Research outputs

  1. 2019
  2. A novel approach to medical radioisotope production using inverse kinematics: A successful production test of the theranostic radionuclide 67 Cu

    Souliotis, G. A., Rodrigues, M. R. D., Wang, K., Iacob, V. E., Nica, N., Roeder, B., Tabacaru, G., Yu, M. M., Zanotti Fregonara, P. & Bonasera, A., Jul 1 2019, In : Applied Radiation and Isotopes. 149, p. 89-95 7 p.

    Research output: Contribution to journalArticle

  3. Neuroinflammation in neocortical epilepsy measured by PET imaging of translocator protein

    Dickstein, L. P., Liow, J. S., Austermuehle, A., Zoghbi, S., Inati, S. K., Zaghloul, K., Zanotti Fregonara, P. & Theodore, W. H., Jun 1 2019, In : Epilepsia. 60, 6, p. 1248-1254 7 p.

    Research output: Contribution to journalArticle

  4. 18 F-FLT PET/MRI for bone marrow failure syndrome-initial experience

    Tsujikawa, T., Tasaki, T., Hosono, N., Mori, T., Makino, A., Kiyono, Y., Zanotti Fregonara, P., Yamauchi, T. & Okazawa, H., Jan 1 2019, In : EJNMMI Research. 9, 16.

    Research output: Contribution to journalArticle

  5. Evaluation of a PET radioligand to image O-GlcNAcase in brain and periphery of rhesus monkey and knock-out mouse

    Paul, S., Haskali, M. B., Liow, J. S., Zoghbi, S. S., Barth, V. N., Kolodrubetz, M. C., Bond, M. R., Morse, C. L., Gladding, R. L., Frankland, M. P., Kant, N., Slieker, L., Shcherbinin, S., Nuthall, H. N., Zanotti Fregonara, P., Hanover, J. A., Jesudason, C., Pike, V. W. & Innis, R. B., Jan 1 2019, In : Journal of Nuclear Medicine. 60, 1, p. 129-134 6 p.

    Research output: Contribution to journalArticle

  6. Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain

    Zanotti Fregonara, P., Pascual, M. B., Veronese, M., Yu, M. M., Beers, D., Appel, S. H. & Masdeu, J. C., Jan 1 2019, In : European Journal of Nuclear Medicine and Molecular Imaging.

    Research output: Contribution to journalArticle

  7. The validity of 18F-GE180 as a TSPO imaging agent

    Zanotti Fregonara, P., Veronese, M., Pascual, M. B., Rostomily, R. C., Turkheimer, F. & Masdeu, J. C., Jan 1 2019, (Accepted/In press) In : European Journal of Nuclear Medicine and Molecular Imaging.

    Research output: Contribution to journalArticle

  8. 2018
  9. Decreased Cannabinoid CB1 Receptors in Male Tobacco Smokers Examined With Positron Emission Tomography

    Hirvonen, J., Zanotti Fregonara, P., Gorelick, D. A., Lyoo, C. H., Rallis-Frutos, D., Morse, C., Zoghbi, S. S., Pike, V. W., Volkow, N. D., Huestis, M. A. & Innis, R. B., Nov 15 2018, In : Biological Psychiatry. 84, 10, p. 715-721 7 p.

    Research output: Contribution to journalArticle

  10. Patient-specific computational model and dosimetry calculations for PET/CT of a patient pregnant with twins

    Xie, T., Zanotti Fregonara, P., Edet-Sanson, A. & Zaidi, H., Sep 1 2018, In : Journal of Nuclear Medicine. 59, 9, p. 1451-1458 8 p.

    Research output: Contribution to journalArticle

  11. Head-to-head comparison of 11C-PBR28 and 18F-GE180 for quantification of the translocator protein in the human brain

    Zanotti-Fregonara, P., Pascual, B., Rizzo, G., Yu, M., Pal, N., Beers, D., Carter, R., Appel, S. H., Atassi, N. & Masdeu, J. C., Aug 1 2018, In : Journal of Nuclear Medicine. 59, 8, p. 1260-1266 7 p.

