Paul Webb, PhD

Former affiliations
  • 12132 Citations
  • 51 h-Index
1987 …2019

Research output per year

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Personal profile

Personal profile

After completion of his fellowship in the Metabolic Research Unit at the University of California at San Francisco (UCSF) in 1994, Dr. Webb joined the permanent research staff there in the laboratory of Dr. John Baxter. He rose through the ranks and, in 1999, became an Assistant Research Biochemist Level IV. In 2001, Dr. Webb joined the Diabetes Center at UCSF where he was quickly promoted to an Associate Researcher Level IV. He spent a year as a visiting professor in Biochemistry at the University of San Francisco in 2005 where he taught several courses in biochemistry. He has co-written over 130 manuscripts that have been published in peer-reviewed publications.

Research interests

Dr. Webb's main research interests are investigations into the principles of nuclear hormone receptor structure and function, as well as studies of the actions of pharmaceutical agents to selectively modulate actions of these proteins. Research approaches include X-ray structural analysis, targeted mutagenesis to understand receptor structure, detailed analysis of gene expression and genome wide sequence interactions and collaborative studies to determine the metabolic effects of drugs in preclinical models.

Education/Academic qualification

Postdoctoral Fellowship, Immunology Department, University of California, San Francisco, CA

Biochemistry & Molecular Biology, PhD, Imperial Cancer Research Fund, London University, London

Postdoctoral Fellowship, Metabolic Research Unit, University of California, San Francisco, CA

Biochemistry, MA, Pembroke College, Oxford University

Free-text keywords

  • Diabetes
  • Nuclear hormone receptor
  • Ligand design

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Projects

Research Output

HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells

Quintela, M., Sieglaff, D. H., Gazze, A. S., Zhang, A., Gonzalez, D., Francis, L., Webb, P. & Conlan, R. S., Apr 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 17, p. 254-265 12 p.

Research output: Contribution to journalArticle

  • 8 Scopus citations

    Protein disulfide isomerase modulates the activation of thyroid hormone receptors

    Campos, J. L. O., Doratioto, T. R., Videira, N. B., Ribeiro Filho, H. V., Batista, F. A. H., Fattori, J., Indolfo, N. D. C., Nakahira, M., Bajgelman, M. C., Cvoro, A., Laurindo, F. R. M., Webb, P. & Figueira, A. C. M., 2019, In : Frontiers in Endocrinology. 10, JAN

    Research output: Contribution to journalArticle

  • Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen

    De Jesus Cortez, F., Nguyen, P., Truillet, C., Tian, B., Kuchenbecker, K. M., Evans, M. J., Webb, P., Jacobson, M. P., Fletterick, R. J. & England, P. M., Dec 15 2017, In : ACS Chemical Biology. 12, 12, p. 2934-2939 6 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis

    Bado, I., Nikolos, F., Rajapaksa, G., Wu, W., Castaneda, J., Krishnamurthy, S., Webb, P., Gustafsson, J. Å. & Thomas, C., Jul 3 2017, In : Breast Cancer Research. 19, 1, 79.

    Research output: Contribution to journalArticle

  • 13 Scopus citations

    3,5-diodothyronine (3,5-T2) Reduces Blood Glucose Independently of Insulin Sensitization in Obese Mice

    Teixeira, S. D. S., Filgueira, C. S., Sieglaff, D. H., Benod, C., Villagomez, R., Minze, L. J., Zhang, A., Webb, P. & Nunes, M. T., Oct 22 2016, In : Acta physiologica (Oxford, England).

    Research output: Contribution to journalArticle

  • 23 Scopus citations