• 2567 Citations
  • 30 h-Index
20042020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

3,4-Dihydroxybenzalacetone (DBL) Prevents Aging-Induced Myocardial Changes in Senescence-Accelerated Mouse-Prone 8 (SAMP8) Mice

Giridharan, V. V., Karupppagounder, V., Arumugam, S., Nakamura, Y., Guha, A., Barichello, T., Quevedo, J., Watanabe, K., Konishi, T. & Thandavarayan, R. A., Mar 3 2020, In : Cells. 9, 3

Research output: Contribution to journalArticle

Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice

Pitchaimani, V., Arumugam, S., Thandavarayan, R. A., Karuppagounder, V., Afrin, M. R., Sreedhar, R., Harima, M., Nakamura, M., Watanabe, K., Kodama, S., Fujihara, K. & Sone, H., Jul 2020, In : Neurochemistry International. 137, 104745.

Research output: Contribution to journalArticle

Single-cell RNA sequencing analysis of SARS-CoV-2 entry receptors in human organoids

Mahalingam, R., Dharmalingam, P., Santhanam, A., Kotla, S., Davuluri, G., Karmouty-Quintana, H., Ashrith, G. & Thandavarayan, R. A., 2020, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Open Access
2019

Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema

Collum, S. D., Molina, J. G., Hanmandlu, A., Bi, W., Pedroza, M., Mertens, T. C. J., Wareing, N., Wei, W., Wilson, C., Sun, W., Rajadas, J., Bollyky, P. L., Philip, K. M., Ren, D., Amirthalingam Thandavarayan, R., Bruckner, B. A., Xia, Y., Blackburn, M. R. & Karmouty-Quintana, H., May 15 2019, In : DMM Disease Models and Mechanisms. 12, 5, dmm038711.

Research output: Contribution to journalArticle

3 Scopus citations

Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation

Weng, T., Ko, J., Masamha, C. P., Xia, Z., Xiang, Y., Chen, N. Y., Molina, J. G., Collum, S., Mertens, T. C., Luo, F., Philip, K., Davies, J., Huang, J., Wilson, C., Thandavarayan, R. A., Bruckner, B. A., Jyothula, S. S. K., Volcik, K. A., Li, L., Han, L. & 5 others, Li, W., Assassi, S., Karmouty-Quintana, H., Wagner, E. J. & Blackburn, M. R., May 1 2019, In : Journal of Clinical Investigation. 129, 5, p. 1984-1999 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dysfunction of iPSC-derived endothelial cells in human Hutchinson–Gilford progeria syndrome

Matrone, G., Thandavarayan, R. A., Walther, B. K., Meng, S., Mojiri, A. & Cooke, J. P., Oct 2 2019, In : Cell Cycle. 18, 19, p. 2495-2508 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

Karuppagounder, V., Bajpai, A., Meng, S., Arumugam, S., Sreedhar, R., Giridharan, V. V., Guha, A., Bhimaraj, A., Youker, K. A., Palaniyandi, S. S., Karmouty-Quintana, H., Kamal, F., Spiller, K. L., Watanabe, K. & Thandavarayan, R. A., Jul 2018, In : PLoS ONE. 13, 7, e0200697.

Research output: Contribution to journalArticle

2 Scopus citations

Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 22) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography

Pan, G., Munukutla, S., Kar, A., Gardinier, J., Thandavarayan, R. A. & Palaniyandi, S. S., Apr 2018, In : PLoS ONE. 13, 4, e0195796.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy

Watanabe, K., Sreedhar, R., Thandavarayan, R. A., Karuppagounder, V., Giridharan, V. V., Antony, S., Harima, M., Nakamura, M., Suzuki, K., Suzuki, H., Sone, H. & Arumugam, S., Mar 1 2017, In : BioFactors. 43, 2, p. 187-194 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Lipid-polymer hybrid nanoparticle-mediated therapeutics delivery: Advances and challenges

