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Personal profile

Personal profile

After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.

Research interests

One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.

Education/Academic qualification

Clinical Transplant , Clinical Fellowship, Dumont-UCLA Transplant Center

Jul 1 1996Jun 30 1998

Award Date: Jun 30 1998

General Surgery, Residency, The University of Texas Health Science Center at Houston

Jul 1 1989Jun 30 1996

Award Date: Jun 30 1996

MD, University of Cairo Medical School

Jul 1 1975Jun 30 1980

Award Date: Jun 30 1980

Immunology, PhD, The University of Texas Health Science Center

Research Area Keywords

  • Transplantation
  • Immunobiology & Inflammation
  • Clinical Translation & Trials

Free-text keywords

  • Liver disease
  • Hepatocellular carcinoma
  • Liver transplant
  • Transplantation
  • Liver resection

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Projects

Research Output

Delayed implantation of pumped kidneys decreases renal allograft futility in combined liver-kidney transplantation

Lunsford, K. E., Agopian, V. G., Yi, S., Nguyen, D. T. M., Graviss, E. A., Harlander-Locke, M. P., Saharia, A., Kaldas, F. M., Mobley, C. M., Zarrinpar, A., Hobeika, M. J., Veale, J. L., Podder, H., Farmer, D. G., Knight, R. J., Danovitch, G. M., Gritsch, H. A., Li, X. C., Ghobrial, R. M., Busuttil, R. W. & 1 others, Gaber, A. O., Aug 1 2020, In : Transplantation. 104, 8, p. 1591-1603 13 p.

Research output: Contribution to journalArticle

  • 3 Scopus citations

    Development of child immunity in the context of COVID-19 pandemic

    Kloc, M., Ghobrial, R. M., Kuchar, E., Lewicki, S. & Kubiak, J. Z., Aug 1 2020, In : Clinical Immunology. 217, 108510.

    Research output: Contribution to journalReview article

  • 3 Scopus citations

    Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics

    Chen, S., Zhang, L., Ying, Y., Wang, Y., Arnold, P. R., Wang, G., Li, J., Ghobrial, R. M., Chen, W., Xiao, X. & Li, X. C., Sep 1 2020, In : American Journal of Transplantation. 20, 9, p. 2366-2379 14 p.

    Research output: Contribution to journalArticle

  • How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?

    Kloc, M., Ghobrial, R. M. & Kubiak, J. Z., Aug 1 2020, In : Immunology Letters. 224, p. 28-29 2 p.

    Research output: Contribution to journalLetter

  • 3 Scopus citations

    Liver Transplantation for Cholangiocarcinoma and Mixed Hepatocellular Cholangiocarcinoma: Working Group Report from the ILTS Transplant Oncology Consensus Conference

    Sapisochin, G., Javle, M., Lerut, J., Ohtsuka, M., Ghobrial, M., Hibi, T., Kwan, N. M. & Heimbach, J., Jan 1 2020, In : Transplantation. p. 1125-1130 6 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations