Research outputs

  1. 2019
  2. Cancer Treatment (CTCT) Promotes Oxidative Stress and Alters Monocyte/ macrophage Biology

    Kotla, S., Zhang, A., Ae Ko, K., Imanishi, M., Mazhar, H., Thomas, T., Gi, Y., Vu, H. T., Krishnan, S., McBeath, E., Lin, S., Kleinerman, E., Schadler, K., Fujiwara, K., Gupte, A. A., Le, N-T., Hamilton, D. J. & Abe, J. I., Dec 2019, In : Free Radical Biology and Medicine. 145, S1, p. S134

    Research output: Contribution to journalConference article

  3. Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase

    Kotla, S., Le, N-T., Vu, H. T., Ko, K. A., Gi, Y. J., Thomas, T. N., Giancursio, C., Lusis, A. J., Cooke, J. P., Fujiwara, K. & Abe, J. I., Nov 1 2019, In : Metabolism: Clinical and Experimental. 100, 153962.

    Research output: Contribution to journalArticle

  4. The Ser/Thr kinase p90RSK promotes kidney fibrosis by modulating fibroblast-epithelial crosstalk

    Lin, L., Shi, C., Sun, Z., Le, N-T., Abe, J. I. & Hu, K., Jun 21 2019, In : Journal of Biological Chemistry. 294, 25, p. 9901-9910 10 p.

    Research output: Contribution to journalArticle

  5. Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2–interacting protein

    Kotla, S., Vu, H. T., Ko, K. A., Wang, Y., Imanishi, M., Heo, K. S., Fujii, Y., Thomas, T. N., Gi, Y. J., Mazhar, H., Paez-Mayorga, J., Shin, J. H., Tao, Y., Giancursio, C. J., Medina, J. L. M., Taunton, J., Lusis, A. J., Cooke, J. P., Fujiwara, K., Le, N-T. & 1 othersAbe, J. I., May 2 2019, In : JCI Insight. 4, 9, e124867.

    Research output: Contribution to journalArticle

  6. MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis

    Abe, J-I., Ko, K. A., Kotla, S., Wang, Y., Paez-Mayorga, J., Shin, I. J., Imanishi, M., Vu, H. T., Tao, Y., Leiva-Juarez, M. M., Thomas, T. N., Medina, J. L., Won, J. H., Fujii, Y., Giancursio, C. J., McBeath, E., Shin, J-H., Guzman, L., Abe, R. J., Taunton, J. & 6 othersMochizuki, N., Faubion, W., Cooke, J. P., Fujiwara, K., Evans, S. E. & Le, N-T., Apr 4 2019, In : JCI Insight. 4, 7

    Research output: Contribution to journalArticle

  7. Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals

    Singh, M. V., Kotla, S., Le, N-T., Ae Ko, K., Heo, K-S., Wang, Y., Fujii, Y., Thi Vu, H., McBeath, E., Thomas, T. N., Jin Gi, Y., Tao, Y., Medina, J. L., Taunton, J., Carson, N., Dogra, V., Doyley, M. M., Tyrell, A., Lu, W., Qiu, X. & 7 othersStirpe, N. E., Gates, K. J., Hurley, C., Fujiwara, K., Maggirwar, S. B., Schifitto, G. & Abe, J-I., Feb 26 2019, In : Circulation. 139, 9, p. 1199-1216 18 p.

    Research output: Contribution to journalArticle

  8. 2018
  9. MicroRNA 199a and the eNOS (Endothelial NO Synthase)/NO Pathway

    Le, N-T. & Abe, J. I., Oct 1 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 10, p. 2278-2280 3 p.

    Research output: Contribution to journalEditorial

  10. Ponatinib Activates an Inflammatory Response in Endothelial Cells via ERK5 SUMOylation

    Paez-Mayorga, J., Chen, A. L., Kotla, S., Tao, Y., Abe, R. J., He, E. D., Danysh, B. P., Hofmann, M. C. C. & Le, N-T., Sep 6 2018, In : Frontiers in cardiovascular medicine. 5, 125.

    Research output: Contribution to journalArticle

  11. Ionizing Radiation Induces Endothelial Inflammation and Apoptosis via p90RSK-Mediated ERK5 S496 Phosphorylation

    Vu, H. T., Kotla, S., Ko, K. A., Fujii, Y., Tao, Y., Medina, J., Thomas, T., Hada, M., Sood, A. K., Singh, P. K., Milgrom, S. A., Krishnan, S., Fujiwara, K., Le, N-T. & Abe, J. I., Mar 14 2018, In : Frontiers in cardiovascular medicine. 5, p. 23 23.