    Research output: Contribution to journalArticle

  12. A longitudinal study on deep brain stimulation of the medial forebrain bundle for treatment-resistant depression

    Fenoy, A. J., Schulz, P. E., Selvaraj, S., Burrows, C. L., Zunta-Soares, G., Durkin, K., Zanotti Fregonara, P., Quevedo, J. & Soares, J. C., Jun 4 2018, In : Translational psychiatry. 8, 1, 111.

    Research output: Contribution to journalArticle

  13. Advantages and limits of targeted radionuclide therapy with somatostatin antagonists

    Hindie, E., Morgat, C., Zanotti Fregonara, P., Haissaguerre, M., Bordenave, L. & Tabarin, A., Mar 1 2018, In : Journal of Nuclear Medicine. 59, 3, p. 546-547 2 p.

    Research output: Contribution to journalLetter

  14. Somatostatin antagonists for radioligand therapy of nonendocrine tumors

    Hindie, E., Zanotti Fregonara, P. & Morgat, C., Mar 1 2018, In : Journal of Nuclear Medicine. 59, 3, 1 p.

    Research output: Contribution to journalLetter

  15. Building a database for brain 18 kDa translocator protein imaged using [11C]PBR28 in healthy subjects

    Paul, S., Gallagher, E., Liow, J. S., Mabins, S., Henry, K., Zoghbi, S. S., Gunn, R. N., Kreisl, W. C., Richards, E. M., Zanotti Fregonara, P., Morse, C. L., Hong, J., Kowalski, A., Pike, V. W., Innis, R. B. & Fujita, M., 2018, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

    Research output: Contribution to journalArticle

  16. PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects

    Richards, E. M., Zanotti Fregonara, P., Fujita, M., Newman, L., Farmer, C., Ballard, E. D., Machado-Vieira, R., Yuan, P., Niciu, M. J., Lyoo, C. H., Henter, I. D., Salvadore, G., Drevets, W. C., Kolb, H., Innis, R. B. & Zarate, C. A., 2018, In : EJNMMI Research. 8, 57.

    Research output: Contribution to journalArticle

  17. 2017
  18. New fetal radiation doses for18F-FDG based on human data

    Zanotti Fregonara, P. & Stabin, M. G., Nov 1 2017, In : Journal of Nuclear Medicine. 58, 11, p. 1865-1866 2 p.

    Research output: Contribution to journalArticle

  19. On the role of interim fluorine-18–labeled fluorodeoxyglucose positron emission tomography in early-stage favorable hodgkin lymphoma

    Hindié, E., Mesguich, C. & Zanotti Fregonara, P., Aug 20 2017, In : Journal of Clinical Oncology. 35, 24, p. 2851-2852 2 p.

    Research output: Contribution to journalLetter

  20. Linear no-threshold hypothesis at the hospital: When raDioprotection becomes a nosocomial hazard

    Zanotti Fregonara, P. & HinDie, E., Aug 1 2017, In : Journal of Nuclear Medicine. 58, 8, p. 1355 1 p.

    Research output: Contribution to journalLetter

  21. Predicting the outcome of peptide receptor radionuclide therapy in neuroendocrine tumors: the importance of dual-tracer imaging

    Zanotti-Fregonara, P., Morgat, C., Champion, C. & Hindié, E., Mar 10 2017, (Accepted/In press) In : European Journal of Nuclear Medicine and Molecular Imaging. p. 1-2 2 p.

    Research output: Contribution to journalArticle

  22. Performing nuclear medicine examinations in pregnant women

    Zanotti Fregonara, P. & Hindie, E., Jan 10 2017, (Accepted/In press) In : Physica Medica.

    Research output: Contribution to journalArticle

  23. 18F-FDG Imaging of Chronic Inflammation Associated With Promontofixation of the Uterus

    Meyer, M., Fernandez, P. & Zanotti Fregonara, P., Jan 1 2017, In : Clinical nuclear medicine. 42, 1, p. 42-43 2 p.

