Projects per year
Personal profile
Personal profile
Philip J. Horner, Ph.D., received a Ph.D. in physiology from Ohio State University in 1995. He did post-doctoral training with Dr. Fred H. Gage and became a staff scientist in the Lab of Genetics at the Salk Institute in 1998. In 2001, Dr. Horner joined the faculty of the Department of Neurological Surgery at the University of Washington in Seattle. He directed a laboratory at the UW South Lake Union Campus and was a member of the Institute for Stem Cell and Regenerative Medicine. In 2015, Dr. Horner became the Scientific Director of the Center for Neuroregenerative Medicine and the Co-Director, Center for Regenerative and Restorative Neurosurgery at the Houston Methodist Research Institute in Houston Texas. Dr. Horner’s research focuses on the role of glial and neural progenitor cells in the regeneration of the injured and aging nervous system.
Research interests
The Horner lab is focused on the interaction between glial and neural cells following central nervous system challenge and specifically: 1) mechanisms of adult stem cell‐derived lesion remodeling/repair and 2) role of gliogenesis and gliosis in neural degeneration. Over the past decades, researchers have observed that the human brain and spinal cord retain a population of stem cells with the capacity to replace neurons and glia. However, during normal aging and following trauma or disease, the brain and spinal cord stem cells fail to replace needed circuitry. The Horner lab has been developing approaches to modify and amplify the fate of neural stem cells to increase cellular repair after spinal cord and brain injury. Together with electrical stimulation, the lab has shown that regeneration of neural circuitry offers hope for repair nervous system. Together with clinical research partners at Houston Methodist and our global partners, the Horner lab seeks to move from bench to bedside by engineering new neural circuits in people with chronic paralysis in order to restore hand function. Neural regeneration strategies are also being applied to stroke, head injury, glaucoma and motor/cognitive decline associated with aging.
Education/Academic qualification
Neurobiology, Postdoctoral Fellowship, The Salk Institute for Biological Studies
Award Date: Jun 30 2001
Physiology, PhD, The Ohio State University
Award Date: Jun 30 1995
Physiology, MS, The Ohio State University
Award Date: Jun 30 1992
Biochemistry & Molecular Biology, BS, University of Nevada, Reno
Award Date: Jun 30 1988
External positions
Professor of Physiology in Neurological Surgery, Weill Cornell Medical College
Jul 2016 → …
Research Area Keywords
- Neurosciences
- Regenerative Medicine
Free-text keywords
- Myelin
- Spinal cord
- Neural stem cells
- Optogenetics
- Multiple sclerosis
- Neural trauma
- Stroke
- Regeneration
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
Spinal Neuromodulation to Promote Physiologic and Molecular Plasticity in the Injured Spinal Cord
9/20/23 → 8/31/28
Project: Federal Funding Agencies
-
Patricia Levy Zusman International Workshop on Neuroregeneration (Zusman Workshop)
12/15/22 → 12/14/23
Project: Federal Funding Agencies
-
Training in Neural Control of organ Degeneration and Regeneration (NeuralCODR)
7/1/22 → 6/30/27
Project: Federal Funding Agencies
-
Cortical stimulation leads to shortened myelin sheaths and increased axonal branching in spared axons after cervical spinal cord injury
Kondiles, B. R., Murphy, R. L., Widman, A. J., Perlmutter, S. I. & Horner, P. J., Aug 2023, In: GLIA. 71, 8, p. 1947-1959 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury
Wei, H., Wu, X., Withrow, J., Cuevas-Diaz Duran, R., Singh, S., Chaboub, L. S., Rakshit, J., Mejia, J., Rolfe, A., Herrera, J. J., Horner, P. J. & Wu, J. Q., May 30 2023, In: Cell Reports. 42, 5, 112486.Research output: Contribution to journal › Article › peer-review
Open Access -
Magnetic Resonance-Guided Stereotaxy for Infusions to the Pig Brain
Cruz-Garza, J. G., Taghlabi, K. M., Bhenderu, L. S., Gupta, S., Pandey, A., Frazier, A. M., Brisbay, S., Patterson, J. D., Salegio, E. A., Kantorak, C. J., Karmonik, C., Horner, P. J., Rostomily, R. C. & Faraji, A. H., Mar 31 2023, In: Journal of Visualized Experiments. 2023, 193, e64079.Research output: Contribution to journal › Article › peer-review
Open Access -
Rigor and Reproducibility in Analysis of Rodent Behavior Utilizing the Forelimb Reaching Task Following a Cervical Spinal Cord Injury
Salazar, B. H., Hoffman, K. A., Fraizer, A. M., Humes, F., Hogan, M. K., Horner, M. A., Yadegar, T., Trusler, S., Hamilton, G. F. & Horner, P. J., Feb 15 2023, In: Behavioural Brain Research. 439, 114188.Research output: Contribution to journal › Article › peer-review
-
Assessing Gq-GPCR–induced human astrocyte reactivity using bioengineered neural organoids
Cvetkovic, C., Patel, R., Shetty, A., Hogan, M. K., Anderson, M., Basu, N., Aghlara-Fotovat, S., Ramesh, S., Sardar, D., Veiseh, O., Ward, M. E., Deneen, B., Horner, P. J. & Krencik, R., Feb 9 2022, In: Journal of Cell Biology. 221, 4, e202107135.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations