Research outputs

  1. 2019
  2. Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

    Mitra, J., Guerrero, E. N., Hegde, P. M., Liachko, N. F., Wang, H., Vasquez, V., Gao, J., Pandey, A., Paul Taylor, J., Kraemer, B. C., Wu, P., Boldogh, I., Garruto, R. M., Mitra, S., Rao, K. S. & Hegde, M., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4696-4705 10 p.

    Research output: Contribution to journalArticle

  3. 2018
  4. Sinomenine hydrochloride sensitizes cervical cancer cells to ionizing radiation by impairing DNA damage response

    Zhang, D., Dong, Y., Zhao, Y., Zhou, C., Qian, Y., Hegde, M., Wang, H. & Han, S., Nov 1 2018, In : Oncology reports. 40, 5, p. 2886-2895 10 p.

    Research output: Contribution to journalArticle

  5. Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

    Wang, H., Guo, W., Mitra, J., Hegde, P. M., Vandoorne, T., Eckelmann, B. J., Mitra, S., Tomkinson, A. E., Van Den Bosch, L. & Hegde, M. L., Sep 11 2018, In : Nature communications. 9, 1, 3683.

    Research output: Contribution to journalArticle

  6. Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress

    Sengupta, S., Yang, C., Hegde, M. L., Hegde, P. M., Mitra, J., Pandey, A., Dutta, A., Datarwala, A. T., Bhakat, K. K. & Mitra, S., Apr 17 2018, In : DNA Repair. 66-67, p. 1-10 10 p.

    Research output: Contribution to journalArticle

  7. An inducible alpha-synuclein expressing neuronal cell line model for Parkinson's disease

    Vasquez, V., Mitra, J., Perry, G., Rao, K. S. & Hegde, M., Jan 1 2018, In : Journal of Alzheimer's Disease. 66, 2, p. 453-460 8 p.

    Research output: Contribution to journalArticle

  8. Cannabinoid exposure during pregnancy and its impact on immune function

    Dong, C., Chen, J., Harrington, A., Vinod, K. Y., Hegde, M. & Hegde, V. L., Jan 1 2018, (Accepted/In press) In : Cellular and Molecular Life Sciences.

    Research output: Contribution to journalArticle

  9. Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs

    Okonkwo, A., Mitra, J., Johnson, G. S., Li, L., Dashwood, W. M., Hegde, M., Yue, C., Dashwood, R. H. & Rajendran, P., 2018, (Accepted/In press) In : Molecular Nutrition and Food Research.

    Research output: Contribution to journalArticle

  10. 2017
  11. Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase

    Rangaswamy, S., Pandey, A., Mitra, S. & Hegde, M. L., Jun 30 2017, In : Genes. 8, 7

    Research output: Contribution to journalArticle

  12. DNA damage responses in central nervous system and age-associated neurodegeneration

    Hegde, M. L., Bohr, V. A. & Mitra, S., Jan 1 2017, In : Mechanisms of Ageing and Development. 161, p. 1-3 3 p.

    Research output: Contribution to journalEditorial

  13. An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?

    Nookala, A. R., Mitra, J., Chaudhari, N. S., Hegde, M. & Kumar, A., 2017, In : Journal of Alzheimer's Disease. 60, s1, p. S169-S193

    Research output: Contribution to journalReview article

  14. Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis

    Wang, H., Peng, B., Pandita, R. K., Engler, D. A., Matsunami, R. K., Xu, X., Hegde, P. M., Butler, E. B., Pandita, T. K., Mitra, S., Xu, B. & Hegde, M. L., 2017, In : Oncotarget. 8, 30, p. 48671-48687 17 p.

    Research output: Contribution to journalArticle

  15. Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease

    Vasquez, V., Mitra, J., Hegde, P. M., Pandey, A., Sengupta, S., Mitra, S., Rao, S. K. & Hegde, M. L., 2017, In : Journal of Alzheimer's Disease. 60, s1, p. S133-S150

    Research output: Contribution to journalArticle

  16. 2016
  17. Human AP-endonuclease (APE1) is acetylated at DNA damage sites in chromatin and acetylation modulates its DNA repair activity

    Roychoudhury, S., Nath, S., Song, H., Hegde, M. L., Bellot, L. J., Mantha, A. K., Sengupta, S., Ray, S., Natarajan, A. & Bhakat, K. K., Dec 19 2016, In : Molecular and Cellular Biology.

