• 2567 Citations
  • 30 h-Index
20042020

Research output per year

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Research Output

2020

3,4-Dihydroxybenzalacetone (DBL) Prevents Aging-Induced Myocardial Changes in Senescence-Accelerated Mouse-Prone 8 (SAMP8) Mice

Giridharan, V. V., Karupppagounder, V., Arumugam, S., Nakamura, Y., Guha, A., Barichello, T., Quevedo, J., Watanabe, K., Konishi, T. & Thandavarayan, R. A., Mar 3 2020, In : Cells. 9, 3

Research output: Contribution to journalArticle

Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice

Pitchaimani, V., Arumugam, S., Thandavarayan, R. A., Karuppagounder, V., Afrin, M. R., Sreedhar, R., Harima, M., Nakamura, M., Watanabe, K., Kodama, S., Fujihara, K. & Sone, H., Jul 2020, In : Neurochemistry International. 137, 104745.

Research output: Contribution to journalArticle

Pathophysiology of Acute and Chronic Right Heart Failure

Thandavarayan, R. A., Chitturi, K. R. & Guha, A., May 2020, In : Cardiology Clinics. 38, 2, p. 149-160 12 p.

Research output: Contribution to journalReview article

Single-cell RNA sequencing analysis of SARS-CoV-2 entry receptors in human organoids

Mahalingam, R., Dharmalingam, P., Santhanam, A., Kotla, S., Davuluri, G., Karmouty-Quintana, H., Ashrith, G. & Thandavarayan, R. A., 2020, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Open Access
2019

Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema

Collum, S. D., Molina, J. G., Hanmandlu, A., Bi, W., Pedroza, M., Mertens, T. C. J., Wareing, N., Wei, W., Wilson, C., Sun, W., Rajadas, J., Bollyky, P. L., Philip, K. M., Ren, D., Amirthalingam Thandavarayan, R., Bruckner, B. A., Xia, Y., Blackburn, M. R. & Karmouty-Quintana, H., May 15 2019, In : DMM Disease Models and Mechanisms. 12, 5, dmm038711.

Research output: Contribution to journalArticle

3 Scopus citations

Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation

Weng, T., Ko, J., Masamha, C. P., Xia, Z., Xiang, Y., Chen, N. Y., Molina, J. G., Collum, S., Mertens, T. C., Luo, F., Philip, K., Davies, J., Huang, J., Wilson, C., Thandavarayan, R. A., Bruckner, B. A., Jyothula, S. S. K., Volcik, K. A., Li, L., Han, L. & 5 others, Li, W., Assassi, S., Karmouty-Quintana, H., Wagner, E. J. & Blackburn, M. R., May 1 2019, In : Journal of Clinical Investigation. 129, 5, p. 1984-1999 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dysfunction of iPSC-derived endothelial cells in human Hutchinson–Gilford progeria syndrome

Matrone, G., Thandavarayan, R. A., Walther, B. K., Meng, S., Mojiri, A. & Cooke, J. P., Oct 2 2019, In : Cell Cycle. 18, 19, p. 2495-2508 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

Karuppagounder, V., Bajpai, A., Meng, S., Arumugam, S., Sreedhar, R., Giridharan, V. V., Guha, A., Bhimaraj, A., Youker, K. A., Palaniyandi, S. S., Karmouty-Quintana, H., Kamal, F., Spiller, K. L., Watanabe, K. & Thandavarayan, R. A., Jul 2018, In : PLoS ONE. 13, 7, e0200697.

Research output: Contribution to journalArticle

2 Scopus citations

Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming

Meng, S., Chanda, P., Thandavarayan, R. A. & Cooke, J. P., Jul 10 2018, In : Antioxidants and Redox Signaling. 29, 2, p. 205-218 14 p.

Research output: Contribution to journalReview article

5 Scopus citations

Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 22) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography

Pan, G., Munukutla, S., Kar, A., Gardinier, J., Thandavarayan, R. A. & Palaniyandi, S. S., Apr 2018, In : PLoS ONE. 13, 4, e0195796.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy

Watanabe, K., Sreedhar, R., Thandavarayan, R. A., Karuppagounder, V., Giridharan, V. V., Antony, S., Harima, M., Nakamura, M., Suzuki, K., Suzuki, H., Sone, H. & Arumugam, S., Mar 1 2017, In : BioFactors. 43, 2, p. 187-194 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Japanese Kampo Medicine for Aging-Related Neurological Diseases

