Personal profile

Dr. Krencik received his PhD in neuroscience at the University of Wisconsin-Madison under the supervision of Dr. Su-Chun Zhang. During this time, he devised the first cellular system for the efficient generation of human glial progenitors and astrocyte subtypes from pluripotent stem cells and characterized their functionality. This system has been experimentally utilized for cellular replacement therapy to promote learning and memory and to improve the maturity of neuronal subtypes. Furthermore, this powerful approach has become the high standard in research laboratories throughout the world to study various aspects of human disease. To understand how human astrocytes respond and signal to neurons in the context of neurodevelopmental disorders, Dr. Krencik conducted research as a postdoctoral fellow at the University of California-San Francisco under the mentorship of Dr. Erik Ullian and co-mentorship of Dr. David Rowitch. These studies led to several novel and important discoveries including the identification of a possible mechanism for astrocytes in controlling the timing of synaptic plasticity. More recently, he has been optimizing three dimensional in vitro cocultures of the human nervous system as an improved disease model and platform for neuroregeneration. His research goals and schemes have been summarized in numerous review articles and he enjoys interacting with the scientific community at conferences and through collaborative research projects. 

Research interests

The Krencik lab is specifically focused on understanding the functional relationship of human neurons and astrocytes in normal and injured states. We employ novel three-dimensional human pluripotent stem cell-based culture techniques, optogenetic methods, electrophysiology, transplantations and molecular/biochemical approaches to answer vital questions and accelerate progress in neuroregeneration including cellular engraftment therapy and drug discovery. In addition, we work with the Neurosurgery Department and other institutions at the Texas Medical Center with the goal of translating innovative neuroscience research discoveries into clinical therapies for restoration of the nervous system after injury and disease.

Keywords

    Research Area Keywords

  • Neurosciences
  • Regenerative Medicine

    Free-text keywords

  • Neuroregeneration, Neuroscience, Spinal cord, Spinal cord Injury, Stem cells, Neural stem cells, Astrocytes, Neuron-Glia interactions, Physiology, Disease modeling, Translational medicine

Fingerprint

Astrocytes
Concept: Astrocytes
Weight: 100%
Domain: Medicine & Life Sciences
Pluripotent Stem Cells
Concept: Pluripotent Stem Cells
Weight: 73%
Domain: Medicine & Life Sciences
Stem cells
Concept: Stem cells
Weight: 49%
Domain: Chemical Compounds
Neurons
Concept: Neurons
Weight: 28%
Domain: Medicine & Life Sciences
Induced Pluripotent Stem Cells
Concept: Induced Pluripotent Stem Cells
Weight: 20%
Domain: Medicine & Life Sciences
Stem Cells
Concept: Stem Cells
Weight: 17%
Domain: Medicine & Life Sciences
Coculture Techniques
Concept: Coculture Techniques
Weight: 17%
Domain: Medicine & Life Sciences
Cholinergic Neurons
Concept: Cholinergic Neurons
Weight: 16%
Domain: Medicine & Life Sciences
Brain
Concept: Brain
Weight: 14%
Domain: Medicine & Life Sciences
Costello Syndrome
Concept: Costello Syndrome
Weight: 13%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Robert C. Krencik is tagged with the concept

Journals

The Journal of biological chemistry

ISSNs: 0021-9258

American Society for Biochemistry and Molecular Biology Inc.

Journal

2

Nature Biotechnology

ISSNs: 1087-0156

Nature Publishing Group

Journal

2

Cell Reports

Additional searchable ISSN (Electronic): 2211-1247

Cell Press

Journal

1

Journal of visualized experiments : JoVE

ISSNs: 1940-087X

Additional searchable ISSN (Electronic): 1940-087X

MYJoVE Corporation

Journal

1

Brain Research Bulletin

ISSNs: 0361-9230

Additional searchable ISSN (Electronic): 1873-2747

Elsevier

Journal

1
has published Research OutputsResearch Output by Robert C. Krencik

Research Network

Visualization: Institutional Network

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Robert C. Krencik

Visualization: Co-author Network

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Robert C. Krencik

Shared Pub. External Organizations

University of California at San Francisco

External organization: Academic

2

Waisman Center, University of Wisconsin, Madison, WI, USA.

External organization: Unknown

2

Department of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143, USA.

External organization: Unknown

2

Department of Pediatrics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, California 94143, USA.

External organization: Unknown

2

Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin, USA.

External organization: Unknown

2
has Research OutputsResearch Output by Robert C. Krencik

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Robert C. Krencik

Shared Pub. External co-authors

Erik M Ullian

External person

5

Yan Liu

External person

4

Su Chun Zhang

External person

4

Erik M. Ullian

External person

3

Zhuang-Yin Qu

External person

2
has co-authored Research OutputsResearch Output with Robert C. Krencik

ID: 29603732