    Research output: Contribution to journalArticle

  12. Regulation of Kir2.1 Function Under Shear Stress and Cholesterol Loading

    Le, N-T. & Abe, J-I., Mar 3 2018, In : Journal of the American Heart Association. 7, 5

    Research output: Contribution to journalArticle

  13. Induction of the pneumococcal vncRS operon by lactoferrin is essential for pneumonia

    Ghosh, P., Kwon, H., Park, S-S., Kim, G-L., Choi, S-Y., Kim, E-H., Tran, T. D-H., Seon, S. H., Le, N. T., Iqbal, H., Lee, S., Pyo, S. & Rhee, D-K., 2018, In : Virulence. 9, 1, p. 1562-1575 14 p.

    Research output: Contribution to journalArticle

  14. 2017
  15. Sub-cellular localization specific SUMOylation in the heart

    Le, N-T., Martin, J. F., Fujiwara, K. & Abe, J-I., Aug 2017, In : Biochimica et Biophysica Acta - General Subjects. 1863, 8, p. 2041-2055 15 p.

    Research output: Contribution to journalArticle

  16. Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer

    Lin, S. C., Lee, Y. C., Yu, G., Cheng, C. J., Zhou, X., Chu, K., Murshed, M., Le, N. T., Baseler, L., Abe, J. I., Fujiwara, K., deCrombrugghe, B., Logothetis, C. J., Gallick, G. E., Yu-Lee, L. Y., Maity, S. N. & Lin, S. H., Jun 5 2017, In : Developmental Cell. 41, 5, p. 467-480.e3

    Research output: Contribution to journalArticle

  17. Flow signaling and atherosclerosis

    Le, N-T., Sandhu, U. G., Quintana-Quezada, R. A., Hoang, N. M., Fujiwara, K. & Abe, J-I., May 2017, In : Cellular and Molecular Life Sciences. 74, 10, p. 1835-1858 24 p.

    Research output: Contribution to journalReview article

  18. Coordination of Cellular Localization-Dependent Effects of Sumoylation in Regulating Cardiovascular and Neurological Diseases

    Abe, J-I., Sandhu, U. G., Hoang, N. M., Thangam, M., Quintana-Quezada, R. A., Fujiwara, K. & Le, N. T., 2017, In : Advances in Experimental Medicine and Biology. 963, p. 337-358 22 p.

    Research output: Contribution to journalReview article

  19. 2015
  20. Role for SUMOylation in disturbed flow-induced atherosclerotic plaque formation

    Abe, J. I., Le, N-T. & Heo, K. S., Sep 1 2015, In : Biomedical Engineering Letters. 5, 3, p. 162-171 10 p.

    Research output: Contribution to journalReview article

  21. Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion

    Cameron, S. J., Ture, S. K., Mickelsen, D., Chakrabarti, E., Modjeski, K. L., McNitt, S., Seaberry, M., Field, D. J., Le, N-T., Abe, J-I. & Morrell, C. N., Jul 7 2015, In : Circulation. 132, 1, p. 47-58 12 p.

    Research output: Contribution to journalArticle

  22. Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function

    Heo, K-S., Le, N-T., Cushman, H. J., Giancursio, C. J., Chang, E., Woo, C-H., Sullivan, M. A., Taunton, J., Yeh, E. T. H., Fujiwara, K. & Abe, J., Mar 2 2015, In : The Journal of clinical investigation. 125, 3, p. 1299-310 12 p.

    Research output: Contribution to journalArticle

  23. Erratum for Le et al., Modulation of Adherence, Invasion, and Tumor Necrosis Factor Alpha Secretion during the Early Stages of Infection by Streptococcus pneumoniae ClpL

    Le, N-T., Jeong, H-Y., Kwon, H-Y., Ogunniyi, A. D., Paton, J. C., Pyo, S-N. & Rhee, D-K., Mar 2015, In : Infection and Immunity. 83, 3, p. 1224

    Research output: Contribution to journalArticle

  24. 2014
  25. Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents

    Le, N-T., Takei, Y., Izawa-Ishizawa, Y., Heo, K-S., Lee, H., Smrcka, A. V., Miller, B. L., Ko, K. A., Ture, S., Morrell, C., Fujiwara, K., Akaike, M. & Abe, J., Oct 1 2014, In : Journal of Immunology. 193, 7, p. 3803-15 13 p.

