Projects per year
Personal profile
Personal profile
After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.
Research interests
One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.
Education/Academic qualification
Clinical Transplant , Clinical Fellowship, Dumont-UCLA Transplant Center
Jul 1 1996 → Jun 30 1998
Award Date: Jun 30 1998
General Surgery, Residency, University of Texas Health Science Center at Houston
Jul 1 1989 → Jun 30 1996
Award Date: Jun 30 1996
MD, University of Cairo Medical School
Jul 1 1975 → Jun 30 1980
Award Date: Jun 30 1980
Immunology, PhD, University of Texas Health Science Center at Houston
External positions
Professor of Surgery, Weill Cornell Medicine
Mar 1 2010 → …
Research Area Keywords
- Transplantation
- Immunobiology & Inflammation
- Clinical Translation & Trials
Free-text keywords
- Liver disease
- Hepatocellular carcinoma
- Liver transplant
- Transplantation
- Liver resection
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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A Phase 2, Randomized, Placebo-Controlled Study to Evaluate Belumosudil for the Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantation
Gaber, A. O. (PI), Ghobrial, R. M. (Key Personnel), Graviss, E. A. (Key Personnel), Hobeika, M. J. (Key Personnel), Kloc, M. (Key Personnel), Moore, L. W. (Key Personnel), Rizk, E. (Key Personnel), Schroder, P. (Key Personnel) & Yi, S. (Key Personnel)
4/21/25 → …
Project: Clinical Trial
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4/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)
Ghobrial, R. M. (PI)
8/1/23 → 7/31/30
Project: Federal Funding Agencies
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Ensuring Informed Decision-Making for Paired Kidney Donation: A National Kidney Registry Education Collaborative
Waterman, A. D. (PI), Gaber, A. O. (Key Personnel), Ghobrial, R. M. (Key Personnel) & Moore, L. W. (Key Personnel)
3/14/23 → …
Project: Clinical Trial
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Atezolizumab and Bevacizumab Pre-Liver Transplantation for Patients with Hepatocellular Carcinoma Beyond Milan Criteria: A Feasibility Study
Abdelrahim, M. (PI), Connor, A. A. (Key Personnel), Ghobrial, R. M. (Key Personnel), Gibbs, J. M. (Key Personnel), Graviss, E. A. (Key Personnel), Gupta, N. (Key Personnel), Kodali, S. (Key Personnel), Mobley, C. M. (Key Personnel), Moore, L. W. (Key Personnel), Rizk, E. (Key Personnel), Saharia, A. (Key Personnel), Singh, M. (Key Personnel) & Victor, III, D. W. (Key Personnel)
1/18/23 → …
Project: Clinical Trial
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A Phase II and Biomarker Study of Dual VEGF/PD-L1 Blockade in Neoadjuvant Setting in Resectable Hepatocellular Carcinoma Patients
Ghobrial, R. M. (PI), Abdelrahim, M. (Key Personnel) & Kodali, S. (Key Personnel)
4/1/21 → 3/31/26
Project: Federal Funding Agencies
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Disparities in liver transplantation for metabolic dysfunction-associated steatohepatitis-associated hepatocellular carcinoma
Victor, D. W., Kodali, S., Noureddin, M., Brombosz, E. W., Lopez, A., Basra, T., Graviss, E. A., Nguyen, D. T., Saharia, A., Connor, A. A., Abdelrahim, M., Cheah, Y. L., Simon, C. J., Hobeika, M. J., Mobley, C. M. & Ghobrial, R. M., Sep 18 2025, In: World Journal of Transplantation. 15, 3, 101997.Research output: Contribution to journal › Article › peer-review
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Neoadjuvant Multiagent Systemic Therapy Approach to Liver Transplantation for Perihilar Cholangiocarcinoma
Soliman, N., Connor, A. A., Saharia, A., Kodali, S., Elaileh, A., Patel, K., Semaan, S., Basra, T., Victor, D. W., Simon, C. J., Cheah, Y. L., Hobeika, M. J., Mobley, C. M., Divatia, M., Dhingra, S., Schwartz, M., Maqsood, A., Heyne, K., Abdelrahim, M. & Javle, M. & 3 others, , Mar 2025, In: Transplantation Direct. 11, 3, p. e1760 e1760.Research output: Contribution to journal › Article › peer-review
Open Access -
Outcomes for Early Liver Transplantation for Alcohol-associated Liver Disease in High-acuity Liver Transplant Recipients with Alcohol Use Disorder
Meinders, A. M., Connor, A. A., Ontiveros, J., Elaileh, A., Patel, K., Todd, J., Nottage, D. L., Brombosz, E. W., Moore, L. W., Simon, C. J., Cheah, Y. L., Hobeika, M. J., Mobley, C. M., Saharia, A., Basra, T., Kodali, S., Victor, D. W., Lee, B. P., Terrault, N. & Li, X. C. & 2 others, , Mar 20 2025, In: Transplantation Direct. 11, 4, e1776.Research output: Contribution to journal › Article › peer-review
Open Access -
Sorafenib as Adjuvant Therapy Post-Liver Transplant: A Single-center Experience
Hassanain, H., Connor, A. A., Brombosz, E. W., Patel, K., Elaileh, A., Basra, T., Kodali, S., Victor, D. W., Simon, C. J., Cheah, Y. L., Hobeika, M. J., Mobley, C. M., Saharia, A., Dhingra, S., Schwartz, M., Maqsood, A., Heyne, K., Kaseb, A. O., Vauthey, J. N. & Gaber, A. O. & 2 others, , Jan 23 2025, In: Transplantation Direct. 11, 2, p. e1746Research output: Contribution to journal › Article › peer-review
Open Access -
The 2024 ILTS-ILCA consensus recommendations for liver transplantation for hepatocellular carcinoma and intrahepatic cholangiocarcinoma
Kodali, S., Kulik, L., D'Allessio, A., De Martin, E., Hakeem, A. R., Lewinska, M., Lindsey, S., Liu, K., Maravic, Z., Patel, M. S., Pinato, D., Rammohan, A., Rich, N., Sanduzzi Zamparelli, M., Victor, D. W., Vinaxia, C., Brombosz, E. W., Villanueva, A., Meyer, T. & Selzner, N. & 3 others, , 2025, (Accepted/In press) In: Liver Transplantation. 10.1097/LVT.0000000000000589.Research output: Contribution to journal › Article › peer-review
Prizes
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President, International Liver Transplantation Society (ILTS)
Ghobrial, R. M. (Recipient), Jul 1 2023
Prize: National/international honor