Research outputs

  1. 2019
  2. Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis

    Kachroo, P., Eraso, J. M., Beres, S. B., Olsen, R. J., Zhu, L., Nasser, W., Bernard, P. E., Cantu, C. C., Saavedra, M. O., Arredondo, M. J., Strope, B., Do, H., Kumaraswami, M., Vuopio, J., Gröndahl-Yli-Hannuksela, K., Kristinsson, K. G., Gottfredsson, M., Pesonen, M., Pensar, J., Davenport, E. R. & 11 othersClark, A. G., Corander, J., Caugant, D. A., Gaini, S., Magnussen, M. D., Kubiak, S. L., Nguyen, H. A. T., Long, S. W., Porter, A. R., DeLeo, F. R. & Musser, J. M., Mar 1 2019, In : Nature Genetics. 51, 3, p. 548-559 12 p.

    Research output: Contribution to journalArticle

  3. 2018
  4. Phosphatase activity of the control of virulence sensor kinase CovS is critical for the pathogenesis of group A streptococcus

    Horstmann, N., Tran, C. N., Brumlow, C., DebRoy, S., Yao, H., Nogueras Gonzalez, G., Makthal, N., Kumaraswami, M. & Shelburne, S. A., Oct 1 2018, In : PLoS Pathogens. 14, 10, e1007354.

    Research output: Contribution to journalArticle

  5. Signaling by a conserved quorum sensing pathway contributes to growth ex vivo and oropharyngeal colonization of human pathogen group A streptococcus

    Makthal, N., Do, H., VanderWal, A. R., Olsen, R. J., Musser, J. M. & Kumaraswami, M., May 1 2018, In : Infection and Immunity. 86, 5, e00169-18.

    Research output: Contribution to journalArticle

  6. 2017
  7. Zinc'ing it out: Zinc homeostasis mechanisms and their impact on the pathogenesis of human pathogen group A streptococcus

    Makthal, N. & Kumaraswami, M., Dec 1 2017, In : Metallomics. 9, 12, p. 1693-1702 10 p.

    Research output: Contribution to journalArticle

  8. Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen

    Do, H., Makthal, N., VanderWal, A. R., Rettel, M., Savitski, M. M., Peschek, N., Papenfort, K., Olsen, R. J., Musser, J. M. & Kumaraswami, M., Sep 18 2017, In : Proceedings of the National Academy of Sciences.

    Research output: Contribution to journalArticle

  9. Iron efflux by PmtA is critical for oxidative stress resistance and contributes significantly to group A Streptococcus virulence

    VanderWal, A. R., Makthal, N., Pinochet-Barros, A., Helmann, J. D., Olsen, R. J. & Kumaraswami, M., Jun 1 2017, In : Infection and Immunity. 85, 6, e00091-17.

    Research output: Contribution to journalArticle

  10. A Critical Role of Zinc Importer AdcABC in Group A Streptococcus-Host Interactions During Infection and Its Implications for Vaccine Development

    Makthal, N., Nguyen, K., Do, H., Gavagan, M., Chandrangsu, P., Helmann, J. D., Olsen, R. J. & Kumaraswami, M., Jan 10 2017, (Accepted/In press) In : EBioMedicine.

    Research output: Contribution to journalArticle

  11. Multimerization of the Virulence-Enhancing Group A Streptococcus Transcription Factor RivR Is Required for Regulatory Activity

    Ramalinga, A., Danger, J. L., Makthal, N., Kumaraswami, M. & Sumby, P., Jan 1 2017, In : Journal of Bacteriology. 199, 1

    Research output: Contribution to journalArticle

  12. 2016
  13. Structural Mechanisms of Peptide Recognition and Allosteric Modulation of Gene Regulation by the RRNPP Family of Quorum-Sensing Regulators

    Do, H. & Kumaraswami, M., Jul 17 2016, In : Journal of molecular biology. 428, 14, p. 2793-2804 12 p.

