Personal profile

After completing his fellowship in hematopathology, Dr. Olsen became an Instructor in Houston Methodist Research Institute. He was recently awarded a Fellow-to-Faculty transition award from the American Heart Association to investigate virulence genetics in group A Streptococcus. The study will focus on why certain strains are more capable of causing necrotizing fasciitis, or the devastating “flesh eating” disease. He is a member of several professional societies.

Research interests

The research in Dr. Olsen’s laboratory is focused on studying the molecular pathogenesis of invasive group A Streptococcus (GAS) infections such as necrotizing fasciitis (NF, also termed the “flesh eating infection”). During the past several years, there have been marked advances in the study of GAS genetics and epidemiology, but overall knowledge of the key molecular pathways and host-pathogen interactions mediating GAS virulence in invasive deep soft tissue infections remains largely incomplete. Previous studies in the Musser laboratory suggest that the metal transporter of the Streptococcus regulator (mtsR) regulatory gene and/or the genes under its control (the “mtsR Axis”) may play an important role in GAS NF. Dr. Olsen’s laboratory uses an integrated molecular approach to study the “mtsR Axis” in GAS NF. Affymetrix GAS gene expression microarray analysis, Luminex-based human serum protein profiling, tissue microarray examination, flow cytometric analysis, in vivo molecular imaging, quantitative microbial culture, and in vitro immunologic assays will be used for the detailed study of specimens derived from preclinical models and human patients. The long-term goal is to leverage knowledge gained to aid the development of new diagnostic tools, vaccine strategies, and therapeutic agents that will significantly improve patient care.

Keywords

    Free-text keywords

  • Group A Streptococcus, Necrotizing fasciitis, Invasive infection, Pathogen-host interactions, Microbial virulence

Fingerprint

Streptococcus
Concept: Streptococcus
Weight: 100%
Domain: Medicine & Life Sciences
Virulence
Concept: Virulence
Weight: 66%
Domain: Medicine & Life Sciences
Streptococcus pyogenes
Concept: Streptococcus pyogenes
Weight: 54%
Domain: Medicine & Life Sciences
Genome
Concept: Genome
Weight: 43%
Domain: Medicine & Life Sciences
Infection
Concept: Infection
Weight: 34%
Domain: Medicine & Life Sciences
Necrotizing Fasciitis
Concept: Necrotizing Fasciitis
Weight: 27%
Domain: Medicine & Life Sciences
Genes
Concept: Genes
Weight: 23%
Domain: Medicine & Life Sciences
Mutation
Concept: Mutation
Weight: 22%
Domain: Medicine & Life Sciences
Methicillin-Resistant Staphylococcus aureus
Concept: Methicillin-Resistant Staphylococcus aureus
Weight: 17%
Domain: Medicine & Life Sciences
Staphylococcus aureus
Concept: Staphylococcus aureus
Weight: 16%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Randall J. Olsen is tagged with the concept

Journals

Archives of Pathology and Laboratory Medicine

ISSNs: 0003-9985, 1543-2165, 0363-0153

Additional searchable ISSN (Electronic): 1543-2165

College of American Pathologists

Journal

18

Infection and Immunity

ISSNs: 0019-9567

American Society for Microbiology

Journal

13

Journal of Clinical Microbiology

ISSNs: 0095-1137

Additional searchable ISSN (Electronic): 1098-660X

American Society for Microbiology

Journal

6

mBio

ISSNs: 2161-2129

Additional searchable ISSN (Electronic): 2150-7511

American Society for Microbiology

Journal

5

American Journal of Pathology

ISSNs: 0002-9440

Elsevier

Journal

4
has published Research OutputsResearch Output by Randall J. Olsen

Research Network

Visualization: Institutional Network

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Randall J. Olsen

Visualization: Co-author Network

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Randall J. Olsen

Shared Pub. Internal Organizations

Department of Medicine

Organizational unit: Departments

7

Department of Pharmacy

Organizational unit: Departments

6

Department of Surgery

Organizational unit: Departments

3

J.C. Walter Jr. Transplant Center

Organizational unit: Centers of Excellence

2

Neurological Institute

Organizational unit: Centers of Excellence

1
has Research OutputsResearch Output by Randall J. Olsen

Shared Pub. External Organizations

Houston Methodist Research Institute

External organization: Unknown

59

Baylor College of Medicine

External organization: Unknown

22

University of Texas M. D. Anderson Cancer Center

External organization: Unknown

11

Houston Methodist Hospital

External organization: Medical

10

Weill Medical College of Cornell University

External organization: Unknown

7
has Research OutputsResearch Output by Randall J. Olsen

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Randall J. Olsen

Shared Pub. External co-authors

Concepcion C. Cantu

External person

17

Anthony R. Flores

External person

15

Nishanth Makthal

External person

13

Patricia Cernoch

External person

11

Luchang Zhu

External person

11
has co-authored Research OutputsResearch Output with Randall J. Olsen

ID: 2283089