Personal profile

After completion of his fellowship in the Metabolic Research Unit at the University of California at San Francisco (UCSF) in 1994, Dr. Webb joined the permanent research staff there in the laboratory of Dr. John Baxter. He rose through the ranks and, in 1999, became an Assistant Research Biochemist Level IV. In 2001, Dr. Webb joined the Diabetes Center at UCSF where he was quickly promoted to an Associate Researcher Level IV. He spent a year as a visiting professor in Biochemistry at the University of San Francisco in 2005 where he taught several courses in biochemistry. He has co-written over 130 manuscripts that have been published in peer-reviewed publications.

Research interests

Dr. Webb's main research interests are investigations into the principles of nuclear hormone receptor structure and function, as well as studies of the actions of pharmaceutical agents to selectively modulate actions of these proteins. Research approaches include X-ray structural analysis, targeted mutagenesis to understand receptor structure, detailed analysis of gene expression and genome wide sequence interactions and collaborative studies to determine the metabolic effects of drugs in preclinical models.

Keywords

    Free-text keywords

  • Diabetes, Nuclear hormone receptor, Ligand design

Fingerprint

Thyroid Hormone Receptors
Concept: Thyroid Hormone Receptors
Weight: 100%
Domain: Medicine & Life Sciences
Ligands
Concept: Ligands
Weight: 41%
Domain: Medicine & Life Sciences
Thyroid Hormones
Concept: Thyroid Hormones
Weight: 32%
Domain: Medicine & Life Sciences
Estrogen Receptors
Concept: Estrogen Receptors
Weight: 30%
Domain: Medicine & Life Sciences
Cytoplasmic and Nuclear Receptors
Concept: Cytoplasmic and Nuclear Receptors
Weight: 27%
Domain: Medicine & Life Sciences
Thyroid Hormone Receptors beta
Concept: Thyroid Hormone Receptors beta
Weight: 20%
Domain: Medicine & Life Sciences
Response Elements
Concept: Response Elements
Weight: 18%
Domain: Medicine & Life Sciences
Genes
Concept: Genes
Weight: 17%
Domain: Chemical Compounds
Hormones
Concept: Hormones
Weight: 17%
Domain: Medicine & Life Sciences
Co-Repressor Proteins
Concept: Co-Repressor Proteins
Weight: 15%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Paul Webb is tagged with the concept

Journals

Proceedings of the National Academy of Sciences of the United States of America

ISSNs: 0027-8424

Journal

14

PLoS ONE

Additional searchable ISSN (Electronic): 1932-6203

Public Library of Science

Journal

14

Molecular Endocrinology

ISSNs: 0888-8809

The Endocrine Society

Journal

13

The Journal of biological chemistry

ISSNs: 0021-9258

American Society for Biochemistry and Molecular Biology Inc.

Journal

12

Journal of Steroid Biochemistry and Molecular Biology

ISSNs: 0960-0760

Elsevier Limited

Journal

10
has published Research OutputsResearch Output by Paul Webb

Research Network

Visualization: Institutional Network

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Paul Webb

Visualization: Co-author Network

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Paul Webb

Shared Pub. Internal Organizations

Department of Nanomedicine

Organizational unit: Departments

13

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

4

Lynda K. and David M. Underwood Center for Digestive Disorders

Organizational unit: Centers of Excellence

2

Department of Pathology & Genomic Medicine

Organizational unit: Departments

2

Department of Surgery

Organizational unit: Departments

2
has Research OutputsResearch Output by Paul Webb

Shared Pub. External Organizations

University of California, San Francisco

External organization: Unknown

57

Houston Methodist Research Institute

External organization: Unknown

35

University of São Paulo

External organization: Unknown

23

Universidade Estadual de Campinas

External organization: Unknown

16

University of Brasilia

External organization: Unknown

15
has Research OutputsResearch Output by Paul Webb

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Paul Webb

Shared Pub. External co-authors

John D. Baxter

External person

57

Peter J. Kushner

External person

27

Phuong Nguyen

External person

24

Igor Polikarpov

External person

22

Robert J. Fletterick

External person

19
has co-authored Research OutputsResearch Output with Paul Webb

ID: 2285041