Projects per year
Personal profile
Personal profile
After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.
Research interests
One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.
Education/Academic qualification
Clinical Transplant , Clinical Fellowship, Dumont-UCLA Transplant Center
Jul 1 1996 → Jun 30 1998
Award Date: Jun 30 1998
General Surgery, Residency, University of Texas Health Science Center at Houston
Jul 1 1989 → Jun 30 1996
Award Date: Jun 30 1996
MD, University of Cairo Medical School
Jul 1 1975 → Jun 30 1980
Award Date: Jun 30 1980
Immunology, PhD, University of Texas Health Science Center at Houston
Research Area Keywords
- Transplantation
- Immunobiology & Inflammation
- Clinical Translation & Trials
Free-text keywords
- Liver disease
- Hepatocellular carcinoma
- Liver transplant
- Transplantation
- Liver resection
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A Phase II and Biomarker Study of Dual VEGF/PD-L1 Blockade in Neoadjuvant Setting in Resectable Hepatocellular Carcinoma Patients
Ghobrial, R. M., Abdelrahim, M. & Kodali, S.
4/1/21 → 3/31/26
Project: Federal Funding Agencies
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Transplant Research Biobank
Gaber, A. O., Bernard, D. W., Ghobrial, R. M. & Singh, R.
1/20/21 → …
Project: Clinical Trial
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LEAP-012 - MERCK (7902-012, Site No. 0784) Safety and Efficacy of Lenvatinib (E7080 / MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable / Non-metastatic Hepatocellular Carcinoma (MK-7902-012 / E7080-G000-318 / LEAP-012)
Kodali, S., Abdelrahim, M., Ghobrial, R. M., Gibbs, J. M., Heyne, K., Saharia, A., Shetty, A. & Victor, III, D. W.
3/27/20 → …
Project: Clinical Trial
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Mild Hypothermia and Acute Kidney Injury AKI in Liver Transplantation MHALT Trial
Ghobrial, R. M., Lindberg, S., Mobley, C. M., Saharia, A. & Victor, III, D. W.
2/10/20 → …
Project: Clinical Trial
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Ultra High-Field MR Spectroscopy of Non-alcoholic fatty liver disease
Victor, III, D. W., Ghobrial, R. M., Graviss, E. A., Gupta, N. & Karmonik, C.
1/30/20 → …
Project: Clinical Trial
Research output
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Artificial intelligence to identify harmful alcohol use after early liver transplant for alcohol-associated hepatitis
Lee, B. P., Roth, N., Rao, P., Im, G. Y., Vogel, A. S., Hasbun, J., Roth, Y., Shenoy, A., Arvelakis, A., Ford, L., Dawe, I., Schiano, T. D., Davis, J. P., Rice, J. P., Eswaran, S., Weinberg, E., Han, H., Hsu, C., Fix, O. K., Maddur, H. & 4 others, , Apr 13 2022, (E-pub ahead of print) In: American Journal of Transplantation.Research output: Contribution to journal › Article › peer-review
Open Access -
Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, H. J., Yi, S. G., Mobley, C. M., Saharia, A., Bhimaraj, A., Moore, L. W., Kloc, M., Adrogue, H. E., Graviss, E. A., Nguyen, D. T., Eagar, T. N., Jones, S. L., Ankoma-Sey, V., MacGillivray, T. E., Knight, R. J., Gaber, A. O. & Ghobrial, R. M., Jan 26 2022, (E-pub ahead of print) In: Clinical Transplantation. p. e14600Research output: Contribution to journal › Article › peer-review
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Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, H. J., Yi, S. G., Mobley, C. M., Saharia, A., Bhimaraj, A., Moore, L. W., Kloc, M., Adrogue, H. E., Graviss, E. A., Nguyen, D. T., Eagar, T. N., Jones, S. L., Ankoma-Sey, V., MacGillivray, T. E., Knight, R. J., Gaber, A. O. & Ghobrial, R. M., May 2022, In: Clinical Transplantation. 36, 5, e14600.Research output: Contribution to journal › Article › peer-review
Open Access -
Genetically targeting the BATF family transcription factors BATF and BATF3 in the mouse abrogates effector T cell activities and enables long-term heart allograft survival
Wang, Y., Xiao, X., Kong, G., Wen, M., Wang, G., Ghobrial, R. M., Dong, N., Chen, W. & Li, X. C., Feb 2022, In: American Journal of Transplantation. 22, 2, p. 414-426 13 p.Research output: Contribution to journal › Article › peer-review
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Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant: The OCS Liver PROTECT Randomized Clinical Trial
Markmann, J. F., Abouljoud, M. S., Ghobrial, R. M., Bhati, C. S., Pelletier, S. J., Lu, A. D., Ottmann, S., Klair, T., Eymard, C., Roll, G. R., Magliocca, J., Pruett, T. L., Reyes, J., Black, S. M., Marsh, C. L., Schnickel, G., Kinkhabwala, M., Florman, S. S., Merani, S., Demetris, A. J. & 15 others, , 2022, (Accepted/In press) In: JAMA Surgery. 157, 3, p. 189-198 10 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations