Research output per year
Research output per year
- 1 - 50 out of 80 results
Search results
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2024
FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease
Kodavati, M., Wang, H., Guo, W., Mitra, J., Hegde, P. M., Provasek, V., Rao, V. H. M., Vedula, I., Zhang, A., Mitra, S., Tomkinson, A. E., Hamilton, D. J., Van Den Bosch, L. & Hegde, M. L., Mar 9 2024, In: Nature Communications. 15, 1, 2156.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner
Provasek, V. E., Kodavati, M., Kim, B., Mitra, J. & Hegde, M. L., Dec 2024, In: Molecular Brain. 17, 1, 32.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity
Guo, W., Wang, H., Kumar Tharkeshwar, A., Couthouis, J., Braems, E., Masrori, P., Van Schoor, E., Fan, Y., Ahuja, K., Moisse, M., Jacquemyn, M., Furtado Madeiro da Costa, R., Gajjar, M., Balusu, S., Tricot, T., Fumagalli, L., Hersmus, N., Janky, R., Impens, F., Vanden Berghe, P., & 10 others, Apr 2023, In: Alzheimer's and Dementia. 19, 4, p. 1245-1259 15 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks
Chakraborty, A., Tapryal, N., Islam, A., Sarker, A. H., Manohar, K., Mitra, J., Hegde, M. L. & Hazra, T., Mar 2023, In: Journal of Biological Chemistry. 299, 3, 102991.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons
Provasek, V. E., Kodavati, M., Guo, W., Wang, H., Boldogh, I., Van Den Bosch, L., Britz, G. & Hegde, M. L., Oct 16 2023, In: Cells. 12, 20, 2461.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Parkinson's disease - Perspectives from Alpha-synuclein related pathogenesis and current research
Hegde, M., Apr 30 2023, In: Journal of stem cells & regenerative medicine. 19, 1, p. 22-26 5 p.Research output: Contribution to journal › Article › peer-review
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2022
Pouteria sapota (Red Mamey Fruit): Chemistry and Biological Activity of Carotenoids
Lakey-Beitia, J., Vasquez, V., Mojica-Flores, R., Fuentes C., A. L., Murillo, E., Hegde, M. L. & Rao, K. S., Jul 2022, In: Combinatorial Chemistry and High Throughput Screening. 25, 7, p. 1134-1147 14 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
2021
Computational Evaluation of Interaction between Curcumin Derivatives and Amyloid-β Monomers and Fibrils: Relevance to Alzheimer's Disease
Orjuela, A., Lakey-Beitia, J., Mojica-Flores, R., Hegde, M. L., Lans, I., Alí-Torres, J. & Rao, K. S., 2021, In: Journal of Alzheimer's Disease. 82, s1, p. S321-S333Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin
Bacolla, A., Sengupta, S., Ye, Z., Yang, C., Mitra, J., De-Paula, R. B., Hegde, M. L., Ahmed, Z., Mort, M., Cooper, D. N., Mitra, S. & Tainer, J. A., Jan 11 2021, In: Nucleic Acids Research. 49, 1, p. 221-243 23 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2020
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis
Chakraborty, A., Tapryal, N., Venkova, T., Mitra, J., Vasquez, V., Sarker, A. H., Duarte-Silva, S., Huai, W., Ashizawa, T., Ghosh, G., MacIel, P., Sarkar, P. S., Hegde, M. L., Chen, X. & Hazra, T. K., Apr 7 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 8154-8165 12 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
Sengupta, S., Wang, H., Yang, C., Szczesny, B., Hegde, M. L. & Mitra, S., Sep 8 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 36, p. 22183-22192 10 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle
Dharmalingam, P., Talakatta, G., Mitra, J., Wang, H., Derry, P. J., Nilewski, L. G., McHugh, E. A., Fabian, R. H., Mendoza, K., Vasquez, V., Hegde, P. M., Kakadiaris, E., Roy, T., Boldogh, I., Hegde, V. L., Mitra, S., Tour, J. M., Kent, T. A. & Hegde, M., Mar 24 2020, In: ACS Nano. 14, 3, p. 2827-2846 20 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations -
The Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosis
Derry, P. J., Vo, A. T. T., Gnanansekaran, A., Mitra, J., Liopo, A. V., Hegde, M. L., Tsai, A. L., Tour, J. M. & Kent, T. A., Dec 8 2020, In: Frontiers in Cellular Neuroscience. 14, 603043.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells
Eckelmann, B. J., Bacolla, A., Wang, H., Ye, Z., Guerrero, E. N., Jiang, W., El-Zein, R., Hegde, M. L., Tomkinson, A. E., Tainer, J. A. & Mitra, S., Sep 1 2020, In: NAR Cancer. 2, 3, zcaa013.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells
Eckelmann, B. J., Bacolla, A., Wang, H., Ye, Z., Guerrero, E. N., Jiang, W., El-Zein, R., Hegde, M. L., Tomkinson, A. E., Tainer, J. A. & Mitra, S., Sep 2020, In: NAR cancer. 2, 3, p. zcaa013Research output: Contribution to journal › Article › peer-review
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2019
A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis
Mitra, J. & Hegde, M., 2019, In: Journal of Experimental Neuroscience. 13Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis
Guerrero, E. N., Mitra, J., Wang, H., Rangaswamy, S., Hegde, P. M., Basu, P., Rao, K. S. & Hegde, M., Aug 1 2019, In: Human Molecular Genetics. 28, 5, p. 2459-2476 18 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis
Guerrero, E. N., Mitra, J., Wang, H., Rangaswamy, S., Hegde, P. M., Basu, P., Rao, K. S. & Hegde, M. L., Sep 15 2019, In: Human Molecular Genetics. 28, 18, p. 3161-3162 2 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis
Lakey-Beitia, J., Kumar D, J., Hegde, M. L. & Rao, K. S., Nov 7 2019, In: International journal of molecular sciences. 20, 22, p. 20(22). pii: E5553 PMID: 31703296 .Research output: Contribution to journal › Article › peer-review
66 Scopus citations -
Hexahydropyrrolo[2,3- b]indole Compounds as Potential Therapeutics for Alzheimer's Disease
Doens, D., Valdés-Tresanco, M. E., Vasquez, V., Carreira, M. B., De La Guardia, Y., Stephens, D. E., Nguyen, V. D., Nguyen, V. T., Gu, J., Hegde, M. L., Larionov, O. V., Valiente, P. A., Lleonart, R. & Fernández, P. L., Oct 16 2019, In: ACS Chemical Neuroscience. 10, 10, p. 4250-4263 14 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients
Mitra, J., Hegde, P. M. & Hegde, M. L., Jun 13 2019, In: Molecular Brain. 12, 1, 55.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
Mitra, J., Guerrero, E. N., Hegde, P. M., Liachko, N. F., Wang, H., Vasquez, V., Gao, J., Pandey, A., Paul Taylor, J., Kraemer, B. C., Wu, P., Boldogh, I., Garruto, R. M., Mitra, S., Rao, K. S. & Hegde, M., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4696-4705 10 p.Research output: Contribution to journal › Article › peer-review
Open Access184 Scopus citations -
New mechanisms of dna repair defects in fused in sarcoma–associated neurodegeneration: Stage set for dna repair-based therapeutics?
