Professional Information

Philip J. Horner, Ph.D., received a Ph.D. in physiology from Ohio State University in 1995. He did post-doctoral training with Dr. Fred H. Gage and became a staff scientist in the Lab of Genetics at the Salk Institute in 1998. In 2001, Dr. Horner joined the faculty of the Department of Neurological Surgery at the University of Washington in Seattle. He directed a laboratory at the UW South Lake Union Campus and was a member of the Institute for Stem Cell and Regenerative Medicine. In 2015, Dr. Horner became the Scientific Director of the Center for Neuroregenerative Medicine and the Co-Director, Center for Regenerative and Restorative Neurosurgery at the Houston Methodist Research Institute in Houston Texas. Dr. Horner’s research focuses on the role of glial and neural progenitor cells in the regeneration of the injured and aging nervous system.

Research interests

The Horner lab is focused on the interaction between glial and neural cells following central nervous system challenge and specifically: 1) mechanisms of adult stem cell‐derived lesion remodeling/repair and 2) role of gliogenesis and gliosis in neural degeneration. Over the past decades, researchers have observed that the human brain and spinal cord retain a population of stem cells with the capacity to replace neurons and glia. However, during normal aging and following trauma or disease, the brain and spinal cord stem cells fail to replace needed circuitry. The Horner lab has been developing approaches to modify and amplify the fate of neural stem cells to increase cellular repair after spinal cord and brain injury. Together with electrical stimulation, the lab has shown that regeneration of neural circuitry offers hope for repair nervous system. Together with clinical research partners at Houston Methodist and our global partners, the Horner lab seeks to move from bench to bedside by engineering new neural circuits in people with chronic paralysis in order to restore hand function.  Neural regeneration strategies are also being applied to stroke, head injury, glaucoma and motor/cognitive decline associated with aging. 

Keywords

    Research Area Keywords

  • Neurosciences

    Free-text keywords

  • Myelin, Spinal cord, Neural stem cells, Optogenetics, Multiple sclerosis, Neural trauma, Stroke, Regeneration

Fingerprint

Spinal Cord
Concept: Spinal Cord
Weight: 100%
Domain: Medicine & Life Sciences
Stem Cells
Concept: Stem Cells
Weight: 90%
Domain: Medicine & Life Sciences
Glaucoma
Concept: Glaucoma
Weight: 73%
Domain: Medicine & Life Sciences
Spinal Cord Injuries
Concept: Spinal Cord Injuries
Weight: 70%
Domain: Medicine & Life Sciences
Contusions
Concept: Contusions
Weight: 61%
Domain: Medicine & Life Sciences
Axons
Concept: Axons
Weight: 59%
Domain: Medicine & Life Sciences
Retinal Ganglion Cells
Concept: Retinal Ganglion Cells
Weight: 54%
Domain: Medicine & Life Sciences
Wounds and Injuries
Concept: Wounds and Injuries
Weight: 50%
Domain: Medicine & Life Sciences
Neurons
Concept: Neurons
Weight: 47%
Domain: Medicine & Life Sciences
Inbred DBA Mouse
Concept: Inbred DBA Mouse
Weight: 43%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Philip J. Horner is tagged with the concept

Journals

Journal of Neuroscience

ISSNs: 0270-6474

Society for Neuroscience

Journal

13

Experimental Neurology

ISSNs: 0014-4886

Academic Press

Journal

8

Biomaterials

ISSNs: 0142-9612

Additional searchable ISSN (Electronic): 1878-5905

Elsevier BV

Journal

6

Investigative Ophthalmology and Visual Science

ISSNs: 0146-0404

Association for Research in Vision and Ophthalmology Inc.

Journal

5

Aging Cell

ISSNs: 1474-9718

Additional searchable ISSN (Electronic): 1474-9726

Wiley

Scopus rating (2018): CiteScore 7.42 SJR 3.809 SNIP 1.52

Journal

4
has published Research OutputsResearch Output by Philip J. Horner

Research Network

Visualization: Institutional Network

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Philip J. Horner

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Philip J. Horner

Shared Pub. Internal Organizations

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

10
1

J.C. Walter Jr. Transplant Center

Organizational unit: Centers of Excellence

1

Immunobiology & Transplant Science Center

Organizational unit: Programs

1

Department of Medicine

Organizational unit: Departments

1
has Research OutputsResearch Output by Philip J. Horner

Shared Pub. External Organizations

University of Washington Cardiovascular Health Research Unit

External organization: Unknown

42

University of Washington

External organization: Academic

10

Salk Institute for Biological Studies

External organization: Unknown

7

Ohio State University

External organization: Unknown

6

University of Utah

External organization: Unknown

5
has Research OutputsResearch Output by Philip J. Horner

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Philip J. Horner

Shared Pub. External co-authors

D. L. Sellers

External person

16

S. H. Pun

External person

14

Denise M. Inman

External person

14

David J. Calkins

External person

11

Fred H. Gage

External person

9
has co-authored Research OutputsResearch Output with Philip J. Horner

ID: 17293619