Bose, R. J. C., Ravikumar, R., Karuppagounder, V., Bennet, D., Rangasamy, S. & Amirthalingam Thandavarayan, R., 2017, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

28 Scopus citations

Preparation and characterization of PLGA loaded nanoparticles obtained from D. Melanoxylon Roxb. Leaves for their antiproliferative and antidiabetic activity

Al Rashid, M. H., Bharadwaj, P. V. P. D., Mandal, V., Pal, M., Mandal, S. C. & Thandavarayan, R. A., Jul 1 2017, In : International Journal of Green Pharmacy. 11, 3, p. S438-S447

Research output: Contribution to journalArticle

4 Scopus citations
2016

Alcohol Toxicity in Diabetes and Its Complications: A Double Trouble?

Munukutla, S., Pan, G., Deshpande, M., Thandavarayan, R. A., Krishnamurthy, P. & Palaniyandi, S. S., 2016, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

13 Scopus citations

ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes

Pan, G., Deshpande, M., Thandavarayan, R. A. & Palaniyandi, S. S., 2016, In : Journal of Diabetes Research. 2016, 1390861.

Research output: Contribution to journalArticle

6 Scopus citations

Cardiac mitochondrial respiratory dysfunction and tissue damage in chronic hyperglycemia correlate with reduced aldehyde dehydrogenase-2 activity

Mali, V. R., Pan, G., Deshpande, M., Thandavarayan, R. A., Xu, J., Yang, X. P. & Palaniyandi, S. S., Oct 2016, In : PLoS ONE. 11, 10, e0163158.

Research output: Contribution to journalArticle

13 Scopus citations

Curcumin alleviates renal dysfunction and suppresses inflammation by shifting from M1 to M2 macrophage polarization in daunorubicin induced nephrotoxicity in rats

Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Sreedhar, R., Giridharan, V. V., Afrin, R., Harima, M., Miyashita, S., Hara, M., Suzuki, K., Nakamura, M., Ueno, K. & Watanabe, K., Aug 1 2016, In : Cytokine. 84, p. 1-9 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Fasting time duration modulates the onset of insulin-induced hypoglycemic seizures in mice

Pitchaimani, V., Arumugam, S., Thandavarayan, R. A., Karuppagounder, V., Afrin, M. R., Sreedhar, R., Harima, M., Suzuki, H., Miyashita, S., Nakamura, T., Suzuki, K., Nakamura, M., Ueno, K. & Watanabe, K., Sep 1 2016, In : Epilepsy Research. 125, p. 47-51 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hypothalamic glucagon signaling in fasting hypoglycemia

Pitchaimani, V., Arumugam, S., Thandavarayan, R. A., Karuppagounder, V., Afrin, M. R., Sreedhar, R., Harima, M., Suzuki, H., Miyashita, S., Suzuki, K., Nakamura, M., Ueno, K. & Watanabe, K., May 15 2016, In : Life sciences. 153, p. 118-123 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Impaired ALDH2 activity decreases the mitochondrial respiration in H9C2 cardiomyocytes

Mali, V. R., Deshpande, M., Pan, G., Amirthalingam Thandavarayan, R. & Palaniyandi, S. S., Feb 1 2016, In : Cellular Signalling. 28, 2, p. 1-6 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Increased 4-hydroxy-2-nonenal-induced proteasome dysfunction is correlated with cardiac damage in streptozotocin-injected rats with isoproterenol infusion

Deshpande, M., Mali, V. R., Pan, G., Xu, J., Yang, X. P., Amirthalingam Thandavarayan, R. & Palaniyandi, S. S., Jul 1 2016, In : Cell Biochemistry and Function. 34, 5, p. 334-342 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes

Suresh Babu, S., Amirthalingam Thandavarayan, R., Joladarashi, D., Jeyabal, P., Krishnamurthy, S., Bhimaraj, A., Youker, K. A. & Krishnamurthy, P., Nov 9 2016, In : Scientific Reports. 6, 36207.