Giridharan, V. V., Amirthalingam Thandavarayan, R., Konishi, T. & Quedevo, J., Mar 23 2017, Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation. Elsevier, p. 75-88 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kampo Medicine for Hypertension and Related Disorders

Babu, S. S., Thandavarayan, R. A. & Krishnamurthy, P., Mar 23 2017, Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation. Elsevier, p. 59-67 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Lipid-polymer hybrid nanoparticle-mediated therapeutics delivery: Advances and challenges

Bose, R. J. C., Ravikumar, R., Karuppagounder, V., Bennet, D., Rangasamy, S. & Amirthalingam Thandavarayan, R., 2017, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

28 Scopus citations

Preparation and characterization of PLGA loaded nanoparticles obtained from D. Melanoxylon Roxb. Leaves for their antiproliferative and antidiabetic activity

Al Rashid, M. H., Bharadwaj, P. V. P. D., Mandal, V., Pal, M., Mandal, S. C. & Thandavarayan, R. A., Jul 1 2017, In : International Journal of Green Pharmacy. 11, 3, p. S438-S447

Research output: Contribution to journalArticle

4 Scopus citations

Significance of Japanese Kampo Medicine in Supportive Care of Heart Failure/Function

Joladarashi, D., Thandavarayan, R. A. & Krishnamurthy, P., Mar 23 2017, Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation. Elsevier, p. 47-57 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging

Karuppagounder, V., Arumugam, S., Babu, S. S., Palaniyandi, S. S., Watanabe, K., Cooke, J. P. & Amirthalingam Thandavarayan, R., May 1 2017, In : Ageing Research Reviews. 35, p. 291-296 6 p.

Research output: Contribution to journalReview article

15 Scopus citations

Transflammation: Innate immune signaling in nuclear reprogramming

Meng, S., Chanda, P., Thandavarayan, R. A. & Cooke, J. P., Oct 1 2017, In : Advanced Drug Delivery Reviews. 120, p. 133-141 9 p.

Research output: Contribution to journalReview article

5 Scopus citations
2016

Alcohol Toxicity in Diabetes and Its Complications: A Double Trouble?

Munukutla, S., Pan, G., Deshpande, M., Thandavarayan, R. A., Krishnamurthy, P. & Palaniyandi, S. S., 2016, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

13 Scopus citations

ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes

Pan, G., Deshpande, M., Thandavarayan, R. A. & Palaniyandi, S. S., 2016, In : Journal of Diabetes Research. 2016, 1390861.

Research output: Contribution to journalArticle

6 Scopus citations

Cardiac mitochondrial respiratory dysfunction and tissue damage in chronic hyperglycemia correlate with reduced aldehyde dehydrogenase-2 activity

Mali, V. R., Pan, G., Deshpande, M., Thandavarayan, R. A., Xu, J., Yang, X. P. & Palaniyandi, S. S., Oct 2016, In : PLoS ONE. 11, 10, e0163158.

Research output: Contribution to journalArticle

13 Scopus citations

Curcumin alleviates renal dysfunction and suppresses inflammation by shifting from M1 to M2 macrophage polarization in daunorubicin induced nephrotoxicity in rats

Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Sreedhar, R., Giridharan, V. V., Afrin, R., Harima, M., Miyashita, S., Hara, M., Suzuki, K., Nakamura, M., Ueno, K. & Watanabe, K., Aug 1 2016, In : Cytokine. 84, p. 1-9 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Curcumin as a therapeutic agent in the chemoprevention of inflammatory bowel disease

Sreedhar, R., Arumugam, S., Amirthalingam Thandavarayan, R., Karuppagounder, V. & Watanabe, K., May 1 2016, In : Drug Discovery Today. 21, 5, p. 843-849 7 p.

Research output: Contribution to journalReview article

37 Scopus citations

Erratum to “Hypothalamic glucagon signaling in fasting hypoglycemia” (Life Sci. (2016) 153 (118–123))

Pitchaimani, V., Arumugam, S., Thandavarayan, R. A., Karuppagounder, V., Afrin, M. R., Sreedhar, R., Harima, M., Suzuki, H., Miyashita, S., Suzuki, K., Nakamura, M., Ueno, K. & Watanabe, K., Sep 1 2016, In : Life sciences. 160, 1 p.

