Personal profile

After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.

Research interests

One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.

Keywords

    Research Area Keywords

  • Transplantation
  • Immunobiology & Inflammation
  • Clinical Translation & Trials

    Free-text keywords

  • Liver disease , Hepatocellular carcinoma, Liver transplant, Transplantation, Liver resection

Fingerprint

Liver Transplantation
Concept: Liver Transplantation
Weight: 100%
Domain: Medicine & Life Sciences
Transplants
Concept: Transplants
Weight: 36%
Domain: Medicine & Life Sciences
Liver
Concept: Liver
Weight: 33%
Domain: Medicine & Life Sciences
Allografts
Concept: Allografts
Weight: 28%
Domain: Medicine & Life Sciences
Tissue Donors
Concept: Tissue Donors
Weight: 22%
Domain: Medicine & Life Sciences
Hepatitis C
Concept: Hepatitis C
Weight: 20%
Domain: Medicine & Life Sciences
Living Donors
Concept: Living Donors
Weight: 19%
Domain: Medicine & Life Sciences
Hepatocellular Carcinoma
Concept: Hepatocellular Carcinoma
Weight: 18%
Domain: Medicine & Life Sciences
End Stage Liver Disease
Concept: End Stage Liver Disease
Weight: 14%
Domain: Medicine & Life Sciences
Transplantation
Concept: Transplantation
Weight: 13%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by R. Mark Ghobrial is tagged with the concept

Journals

Liver Transplantation

ISSNs: 1527-6465

Additional searchable ISSN (Electronic): 1527-6473

Wiley

Journal

37

Transplantation proceedings

ISSNs: 0041-1345

Elsevier

Journal

21

Transplantation

ISSNs: 0041-1337

Lippincott Williams and Wilkins

Journal

18

Annals of Surgery

ISSNs: 0003-4932

Lippincott Williams and Wilkins

Journal

15

American Journal of Transplantation

ISSNs: 1600-6135

Additional searchable ISSN (Electronic): 1600-6143

Wiley

Journal

12
has published Research OutputsResearch Output by R. Mark Ghobrial

Research Network

Visualization: Institutional Network

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R. Mark Ghobrial

Visualization: Co-author Network

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R. Mark Ghobrial

Shared Pub. Internal Organizations

Lynda K. and David M. Underwood Center for Digestive Disorders

Organizational unit: Centers of Excellence

20

Department of Medicine

Organizational unit: Departments

19

Houston Methodist Sugar Land Hospital

Organizational unit: Schools & Hospitals

13

Department of Pathology & Genomic Medicine

Organizational unit: Departments

7
7
has Research OutputsResearch Output by R. Mark Ghobrial

Shared Pub. External Organizations

UCLA School of Medicine

External organization: Unknown

64

UCLA Medical Center

External organization: Unknown

47

University of California, Los Angeles

External organization: Unknown

22

Houston Methodist Research Institute

External organization: Unknown

21

University of California, San Francisco

External organization: Unknown

12
has Research OutputsResearch Output by R. Mark Ghobrial

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with R. Mark Ghobrial

Shared Pub. External co-authors

R. W. Busuttil

External person

94

D. G. Farmer

External person

66

H. Yersiz

External person

49

Sammy Saab

External person

34

L. I. Goldstein

External person

31
has co-authored Research OutputsResearch Output with R. Mark Ghobrial

ID: 2287372