Research output: Contribution to journalArticle

16 Scopus citations

MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1

Jeyabal, P., Thandavarayan, R. A., Joladarashi, D., Suresh Babu, S., Krishnamurthy, S., Bhimaraj, A., Youker, K. A., Kishore, R. & Krishnamurthy, P., Mar 18 2016, In : Biochemical and Biophysical Research Communications. 471, 4, p. 423-429 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice

Karuppagounder, V., Giridharan, V. V., Arumugam, S., Sreedhar, R., Palaniyandi, S. S., Krishnamurthy, P., Quevedo, J., Watanabe, K., Konishi, T. & Thandavarayan, R. A., Apr 2016, In : PLoS ONE. 11, 4, e0152922.

Research output: Contribution to journalArticle

25 Scopus citations

Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice

Sreedhar, R., Giridharan, V. V., Arumugam, S., Karuppagounder, V., Palaniyandi, S. S., Krishnamurthy, P., Quevedo, J., Watanabe, K., Konishi, T. & Thandavarayan, R. A., Jul 1 2016, In : BioFactors. 42, 4, p. 368-375 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015
4 Scopus citations

Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic rats

Afrin, R., Arumugam, S., Soetikno, V., Thandavarayan, R. A., Pitchaimani, V., Karuppagounder, V., Sreedhar, R., Harima, M., Suzuki, H., Miyashita, S., Nomoto, M., Suzuki, K. & Watanabe, K., Mar 1 2015, In : Free Radical Research. 49, 3, p. 279-289 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Jumihaidokuto effectively inhibits colon inflammation and apoptosis in mice with acute colitis

Sreedhar, R., Arumugam, S., Karuppagounder, V., Thandavarayan, R. A., Giridharan, V. V., Pitchaimani, V., Afrin, M. R., Harima, M., Nakamura, T., Nakamura, M., Suzuki, K. & Watanabe, K., Dec 1 2015, In : International Immunopharmacology. 29, 2, p. 957-963 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Modulation of HMGB1 translocation and RAGE/NFκB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice

Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Pitchaimani, V., Sreedhar, R., Afrin, R., Harima, M., Suzuki, H., Nomoto, M., Miyashita, S., Suzuki, K., Nakamura, M. & Watanabe, K., Jun 1 2015, In : Experimental Dermatology. 24, 6, p. 418-423 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Myocardial 14-3-3η protein protects against mitochondria mediated apoptosis

Sreedhar, R., Arumugam, S., Thandavarayan, R. A., Giridharan, V. V., Karuppagounder, V., Pitchaimani, V., Afrin, R., Miyashita, S., Nomoto, M., Harima, M., Gurusamy, N., Suzuki, K. & Watanabe, K., Apr 1 2015, In : Cellular Signalling. 27, 4, p. 770-776 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2-NFκB p65 mediated inflammation

Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Pitchaimani, V., Sreedhar, R., Afrin, R., Harima, M., Suzuki, H., Suzuki, K., Nakamura, M., Ueno, K. & Watanabe, K., Jun 12 2015, In : International Immunopharmacology. 28, 1, p. 154-159 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Pruni cortex ameliorates skin inflammation possibly through HMGB1-NFκB pathway in house dust mite induced atopic dermatitis NC/Nga transgenic mice

Watanabe, K., Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Pitchaimani, V., Sreedhar, R., Afrin, R., Harima, M., Suzuki, H., Suzuki, K., Nakamura, T., Nomoto, M., Miyashita, S., Fukumoto, K. & Ueno, K., May 1 2015, In : Journal of Clinical Biochemistry and Nutrition. 56, 3, p. 186-194 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Schisandrin b prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of mapk/p53 signaling

Thandavarayan, R. A., Giridharan, V. V., Arumugam, S., Suzuki, K., Ko, K. M., Krishnamurthy, P., Watanabe, K. & Konishi, T., Mar 5 2015, In : PLoS ONE. 10, 3, e0119214.

