Research outputs

  1. 2020
  2. Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective

    Kodavati, M., Wang, H. & Hegde, M., Apr 24 2020, In : Cells. 9, 4

    Research output: Contribution to journalReview article

  3. Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis

    Chakraborty, A., Tapryal, N., Venkova, T., Mitra, J., Vasquez, V., Sarker, A. H., Duarte-Silva, S., Huai, W., Ashizawa, T., Ghosh, G., MacIel, P., Sarkar, P. S., Hegde, M., Chen, X. & Hazra, T. K., Apr 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 8154-8165 12 p.

    Research output: Contribution to journalArticle

  4. Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle

    Dharmalingam, P., Talakatta, G., Mitra, J., Wang, H., Derry, P. J., Nilewski, L. G., McHugh, E. A., Fabian, R. H., Mendoza, K., Vasquez, V., Hegde, P. M., Kakadiaris, E., Roy, T., Boldogh, I., Hegde, V. L., Mitra, S., Tour, J. M., Kent, T. A. & Hegde, M., Mar 24 2020, In : ACS Nano. 14, 3, p. 2827-2846 20 p.

    Research output: Contribution to journalArticle

  5. A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson's disease: Emerging concepts and challenges

    Vasquez, V., Mitra, J., Wang, H., Hegde, P. M., Rao, K. S. & Hegde, M., Feb 1 2020, In : Progress in Neurobiology. 185, 101729.

    Research output: Contribution to journalReview article

  6. Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective

    Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Kent, T. A. & Tsa, A-L., Jan 1 2020, In : Progress in Neurobiology. 184, p. 101716 101716.

    Research output: Contribution to journalReview article

  7. 2019
  8. RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease

    Wang, H., Rangaswamy, S., Kodavati, M., Mitra, J., Guo, W., Guerrero, E. N., Van Den Bosch, L. & Hegde, M., Dec 4 2019, In : Molecular Brain. 12, 1, 103.

    Research output: Contribution to journalArticle

  9. Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis

    Lakey-Beitia, J., Kumar D, J., Hegde, M. L. & Rao, K. S., Nov 7 2019, In : International journal of molecular sciences. 20, 22, p. 20(22). pii: E5553 PMID: 31703296 .

    Research output: Contribution to journalArticle

  10. Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis

    Guerrero, E. N., Mitra, J., Wang, H., Rangaswamy, S., Hegde, P. M., Basu, P., Rao, K. S. & Hegde, M. L., Sep 15 2019, In : Human Molecular Genetics. 28, 18, p. 3161-3162 2 p.

    Research output: Contribution to journalArticle

  11. Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis

    Guerrero, E. N., Mitra, J., Wang, H., Rangaswamy, S., Hegde, P. M., Basu, P., Rao, K. S. & Hegde, M., Aug 1 2019, In : Human Molecular Genetics. 28, 5, p. 2459-2476 18 p.

    Research output: Contribution to journalArticle

  12. Cannabinoid exposure during pregnancy and its impact on immune function

    Dong, C., Chen, J., Harrington, A., Vinod, K. Y., Hegde, M. & Hegde, V. L., Feb 28 2019, In : Cellular and Molecular Life Sciences. 76, 4, p. 729-743 15 p.

    Research output: Contribution to journalReview article

  13. Hexahydropyrrolo[2,3- b]indole Compounds as Potential Therapeutics for Alzheimer's Disease

    Doens, D., Valdés-Tresanco, M. E., Vasquez, V., Carreira, M. B., De La Guardia, Y., Stephens, D. E., Nguyen, V. D., Nguyen, V. T., Gu, J., Hegde, M., Larionov, O. V., Valiente, P. A., Lleonart, R. & Fernández, P. L., Jan 1 2019, In : ACS Chemical Neuroscience.

    Research output: Contribution to journalArticle

  14. Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

    Mitra, J., Guerrero, E. N., Hegde, P. M., Liachko, N. F., Wang, H., Vasquez, V., Gao, J., Pandey, A., Paul Taylor, J., Kraemer, B. C., Wu, P., Boldogh, I., Garruto, R. M., Mitra, S., Rao, K. S. & Hegde, M., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4696-4705 10 p.