    Research output: Contribution to journalArticle

  18. Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex

    Dutta, A., Eckelmann, B., Adhikari, S., Ahmed, K. M., Sengupta, S., Pandey, A., Hegde, P. M., Tsai, M-S., Tainer, J. A., Weinfeld, M., Hegde, M. L. & Mitra, S., Dec 19 2016, In : Nucleic acids research. 45, 5, p. 2585-2599 15 p.

    Research output: Contribution to journalArticle

  19. Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor κB-driven gene expression

    Pan, L., Zhu, B., Hao, W., Zeng, X., Vlahopoulos, S. A., Hazra, T. K., Hegde, M. L., Radak, Z., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2 2016, In : The Journal of biological chemistry. 291, 49, p. 25553-25566 14 p.

    Research output: Contribution to journalArticle

  20. Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A

    Yang, C., Sengupta, S., Hegde, P. M., Mitra, J., Jiang, S., Holey, B., Sarker, A. H., Tsai, M-S., Hegde, M. L. & Mitra, S., Oct 27 2016, In : Nucleic acids research. 45, 2, p. 739-748 10 p.

    Research output: Contribution to journalArticle

  21. TDP-43/FUS in motor neuron disease: Complexity and challenges

    Guerrero, E. N., Wang, H., Mitra, J., Hegde, P. M., Stowell, S. E., Liachko, N. F., Kraemer, B. C., Garruto, R. M., Rao, K. S. & Hegde, M. L., Oct 1 2016, In : Progress in Neurobiology. 145-146, p. 78-97 20 p.

    Research output: Contribution to journalReview article

  22. Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?

    Wang, H., Dharmalingam, P., Vasquez, V., Mitra, J., Boldogh, I., Rao, K. S., Kent, T. A., Mitra, S. & Hegde, M. L., Sep 20 2016, In : Mechanisms of Ageing and Development.

    Research output: Contribution to journalArticle

  23. 8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging

    German, P., Saenz, D., Szaniszlo, P., Aguilera-Aguirre, L., Pan, L., Hegde, M. L., Bacsi, A., Hajas, G., Radak, Z., Ba, X., Mitra, S., Papaconstantinou, J. & Boldogh, I., Jun 21 2016, In : Mechanisms of Ageing and Development.

    Research output: Contribution to journalArticle

  24. Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions

    Hegde, M. L., Dutta, A., Yang, C., Mantha, A. K., Hegde, P. M., Pandey, A., Sengupta, S., Yu, Y., Calsou, P., Chen, D., Lees-Miller, S. P. & Mitra, S., Jun 9 2016, In : Oncotarget.

    Research output: Contribution to journalArticle

  25. Ion-catalyzed reactive oxygen species in sporadic models of parkinson’s disease

    Vasquez, V., Mitra, J., Guerrero, E. N., Hegde, P. M., Rao, K. S. & Hegde, M. L., Jan 1 2016, Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease. Springer International Publishing, p. 75-113 39 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  26. 2015
  27. Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

    Aguilera-Aguirre, L., Hosoki, K., Bacsi, A., Radák, Z., Sur, S., Hegde, M. L., Tian, B., Saavedra-Molina, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 20-33 14 p.

    Research output: Contribution to journalArticle

  28. The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: Dominant negative function of the CTD

    Hegde, P. M., Dutta, A., Sengupta, S., Mitra, J., Adhikari, S., Tomkinson, A. E., Li, G. M., Boldogh, I., Hazra, T. K., Mitra, S. & Hegde, M. L., Aug 21 2015, In : Journal of Biological Chemistry. 290, 34, p. 20919-20933 15 p.

    Research output: Contribution to journalArticle

  29. Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells

    Patel, P. R., Hegde, M. L., Theruvathu, J., Mitra, S. A., Boldogh, I. & Sowers, L., Jul 15 2015, In : Journal of Bioanalysis & Biomedicine. 7, 3, p. 75-80 6 p.

    Research output: Contribution to journalArticle

  30. New paradigms in the repair of oxidative damage in human genome: Mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins

    Dutta, A., Yang, C., Sengupta, S., Mitra, S. & Hegde, M. L., May 1 2015, In : Cellular and Molecular Life Sciences. 72, 9, p. 1679-1698 20 p.