Research output: Contribution to journalArticle

65 Scopus citations

Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing

Thandavarayan, R. A., Garikipati, V. N. S., Joladarashi, D., Suresh Babu, S., Jeyabal, P., Verma, S. K., Mackie, A. R., Khan, M., Arumugam, S., Watanabe, K., Kishore, R. & Krishnamurthy, P., Oct 1 2015, In : Experimental Dermatology. 24, 10, p. 773-778 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Small interfering RNA therapy against carbohydrate sulfotransferase 15 inhibits cardiac remodeling in rats with dilated cardiomyopathy

Watanabe, K., Arumugam, S., Sreedhar, R., Thandavarayan, R. A., Nakamura, T., Nakamura, M., Harima, M., Yoneyama, H. & Suzuki, K., Jul 1 2015, In : Cellular Signalling. 27, 7, p. 1517-1524 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression

Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Pitchaimani, V., Sreedhar, R., Afrin, R., Harima, M., Suzuki, H., Nomoto, M., Miyashita, S., Suzuki, K., Nakamura, M., Ueno, K. & Watanabe, K., Dec 1 2015, In : Cytokine. 76, 2, p. 206-213 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Telmisartan treatment targets inflammatory cytokines to suppress the pathogenesis of acute colitis induced by dextran sulphate sodium

Arumugam, S., Sreedhar, R., Thandavarayan, R. A., Giridharan, V. V., Karuppagounder, V., Pitchaimani, V., Afrin, M. R., Miyashita, S., Nomoto, M., Harima, M., Suzuki, H., Nakamura, T., Nakamura, M., Suzuki, K. & Watanabe, K., Dec 3 2015, In : Cytokine. 74, 2, p. 305-312 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Toki-shakuyaku-san, a Japanese kampo medicine, reduces colon inflammation in a mouse model of acute colitis

Sreedhar, R., Arumugam, S., Thandavarayan, R. A., Giridharan, V. V., Karuppagounder, V., Pitchaimani, V., Afrin, R., Harima, M., Nakamura, T., Ueno, K., Nakamura, M., Suzuki, K. & Watanabe, K., Dec 1 2015, In : International Immunopharmacology. 29, 2, p. 869-875 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Comparative evaluation of torasemide and furosemide on rats with streptozotocin-induced diabetic nephropathy

Arumugam, S., Sreedhar, R., Miyashita, S., Karuppagounder, V., Thandavarayan, R. A., Giridharan, V. V., Pitchaimani, V., Afrin, R., Harima, M., Suzuki, K. & Watanabe, K., Aug 2014, In : Experimental and Molecular Pathology. 97, 1, p. 137-143 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Fasting mediated increase in p-BADser155 and p-AKTser473 in the prefrontal cortex of mice

Pitchaimani, V., Arumugam, S., Thandavarayan, R. A., Karuppagounder, V., Sreedhar, R., Afrin, R., Harima, M., Suzuki, H., Miyashita, S., Nomoto, M., Sone, H., Suzuki, K. & Watanabe, K., Sep 5 2014, In : Neuroscience Letters. 579, p. 134-139 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Olmesartan protects against oxidative stress possibly through the Nrf2 signaling pathway and inhibits inflammation in daunorubicin-induced nephrotoxicity in rats

Gounder, V. K., Arumugam, S., Arozal, W., Thandavarayan, R. A., Pitchaimani, V., Harima, M., Suzuki, K., Nomoto, M. & Watanabe, K., Feb 2014, In : International Immunopharmacology. 18, 2, p. 282-289 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Prevention of DSS induced acute colitis by Petit Vert, a newly developed function improved vegetable, in mice

Thandavarayan, R. A., Pitchaimani, V., Karuppagounder, V., Harima, M., Nishizawa, Y., Sasaki, K., Suzuki, K., Konishi, T. & Watanabe, K., Jul 2014, In : PharmaNutrition. 2, 3, p. 129-134 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice

Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Pitchaimani, V., Sreedhar, R., Afrin, R., Harima, M., Suzuki, H., Nomoto, M., Miyashita, S., Suzuki, K. & Watanabe, K., Dec 2014, In : International Immunopharmacology. 23, 2, p. 617-623 7 p.