    Research output: Contribution to journalArticle

  15. New mechanisms of dna repair defects in fused in sarcoma–associated neurodegeneration: Stage set for dna repair-based therapeutics?

    Wang, H. & Hegde, M., Jan 1 2019, In : Journal of Experimental Neuroscience. 13

    Research output: Contribution to journalArticle

  16. A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis

    Mitra, J. & Hegde, M., 2019, In : Journal of Experimental Neuroscience. 13

    Research output: Contribution to journalArticle

  17. 2018
  18. Sinomenine hydrochloride sensitizes cervical cancer cells to ionizing radiation by impairing DNA damage response

    Zhang, D., Dong, Y., Zhao, Y., Zhou, C., Qian, Y., Hegde, M., Wang, H. & Han, S., Nov 1 2018, In : Oncology Reports. 40, 5, p. 2886-2895 10 p.

    Research output: Contribution to journalArticle

  19. Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

    Wang, H., Guo, W., Mitra, J., Hegde, P. M., Vandoorne, T., Eckelmann, B. J., Mitra, S., Tomkinson, A. E., Van Den Bosch, L. & Hegde, M. L., Sep 11 2018, In : Nature communications. 9, 1, 3683.

    Research output: Contribution to journalArticle

  20. Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs

    Okonkwo, A., Mitra, J., Johnson, G. S., Li, L., Dashwood, W. M., Hegde, M., Yue, C., Dashwood, R. H. & Rajendran, P., Sep 1 2018, In : Molecular Nutrition and Food Research. 62, 18, 1800228.

    Research output: Contribution to journalArticle

  21. Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress

    Sengupta, S., Yang, C., Hegde, M. L., Hegde, P. M., Mitra, J., Pandey, A., Dutta, A., Datarwala, A. T., Bhakat, K. K. & Mitra, S., Apr 17 2018, In : DNA Repair. 66-67, p. 1-10 10 p.

    Research output: Contribution to journalArticle

  22. An inducible alpha-synuclein expressing neuronal cell line model for Parkinson's disease

    Vasquez, V., Mitra, J., Perry, G., Rao, K. S. & Hegde, M., Jan 1 2018, In : Journal of Alzheimer's Disease. 66, 2, p. 453-460 8 p.

    Research output: Contribution to journalArticle

  23. 2017
  24. Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase

    Rangaswamy, S., Pandey, A., Mitra, S. & Hegde, M. L., Jun 30 2017, In : Genes. 8, 7

    Research output: Contribution to journalArticle

  25. An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?

    Nookala, A. R., Mitra, J., Chaudhari, N. S., Hegde, M. & Kumar, A., Jan 1 2017, In : Journal of Alzheimer's Disease. 60, s1, p. S169-S193

    Research output: Contribution to journalReview article

  26. DNA damage responses in central nervous system and age-associated neurodegeneration

    Hegde, M. L., Bohr, V. A. & Mitra, S., Jan 1 2017, In : Mechanisms of Ageing and Development. 161, p. 1-3 3 p.

    Research output: Contribution to journalEditorial

  27. Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis

    Wang, H., Peng, B., Pandita, R. K., Engler, D. A., Matsunami, R. K., Xu, X., Hegde, P. M., Butler, E. B., Pandita, T. K., Mitra, S., Xu, B. & Hegde, M. L., 2017, In : Oncotarget. 8, 30, p. 48671-48687 17 p.

    Research output: Contribution to journalArticle

  28. Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease

    Vasquez, V., Mitra, J., Hegde, P. M., Pandey, A., Sengupta, S., Mitra, S., Rao, S. K. & Hegde, M. L., 2017, In : Journal of Alzheimer's Disease. 60, s1, p. S133-S150

    Research output: Contribution to journalArticle

  29. 2016
  30. Human AP-endonuclease (APE1) is acetylated at DNA damage sites in chromatin and acetylation modulates its DNA repair activity

    Roychoudhury, S., Nath, S., Song, H., Hegde, M. L., Bellot, L. J., Mantha, A. K., Sengupta, S., Ray, S., Natarajan, A. & Bhakat, K. K., Dec 19 2016, In : Molecular and Cellular Biology.

