• 3260 Citations
  • 31 h-Index
19952020

Research output per year

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Personal profile

Personal profile

Dr. El-Zein earned her Medical Degree followed by a Masters in Human Genetics from the University of Alexandria. She then completed her Doctoral degree in Human Biological Chemistry and Genetics at the University of Texas Medical Branch with a focus on cancer genetics. In 1997, she joined the University of Texas MD Anderson Cancer Center as a postdoctoral fellow and rose through the ranks to Associate Professor in the Department of Epidemiology. In 2015, Dr. El-Zein joined Houston Methodist as a Professor in the Department of Radiology and a full member of the Research Institute.

Dr. El-Zein is an active member of the national and international scientific community. She serves/served as a reviewer for the National Institute of Health, National Lung, Heart and Blood Institute and the American Cancer Society. Internationally, she is a grant reviewer for the Italian Ministry of Health. Dr. El-Zein also serves as a peer reviewer for several high impact journals.

Research interests

Dr. El-Zein’s research focus is on understanding the role of gene-environment interactions in the risk of cancer development. She has developed expertise in the area of biomarkers and genetic susceptibility to disease. She has applied unique markers to identify several inherited genetic traits that influence human sensitivity to different cancers such as lung, breast and lymphomas. Dr. El-Zein’s laboratory has a translational research approach, and is currently studying human populations using quantitative imaging coupled with molecular biomarkers to identify unique signatures that would improve the power of cancer risk assessment models. The results from these studies are providing new information that has significant and practical public health implications in the area of early detection and primary prevention of disease. The overall goal is to develop novel approaches to identify susceptible individuals at high risk of developing lung and breast cancers. New knowledge generated from these research endeavors are geared to fulfill the need for rapid and efficient translation of emerging new technologies and approaches for improved patient management, early detection and prevention.Dr. El-Zein’s research focus is on understanding the role of gene-environment interactions in the risk of cancer development. She has developed expertise in the area of genotypic and phenotypic biomarkers and genetic susceptibility to disease. She has applied these unique markers to identify several inherited genetic traits that influence human sensitivity to different cancers such as lung, breast and lymphomas. Dr. El-Zein’s laboratory has a translational research approach, and is currently studying human populations using quantitative imaging coupled with molecular biomarkers to identify unique signatures that would improve the power of cancer risk assessment models. The results from these studies are providing new information that has significant and practical public health implications in the area of early detection and primary prevention of disease. The overall goal is to develop novel approaches to identify susceptible individuals at high risk of developing lung and breast cancers. New knowledge generated from these research endeavors are geared to fulfill the need for rapid and efficient translation of emerging new technologies and approaches for improved patient management, early detection and prevention.

Education/Academic qualification

MBBCh, Alexandria University

MS, Alexandria University

Postdoctoral Fellowship, The University of Texas MD Anderson Cancer Center

PhD, The University of Texas Medical Branch

External positions

Adjunct Professor, The University of Texas MD Anderson Cancer Center

Sep 1 2016 → …

Adjunct Associate Professor of Epidemiology, University of Texas School of Public Helath

Sep 1 2009 → …

Research Area Keywords

  • Cancer
  • Precision Medicine
  • Imaging & Radiology

Free-text keywords

  • Lung cancer
  • Breast cancer
  • Genetic instability
  • Genetic susceptibility

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Projects

Research Output

Identification of circulating tumor cells using 4-color fluorescence in situ hybridization: Validation of a noninvasive aid for ruling out lung cancer in patients with low-dose computed tomography–detected lung nodules

Katz, R. L., Zaidi, T. M., Pujara, D., Shanbhag, N. D., Truong, D., Patil, S., Mehran, R. J., El-Zein, R. A., Shete, S. S. & Kuban, J. D., Aug 1 2020, In : Cancer cytopathology. 128, 8, p. 553-562 10 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Micronuclei and disease – Report of HUMN project workshop at Rennes 2019 EEMGS conference

    Fenech, M., Holland, N., Kirsch-Volders, M., Knudsen, L. E., Wagner, K. H., Stopper, H., Knasmueller, S., Bolognesi, C., El-Zein, R. & Bonassi, S., Feb 1 2020, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 850-851, 503133.

    Research output: Contribution to journalShort survey

  • 1 Scopus citations

    Driver mutations in normal airway epithelium elucidate spatiotemporal resolution of lung cancer

    Kadara, H., Sivakumar, S., Jakubek, Y., Anthony San Lucas, F., Lang, W., McDowell, T., Weber, Z., Behrens, C., Davies, G. E., Kalhor, N., Moran, C., El-Zein, R., Mehran, R., Swisher, S. G., Wang, J., Zhang, J., Fujimoto, J., Fowler, J., Heymach, J. V., Dubinett, S. & 4 others, Spira, A. E., Ehli, E. A., Wistuba, I. I. & Scheet, P., Sep 15 2019, In : American journal of respiratory and critical care medicine. 200, 6, p. 742-750 9 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Temporal mammographic registration for evaluation of architecture changes in cancer risk assessment

    Mendel, K., Li, H., Tayob, N., El-Zein, R., Bedrosian, I. & Giger, M., Jan 1 2019, Medical Imaging 2019: Computer-Aided Diagnosis. Mori, K. & Hahn, H. K. (eds.). SPIE, Vol. 10950. 1095041

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  • Prizes

    Aging Center Award

    El-Zein, Randa (Recipient), 1997

    Prize: Prize (including medals and awards)

    Business and Professional Women Award

    El-Zein, Randa (Recipient), 2008

    Prize: Prize (including medals and awards)

    Grant Writing Award

    El-Zein, Randa (Recipient), 1999

    Prize: Prize (including medals and awards)

    New Investigators Award

    El-Zein, Randa (Recipient), 1999

    Prize: Prize (including medals and awards)

    President's Award for Research Excellence

    El-Zein, Randa (Recipient), 2015

    Prize: Prize (including medals and awards)