    Research output: Contribution to journalArticle

  24. Standardized input function for 18F-FDG PET studies in mice: A cautionary study

    Meyer, M., Le-Bras, L., Fernandez, P. & Zanotti Fregonara, P., Jan 1 2017, In : PLoS ONE. 12, 1, e0168667.

    Research output: Contribution to journalArticle

  25. Generalization of endothelial modelling of TSPO PET imaging: Considerations on tracer affinities

    Rizzo, G., Veronese, M., Tonietto, M., Bodini, B., Stankoff, B., Wimberley, C., Lavisse, S., Bottlaender, M., Bloomfield, P. S., Howes, O., Zanotti Fregonara, P., Turkheimer, F. E. & Bertoldo, A., 2017, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

    Research output: Contribution to journalArticle

  26. Re: 13I and 124I accumulation in a thymic cyst

    Zanotti-Fregonara, P. & Hindie, E., 2017, In : Clinical nuclear medicine. 42, 7, p. 576 1 p.

    Research output: Contribution to journalLetter

  27. 2016
  28. Re: 131I and 124I Accumulation in a Thymic Cyst

    Zanotti-Fregonara, P. & Hindie, E., Dec 28 2016, (Accepted/In press) In : Clinical nuclear medicine.

    Research output: Contribution to journalArticle

  29. New fetal dose estimates from 18F-FDG administered during pregnancy: Standardization of dose calculations and estimations with voxel-based anthropomorphic phantoms

    Zanotti-Fregonara, P., Chastan, M., Edet-Sanson, A., Ekmekcioglu, O., Erdogan, E. B., Hapdey, S., Hindie, E. & Stabin, M. G., Nov 1 2016, In : Journal of Nuclear Medicine. 57, 11, p. 1760-1763 4 p.

    Research output: Contribution to journalArticle

  30. Putative Physiopathological Explanation for the “Sock Sign” in Bone Scans

    de Vaugelade, C., Pinaquy, J. B., Fernandez, P., Bordenave, L., Hindie, E. & Zanotti-Fregonara, P., May 13 2016, (Accepted/In press) In : Clinical nuclear medicine.

    Research output: Contribution to journalArticle

  31. Dose deposits from90Y,177Lu,111In, and161Tb in micrometastases of various sizes: Implications for radiopharmaceutical therapy

    Hindie, E., Zanotti-Fregonara, P., Quinto, M. A., Morgat, C. & Champion, C., May 1 2016, In : Journal of Nuclear Medicine. 57, 5, p. 759-764 6 p.

    Research output: Contribution to journalArticle

  32. Interest of [18F]fluorodeoxyglucose positron emission tomography/computed tomography for the diagnosis of relapse in patients with spinal infection: A prospective study

    Dauchy, F. A., Dutertre, A., Lawson-Ayayi, S., de Clermont-Gallerande, H., Fournier, C., Zanotti-Fregonara, P., Dutronc, H., Vital, J. M., Dupon, M. & Fernandez, P., May 1 2016, In : Clinical Microbiology and Infection. 22, 5, p. 438-443 6 p.

    Research output: Contribution to journalArticle

  33. Measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade: The genomic plot

    Veronese, M., Zanotti-Fregonara, P., Rizzo, G., Bertoldo, A., Innis, R. B. & Turkheimer, F. E., Apr 15 2016, In : NeuroImage. 130, p. 1-12 12 p.

    Research output: Contribution to journalArticle

  34. Plasma radiometabolite correction in dynamic PET studies: Insights on the available modeling approaches

    Tonietto, M., Rizzo, G., Veronese, M., Fujita, M., Zoghbi, S. S., Zanotti-Fregonara, P. & Bertoldo, A., Feb 1 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 2, p. 326-339 14 p.

    Research output: Contribution to journalReview article

  35. The PET radioligand 18F-FIMX images and quantifies metabotropic glutamate receptor 1 in proportion to the regional density of its gene transcript in human brain

    Zanotti-Fregonara, P., Xu, R., Zoghbi, S. S., Liow, J. S., Fujita, M., Veronese, M., GladDing, R. L., Rallis-Frutos, D., Hong, J., Pike, V. W. & Innis, R. B., Feb 1 2016, In : Journal of Nuclear Medicine. 57, 2, p. 242-247 6 p.