    Research output: Contribution to journalArticle

  31. Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex

    Dutta, A., Eckelmann, B., Adhikari, S., Ahmed, K. M., Sengupta, S., Pandey, A., Hegde, P. M., Tsai, M-S., Tainer, J. A., Weinfeld, M., Hegde, M. L. & Mitra, S., Dec 19 2016, In : Nucleic acids research. 45, 5, p. 2585-2599 15 p.

    Research output: Contribution to journalArticle

  32. Oxidized guanine base lesions function in 8-oxoguanine DNA glycosylase-1-mediated epigenetic regulation of nuclear factor κB-driven gene expression

    Pan, L., Zhu, B., Hao, W., Zeng, X., Vlahopoulos, S. A., Hazra, T. K., Hegde, M. L., Radak, Z., Bacsi, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 2 2016, In : The Journal of biological chemistry. 291, 49, p. 25553-25566 14 p.

    Research output: Contribution to journalArticle

  33. Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A

    Yang, C., Sengupta, S., Hegde, P. M., Mitra, J., Jiang, S., Holey, B., Sarker, A. H., Tsai, M-S., Hegde, M. L. & Mitra, S., Oct 27 2016, In : Nucleic acids research. 45, 2, p. 739-748 10 p.

    Research output: Contribution to journalArticle

  34. TDP-43/FUS in motor neuron disease: Complexity and challenges

    Guerrero, E. N., Wang, H., Mitra, J., Hegde, P. M., Stowell, S. E., Liachko, N. F., Kraemer, B. C., Garruto, R. M., Rao, K. S. & Hegde, M. L., Oct 1 2016, In : Progress in Neurobiology. 145-146, p. 78-97 20 p.

    Research output: Contribution to journalReview article

  35. Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?

    Wang, H., Dharmalingam, P., Vasquez, V., Mitra, J., Boldogh, I., Rao, K. S., Kent, T. A., Mitra, S. & Hegde, M. L., Sep 20 2016, In : Mechanisms of Ageing and Development.

    Research output: Contribution to journalArticle

  36. 8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging

    German, P., Saenz, D., Szaniszlo, P., Aguilera-Aguirre, L., Pan, L., Hegde, M. L., Bacsi, A., Hajas, G., Radak, Z., Ba, X., Mitra, S., Papaconstantinou, J. & Boldogh, I., Jun 21 2016, In : Mechanisms of Ageing and Development.

    Research output: Contribution to journalArticle

  37. Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions

    Hegde, M. L., Dutta, A., Yang, C., Mantha, A. K., Hegde, P. M., Pandey, A., Sengupta, S., Yu, Y., Calsou, P., Chen, D., Lees-Miller, S. P. & Mitra, S., Jun 9 2016, In : Oncotarget.

    Research output: Contribution to journalArticle

  38. Ion-catalyzed reactive oxygen species in sporadic models of parkinson’s disease

    Vasquez, V., Mitra, J., Guerrero, E. N., Hegde, P. M., Rao, K. S. & Hegde, M. L., Jan 1 2016, Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease. Springer International Publishing, p. 75-113 39 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  39. 2015
  40. Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

    Aguilera-Aguirre, L., Hosoki, K., Bacsi, A., Radák, Z., Sur, S., Hegde, M., Tian, B., Saavedra-Molina, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 20-33 14 p.

    Research output: Contribution to journalArticle

  41. The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: Dominant negative function of the CTD

    Hegde, P. M., Dutta, A., Sengupta, S., Mitra, J., Adhikari, S., Tomkinson, A. E., Li, G. M., Boldogh, I., Hazra, T. K., Mitra, S. & Hegde, M. L., Aug 21 2015, In : Journal of Biological Chemistry. 290, 34, p. 20919-20933 15 p.

    Research output: Contribution to journalArticle

  42. Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells

    Patel, P. R., Hegde, M. L., Theruvathu, J., Mitra, S. A., Boldogh, I. & Sowers, L., Jul 15 2015, In : Journal of Bioanalysis & Biomedicine. 7, 3, p. 75-80 6 p.

    Research output: Contribution to journalArticle

  43. New paradigms in the repair of oxidative damage in human genome: Mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins

    Dutta, A., Yang, C., Sengupta, S., Mitra, S. & Hegde, M. L., May 1 2015, In : Cellular and Molecular Life Sciences. 72, 9, p. 1679-1698 20 p.