Research output: Contribution to journalComment/debate

Fasting time duration modulates the onset of insulin-induced hypoglycemic seizures in mice

Pitchaimani, V., Arumugam, S., Thandavarayan, R. A., Karuppagounder, V., Afrin, M. R., Sreedhar, R., Harima, M., Suzuki, H., Miyashita, S., Nakamura, T., Suzuki, K., Nakamura, M., Ueno, K. & Watanabe, K., Sep 1 2016, In : Epilepsy Research. 125, p. 47-51 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hypothalamic glucagon signaling in fasting hypoglycemia

Pitchaimani, V., Arumugam, S., Thandavarayan, R. A., Karuppagounder, V., Afrin, M. R., Sreedhar, R., Harima, M., Suzuki, H., Miyashita, S., Suzuki, K., Nakamura, M., Ueno, K. & Watanabe, K., May 15 2016, In : Life sciences. 153, p. 118-123 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Impaired ALDH2 activity decreases the mitochondrial respiration in H9C2 cardiomyocytes

Mali, V. R., Deshpande, M., Pan, G., Amirthalingam Thandavarayan, R. & Palaniyandi, S. S., Feb 1 2016, In : Cellular Signalling. 28, 2, p. 1-6 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Increased 4-hydroxy-2-nonenal-induced proteasome dysfunction is correlated with cardiac damage in streptozotocin-injected rats with isoproterenol infusion

Deshpande, M., Mali, V. R., Pan, G., Xu, J., Yang, X. P., Amirthalingam Thandavarayan, R. & Palaniyandi, S. S., Jul 1 2016, In : Cell Biochemistry and Function. 34, 5, p. 334-342 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes

Suresh Babu, S., Amirthalingam Thandavarayan, R., Joladarashi, D., Jeyabal, P., Krishnamurthy, S., Bhimaraj, A., Youker, K. A. & Krishnamurthy, P., Nov 9 2016, In : Scientific Reports. 6, 36207.

Research output: Contribution to journalArticle

16 Scopus citations

MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1

Jeyabal, P., Thandavarayan, R. A., Joladarashi, D., Suresh Babu, S., Krishnamurthy, S., Bhimaraj, A., Youker, K. A., Kishore, R. & Krishnamurthy, P., Mar 18 2016, In : Biochemical and Biophysical Research Communications. 471, 4, p. 423-429 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice

Karuppagounder, V., Giridharan, V. V., Arumugam, S., Sreedhar, R., Palaniyandi, S. S., Krishnamurthy, P., Quevedo, J., Watanabe, K., Konishi, T. & Thandavarayan, R. A., Apr 2016, In : PLoS ONE. 11, 4, e0152922.

Research output: Contribution to journalArticle

25 Scopus citations

Molecular targets of quercetin with anti-inflammatory properties in atopic dermatitis

Karuppagounder, V., Arumugam, S., Amirthalingam Thandavarayan, R., Sreedhar, R., Giridharan, V. V. & Watanabe, K., Apr 1 2016, In : Drug Discovery Today. 21, 4, p. 632-639 8 p.

Research output: Contribution to journalReview article

44 Scopus citations

Naringenin ameliorates skin inflammation and accelerates phenotypic reprogramming from M1 to M2 macrophage polarization in atopic dermatitis NC/Nga mouse model

Karuppagounder, V., Arumugam, S., Amirthalingam Thandavarayan, R., Sreedhar, R., Giridharan, V. V., Pitchaimani, V., Afrin, R., Harima, M., Krishnamurthy, P., Suzuki, K., Nakamura, M., Ueno, K. & Watanabe, K., May 1 2016, In : Experimental Dermatology. 25, 5, p. 404-407 4 p.

Research output: Contribution to journalLetter

15 Scopus citations

Newer insights into the role of miRNA a tiny genetic tool in psychiatric disorders: focus on post-traumatic stress disorder

Giridharan, V. V., Thandavarayan, R. A., Fries, G. R., Walss-Bass, C., Barichello, T., Justice, N. J., Reddy, M. K. & Quevedo, J., Nov 15 2016, In : Translational Psychiatry. 6, 11, p. e954

Research output: Contribution to journalReview article

12 Scopus citations

Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice

Sreedhar, R., Giridharan, V. V., Arumugam, S., Karuppagounder, V., Palaniyandi, S. S., Krishnamurthy, P., Quevedo, J., Watanabe, K., Konishi, T. & Thandavarayan, R. A., Jul 1 2016, In : BioFactors. 42, 4, p. 368-375 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Targeting fatty acid metabolism in heart failure: Is it a suitable therapeutic approach?

Arumugam, S., Sreedhar, R., Amirthalingam Thandavarayan, R., Karuppagounder, V. & Watanabe, K., Jun 1 2016, In : Drug Discovery Today. 21, 6, p. 1003-1008 6 p.

