Personal profile

Dr. Nhat-Tu Le earned Bachelor and Master of Science degrees in microbiology from the University of Science in Ho Chi Minh City, Vietnam.  In 2008 she completed her PhD, also in microbiology, at Sungkyungkwan University College of Pharmacy in South Korea. The focus of her PhD training was to understand the roles of the Streptococcus pneumoniae heat shock protein ClpL in pneumococcal adherence to host cells. Her first study was published in 2007, describing the effects of Streptococcus pneumoniae heat shock protein ClpL (Caseinolytic protease L) in pathogenesis and translocation of virulence factors.  Dr. Le’s postdoctoral training was under the guidance of Dr. Jun-ichi Abe at the University of Rochester studying the role of endothelial p90RSK-ERK5 complex in the heart and the vessel. Before joining Houston Methodist in July of 2017, Dr. Le was an assistant professor at MD Anderson Cancer Center since 2014.

Research interests

Many agents used in cancer treatment result in significant vascular complications such as angina, myocardial infarction, venous or arterial thrombosis, and newly developed or worsened hypertension. These events are caused by the dysfunction of endothelial cells including apoptosis, inflammation, and decreased NO production. Nhat Tu Le’s research group has developed various systems to examine disturbed flow-induced signaling both in vitro and in vivo, and found the formation of a pro-inflammatory and pro-Senescence complex consisting of p90RSK, shelterin complex member, and p65. They have also found that endothelial ERK5 plays a role in regulating statin-induced anti-inflammatory effect using the mouse heart transplantation model. Recently, she discovered MAGI1 (the membrane-associated guanylate kinase-1) as an unexplored molecule that regulates both endothelial inflammation and anti-viral response. Our long-term goal is to establish an “Onco-cardiology” research field at the Houston Methodist Research Institute.

Keywords

    Research Area Keywords

  • Regenerative Medicine
  • Heart & Vascular

Fingerprint

Sumoylation
Concept: Sumoylation
Weight: 100%
Domain: Medicine & Life Sciences
Endothelial Cells
Concept: Endothelial Cells
Weight: 78%
Domain: Medicine & Life Sciences
Apoptosis
Concept: Apoptosis
Weight: 46%
Domain: Medicine & Life Sciences
Atherosclerosis
Concept: Atherosclerosis
Weight: 46%
Domain: Medicine & Life Sciences
Phosphorylation
Concept: Phosphorylation
Weight: 44%
Domain: Medicine & Life Sciences
Mitogen-Activated Protein Kinase 7
Concept: Mitogen-Activated Protein Kinase 7
Weight: 35%
Domain: Medicine & Life Sciences
SUMO-1 Protein
Concept: SUMO-1 Protein
Weight: 33%
Domain: Medicine & Life Sciences
Streptococcus pneumoniae
Concept: Streptococcus pneumoniae
Weight: 33%
Domain: Medicine & Life Sciences
Ubiquitin
Concept: Ubiquitin
Weight: 32%
Domain: Medicine & Life Sciences
Inflammation
Concept: Inflammation
Weight: 30%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Nhat-Tu Le is tagged with the concept

Journals

Circulation

ISSNs: 0009-7322, 1524-4539

Lippincott Williams and Wilkins

Journal

3

Infection and Immunity

ISSNs: 0019-9567

American Society for Microbiology

Journal

3

JCI Insight

ISSNs: 2379-3708

Additional searchable ISSN (Electronic): 2379-3708

The American Society for Clinical Investigation

Scopus rating (2018): CiteScore 5.33

Journal

3

Circulation research

ISSNs: 0009-7330

Additional searchable ISSN (Electronic): 1524-4571

Lippincott Williams and Wilkins

Journal

2

Arteriosclerosis, thrombosis, and vascular biology

ISSNs: 1079-5642, 1524-4636

Lippincott Williams and Wilkins

Journal

2
has published Research OutputsResearch Output by Nhat-Tu Le

Research Network

Visualization: Institutional Network

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Nhat-Tu Le

Visualization: Co-author Network

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Nhat-Tu Le

Shared Pub. Internal Organizations

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

2

Department of Cardiology

Organizational unit: Departments

1
has Research OutputsResearch Output by Nhat-Tu Le

Shared Pub. External Organizations

University of Rochester Medical Center

External organization: Academic

10

University of Texas M. D. Anderson Cancer Center

External organization: Unknown

4

Department of Cardiovascular Sciences, Houston Methodist Research Institute,

External organization: Academic

3

Department of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Unit 1101, 1515 Holcombe Blvd., Houston, Texas, 77030-4009, USA. nle3@mdanderson.org.

External organization: Unknown

2

Program in Chemistry and Chemical Biology, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.

External organization: Unknown

2
has Research OutputsResearch Output by Nhat-Tu Le

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Nhat-Tu Le

Shared Pub. External co-authors

Jun ichi Abe

External person

23

Keigi Fujiwara

External person

18

Kyung-Sun Heo

External person

11

Eugene Chang

External person

8

Chang-Hoon Woo

External person

7
has co-authored Research OutputsResearch Output with Nhat-Tu Le

ID: 32959173