    Research output: Contribution to journalArticle

  44. Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential

    Mitra, J., Vasquez, V., Hegde, P. M., Boldogh, I., Mitra, S., Kent, T. A., Rao, K. S. & Hegde, M. L., Feb 27 2015, In : Neurological Research and Therapy. 1, 2

    Research output: Contribution to journalArticle

  45. A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells

    Wang, H., Adhikari, S., Butler, E. B., Pandita, T. K., Mitra, S. & Hegde, M. L., Jan 24 2015, In : Jacobs Journal of Radiation Oncology. 1, 1:003.

    Research output: Contribution to journalArticle

  46. The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

    Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. S. & Hazra, T. K., Jan 1 2015, In : PLoS Genetics. 11, 1, e1004749.

    Research output: Contribution to journalArticle

  47. 2014
  48. The role of 8-oxoguanine DNA glycosylase-1 in inflammation

    Ba, X., Aguilera-Aguirre, L., Rashid, Q. T. A. N., Bacsi, A., Radak, Z., Sur, S., Hosoki, K., Hegde, M. & Boldogh, I., Sep 23 2014, In : International journal of molecular sciences. 15, 9, p. 16975-16997 23 p.

    Research output: Contribution to journalReview article

  49. New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases

    Mitra, J., Guerrero, E. N., Hegde, P. M., Wang, H., Boldogh, I., Rao, K. S., Mitra, S. & Hegde, M., Sep 1 2014, In : Biomolecules. 4, 3, p. 678-703 26 p.

    Research output: Contribution to journalReview article

  50. MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice

    Gupta, A., Hunt, C. R., Hegde, M., Chakraborty, S., Udayakumar, D., Horikoshi, N., Singh, M., Ramnarain, D. B., Hittelman, W. N., Namjoshi, S., Asaithamby, A., Hazra, T. K., Ludwig, T., Pandita, R. K., Tyler, J. K. & Pandita, T. K., Jul 10 2014, In : Cell Reports. 8, 1, p. 177-189 13 p.

    Research output: Contribution to journalArticle

  51. MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice

    Gupta, A., Hunt, C. R., Hegde, M., Chakraborty, S., Udayakumar, D., Horikoshi, N., Singh, M., Ramnarain, D. B., Hittelman, W. N., Namjoshi, S., Asaithamby, A., Hazra, T. K., Ludwig, T., Pandita, R. K., Tyler, J. K. & Pandita, T. K., Jul 10 2014, In : Cell Reports. 8, 1, 1 p.

    Research output: Contribution to journalComment/debate

  52. 8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization

    Luo, J., Hosoki, K., Bacsi, A., Radak, Z., Hegde, M., Sur, S., Hazra, T. K., Brasier, A. R., Ba, X. & Boldogh, I., Jan 1 2014, In : Free Radical Biology and Medicine. 73, p. 430-438 9 p.

    Research output: Contribution to journalArticle

  53. Identification and characterization of a basic thaumatin-like protein (TLP 2) as an allergen in sapodilla plum (Manilkara zapota)

    Hegde, V. L., Ashok Kumar, H. G., Sreenath, K., Hegde, M. & Venkatesh, Y. P., Jan 1 2014, In : Molecular Nutrition and Food Research. 58, 4, p. 894-902 9 p.

    Research output: Contribution to journalArticle

  54. Molecular characterization of neuroprotective activities of plant based products could revive their utilization and lead discovery of new drug candidates for brain diseases

    Hegde, M., Jan 1 2014, In : Journal of Pharmacy and Bioallied Sciences. 6, 2, p. 63-64 2 p.

    Research output: Contribution to journalEditorial

  55. 2013
  56. Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

    German, P., Szaniszlo, P., Hajas, G., Radak, Z., Bacsi, A., Hazra, T. K., Hegde, M., Ba, X. & Boldogh, I., Oct 1 2013, In : DNA Repair. 12, 10, p. 856-863 8 p.

    Research output: Contribution to journalArticle

  57. Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

    Hegde, M., Hegde, P. M., Bellot, L. J., Mandal, S. M., Hazra, T. K., Li, G. M., Boldogh, I., Tomkinson, A. E. & Mitra, S., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33

    Research output: Contribution to journalArticle

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