    Research output: Contribution to journalArticle

  31. Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential

    Mitra, J., Vasquez, V., Hegde, P. M., Boldogh, I., Mitra, S., Kent, T. A., Rao, K. S. & Hegde, M. L., Feb 27 2015, In : Neurological Research and Therapy. 1, 2

    Research output: Contribution to journalArticle

  32. A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells

    Wang, H., Adhikari, S., Butler, E. B., Pandita, T. K., Mitra, S. & Hegde, M. L., Jan 24 2015, In : Jacobs Journal of Radiation Oncology. 1, 1:003.

    Research output: Contribution to journalArticle

  33. The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

    Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. S. & Hazra, T. K., 2015, In : PLoS Genetics. 11, 1, e1004749.

    Research output: Contribution to journalArticle

  34. 2014
  35. The role of 8-oxoguanine DNA glycosylase-1 in inflammation

    Ba, X., Aguilera-Aguirre, L., Rashid, Q. T. A. N., Bacsi, A., Radak, Z., Sur, S., Hosoki, K., Hegde, M. L. & Boldogh, I., Sep 23 2014, In : International Journal of Molecular Sciences. 15, 9, p. 16975-16997 23 p.

    Research output: Contribution to journalArticle

  36. MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice

    Gupta, A., Hunt, C. R., Hegde, M., Chakraborty, S., Udayakumar, D., Horikoshi, N., Singh, M., Ramnarain, D. B., Hittelman, W. N., Namjoshi, S., Asaithamby, A., Hazra, T. K., Ludwig, T., Pandita, R. K., Tyler, J. K. & Pandita, T. K., Jul 10 2014, In : Cell Reports. 8, 1, p. 177-189 13 p.

    Research output: Contribution to journalArticle

  37. MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice

    Gupta, A., Hunt, C. R., Hegde, M., Chakraborty, S., Udayakumar, D., Horikoshi, N., Singh, M., Ramnarain, D. B., Hittelman, W. N., Namjoshi, S., Asaithamby, A., Hazra, T. K., Ludwig, T., Pandita, R. K., Tyler, J. K. & Pandita, T. K., Jul 10 2014, In : Cell Reports. 8, 1

    Research output: Contribution to journalArticle

  38. 8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization

    Luo, J., Hosoki, K., Bacsi, A., Radak, Z., Hegde, M., Sur, S., Hazra, T. K., Brasier, A. R., Ba, X. & Boldogh, I., Jan 1 2014, In : Free Radical Biology and Medicine. 73, p. 430-438 9 p.

    Research output: Contribution to journalArticle

  39. Identification and characterization of a basic thaumatin-like protein (TLP 2) as an allergen in sapodilla plum (Manilkara zapota)

    Hegde, V. L., Ashok Kumar, H. G., Sreenath, K., Hegde, M. & Venkatesh, Y. P., Jan 1 2014, In : Molecular Nutrition and Food Research. 58, 4, p. 894-902 9 p.

    Research output: Contribution to journalArticle

  40. Molecular characterization of neuroprotective activities of plant based products could revive their utilization and lead discovery of new drug candidates for brain diseases

    Hegde, M., Jan 1 2014, In : Journal of Pharmacy and Bioallied Sciences. 6, 2, p. 63-64 2 p.

    Research output: Contribution to journalArticle

  41. New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases

    Mitra, J., Guerrero, E. N., Hegde, P. M., Wang, H., Boldogh, I., Rao, K. S. H., Mitra, S. & Hegde, M., 2014, In : Biomolecules. 4, 3, p. 678-703 26 p.

    Research output: Contribution to journalArticle

  42. 2013
  43. Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

    German, P., Szaniszlo, P., Hajas, G., Radak, Z., Bacsi, A., Hazra, T. K., Hegde, M., Ba, X. & Boldogh, I., Oct 1 2013, In : DNA Repair. 12, 10, p. 856-863 8 p.

    Research output: Contribution to journalArticle

  44. Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

    Hegde, M., Hegde, P. M., Bellot, L. J., Mandal, S. M., Hazra, T. K., Li, G. M., Boldogh, I., Tomkinson, A. E. & Mitra, S., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33

    Research output: Contribution to journalArticle

  45. The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions

    Hegde, M., Tsutakawa, S. E., Hegde, P. M., Holthauzen, L. M. F., Li, J., Oezguen, N., Hilser, V. J., Tainer, J. A. & Mitra, S., Jul 10 2013, In : Journal of molecular biology. 425, 13, p. 2359-2371 13 p.

