zhang, Z., Zhou, W., Wang, A. J., Heddleston, J. M., Pinna, C. M. A., Hubaud, A., Stadler, B., Choi, M., Bar, M., Tewari, M., Liu, A., Vessella, R., Rostomily, R., Born, D., Horwitz, M., Ware, C., Blau, C. A., Cleary, M. A., Rich, J. N. & 1 others, Ruohola-Baker, H., Jul 1 2011, In : Cancer research. 71, 13, p. 4640-4652 13 p.

Research output: Contribution to journalArticle

328 Scopus citations

Increased re-entry into cell cycle mitigates age-related neurogenic decline in the murine subventricular zone

Stoll, E. A., Habibi, B. A., Mikheev, A. M., Lasiene, J., Massey, S. C., Swanson, K. R., Rostomily, R. C. & Horner, P. J., Dec 2011, In : STEM CELLS. 29, 12, p. 2005-2017 13 p.

Research output: Contribution to journalArticle

20 Scopus citations
2010

Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion

Rostomily, R. C., Born, D. E., Beyer, R. P., Jin, J., Alvord, E. C., Mikheev, A. M., Matthews, R. T., Pan, C., Khorasani, L., Sonnen, J. A., Montine, T. J., Shi, M. & Zhang, J., May 7 2010, In : Journal of Proteome Research. 9, 5, p. 2610-2618 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

TWIST1 promotes invasion through mesenchymal change in human glioblastoma

Mikheeva, S. A., Mikheev, A. M., Petit, A., Beyer, R., Oxford, R. G., Khorasani, L., Maxwell, J. P., Glackin, C. A., Wakimoto, H., González-Herrero, I., Sánchez-García, I., Silber, J. R., Horner, P. J. & Rostomily, R. C., Jul 20 2010, In : Molecular Cancer. 9, 194.

Research output: Contribution to journalArticle

169 Scopus citations
2009

A syngeneic glioma model to assess the impact of neural progenitor target cell age on tumor malignancy

Mikheev, A. M., Stoll, E. A., Mikheeva, S. A., Maxwell, J. P., Jankowski, P. P., Ray, S., Uo, T., Morrison, R. S., Horner, P. J. & Rostomily, R. C., 2009, In : Aging Cell. 8, 4, p. 499-501 3 p.

Research output: Contribution to journalArticle

15 Scopus citations

Quantitative analysis of mitotic Olig2 cells in adult human brain and gliomas: Implications for glioma histogenesis and biology

Rhee, W., Ray, S., Yokoo, H., Hoane, M. E., Lee, C. C., Mikheev, A. M., Horner, P. J. & Rostomily, R. C., 2009, In : GLIA. 57, 5, p. 510-523 14 p.

Research output: Contribution to journalArticle

38 Scopus citations
2008

A mathematical modelling tool for predicting survival of individual patients following resection of glioblastoma: A proof of principle

Swanson, K. R., Rostomily, R. C. & Alvord, E. C., Jan 15 2008, In : British Journal of Cancer. 98, 1, p. 113-119 7 p.

Research output: Contribution to journalArticle

151 Scopus citations

Dickkopf-1 mediated tumor suppression in human breast carcinoma cells

Mikheev, A. M., Mikheeva, S. A., Maxwell, J. P., Rivo, J. V., Rostomily, R. C., Swisshelm, K. & Zarbl, H., Nov 1 2008, In : Breast Cancer Research and Treatment. 112, 2, p. 263-273 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Regional hypoxia in glioblastoma multiforme quantified with [ 18F] fluoromisonidazole positron emission tomography before radiotherapy: Correlation with time to progression and survival

Spence, A. M., Muzi, M., Swanson, K. R., O'Sullivan, F., Rockhill, J. K., Rajendran, J. G., Adamsen, T. C. H., Link, J. M., Swanson, P. E., Yagle, K. J., Rostomily, R. C., Silbergeld, D. L. & Krohn, K. A., May 1 2008, In : Clinical Cancer Research. 14, 9, p. 2623-2630 8 p.

Research output: Contribution to journalArticle

202 Scopus citations

Superior semicircular canal dehiscence syndrome: Successful treatment with repair of the middle fossa floor: Technical case report

Peterson, E. C., Lazar, D. A., Nemecek, A. N., Duckert, L. & Rostomily, R., Dec 2008, In : Neurosurgery. 63, 6, p. 1207-1208 2 p.