    Research output: Contribution to journalArticle

  14. Structural and functional analysis of RopB: A major virulence regulator in Streptococcus pyogenes

    Makthal, N., Gavagan, M., Do, H., Olsen, R. J., Musser, J. M. & Kumaraswami, M., Mar 1 2016, In : Molecular Microbiology. 99, 6, p. 1119-1133 15 p.

    Research output: Contribution to journalArticle

  15. 2015
  16. Adhesin competence repressor (AdcR) from Streptococcus pyogenes controls adaptive responses to zinc limitation and contributes to virulence

    Sanson, M., Makthal, N., Flores, A. R., Olsen, R. J., Musser, J. M. & Kumaraswami, M., Sep 1 2015, In : Nucleic acids research. 43, 1, p. 418-432 15 p.

    Research output: Contribution to journalArticle

  17. Phosphorylation events in the multiple gene regulator of group A Streptococcus significantly influence global gene expression and virulence

    Sanson, M., Makthal, N., Gavagan, M., Cantu, C., Olsen, R. J., Musser, J. M. & Kumaraswami, M., 2015, In : Infection and Immunity. 83, 6, p. 2382-2395 14 p.

    Research output: Contribution to journalArticle

  18. The FasX small regulatory RNA negatively regulates the expression of two fibronectin-binding proteins in group a streptococcus

    Danger, J. L., Makthal, N., Kumaraswami, M. & Sumby, P., 2015, In : Journal of Bacteriology. 197, 23, p. 3720-3730 11 p.

    Research output: Contribution to journalArticle

  19. 2014
  20. Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling

    Dave, B., Granados-Principal, S., Zhu, R., Benz, S., Rabizadeh, S., Soon-Shiong, P., Yu, K. D., Shao, Z., Li, X., Gilcrease, M., Lai, Z., Chen, Y., Huang, T. H. M., Shen, H., Liu, X., Ferrari, M., Zhan, M., Wong, S. T. C., Kumaraswami, M., Mittal, V. & 3 othersChen, X., Gross, S. S. & Chang, J. C., Jan 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 24, p. 8838-8843 6 p.

    Research output: Contribution to journalArticle

  21. A naturally occurring single amino acid replacement in multiple gene regulator of group a streptococcus significantly increases virulence

    Sanson, M., O'Neill, B. E., Kachroo, P., Anderson, J. R., Flores, A. R., Valson, C., Cantu, C. C., Makthal, N., Karmonik, C., Fittipaldi, N., Kumaraswami, M., Musser, J. M. & Olsen, R. J., 2014, In : American Journal of Pathology. 185, 2, p. 462-471 10 p.

    Research output: Contribution to journalArticle

  22. 2013
  23. Natural variation in the promoter of the gene encoding the mga regulator alters host-pathogen interactions in group a streptococcus carrier strains

    Flores, A. R., Olsen, R. J., Wunsche, A., Kumaraswami, M., Shelburne, S. A., Carroll, R. K. & Musser, J. M., Nov 1 2013, In : Infection and Immunity. 81, 11, p. 4128-4138 11 p.

    Research output: Contribution to journalArticle

  24. Functional consequences of substitution mutations in mepr, a repressor of the staphylococcus aureus mepa multidrug efflux pump gene

    Schindler, B. D., Seo, S. M., Jacinto, P. L., Kumaraswami, M., Birukou, I., Brennan, R. G. & Kaatz, G. W., Aug 7 2013, In : Journal of Bacteriology. 195, 16, p. 3651-3662 12 p.

    Research output: Contribution to journalArticle

  25. Crystal structure of peroxide stress regulator from streptococcus pyogenes provides functional insights into the mechanism of oxidative stress sensing

    Makthal, N., Rastegari, S., Sanson, M., Ma, Z., Olsen, R. J., Helmann, J. D., Musser, J. M. & Kumaraswami, M., Jun 21 2013, In : Journal of Biological Chemistry. 288, 25, p. 18311-18324 14 p.

