Personal profile

Dr. Hegde earned his Ph.D. in Biochemistry and Neurosciences from the University of Mysore, India in 2006. He performed his graduate research at the Max-Planck Institute of Biophysical Chemistry, Gottingen, Germany as a DST-DAAD visiting fellow, and at the Indian Institute of Science (IISc), Bangalore, India. He held an Assistant Professor appointment at the University of Texas Medical Branch at Galveston, Texas, USA before becoming a member of the Houston Methodist Research Institute in 2013. As a member of the Research Institute cancer and neuroscience research programs, he directs a research program focusing on understanding the role of genome damage repair in cell death (neurodegenerative diseases) and cell proliferation (cancer) and its potential exploitation in therapeutics. Dr. Hegde has also been a member of grant review boards for the Alzheimer’s Association, USA, Netherlands Organization for Scientific Research, French Scientific Grants (FMRM) and the Motor Neuron Disease Association, UK, in addition to NIH and DOD-CDMRP study sections. He is a Deputy Chief Editor for the Springer Journal Metabolic Brain Disease and Associate Editor for the Journal of Alzheimer’s Disease and serves on the editorial boards of the American Journal of Neurodegenerative Diseases, Jacobs Journal of Radiation Oncology and Research, Journal Neuroscience Research and Therapeutics, the Chinese Journal of Biology, and a peer-reviewer for more than 30 international journals.

Dr. Hegde has published over 75 peer-reviewed publications including more than a dozen as senior author. He has also published five book chapters and fundamental review articles which have received nearly 5000 citations. He has received several awards including gold medals in Masters, New Investigator awards from the Alzheimer’s Association, the Environmental Mutagenesis Society, Researcher of the Month (May 2011) at UTMB and prestigious Gopal Krishna Memorial Young Scientist award from ASIOA. He has recently been awarded the Career Cornerstone award from Houston Methodist for outstanding contribution to translational research.

Research interests

Dr. Hegde’s research program focuses on delineating the molecular mechanisms underlying neurodegenerative diseases with a primary emphasis on genome damage and their repair inhibitions/deficiencies in neurons. His laboratory is interested in Amyotrophic Lateral Sclerosis (ALS), Parkinson’s Disease (PD) and Stroke. He showed that DNA repair inhibitions/deficiencies play a key role in the etiology of neurodegenerative diseases. He demonstrated that transition metals, iron and copper, act as a ‘double whammy’ by both inducing DNA damage and by inhibiting their repair via direct binding and oxidation of NEIL enzymes involved in oxidized DNA base repair. These studies were funded by American Parkinson’s Disease Association. His current studies focus on characterizing the role of ALS-linked RNA binding protein TDP-43 in DNA double-strand break repair and testing the hypothesis that TDP-43’s nuclear clearance and aggregation in ALS (and other neurodegenerative diseases) cause deficient DNA double-strand repair and contributes significantly to cell death. In another project funded by Alzheimer’s Association’s New Investigator grant, he is delineating the mechanism of genotoxicity of amyloid proteins and exploring its prevention by natural compounds. In collaboration with Dr. Sankar Mitra, he is also exploring the potential of genome repair inhibitions in cancer therapeutics. Dr. Hegde’s research program is supported by NIH/NINDS R01, Muscular Dystrophy Association, ALS Association, Alzheimer’s Association and Melo Foundation.

Keywords

    Research Area Keywords

  • Cancer
  • Molecular Medicine
  • Neurosciences

    Free-text keywords

  • Genome damage response, DNA repair, Neurodegenerative diseases, Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis (ALS, Stroke

External positions

Texas A&M University

Jan 1 2016 → …

Fingerprint

DNA Glycosylases
Concept: DNA Glycosylases
Weight: 100%
Domain: Medicine & Life Sciences
DNA Repair
Concept: DNA Repair
Weight: 74%
Domain: Medicine & Life Sciences
Repair
Concept: Repair
Weight: 48%
Domain: Chemical Compounds
DNA
Concept: DNA
Weight: 44%
Domain: Medicine & Life Sciences
DNA Damage
Concept: DNA Damage
Weight: 39%
Domain: Medicine & Life Sciences
Genome
Concept: Genome
Weight: 38%
Domain: Medicine & Life Sciences
Parkinson Disease
Concept: Parkinson Disease
Weight: 30%
Domain: Medicine & Life Sciences
Reactive Oxygen Species
Concept: Reactive Oxygen Species
Weight: 28%
Domain: Medicine & Life Sciences
alpha-Synuclein
Concept: alpha-Synuclein
Weight: 27%
Domain: Medicine & Life Sciences
Genes
Concept: Genes
Weight: 25%
Domain: Chemical Compounds
Research OutputsResearch Output authored by Muralidhar Hegde is tagged with the concept

Journals

The Journal of biological chemistry

ISSNs: 0021-9258

American Society for Biochemistry and Molecular Biology Inc.

Journal

11

Journal of Alzheimer's Disease

ISSNs: 1387-2877

Additional searchable ISSN (Electronic): 1875-8908

IOS Press

Journal

5

Cellular and Molecular Life Sciences

ISSNs: 1420-682X, 0014-4754

Additional searchable ISSN (Electronic): 1420-9071

Birkhauser Verlag Basel

Journal

4

DNA Repair

ISSNs: 1568-7864

Additional searchable ISSN (Electronic): 1568-7856

Elsevier

Journal

4

Archives of Biochemistry and Biophysics

ISSNs: 0003-9861

Academic Press

Journal

4
has published Research OutputsResearch Output by Muralidhar Hegde

Research Network

Visualization: Institutional Network

Click on a line in the diagram to see collaboration details.

Click icons to see information about the content.

Muralidhar Hegde

Visualization: Co-author Network

Click on a line in the diagram to see collaboration details.

Click icons to see information about the content.

Muralidhar Hegde

Shared Pub. Internal Organizations

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

2

Neurological Institute

Organizational unit: Centers of Excellence

1

Stanley H. Appel Department of Neurology

Organizational unit: Departments

1
has Research OutputsResearch Output by Muralidhar Hegde

Shared Pub. External Organizations

UT Medical Branch at Galveston

External organization: Unknown

28

Central Food Technological Research Institute India

External organization: Unknown

15

Department of Radiation Oncology, Houston Methodist Research Institute

External organization: Academic

6

Houston Methodist Hospital

External organization: Medical

6

Houston Methodist Research Institute

External organization: Unknown

6
has Research OutputsResearch Output by Muralidhar Hegde

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Muralidhar Hegde

Shared Pub. External co-authors

Pavana M. Hegde

External person

23

Tapas K. Hazra

External person

20

Istvan Boldogh

External person

17

Joy Mitra

External person

14

K. S J Rao

External person

11
has co-authored Research OutputsResearch Output with Muralidhar Hegde

ID: 2287690