Projects per year
Personal profile
Personal profile
After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.
Research interests
One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.
Education/Academic qualification
Clinical Transplant , Clinical Fellowship, Dumont-UCLA Transplant Center
Jul 1 1996 → Jun 30 1998
Award Date: Jun 30 1998
General Surgery, Residency, The University of Texas Health Science Center at Houston
Jul 1 1989 → Jun 30 1996
Award Date: Jun 30 1996
MD, University of Cairo Medical School
Jul 1 1975 → Jun 30 1980
Award Date: Jun 30 1980
Immunology, PhD, The University of Texas Health Science Center
Research Area Keywords
- Transplantation
- Immunobiology & Inflammation
- Clinical Translation & Trials
Free-text keywords
- Liver disease
- Hepatocellular carcinoma
- Liver transplant
- Transplantation
- Liver resection
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Projects
LEAP-012 - MERCK (7902-012, Site No. 0784)
Ghobrial, R. M., Abdelrahim, M., Gibbs, J. M., Heyne, K., Shetty, A. & Victor, III, D. W.
3/27/20 → …
Project: Clinical Trial
Mild Hypothermia and Acute Kidney Injury AKI in Liver Transplantation MHALT Trial
Ghobrial, R. M., Lindberg, S. A., Mobley, C. M., Saharia, A. & Victor, III, D. W.
2/10/20 → …
Project: Clinical Trial
Ultra High-Field MR Spectroscopy of Non-alcoholic fatty liver disease
Victor, III, D. W., Ghobrial, R. M., Graviss, E. A., Gupta, N. & Karmonik, C.
1/30/20 → …
Project: Clinical Trial
GILENYA
Ibrahim, H. N., Gaber, A. O., Ghobrial, R. M., Graviss, E. A., Kloc, M. & Moore, L. W.
1/13/20 → …
Project: Clinical Trial
CONTRAIL I - CFZ533A2202 (Site 1006)
Mobley, C. M., Ghobrial, R. M., Hobeika, M. J. & Saharia, A.
12/17/19 → …
Project: Clinical Trial
Research Output
Delayed implantation of pumped kidneys decreases renal allograft futility in combined liver-kidney transplantation
Lunsford, K. E., Agopian, V. G., Yi, S., Nguyen, D. T. M., Graviss, E. A., Harlander-Locke, M. P., Saharia, A., Kaldas, F. M., Mobley, C. M., Zarrinpar, A., Hobeika, M. J., Veale, J. L., Podder, H., Farmer, D. G., Knight, R. J., Danovitch, G. M., Gritsch, H. A., Li, X. C., Ghobrial, R. M., Busuttil, R. W. & 1 others, , Aug 1 2020, In : Transplantation. 104, 8, p. 1591-1603 13 p.Research output: Contribution to journal › Article
3
Scopus
citations
Development of child immunity in the context of COVID-19 pandemic
Kloc, M., Ghobrial, R. M., Kuchar, E., Lewicki, S. & Kubiak, J. Z., Aug 1 2020, In : Clinical Immunology. 217, 108510.Research output: Contribution to journal › Review article
3
Scopus
citations
Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics
Chen, S., Zhang, L., Ying, Y., Wang, Y., Arnold, P. R., Wang, G., Li, J., Ghobrial, R. M., Chen, W., Xiao, X. & Li, X. C., Sep 1 2020, In : American Journal of Transplantation. 20, 9, p. 2366-2379 14 p.Research output: Contribution to journal › Article
How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?
Kloc, M., Ghobrial, R. M. & Kubiak, J. Z., Aug 1 2020, In : Immunology Letters. 224, p. 28-29 2 p.Research output: Contribution to journal › Letter
3
Scopus
citations
Liver Transplantation for Cholangiocarcinoma and Mixed Hepatocellular Cholangiocarcinoma: Working Group Report from the ILTS Transplant Oncology Consensus Conference
Sapisochin, G., Javle, M., Lerut, J., Ohtsuka, M., Ghobrial, M., Hibi, T., Kwan, N. M. & Heimbach, J., Jan 1 2020, In : Transplantation. p. 1125-1130 6 p.Research output: Contribution to journal › Review article
1
Scopus
citations