Research output: Contribution to journalArticle

41 Scopus citations
2013

Mulberry leaf diet protects against progression of experimental autoimmune myocarditis to dilated cardiomyopathy via modulation of oxidative stress and MAPK-mediated apoptosis

Arumugam, S., Mito, S., Thandavarayan, R. A., Giridharan, V. V., Pitchaimani, V., Karuppagounder, V., Harima, M., Nomoto, M., Suzuki, K. & Watanabe, K., Dec 2013, In : Cardiovascular Therapeutics. 31, 6, p. 352-362 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2012

Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy

Arumugam, S., Thandavarayan, R. A., Veeraveedu, P. T., Nakamura, T., Arozal, W., Sari, F. R., Giridharan, V. V., Soetikno, V., Palaniyandi, S. S., Harima, M., Suzuki, K., Nagata, M., Kodama, M. & Watanabe, K., Sep 2012, In : Journal of Cellular and Molecular Medicine. 16, 9, p. 2176-2185 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: Involvement of ACE2-Ang (1-7)-mas axis

Arumugam, S., Thandavarayan, R. A., Palaniyandi, S. S., Giridharan, V. V., Arozal, W., Sari, F. R., Soetikno, V., Harima, M., Suzuki, K., Kodama, M. & Watanabe, K., Jan 27 2012, In : Toxicology. 291, 1-3, p. 139-145 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: Possible involvement of PKC-MAPK signaling pathway

Soetikno, V., Sari, F. R., Sukumaran, V., Lakshmanan, A. P., Mito, S., Harima, M., Thandavarayan, R. A., Suzuki, K., Nagata, M., Takagi, R. & Watanabe, K., Oct 9 2012, In : European Journal of Pharmaceutical Sciences. 47, 3, p. 604-614 11 p.

Research output: Contribution to journalArticle

100 Scopus citations

Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant

Arumugam, S., Thandavarayan, R. A., Veeraveedu, P. T., Giridharan, V. V., Soetikno, V., Harima, M., Suzuki, K., Nagata, M., Tagaki, R., Kodama, M. & Watanabe, K., Oct 2012, In : Experimental and Molecular Pathology. 93, 2, p. 183-189 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Irsogladine maleate ameliorates infl ammation and fi brosis in mice with chronic colitis induced by dextran sulfate sodium

Yamaguchi, H., Suzuki, K., Nagata, M., Kawase, T., Sukumaran, V., Thandavarayan, R. A., Kawauchi, Y., Yokoyama, J., Tomita, M., Kawachi, H., Watanabe, K., Yoneyama, H., Asakura, H. & Takagi, R., Jun 2012, In : Medical Molecular Morphology. 45, 3, p. 140-151 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats

Lakshmanan, A. P., Harima, M., Sukumaran, V., Soetikno, V., Thandavarayan, R. A., Suzuki, K., Kodama, M., Nagata, M., Takagi, R. & Watanabe, K., Mar 1 2012, In : Biochemical pharmacology. 83, 5, p. 653-660 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Modulation of AT-1R/MAPK cascade by an olmesartan treatment attenuates diabetic nephropathy in streptozotocin-induced diabetic mice

Lakshmanan, A. P., Thandavarayan, R. A., Watanabe, K., Sari, F. R., Meilei, H., Giridharan, V. V., Sukumaran, V., Soetikno, V., Arumugam, S., Suzuki, K. & Kodama, M., Jan 2 2012, In : Molecular and cellular endocrinology. 348, 1, p. 104-111 8 p.

Research output: Contribution to journalArticle

30 Scopus citations