    Research output: Contribution to journalArticle

  46. 8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1

    Hajas, G., Bacsi, A., Aguilera-Aguirre, L., Hegde, M., Tapas, K. H., Sur, S., Radak, Z., Ba, X. & Boldogh, I., May 28 2013, In : Free Radical Biology and Medicine. 61, p. 384-394 11 p.

    Research output: Contribution to journalArticle

  47. Recent advances in α-synuclein functions, advanced glycation, and toxicity: implications for Parkinson's disease.

    Guerrero, E., Vasudevaraju, P., Hegde, M. L., Britton, G. B. & Rao, K. S., Apr 1 2013, In : Molecular neurobiology. 47, 2, p. 525-536 12 p.

    Research output: Contribution to journalArticle

  48. 2012
  49. The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites

    Della-Maria, J., Hegde, M. L., McNeill, D. R., Matsumoto, Y., Tsai, M. S., Ellenberger, T., Wilson, D. M., Mitra, S. & Tomkinson, A. E., Nov 9 2012, In : Journal of Biological Chemistry. 287, 46, p. 39233-39244 12 p.

    Research output: Contribution to journalArticle

  50. Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction

    Hegde, M., Banerjee, S., Hegde, P. M., Bellot, L. J., Hazra, T. K., Boldogh, I. & Mitra, S., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34202-34211 10 p.

    Research output: Contribution to journalArticle

  51. Oxidized base damage and single-strand break repair in mammalian genomes: Role of disordered regions and posttranslational modifications in early enzymes

    Hegde, M., Izumi, T. & Mitra, S., Jul 3 2012, In : Progress in Molecular Biology and Translational Science. 110, p. 123-153 31 p.

    Research output: Contribution to journalArticle

  52. Activation of Ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine

    Boldogh, I., Hajas, G., Aguilera-Aguirre, L., Hegde, M., Radak, Z., Bacsi, A., Sur, S., Hazra, T. K. & Mitra, S., Jun 15 2012, In : Journal of Biological Chemistry. 287, 25, p. 20769-20773 5 p.

    Research output: Contribution to journalArticle

  53. Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

    Dey, S., Maiti, A. K., Hegde, M., Hegde, P. M., Boldogh, I., Sarkar, P. S., Abdel-Rahman, S. Z., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T. K., Jun 1 2012, In : DNA Repair. 11, 6, p. 570-578 9 p.

    Research output: Contribution to journalArticle

  54. New evidence on α-synuclein and Tau binding to conformation and sequence specific GC* rich DNA: Relevance to neurological disorders

    Vasudevaraju, P., Guerrero, E., Hegde, M., Collen, T. B., Britton, G. B. & Rao, K. S., Apr 1 2012, In : Journal of Pharmacy and Bioallied Sciences. 4, 2, p. 112-117 6 p.

    Research output: Contribution to journalArticle

  55. Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases

    Hegde, M., Mantha, A. K., Hazra, T. K., Bhakat, K. K., Mitra, S. & Szczesny, B., Apr 1 2012, In : Mechanisms of Ageing and Development. 133, 4, p. 157-168 12 p.

    Research output: Contribution to journalArticle

  56. Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′-phosphatase in maintenance of mitochondrial genome

    Mandal, S. M., Hegde, M., Chatterjee, A., Hegde, P. M., Szczesny, B., Banerjee, D., Boldogh, I., Gao, R., Falkenberg, M., Gustafsson, C. M., Sarkar, P. S. & Hazra, T. K., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2819-2829 11 p.

    Research output: Contribution to journalArticle

  57. Human DNA glycosylase NEIL1's interactions with downstream repair proteins is critical for efficient repair of oxidized DNA base damage and enhanced cell survival

    Hegde, M. L., Hegde, P. M., Arijit, D., Boldogh, I. & Mitra, S., 2012, In : Biomolecules. 2, 4, p. 564-578 15 p.

    Research output: Contribution to journalArticle

  58. 2011
  59. Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer

    Zheng, L., Dai, H., Hegde, M., Zhou, M., Guo, Z., Wu, X., Wu, J., Su, L., Zhong, X., Mitra, S., Huang, Q., Kernstine, K. H., Pfeifer, G. P. & Shen, B., Jul 1 2011, In : Cell Research. 21, 7, p. 1052-1067 16 p.

    Research output: Contribution to journalArticle

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