Muthiah Kumaraswami, PhD

Associate Professor of Pathology and Genomic Medicine, Academic Institute
Associate Member, Research Institute
Center for Molecular & Translational Human Infectious Diseases Research
Department of Pathology & Genomic Medicine
Houston Methodist

Source: Scopus
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Personal profile

Dr. Kumaraswami received his Ph.D. in microbiology and immunology from the University of Tennessee Health Sciences Center in Memphis. He then completed a postdoctoral fellowship at The University of Texas M.D. Anderson Cancer Center in Houston, Texas. In 2008, Dr. Kumaraswami received the Amgen Award for Basic Science Research from the M.D. Anderson Alumni and Faculty Association. He joined the Center for Molecular and Translational Human Infectious Diseases Research at The Methodist Hospital Research Institute in 2010.

Research interests

Dr. Kumaraswami conducts translational research on the gene regulatory and drug-binding mechanisms of transcription regulators in bacterial pathogens such as Staphylococcus aureus. His research focuses on three major proteins (RopB, RofA, and RocA) that are involved in the coordinated regulation of virulence gene expression and group A streptococci pathogenesis.

Education/Academic qualification

Veterinary Sciences, BVSc, Tamilnadu Veterinary and Animal Sciences, Chennai

Microbial Genetics and Structural Biology, PhD, The University of Tennessee Health Science Center

Structural Biology, Postdoctoral Fellowship, University of Texas MD Anderson Cancer Center

Free-text keywords

GAS pathogenesis
Staphylococcus Aureus

Research Area Keywords

Infectious Disease & Pathology

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3 Finished
3 Active

Molecular mechanism of streptococcal adaptation to host nutritional defenses
Kumaraswami, M. & Olsen, R. J.
2/25/20 → 1/31/25
Project: Federal Funding Agencies
The role of the gut microbiome in the neuropathology of traumatic brain injury
Villapol, S. & Kumaraswami, M.
10/1/18 → 3/31/21
Project: Federal Funding Agencies
Molecular mechanism of virulence regulation in Streptococcus pyogenes
Kumaraswami, M. & Olsen, R. J.
National Institutes of Health
3/1/15 → 2/28/21
Project: Federal Funding Agencies
Mechanism of streptococcus virulence regulation by bacterial peptide signals
Kumaraswami, M. & Olsen, R. J.
Natl Inst of AllergyandInfectious Disease
8/15/13 → 7/31/15
Project: Federal Funding Agencies
Genetic control of post embryonic wound healing in Drosophila larvae
Kumaraswami, M.
UT M D Anderson Cancer Center
6/1/13 → 3/31/16
Project: Federal Funding Agencies

611 Citations
16 h-Index
33 Article
1 Review article

Group A Streptococcus AdcR Regulon Participates in Bacterial Defense against Host-Mediated Zinc Sequestration and Contributes to Virulence
Makthal, N., Do, H., Wendel, B. M., Olsen, R. J., Helmann, J. D., Musser, J. M. & Kumaraswami, M., Jul 21 2020, In : Infection and Immunity. 88, 8, e00097-20.
Research output: Contribution to journal › Article
1 Scopus citations
Molecular architecture of early dissemination and massive second wave of the SARS-CoV-2 virus in a major metropolitan area
Long, S. W., Olsen, R. J., Christensen, P. A., Bernard, D. W., Davis, J. J., Shukla, M., Nguyen, M., Saavedra, M. O., Yerramilli, P., Pruitt, L., Subedi, S., Kuo, H. C., Hendrickson, H., Eskandari, G., Nguyen, H. A. T., Long, J. H., Kumaraswami, M., Goike, J., Boutz, D., Gollihar, J. & 5 others, McLellan, J. S., Chou, C. W., Javanmardi, K., Finkelstein, I. J. & Musser, J. M., Nov 1 2020, In : mBio. 11, 6, p. 1-30 30 p., e02707-20.
Research output: Contribution to journal › Article

Open Access
3 Scopus citations
Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway
Do, H., Makthal, N., VanderWal, A. R., Saavedra, M. O., Olsen, R. J., Musser, J. M. & Kumaraswami, M., Jun 13 2019, In : Nature Communications. 10, 1, 2586.
Research output: Contribution to journal › Article
7 Scopus citations
Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis
Kachroo, P., Eraso, J. M., Beres, S. B., Olsen, R. J., Zhu, L., Nasser, W., Bernard, P. E., Cantu, C. C., Saavedra, M. O., Arredondo, M. J., Strope, B., Do, H., Kumaraswami, M., Vuopio, J., Gröndahl-Yli-Hannuksela, K., Kristinsson, K. G., Gottfredsson, M., Pesonen, M., Pensar, J., Davenport, E. R. & 11 others, Clark, A. G., Corander, J., Caugant, D. A., Gaini, S., Magnussen, M. D., Kubiak, S. L., Nguyen, H. A. T., Long, S. W., Porter, A. R., DeLeo, F. R. & Musser, J. M., Mar 1 2019, In : Nature Genetics. 51, 3, p. 548-559 12 p.
Research output: Contribution to journal › Article
23 Scopus citations
Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence
Do, H., Makthal, N., Chandrangsu, P., Olsen, R. J., Helmann, J. D., Musser, J. M. & Kumaraswami, M., Aug 22 2019, In : Nucleic Acids Research. 47, 14, p. 7476-7493 18 p.
Research output: Contribution to journal › Article
5 Scopus citations