Projects per year
Personal profile
Personal profile
Dr. Kumaraswami received his Ph.D. in microbiology and immunology from the University of Tennessee Health Sciences Center in Memphis. He then completed a postdoctoral fellowship at The University of Texas M.D. Anderson Cancer Center in Houston, Texas. In 2008, Dr. Kumaraswami received the Amgen Award for Basic Science Research from the M.D. Anderson Alumni and Faculty Association. He joined the Center for Molecular and Translational Human Infectious Diseases Research at The Methodist Hospital Research Institute in 2010.
Research interests
Dr. Kumaraswami conducts translational research on the gene regulatory and drug-binding mechanisms of transcription regulators in bacterial pathogens such as Staphylococcus aureus. His research focuses on three major proteins (RopB, RofA, and RocA) that are involved in the coordinated regulation of virulence gene expression and group A streptococci pathogenesis.
Education/Academic qualification
Veterinary Sciences, BVSc, Tamilnadu Veterinary and Animal Sciences, Chennai
Microbial Genetics and Structural Biology, PhD, The University of Tennessee Health Science Center
Structural Biology, Postdoctoral Fellowship, University of Texas MD Anderson Cancer Center
Free-text keywords
- GAS pathogenesis
- Staphylococcus Aureus
Research Area Keywords
- Infectious Disease & Pathology
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Projects
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Molecular mechanism of streptococcal adaptation to host nutritional defenses
Kumaraswami, M. & Olsen, R. J.
2/25/20 → 1/31/25
Project: Federal Funding Agencies
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The role of the gut microbiome in the neuropathology of traumatic brain injury
Villapol, S. & Kumaraswami, M.
10/1/18 → 3/31/21
Project: Federal Funding Agencies
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Molecular mechanism of virulence regulation in Streptococcus pyogenes
Kumaraswami, M. & Olsen, R. J.
3/1/15 → 2/28/21
Project: Federal Funding Agencies
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Mechanism of streptococcus virulence regulation by bacterial peptide signals
Kumaraswami, M. & Olsen, R. J.
Natl Inst of AllergyandInfectious Disease
8/15/13 → 7/31/15
Project: Federal Funding Agencies
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Genetic control of post embryonic wound healing in Drosophila larvae
6/1/13 → 3/31/16
Project: Federal Funding Agencies
Research Output
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Group A Streptococcus AdcR Regulon Participates in Bacterial Defense against Host-Mediated Zinc Sequestration and Contributes to Virulence
Makthal, N., Do, H., Wendel, B. M., Olsen, R. J., Helmann, J. D., Musser, J. M. & Kumaraswami, M., Jul 21 2020, In : Infection and Immunity. 88, 8Research output: Contribution to journal › Article
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Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway
Do, H., Makthal, N., VanderWal, A. R., Saavedra, M. O., Olsen, R. J., Musser, J. M. & Kumaraswami, M., Jun 13 2019, In : Nature Communications. 10, 1, 2586.Research output: Contribution to journal › Article
3 Scopus citations -
Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis
Kachroo, P., Eraso, J. M., Beres, S. B., Olsen, R. J., Zhu, L., Nasser, W., Bernard, P. E., Cantu, C. C., Saavedra, M. O., Arredondo, M. J., Strope, B., Do, H., Kumaraswami, M., Vuopio, J., Gröndahl-Yli-Hannuksela, K., Kristinsson, K. G., Gottfredsson, M., Pesonen, M., Pensar, J., Davenport, E. R. & 11 others, , Mar 1 2019, In : Nature Genetics. 51, 3, p. 548-559 12 p.Research output: Contribution to journal › Article
19 Scopus citations -
Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence
Do, H., Makthal, N., Chandrangsu, P., Olsen, R. J., Helmann, J. D., Musser, J. M. & Kumaraswami, M., Aug 22 2019, In : Nucleic Acids Research. 47, 14, p. 7476-7493 18 p.Research output: Contribution to journal › Article
4 Scopus citations -
Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence
Do, H., Makthal, N., Chandrangsu, P., Olsen, R. J., Helmann, J. D., Musser, J. M. & Kumaraswami, M., Sep 5 2019, In : Nucleic Acids Research. 47, 15, p. 8333-8334 2 p.Research output: Contribution to journal › Article