Projects per year
Personal profile
Personal profile
Dr. Nancy Jenkins received her Ph.D. in molecular and cellular biology from Indiana University. Following postdoctoral studies at Harvard Medical School she joined the staff of The Jackson Laboratory and then the National Cancer Institute-Frederick, where she was a Senior Investigator and Head of the Molecular Genetics of Development Section for 22 years. She moved to the Institute of Molecular and Cell Biology in Singapore in 2006, where she served as Deputy Director for most of her stay. In 2011 she returned to the United States to serve as Co-Director of Houston Methodist Cancer Biology Program at Houston Methodist Research Institute. For more than 30 years she has co-headed a laboratory with Neal Copeland; the focus of their current research is cancer genetics. They have co-authored more than 800 papers and are among the most cited biomedical research scientists in the world today. Both have served on numerous scientific advisory and editorial boards and they have consulted for several biotechnology and pharmaceutical companies. Dr. Jenkins and Dr. Copeland are also members of the U.S. National Academy of Sciences.
Research interests
Jenkins and Copeland have modeled many different types of human disease in the mouse, but the focus of their current research is exclusively cancer. They are using the Sleeping Beauty transposable element system to tag and clone genes involved in the initiation, progression and metastasis of cancer. It is hoped that a better understanding of the genetics of cancer will lead to the development of additional targeted therapies for the treatment of various forms of the disease.
Education/Academic qualification
Viral Oncology, Postdoctoral Fellowship, Dana-Farber Cancer Institute
PhD, Indiana University, Bloomington, IN
MA, Indiana University, Bloomington, IN
Mouse Genetics, Postdoctoral Fellowship, The Jackson Laboratory
External positions
Adjunct Professor, Baylor College of Medicine
Jul 1 2013 → …Adjunct Professor
Mar 19 2012 → …Research Area Keywords
- Cancer
Free-text keywords
- Mouse models of cancer
- Insertional mutagenesis
- Forward genetic screens
- High throughput sequencing
- Candidate cancer gene detection
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
- 1 Active
Tumor vasculature-targeted nanotherapeutics for DNA damage response
Shen, H., Jenkins, N. A., Liu, X., Mitra, S. & Yang, C.
12/1/15 → 5/31/21
Project: Federal Funding Agencies
Research Output
Author Correction: A recellularized human colon model identifies cancer driver genes (Nature Biotechnology, (2016), 34, 8, (845-851), 10.1038/nbt.3586)
Chen, H. J., Wei, Z., Sun, J., Bhattacharya, A., Savage, D. J., Serda, R., Mackeyev, Y., Curley, S. A., Bu, P., Wang, L., Chen, S., Cohen-Gould, L., Huang, E., Shen, X., Lipkin, S. M., Copeland, N. G., Jenkins, N. A. & Shuler, M. L., Jul 1 2019, In : Nature Biotechnology. 37, 7, 1 p.Research output: Contribution to journal › Comment/debate
CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes
Takeda, H., Kataoka, S., Nakayama, M., Ali, M. A. E., Oshima, H., Yamamoto, D., Park, J. W., Takegami, Y., An, T., Jenkins, N. A., Copeland, N. G. & Oshima, M., Jul 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15635-15644 10 p.Research output: Contribution to journal › Article
11
Scopus
citations
MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM
Kodama, T., Marian, T. A., Lee, H., Kodama, M., Li, J., Parmacek, M. S., Jenkins, N. A., Copeland, N. G. & Wei, Z., Nov 5 2019, In : Proceedings of the National Academy of Sciences of the United States of America.Research output: Contribution to journal › Article
2
Scopus
citations
The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters
Levine, A. J., Jenkins, N. A. & Copeland, N. G., Jan 14 2019, In : Cancer Cell. 35, 1, p. 10-15 6 p.Research output: Contribution to journal › Review article
11
Scopus
citations
Creation of a myosin Va-TAP-tagged mouse and identification of potential myosin Va-interacting proteins in the cerebellum
Alexander, C. J., Wagner, W., Copeland, N. G., Jenkins, N. A. & Hammer, J. A., Sep 1 2018, In : Cytoskeleton. 75, 9, p. 395-409 15 p.Research output: Contribution to journal › Article
1
Scopus
citations