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Personal profile
My doctorate thesis research was concerning high altitude physiology mainly focusing on memory functions. Stimulation chamber used for inducing hypobaric hypoxia. I performed learning, relearning, memory consolidation and memory retrieval of rats following hypoxia. Animal handling, animal behavior analysis, basic neurotoxicity and neurochemical studies were carried out during the doctorate research. The cholinergic system and cognitive behavior have been well familiarized during hypoxia projects.
First post-doctoral position was offered from University of Turin, Italy where I was focusing on nociceptive pathways and neurotrophic factors using p8-p12 neonatal mice. This study used glial cell derived neurotrophic factors (GDNF) as a molecule to examine the role of analgesic effect. The neurotrophic factors and pain mechanisms have been well familiarized during this project.
The second post-doctoral position was offered from the Department of Neurosciences, School of Medical Sciences, University of Sains Malaysia (USM) in Malaysia. This study was aimed to understand the effect of Normobaric hyperoxia (100% O2) on closed traumatic brain injury in the basal ganglia of mouse models. The stereotactic surgery coordinates at basal ganglia, fluid percussion device for induction of closed brain injury, IntelliCage as automated behavior system, morphology, locomotor behaviors and dopaminergic system has been well familiarized during this project.
The third post-doctoral position was obtained from the Department of Neuropsychopharmacology, University of Sao Paulo, Brazil. The main theme of this laboratory is to understand the fear and anxiety behavior mediated by antipsychotic drugs through different brain regions. This project made me well familiarized in the field of fear and anxiety behavior and role of dopamine in the mediation of the aversive behavior in the midbrain structures.
Then, I joined as a senior lecturer (equivalent to the rank of Associate Professor in North American Universities) in the department of Neuroscience, Universiti Sains Malaysia (USM), Malaysia. Based on my expertise, I established a project on stress neurobiology and alcohol addictive behavior in a mouse model. I received two university level short term grants and two national level grants in Malaysia. Also, I was working as a Co-investigator for other projects dealing with intracerebellar hemorrhage mouse model, effect of hypoxia on Semaphorin family in human hippocampal astrocytes, effects of Centella asiatica on learning and memory, effects of Tualang honey supplement on memory performance and human TB project. I supervised 4 master students and 1 Ph.D student. Also, I have been a co-supervisor for 8 master students. I have experience in project management, supervising students, and administrative work.
Again, I was offered a post-doctoral position in the College of Pharmacy, University of Houston to study the role of presynaptic proteins in alcohol addiction. Currently, I have been working as an Instructor in Radiology, Houston Methodist Research Institute to study the neuroinflammatory markers in the various neurological disorders using PET/MRI imaging in mice and humans. Also, I am involved in a clinical trial for 18F-SMBT-1 in healthy and Alzheimer’s disease patients. On the other hand, I am working on a NAFLD mice model using PET/MRI using PET tracer for liver fibrosis and behavior.
Education/Academic qualification
Neuroscience, PhD, Involvement of cholinergic system in learning and memory of rats; role of anticholinesterase inhibitors, Bharathiar University, Coimbatore, Tamil Nadu, India
Mar 24 2004 → Oct 23 2008
Award Date: Oct 23 2008
External positions
Post-doctoral fellow, University of Houston
Aug 28 2019 → Sep 5 2022
Senior Lecturer, Universiti Sains Malaysia
May 25 2015 → Aug 15 2019
Post-doctoral fellow, University of São Paulo Medical School
Apr 1 2012 → May 19 2015
Post-doctoral fellow, Universiti Sains Malaysia
Nov 1 2010 → Mar 21 2012
Post-doctoral fellow, University of Turin
Jan 15 2009 → Aug 15 2010
Research Area Keywords
- Imaging & Radiology
- Neurosciences
- Clinical Translation & Trials
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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Selective PET imaging of astrocytes and microglia in Alzheimer's disease
Masdeu, J. C. (PI), Pascual, B. (Key Personnel) & Sangu, M. (Key Personnel)
1/19/23 → …
Project: Clinical Trial
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Editorial: Substance use disorder: above and beyond addiction
Kumar, J., Mohamed, W., Borroto-Escuela, D. O., Sangu, M., Rashid, R., Mohamad Isa, M. F. & Shanmugam, P. K., 2024, In: Frontiers in Pharmacology. 15, 1426351.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Effect of Tualang Honey-Mediated Silver Nanoparticles on TNF-α level, Caspase-3 Activity and Hippocampal Morphology in Kainic Acid-Induced Neurodegeneration in Male Rats
Hasim, H., Kuttulebbai, N. M. S. S., Rao, P. V., Muthuraju, S., Che, J. N. & Asari, M. A., Oct 2024, In: IIUM Medical Journal Malaysia. 23, 4, p. 93-101 9 p.Research output: Contribution to journal › Article › peer-review
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Retraction notice to “Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia” [Behav. Brain Res. 203/1 (2009) 1–14, (S0166432809001909), (10.1016/j.bbr.2009.03.026)]
Muthuraju, S., Maiti, P., Solanki, P., Sharma, A. K., Amitabh, Singh, S. B., Prasad, D. & Ilavazhagan, G., Aug 5 2024, In: Behavioural Brain Research. 471, 115088.Research output: Contribution to journal › Comment/debate › peer-review
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Retraction notice to “Hypobaric hypoxia induces dendritic plasticity in cortical and hippocampal pyramidal neurons in rat brain” [Behav. Brain Res. 189/2 (2008) 233–243, (S0166432808000302), (10.1016/j.bbr.2008.01.007)]
Maiti, P., Muthuraju, S., Ilavazhagan, G. & Singh, S. B., Jun 25 2024, In: Behavioural Brain Research. 468, 115016.Research output: Contribution to journal › Comment/debate › peer-review
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The Promising Key Factors Mediating Secondary Neuronal Damage in the Perihematomal Region of Intracerebellar Hemorrhage of Mice
Bhatia, S., Paramasivam, R., Zolkefley, M. K. I. B., Kandasamy, R., Muthuraju, S. & Abdullah, J. M., Oct 2024, In: Journal of Physiological Investigation. 67, 6, p. 321-334 14 p.Research output: Contribution to journal › Article › peer-review
Open Access