Research output: Contribution to journalReview article

18 Scopus citations
2015
4 Scopus citations

Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic rats

Afrin, R., Arumugam, S., Soetikno, V., Thandavarayan, R. A., Pitchaimani, V., Karuppagounder, V., Sreedhar, R., Harima, M., Suzuki, H., Miyashita, S., Nomoto, M., Suzuki, K. & Watanabe, K., Mar 1 2015, In : Free Radical Research. 49, 3, p. 279-289 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Enhancer-associated long noncoding RNAs: A novel frontier with new perception in cardiac regeneration

Jeyabal, P., Thandavarayan, R. A., Suresh Babu, S. & Krishnamurthy, P., Oct 1 2015, In : Trends in Cardiovascular Medicine. 25, 7, p. 603-605 3 p.

Research output: Contribution to journalEditorial

Jumihaidokuto effectively inhibits colon inflammation and apoptosis in mice with acute colitis

Sreedhar, R., Arumugam, S., Karuppagounder, V., Thandavarayan, R. A., Giridharan, V. V., Pitchaimani, V., Afrin, M. R., Harima, M., Nakamura, T., Nakamura, M., Suzuki, K. & Watanabe, K., Dec 1 2015, In : International Immunopharmacology. 29, 2, p. 957-963 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Modulation of HMGB1 translocation and RAGE/NFκB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice

Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Pitchaimani, V., Sreedhar, R., Afrin, R., Harima, M., Suzuki, H., Nomoto, M., Miyashita, S., Suzuki, K., Nakamura, M. & Watanabe, K., Jun 1 2015, In : Experimental Dermatology. 24, 6, p. 418-423 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Myocardial 14-3-3η protein protects against mitochondria mediated apoptosis

Sreedhar, R., Arumugam, S., Thandavarayan, R. A., Giridharan, V. V., Karuppagounder, V., Pitchaimani, V., Afrin, R., Miyashita, S., Nomoto, M., Harima, M., Gurusamy, N., Suzuki, K. & Watanabe, K., Apr 1 2015, In : Cellular Signalling. 27, 4, p. 770-776 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2-NFκB p65 mediated inflammation

Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Pitchaimani, V., Sreedhar, R., Afrin, R., Harima, M., Suzuki, H., Suzuki, K., Nakamura, M., Ueno, K. & Watanabe, K., Jun 12 2015, In : International Immunopharmacology. 28, 1, p. 154-159 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Ocimum sanctum Linn. (Holy Basil) to Improve Cognition

Giridharan, V. V., Amirthalingam Thandavarayan, R. & Konishi, T., Jan 1 2015, Diet and Nutrition in Dementia and Cognitive Decline. Elsevier, p. 1049-1058 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pruni cortex ameliorates skin inflammation possibly through HMGB1-NFκB pathway in house dust mite induced atopic dermatitis NC/Nga transgenic mice

Watanabe, K., Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Pitchaimani, V., Sreedhar, R., Afrin, R., Harima, M., Suzuki, H., Suzuki, K., Nakamura, T., Nomoto, M., Miyashita, S., Fukumoto, K. & Ueno, K., May 1 2015, In : Journal of Clinical Biochemistry and Nutrition. 56, 3, p. 186-194 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Schisandrin b prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of mapk/p53 signaling

Thandavarayan, R. A., Giridharan, V. V., Arumugam, S., Suzuki, K., Ko, K. M., Krishnamurthy, P., Watanabe, K. & Konishi, T., Mar 5 2015, In : PLoS ONE. 10, 3, e0119214.

Research output: Contribution to journalArticle

65 Scopus citations

Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing

Thandavarayan, R. A., Garikipati, V. N. S., Joladarashi, D., Suresh Babu, S., Jeyabal, P., Verma, S. K., Mackie, A. R., Khan, M., Arumugam, S., Watanabe, K., Kishore, R. & Krishnamurthy, P., Oct 1 2015, In : Experimental Dermatology. 24, 10, p. 773-778 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Small interfering RNA therapy against carbohydrate sulfotransferase 15 inhibits cardiac remodeling in rats with dilated cardiomyopathy

Watanabe, K., Arumugam, S., Sreedhar, R., Thandavarayan, R. A., Nakamura, T., Nakamura, M., Harima, M., Yoneyama, H. & Suzuki, K., Jul 1 2015, In : Cellular Signalling. 27, 7, p. 1517-1524 8 p.

Research output: Contribution to journalArticle

14 Scopus citations