    Research output: Contribution to journalArticle

  36. Comparison between three promising β-emitting radionuclides, 67Cu, 47Sc and 161Tb, with emphasis on doses delivered to minimal residual disease

    Champion, C., Quinto, M. A., Morgat, C., Zanotti-Fregonara, P. & Hindié, E., 2016, In : Theranostics. 6, 10, p. 1611-1618 8 p.

    Research output: Contribution to journalArticle

  37. New perspectives offered by nuclear medicine for the imaging and therapy of multiple myeloma

    Mesguich, C., Zanotti-Fregonara, P. & Hindié, E., 2016, In : Theranostics. 6, 2, p. 287-290 4 p.

    Research output: Contribution to journalEditorial

  38. 2015
  39. Improved models for plasma radiometabolite correction and their impact on kinetic quantification in PET studies

    Tonietto, M., Veronese, M., Rizzo, G., Zanotti-Fregonara, P., Lohith, T. G., Fujita, M., Zoghbi, S. S. & Bertoldo, A., Sep 3 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, 9, p. 1462-1469 8 p.

    Research output: Contribution to journalArticle

  40. Focal inhibitory seizure with prolonged deficit in adult Sturge-Weber syndrome

    Aupy, J., Bonnet, C., Arnould, J. S., Fernandez, P., Marchal, C. & Zanotti-Fregonara, P., Sep 1 2015, In : Epileptic Disorders. 17, 3, p. 328-331 4 p.

    Research output: Contribution to journalReview article

  41. Fetal radiation dose from 18F-FDG in pregnant patients imaged with PET, PET/CT, and PET/MR

    Zanotti-Fregonara, P., Laforest, R. & Wallis, J. W., Aug 1 2015, In : Journal of Nuclear Medicine. 56, 8, p. 1218-1222 5 p.

    Research output: Contribution to journalArticle

  42. Neuroinflammation in temporal lobe epilepsy measured using positron emission tomographic imaging of translocator protein

    Gershen, L. D., Zanotti-Fregonara, P., Dustin, I. H., Liow, J. S., Hirvonen, J., Kreisl, W. C., Jenko, K. J., Inati, S. K., Fujita, M., Morse, C. L., Brouwer, C., Hong, J. S., Pike, V. W., Zoghbi, S. S., Innis, R. B. & Theodore, W. H., Aug 1 2015, In : JAMA Neurology. 72, 8, p. 882-888 7 p.

    Research output: Contribution to journalArticle

  43. The methodology of TSPO imaging with positron emission tomography

    Turkheimer, F. E., Rizzo, G., Bloomfield, P. S., Howes, O., Zanotti-Fregonara, P., Bertoldo, A. & Veronese, M., Aug 1 2015, In : Biochemical Society Transactions. 43, p. 586-592 7 p.

    Research output: Contribution to journalReview article

  44. The role of radionuclide imaging in the surgical management of primary hyperparathyroidism

    Hindié, E., Zanotti-Fregonara, P., Tabarin, A., Rubello, D., Morelec, I., Wagner, T., Henry, J. F. & Taïeb, D., May 1 2015, In : Journal of Nuclear Medicine. 56, 5, p. 737-744 8 p.

    Research output: Contribution to journalArticle

  45. Image-derived input function with factor analysis and a-priori information

    Simončič, U. & Zanotti-Fregonara, P., Feb 3 2015, In : Nuclear Medicine Communications. 36, 2, p. 187-193 7 p.

    Research output: Contribution to journalArticle

  46. 2014
  47. [11C]befloxatone distribution is well correlated to monoamine oxidase A protein levels in the human brain

    Zanotti-Fregonara, P. & Bottlaender, M., Dec 11 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 12, p. 1951-1952 2 p.