Research output: Contribution to journalArticle

11 Scopus citations
2007

Dickkopf-1 activates cell death in MDA-MB435 melanoma cells

Mikheev, A. M., Mikheeva, S. A., Rostomily, R. & Zarbl, H., Jan 19 2007, In : Biochemical and Biophysical Research Communications. 352, 3, p. 675-680 6 p.

Research output: Contribution to journalArticle

39 Scopus citations
2006

[F-18]-fluorodeoxyglucose positron emission tomography for targeting radiation dose escalation for patients with glioblastoma multiforme: Clinical outcomes and patterns of failure

Douglas, J. G., Stelzer, K. J., Mankoff, D. A., Tralins, K. S., Krohn, K. A., Muzi, M., Silbergeld, D. L., Rostomily, R. C., Scharnhorst, J. & Spence, A. M., Mar 1 2006, In : International Journal of Radiation Oncology Biology Physics. 64, 3, p. 886-891 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Clinical utility of somatostatin receptor scintigraphic imaging (octreoscan) in esthesioneuroblastoma: A case study and survey of somatostatin receptor subtype expression

Rostomily, R. C., Elias, M., Deng, M., Elias, P., Born, D. E., Muballe, D., Silbergeld, D. L., Futran, N., Weymuller, E. A., Mankoff, D. A. & Eary, J., Apr 2006, In : Head and Neck. 28, 4, p. 305-312 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2005

TWIST is expressed in human gliomas and promotes invasion

Elias, M. C., Tozer, K. R., Silber, J. R., Mikheeva, S., Deng, M., Morrison, R. S., Manning, T. C., Silbergeld, D. L., Glackin, C. A., Reh, T. A. & Rostomily, R. C., Sep 2005, In : Neoplasia. 7, 9, p. 824-837 14 p.

Research output: Contribution to journalArticle

138 Scopus citations
2004

Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy

Bobola, M. S., Emond, M. J., Blank, A., Meade, E. H., Kolstoe, D. D., Berger, M. S., Rostomily, R. C., Silbergeld, D. L., Spence, A. M. & Silber, J. R., Dec 1 2004, In : Clinical Cancer Research. 10, 23, p. 7875-7883 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Intramedullary tuberculoma mimicking primary CNS lymphoma

Mohit, A. A., Santiago, P. & Rostomily, R., Nov 2004, In : Journal of Neurology, Neurosurgery and Psychiatry. 75, 11, p. 1636-1638 3 p.

Research output: Contribution to journalArticle

22 Scopus citations

On-line flow cytometry for real-time surgical guidance

Mesiwala, A. H., Scampavia, L. D., Rabinovitch, P. S., Ruzicka, J. & Rostomily, R. C., Sep 1 2004, In : Neurosurgery. 55, 3, p. 551-559 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Phase II study of concurrent continuous temozolomide (TMZ) and tamoxifen (TMX) for recurrent malignant astrocytic gliomas

Spence, A. M., Peterson, R. A., Scharnhorst, J. D., Silbergeld, D. L. & Rostomily, R. C., Oct 1 2004, In : Journal of Neuro-Oncology. 70, 1, p. 91-95 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Temporomandibular joint-preserving preauricular subtemporal-infratemporal fossa approach: Surgical technique and clinical application

Vilela, M. D. & Rostomily, R. C., Jul 2004, In : Neurosurgery. 55, 1, p. 143-153 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2002

Delayed facial palsy after resection of vestibular schwannoma

Grant, G. A., Rostomily, R. C., Kim, D. K., Mayberg, M. R., Farrell, D., Avellino, A., Duckert, L. G., Gates, G. A. & Winn, H. R., Jan 1 2002, In : Journal of Neurosurgery. 97, 1, p. 93-96 4 p.

Research output: Contribution to journalArticle

43 Scopus citations
2001

Permanent low-activity125I seed placement for the treatment of pediatric brain tumors: Preliminary experience

Rostomily, R. C., Halligan, J., Geyer, R., Stelzer, K., Lindsley, K. & Berger, M. S., Apr 1 2001, In : Pediatric Neurosurgery. 34, 4, p. 198-205 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Posterior fossa ependymoma

Grady, M. S., Judy, K. D., Bigelow, D. C., Sinson, G. P., Rostomily, R. & Winn, H. R., 2001, In : Skull Base. 11, 3, p. 219-223 5 p.

Research output: Contribution to journalArticle