    Research output: Contribution to journalArticle

  26. 2012
  27. Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group a streptococcus

    Olsen, R. J., Laucirica, D. R., Watkins, M. E., Feske, M. L., Garcia-Bustillos, J. R., Vu, C., Cantu, C., Shelburne, S. A., Fittipaldi, N., Kumaraswami, M., Shea, P. R., Flores, A. R., Beres, S. B., Lovgren, M., Tyrrell, G. J., Efstratiou, A., Low, D. E., Van Beneden, C. A. & Musser, J. M., Jun 1 2012, In : Journal of Infectious Diseases. 205, 11, p. 1719-1729 11 p.

    Research output: Contribution to journalArticle

  28. 2011
  29. An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes

    Shelburne, S. A., Olsen, R. J., Makthal, N., Brown, N. G., Sahasrabhojane, P., Watkins, E. M., Palzkill, T., Musser, J. M. & Kumaraswami, M., Dec 1 2011, In : Molecular Microbiology. 82, 6, p. 1481-1495 15 p.

    Research output: Contribution to journalArticle

  30. Genetic analysis of phage Mu Mor protein amino acids involved in DNA minor groove binding and conformational changes

    Kumaraswami, M., Avanigadda, L., Rai, R., Park, H. W. & Howe, M. M., Oct 14 2011, In : Journal of Biological Chemistry. 286, 41, p. 35852-35862 11 p.

    Research output: Contribution to journalArticle

  31. Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis

    Horstmann, N., Sahasrabhojane, P., Suber, B., Kumaraswami, M., Olsen, R. J., Flores, A., Musser, J. M., Brennan, R. G. & Shelburne, S. A., Oct 1 2011, In : PLoS Pathogens. 7, 10, e1002311.

    Research output: Contribution to journalArticle

  32. Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein

    Shelburne, S. A., Sahasrobhajane, P., Suber, B., Keith, D. B., Davenport, M. T., Horstmann, N., Kumaraswami, M., Olsen, R. J., Brennan, R. G. & Musser, J. M., Jul 1 2011, In : Molecular Microbiology. 81, 2, p. 500-514 15 p.

    Research output: Contribution to journalArticle

  33. Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice

    Carroll, R. K., Shelburne, S. A., Olsen, R. J., Suber, B., Sahasrabhojane, P., Kumaraswami, M., Beres, S. B., Shea, P. R., Flores, A. R. & Musser, J. M., May 2 2011, In : Journal of Clinical Investigation. 121, 5, p. 1956-1968 13 p.

    Research output: Contribution to journalArticle

  34. 2010
  35. Plasmid protein TubR uses a distinct mode of HTH-DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition

    Ni, L., Xu, W., Kumaraswami, M. & Schumacher, M. A., Jun 29 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 26, p. 11763-11768 6 p.

    Research output: Contribution to journalArticle

  36. Conformational Plasticity of the Coiled-Coil Domain of BmrR Is Required for bmr Operator Binding: The Structure of Unliganded BmrR

    Kumaraswami, M., Newberry, K. J. & Brennan, R. G., Apr 1 2010, In : Journal of molecular biology. 398, 2, p. 264-275 12 p.

    Research output: Contribution to journalArticle

  37. 2009
  38. Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA

    Kumaraswami, M., Schuman, J. T., Seo, S. M., Kaatz, G. W. & Brennan, R. G., Mar 24 2009, In : Nucleic acids research. 37, 4, p. 1211-1224 14 p.

    Research output: Contribution to journalArticle

  39. 2004
  40. Crystal Structure of the Mor Protein of Bacteriophage Mu, a Member of the Mor/C Family of Transcription Activators

    Kumaraswami, M., Howe, M. M. & Park, H. W., Apr 16 2004, In : Journal of Biological Chemistry. 279, 16, p. 16581-16590 10 p.

    Research output: Contribution to journalArticle

ID: 2281969