Wang, H. & Hegde, M., 2019, In: Journal of Experimental Neuroscience. 13Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease
Wang, H., Rangaswamy, S., Kodavati, M., Mitra, J., Guo, W., Guerrero, E. N., Van Den Bosch, L. & Hegde, M., Dec 4 2019, In: Molecular Brain. 12, 1, 103.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2018
Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress
Sengupta, S., Yang, C., Hegde, M. L., Hegde, P. M., Mitra, J., Pandey, A., Dutta, A., Datarwala, A. T., Bhakat, K. K. & Mitra, S., Apr 27 2018, In: DNA Repair. 66-67, p. 1-10 10 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson's Disease1
Vasquez, V., Mitra, J., Perry, G., Rao, K. S. & Hegde, M. L., 2018, In: Journal of Alzheimer's Disease. 66, 2, p. 453-460 8 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs
Okonkwo, A., Mitra, J., Johnson, G. S., Li, L., Dashwood, W. M., Hegde, M. L., Yue, C., Dashwood, R. H. & Rajendran, P., Sep 2018, In: Molecular Nutrition and Food Research. 62, 18, 1800228.Research output: Contribution to journal › Article › peer-review
47 Scopus citations -
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
Wang, H., Guo, W., Mitra, J., Hegde, P. M., Vandoorne, T., Eckelmann, B. J., Mitra, S., Tomkinson, A. E., Van Den Bosch, L. & Hegde, M. L., Sep 11 2018, In: Nature Communications. 9, 1, 3683.Research output: Contribution to journal › Article › peer-review
Open Access128 Scopus citations -
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
Wang, H., Guo, W., Mitra, J., Hegde, P. M., Vandoorne, T., Eckelmann, B. J., Mitra, S., Tomkinson, A. E., Bosch, L. V. D. & Hegde, M., 2018, In: Nature Communications. 9, 3683Research output: Contribution to journal › Article › peer-review
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Sinomenine hydrochloride sensitizes cervical cancer cells to ionizing radiation by impairing DNA damage response
Zhang, D., Dong, Y., Zhao, Y., Zhou, C., Qian, Y., Hegde, M. L., Wang, H. & Han, S., Nov 2018, In: Oncology Reports. 40, 5, p. 2886-2895 10 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2017
Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
Wang, H., Peng, B., Pandita, R. K., Engler, D. A., Matsunami, R. K., Xu, X., Hegde, P. M., Butler, E. B., Pandita, T. K., Mitra, S., Xu, B. & Hegde, M. L., 2017, In: Oncotarget. 8, 30, p. 48671-48687 17 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease
Vasquez, V., Mitra, J., Hegde, P. M., Pandey, A., Sengupta, S., Mitra, S., Rao, S. K. & Hegde, M. L., 2017, In: Journal of Alzheimer's Disease. 60, s1, p. S133-S150Research output: Contribution to journal › Article › peer-review
62 Scopus citations -
Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase
Rangaswamy, S., Pandey, A., Mitra, S. & Hegde, M. L., Jun 30 2017, In: Genes. 8, 7Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
2016
8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging
German, P., Saenz, D., Szaniszlo, P., Aguilera-Aguirre, L., Pan, L., Hegde, M. L., Bacsi, A., Hajas, G., Radak, Z., Ba, X., Mitra, S., Papaconstantinou, J. & Boldogh, I., Jun 21 2016, In: Mechanisms of Ageing and Development. 161, p. 51-65 15 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?
Wang, H., Dharmalingam, P., Vasquez, V., Mitra, J., Boldogh, I., Rao, K. S., Kent, T. A., Mitra, S. & Hegde, M. L., Sep 20 2016, In: Mechanisms of Ageing and Development.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Human AP-endonuclease (APE1) is acetylated at DNA damage sites in chromatin and acetylation modulates its DNA repair activity
Roychoudhury, S., Nath, S., Song, H., Hegde, M. L., Bellot, L. J., Mantha, A. K., Sengupta, S., Ray, S., Natarajan, A. & Bhakat, K. K., Dec 19 2016, In: Molecular and Cellular Biology.Research output: Contribution to journal › Article › peer-review
36 Scopus citations -
Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
Dutta, A., Eckelmann, B., Adhikari, S., Ahmed, K. M., Sengupta, S., Pandey, A., Hegde, P. M., Tsai, M-S., Tainer, J. A., Weinfeld, M., Hegde, M. L. & Mitra, S., Dec 19 2016, In: Nucleic Acids Research. 45, 5, p. 2585-2599 15 p.Research output: Contribution to journal › Article › peer-review
73 Scopus citations -
Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor κB-driven gene expression
Pan, L., Zhu, B., Hao, W., Zeng, X., Vlahopoulos, S. A., Hazra, T. K., Hegde, M. L., Radak, Z., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2 2016, In: The Journal of biological chemistry. 291, 49, p. 25553-25566 14 p.Research output: Contribution to journal › Article › peer-review
140 Scopus citations -
Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
Yang, C., Sengupta, S., Hegde, P. M., Mitra, J., Jiang, S., Holey, B., Sarker, A. H., Tsai, M-S., Hegde, M. L. & Mitra, S., Oct 27 2016, In: Nucleic Acids Research. 45, 2, p. 739-748 10 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
Hegde, M. L., Dutta, A., Yang, C., Mantha, A. K., Hegde, P. M., Pandey, A., Sengupta, S., Yu, Y., Calsou, P., Chen, D., Lees-Miller, S. P. & Mitra, S., Jun 9 2016, In: Oncotarget.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
2015
A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells
Wang, H., Adhikari, S., Butler, E. B., Pandita, T. K., Mitra, S. & Hegde, M. L., Jan 24 2015, In: Jacobs Journal of Radiation Oncology. 1, 1:003.Research output: Contribution to journal › Article › peer-review
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New paradigms in the repair of oxidative damage in human genome: Mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins
Dutta, A., Yang, C., Sengupta, S., Mitra, S. & Hegde, M. L., May 1 2015, In: Cellular and Molecular Life Sciences. 72, 9, p. 1679-1698 20 p.Research output: Contribution to journal › Article › peer-review
43 Scopus citations -
Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells
Patel, P. R., Hegde, M. L., Theruvathu, J., Mitra, S. A., Boldogh, I. & Sowers, L., Jul 15 2015, In: Journal of Bioanalysis & Biomedicine. 7, 3, p. 75-80 6 p.Research output: Contribution to journal › Article › peer-review
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Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential
Mitra, J., Vasquez, V., Hegde, P. M., Boldogh, I., Mitra, S., Kent, T. A., Rao, K. S. & Hegde, M. L., Feb 27 2015, In: Neurological Research and Therapy. 1, 2Research output: Contribution to journal › Article › peer-review
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The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: Dominant negative function of the CTD
Hegde, P. M., Dutta, A., Sengupta, S., Mitra, J., Adhikari, S., Tomkinson, A. E., Li, G. M., Boldogh, I., Hazra, T. K., Mitra, S. & Hegde, M. L., Aug 21 2015, In: Journal of Biological Chemistry. 290, 34, p. 20919-20933 15 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis
Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. S. & Hazra, T. K., 2015, In: PLoS Genetics. 11, 1, e1004749.Research output: Contribution to journal › Article › peer-review
82 Scopus citations -
Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling
Aguilera-Aguirre, L., Hosoki, K., Bacsi, A., Radák, Z., Sur, S., Hegde, M. L., Tian, B., Saavedra-Molina, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 1 2015, In: Free Radical Biology and Medicine. 89, p. 20-33 14 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
2014
8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization
Luo, J., Hosoki, K., Bacsi, A., Radak, Z., Hegde, M. L., Sur, S., Hazra, T. K., Brasier, A. R., Ba, X. & Boldogh, I., Aug 2014, In: Free Radical Biology and Medicine. 73, p. 430-438 9 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations -
Identification and characterization of a basic thaumatin-like protein (TLP 2) as an allergen in sapodilla plum (Manilkara zapota)
Hegde, V. L., Ashok Kumar, H. G., Sreenath, K., Hegde, M. L. & Venkatesh, Y. P., Apr 2014, In: Molecular Nutrition and Food Research. 58, 4, p. 894-902 9 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice
Gupta, A., Hunt, C. R., Hegde, M. L., Chakraborty, S., Udayakumar, D., Horikoshi, N., Singh, M., Ramnarain, D. B., Hittelman, W. N., Namjoshi, S., Asaithamby, A., Hazra, T. K., Ludwig, T., Pandita, R. K., Tyler, J. K. & Pandita, T. K., Jul 10 2014, In: Cell Reports. 8, 1, p. 177-189 13 p.Research output: Contribution to journal › Article › peer-review
56 Scopus citations