Nancy A. Jenkins, PhD

  • 95467 Citations
  • 155 h-Index
1973 …2019

Research output per year

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Personal profile

Personal profile

Dr. Nancy Jenkins received her Ph.D. in molecular and cellular biology from Indiana University. Following postdoctoral studies at Harvard Medical School she joined the staff of The Jackson Laboratory and then the National Cancer Institute-Frederick, where she was a Senior Investigator and Head of the Molecular Genetics of Development Section for 22 years. She moved to the Institute of Molecular and Cell Biology in Singapore in 2006, where she served as Deputy Director for most of her stay. In 2011 she returned to the United States to serve as Co-Director of Houston Methodist Cancer Biology Program at Houston Methodist Research Institute. For more than 30 years she has co-headed a laboratory with Neal Copeland; the focus of their current research is cancer genetics. They have co-authored more than 800 papers and are among the most cited biomedical research scientists in the world today. Both have served on numerous scientific advisory and editorial boards and they have consulted for several biotechnology and pharmaceutical companies. Dr. Jenkins and Dr. Copeland are also members of the U.S. National Academy of Sciences.

Research interests

Jenkins and Copeland have modeled many different types of human disease in the mouse, but the focus of their current research is exclusively cancer. They are using the Sleeping Beauty transposable element system to tag and clone genes involved in the initiation, progression and metastasis of cancer. It is hoped that a better understanding of the genetics of cancer will lead to the development of additional targeted therapies for the treatment of various forms of the disease.

Education/Academic qualification

Viral Oncology, Postdoctoral Fellowship, Dana-Farber Cancer Institute

PhD, Indiana University, Bloomington, IN

MA, Indiana University, Bloomington, IN

Mouse Genetics, Postdoctoral Fellowship, The Jackson Laboratory

External positions

Adjunct Professor, Baylor College of Medicine

Jul 1 2013 → …

Adjunct Professor

Mar 19 2012 → …

Research Area Keywords

  • Cancer

Free-text keywords

  • Mouse models of cancer
  • Insertional mutagenesis
  • Forward genetic screens
  • High throughput sequencing
  • Candidate cancer gene detection

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Projects

Research Output

Author Correction: A recellularized human colon model identifies cancer driver genes (Nature Biotechnology, (2016), 34, 8, (845-851), 10.1038/nbt.3586)

Chen, H. J., Wei, Z., Sun, J., Bhattacharya, A., Savage, D. J., Serda, R., Mackeyev, Y., Curley, S. A., Bu, P., Wang, L., Chen, S., Cohen-Gould, L., Huang, E., Shen, X., Lipkin, S. M., Copeland, N. G., Jenkins, N. A. & Shuler, M. L., Jul 1 2019, In : Nature Biotechnology. 37, 7, 1 p.

Research output: Contribution to journalComment/debate

  • CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes

    Takeda, H., Kataoka, S., Nakayama, M., Ali, M. A. E., Oshima, H., Yamamoto, D., Park, J. W., Takegami, Y., An, T., Jenkins, N. A., Copeland, N. G. & Oshima, M., Jul 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15635-15644 10 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM

    Kodama, T., Marian, T. A., Lee, H., Kodama, M., Li, J., Parmacek, M. S., Jenkins, N. A., Copeland, N. G. & Wei, Z., Nov 5 2019, In : Proceedings of the National Academy of Sciences of the United States of America.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters

    Levine, A. J., Jenkins, N. A. & Copeland, N. G., Jan 14 2019, In : Cancer Cell. 35, 1, p. 10-15 6 p.

    Research output: Contribution to journalReview article

  • 11 Scopus citations

    Creation of a myosin Va-TAP-tagged mouse and identification of potential myosin Va-interacting proteins in the cerebellum

    Alexander, C. J., Wagner, W., Copeland, N. G., Jenkins, N. A. & Hammer, J. A., Sep 1 2018, In : Cytoskeleton. 75, 9, p. 395-409 15 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations