Projects per year
Personal profile
Personal profile
After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.
Research interests
One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.
Education/Academic qualification
Clinical Transplant , Clinical Fellowship, Dumont-UCLA Transplant Center
Jul 1 1996 → Jun 30 1998
Award Date: Jun 30 1998
General Surgery, Residency, University of Texas Health Science Center at Houston
Jul 1 1989 → Jun 30 1996
Award Date: Jun 30 1996
MD, University of Cairo Medical School
Jul 1 1975 → Jun 30 1980
Award Date: Jun 30 1980
Immunology, PhD, University of Texas Health Science Center at Houston
Research Area Keywords
- Transplantation
- Immunobiology & Inflammation
- Clinical Translation & Trials
Free-text keywords
- Liver disease
- Hepatocellular carcinoma
- Liver transplant
- Transplantation
- Liver resection
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Network
Projects
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LEAP-012 - MERCK (7902-012, Site No. 0784)
Ghobrial, R. M., Abdelrahim, M., Gibbs, J. M., Heyne, K., Shetty, A. & Victor, III, D. W.
3/27/20 → …
Project: Clinical Trial
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Mild Hypothermia and Acute Kidney Injury AKI in Liver Transplantation MHALT Trial
Ghobrial, R. M., Lindberg, S. A., Mobley, C. M., Saharia, A. & Victor, III, D. W.
2/10/20 → …
Project: Clinical Trial
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Ultra High-Field MR Spectroscopy of Non-alcoholic fatty liver disease
Victor, III, D. W., Ghobrial, R. M., Graviss, E. A., Gupta, N. & Karmonik, C.
1/30/20 → …
Project: Clinical Trial
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GILENYA
Ibrahim, H. N., Gaber, A. O., Ghobrial, R. M., Graviss, E. A., Kloc, M. & Moore, L. W.
1/13/20 → …
Project: Clinical Trial
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CONTRAIL I - CFZ533A2202 (Site 1006)
Mobley, C. M., Ghobrial, R. M., Hobeika, M. J. & Saharia, A.
12/17/19 → …
Project: Clinical Trial
Research Output
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Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients
Kloc, M., Ghobrial, R. M., Lipińska-Opałka, A., Wawrzyniak, A., Zdanowski, R., Kalicki, B. & Kubiak, J. Z., Feb 2021, In : Cellular Immunology. 360, 104259.Research output: Contribution to journal › Review article
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Role of macrophages and rhoa pathway in atherosclerosis
Kloc, M., Uosef, A., Kubiak, J. Z. & Ghobrial, R. M., Jan 1 2021, In : International journal of molecular sciences. 22, 1, p. 1-13 13 p., 216.Research output: Contribution to journal › Review article
Open Access -
Delayed implantation of pumped kidneys decreases renal allograft futility in combined liver-kidney transplantation
Lunsford, K. E., Agopian, V. G., Yi, S., Nguyen, D. T. M., Graviss, E. A., Harlander-Locke, M. P., Saharia, A., Kaldas, F. M., Mobley, C. M., Zarrinpar, A., Hobeika, M. J., Veale, J. L., Podder, H., Farmer, D. G., Knight, R. J., Danovitch, G. M., Gritsch, H. A., Li, X. C., Ghobrial, R. M., Busuttil, R. W. & 1 others, , Aug 1 2020, In : Transplantation. 104, 8, p. 1591-1603 13 p.Research output: Contribution to journal › Article
4 Scopus citations -
Development of child immunity in the context of COVID-19 pandemic
Kloc, M., Ghobrial, R. M., Kuchar, E., Lewicki, S. & Kubiak, J. Z., Aug 2020, In : Clinical Immunology. 217, p. 108510 108510.Research output: Contribution to journal › Review article
5 Scopus citations -
Early experience with COVID-19 and solid organ transplantation at a US high-volume transplant center
Yi, S. G., Rogers, A. W., Saharia, A., Aoun, M., Faour, R., Abdelrahim, M., Knight, R. J., Grimes, K., Bullock, S., Hobeika, M., McMillan, R., Mobley, C., Moaddab, M., Huang, H. J., Bhimaraj, A., Ghobrial, R. M. & Gaber, A. O., Nov 1 2020, In : Transplantation. 104, 11, p. 2208-2214 7 p.Research output: Contribution to journal › Article
Open Access12 Scopus citations