    Research output: Contribution to journalArticle

  26. Streptococcus pneumoniae ClpL modulates adherence to A549 human lung cells through Rap1/Rac1 activation

    Nguyen, C. T., Le, N-T., Tran, T. D-H., Kim, E-H., Park, S-S., Luong, T. T., Chung, K-T., Pyo, S. & Rhee, D-K., Sep 2014, In : Infection and Immunity. 82, 9, p. 3802-10 9 p.

    Research output: Contribution to journalArticle

  27. 2013
  28. De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis

    Heo, K-S., Chang, E., Le, N-T., Cushman, H., Yeh, E. T. H., Fujiwara, K. & Abe, J., Mar 15 2013, In : Circulation research. 112, 6, p. 911-23 13 p.

    Research output: Contribution to journalArticle

  29. Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity

    Heo, K-S., Chang, E., Takei, Y., Le, N-T., Woo, C-H., Sullivan, M. A., Morrell, C., Fujiwara, K. & Abe, J., Feb 2013, In : Arteriosclerosis, thrombosis, and vascular biology. 33, 2, p. 321-9 9 p.

    Research output: Contribution to journalArticle

  30. A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis

    Le, N-T., Heo, K-S., Takei, Y., Lee, H., Woo, C-H., Chang, E., McClain, C., Hurley, C., Wang, X., Li, F., Xu, H., Morrell, C., Sullivan, M. A., Cohen, M. S., Serafimova, I. M., Taunton, J., Fujiwara, K. & Abe, J-I., Jan 29 2013, In : Circulation. 127, 4, p. 486-99 14 p.

    Research output: Contribution to journalArticle

  31. 2012
  32. p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction

    Le, N-T., Takei, Y., Shishido, T., Woo, C-H., Chang, E., Heo, K-S., Lee, H., Lu, Y., Morrell, C., Oikawa, M., McClain, C., Wang, X., Tournier, C., Molina, C. A., Taunton, J., Yan, C., Fujiwara, K., Patterson, C., Yang, J. & Abe, J., Feb 17 2012, In : Circulation research. 110, 4, p. 536-50 15 p.

    Research output: Contribution to journalArticle

  33. Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation

    Le, N-T., Corsetti, J. P., Dehoff-Sparks, J. L., Sparks, C. E., Fujiwara, K. & Abe, J-I., 2012, In : International Journal of Inflammation. 2012, p. 678190

    Research output: Contribution to journalArticle

  34. 2011
  35. PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation

    Heo, K-S., Lee, H., Nigro, P., Thomas, T., Le, N-T., Chang, E., McClain, C., Reinhart-King, C. A., King, M. R., Berk, B. C., Fujiwara, K., Woo, C-H. & Abe, J., May 30 2011, In : Journal of Cell Biology. 193, 5, p. 867-84 18 p.

    Research output: Contribution to journalArticle

  36. MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation

    Chang, E., Heo, K-S., Woo, C-H., Lee, H., Le, N-T., Thomas, T. N., Fujiwara, K. & Abe, J., Feb 24 2011, In : Blood. 117, 8, p. 2527-37 11 p.

    Research output: Contribution to journalArticle

  37. 2010
  38. Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor

    Woo, C-H., Le, N-T., Shishido, T., Chang, E., Lee, H., Heo, K-S., Mickelsen, D. M., Lu, Y., McClain, C., Spangenberg, T., Yan, C., Molina, C. A., Yang, J., Patterson, C. & Abe, J., Dec 2010, In : FASEB Journal. 24, 12, p. 4917-28 12 p.

    Research output: Contribution to journalArticle

  39. 2009
  40. Characterization of the Streptococcus pneumoniae BgaC protein as a novel surface β-galactosidase with specific hydrolysis activity for the Galβ1-3GlcNAc moiety of oligosaccharides

    Jeong, J. K., Kwon, O., Lee, Y. M., Oh, D. B., Lee, J. M., Kim, S., Kim, E. H., Le, N-T., Rhee, D. K. & Kang, H. A., May 1 2009, In : Journal of bacteriology. 191, 9, p. 3011-3023 13 p.

    Research output: Contribution to journalArticle

  41. 2007
  42. Modulation of adherence, invasion, and tumor necrosis factor alpha secretion during the early stages of infection by Streptococcus pneumoniae ClpL

    Le, N-T., Jeong, H. Y., Kwon, H. Y., Ogunniyi, A. D., Paton, J. C., Pyo, S. N. & Rhee, D. K., Jun 1 2007, In : Infection and immunity. 75, 6, p. 2996-3005 10 p.

    Research output: Contribution to journalArticle

ID: 32959173