    Research output: Contribution to journalReview article

  48. Imaging of monoamine oxidase-A in the human brain with [11C]befloxatone: Quantification strategies and correlation with mRNA transcription maps

    Zanotti-Fregonara, P., Leroy, C., Rizzo, G., Roumenov, D., Trichard, C., Martinot, J. L. & Bottlaender, M., Dec 10 2014, In : Nuclear Medicine Communications. 35, 12, p. 1254-1261 8 p.

    Research output: Contribution to journalArticle

  49. Application of calibrated image-derived input function to a clinical protocol

    Zanotti-Fregonara, P., Lyoo, C. H., Bar-Hen, A., Liow, J. S., Zoghbi, S. S., Fujita, M. & Innis, R. B., Nov 10 2014, In : Nuclear Medicine Communications. 35, 11, p. 1188-1189 2 p.

    Research output: Contribution to journalLetter

  50. Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971

    Zanotti-Fregonara, P., Zhang, Y., Jenko, K. J., Gladding, R. L., Zoghbi, S. S., Fujita, M., Sbardella, G., Castellano, S., Taliani, S., Martini, C., Innis, R. B., Da Settimo, F. & Pike, V. W., Oct 15 2014, In : ACS Chemical Neuroscience. 5, 10, p. 963-971 9 p.

    Research output: Contribution to journalArticle

  51. Image-derived input function derived from a supervised clustering algorithm: Methodology and validation in a clinical protocol using [ 11C](R)-rolipram

    Lyoo, C. H., Zanotti-Fregonara, P., Zoghbi, S. S., Liow, J. S., Xu, R., Pike, V. W., Zarate, C. A., Fujita, M. & Innis, R. B., Feb 20 2014, In : PLoS ONE. 9, 2, e89101.

    Research output: Contribution to journalArticle

  52. Kinetic modeling without accounting for the vascular component impairs the quantification of [11C]PBR28 brain PET data

    Rizzo, G., Veronese, M., Tonietto, M., Zanotti-Fregonara, P., Turkheimer, F. E. & Bertoldo, A., 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 6, p. 1060-1069 10 p.

    Research output: Contribution to journalArticle

  53. 2013
  54. Synthesis and evaluation in monkey of [18F]4-Fluoro- N -methyl- N -(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([ 18F]FIMX): A promising radioligand for PET imaging of brain metabotropic glutamate receptor 1 (mGluR1)

    Xu, R., Zanotti-Fregonara, P., Zoghbi, S. S., Gladding, R. L., Woock, A. E., Innis, R. B. & Pike, V. W., Nov 27 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9146-9155 10 p.

    Research output: Contribution to journalArticle

  55. Parathyroid scintigraphy in renal hyperparathyroidism: The added diagnostic value of SPECT and SPECT/CT

    Taïeb, D., Ureña-Torres, P., Zanotti-Fregonara, P., Rubello, D., Ferretti, A., Henter, I., Henry, J. F., Schiavi, F., Opocher, G., Blickman, J. G., Colletti, P. M. & Hindié, E., Aug 2013, In : Clinical nuclear medicine. 38, 8, p. 630-635 6 p.

    Research output: Contribution to journalReview article

  56. Reduced cannabinoid CB 1 receptor binding in alcohol dependence measured with positron emission tomography

    Hirvonen, J., Zanotti-Fregonara, P., Umhau, J. C., George, D. T., Rallis-Frutos, D., Lyoo, C. H., Li, C. T., Hines, C. S., Sun, H., Terry, G. E., Morse, C., Zoghbi, S. S., Pike, V. W., Innis, R. B. & Heilig, M., Aug 2013, In : Molecular Psychiatry. 18, 8, p. 916-921 6 p.

    Research output: Contribution to journalArticle

  57. Voxelwise quantification of [11 C](R)-rolipram PET data: A comparison between model-based and data-driven methods

    Rizzo, G., Veronese, M., Zanotti-Fregonara, P. & Bertoldo, A., Jul 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 7, p. 1032-1040 9 p.

    Research output: Contribution to journalArticle

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