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Personal profile

Personal profile

Dr. Hegde earned his Ph.D. in Biochemistry and Neurosciences from the University of Mysore, India in 2006. He performed his graduate research at the Max-Planck Institute of Biophysical Chemistry, Gottingen, Germany as a DST-DAAD visiting fellow, and at the Indian Institute of Science (IISc), Bangalore, India. He held an Assistant Professor appointment at the University of Texas Medical Branch at Galveston, Texas, USA before becoming a member of the Houston Methodist Research Institute in 2013. As a member of the Research Institute cancer and neuroscience research programs, he directs a research program focusing on understanding the role of genome damage repair in cell death (neurodegenerative diseases) and cell proliferation (cancer) and its potential exploitation in therapeutics. Dr. Hegde has also been a member of grant review boards for the Alzheimer’s Association, USA, Netherlands Organization for Scientific Research, French Scientific Grants (FMRM) and the Motor Neuron Disease Association, UK, in addition to NIH and DOD-CDMRP study sections. He is a Deputy Chief Editor for the Springer Journal Metabolic Brain Disease and Associate Editor for the Journal of Alzheimer’s Disease and serves on the editorial boards of the American Journal of Neurodegenerative Diseases, Jacobs Journal of Radiation Oncology and Research, Journal Neuroscience Research and Therapeutics, the Chinese Journal of Biology, and a peer-reviewer for more than 30 international journals.

Dr. Hegde has published over 75 peer-reviewed publications including more than a dozen as senior author. He has also published five book chapters and fundamental review articles which have received nearly 5000 citations. He has received several awards including gold medals in Masters, New Investigator awards from the Alzheimer’s Association, the Environmental Mutagenesis Society, Researcher of the Month (May 2011) at UTMB and prestigious Gopal Krishna Memorial Young Scientist award from ASIOA. He has recently been awarded the Career Cornerstone award from Houston Methodist for outstanding contribution to translational research.

Research interests

Dr. Hegde’s research program focuses on delineating the molecular mechanisms underlying neurodegenerative diseases with a primary emphasis on genome damage and their repair inhibitions/deficiencies in neurons. His laboratory is interested in Amyotrophic Lateral Sclerosis (ALS), Parkinson’s Disease (PD) and Stroke. He showed that DNA repair inhibitions/deficiencies play a key role in the etiology of neurodegenerative diseases. He demonstrated that transition metals, iron and copper, act as a ‘double whammy’ by both inducing DNA damage and by inhibiting their repair via direct binding and oxidation of NEIL enzymes involved in oxidized DNA base repair. These studies were funded by American Parkinson’s Disease Association. His current studies focus on characterizing the role of ALS-linked RNA binding protein TDP-43 in DNA double-strand break repair and testing the hypothesis that TDP-43’s nuclear clearance and aggregation in ALS (and other neurodegenerative diseases) cause deficient DNA double-strand repair and contributes significantly to cell death. In another project funded by Alzheimer’s Association’s New Investigator grant, he is delineating the mechanism of genotoxicity of amyloid proteins and exploring its prevention by natural compounds. In collaboration with Dr. Sankar Mitra, he is also exploring the potential of genome repair inhibitions in cancer therapeutics. Dr. Hegde’s research program is supported by NIH/NINDS R01, Muscular Dystrophy Association, ALS Association, Alzheimer’s Association and Melo Foundation.

Education/Academic qualification

Postdoctoral Associate, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston

Biochemistry, MS, Karnataka University

Biochemistry/Neurochemistry , PhD, University of Mysore, Karnataka

External positions

Texas A&M University

Jan 1 2016 → …

Research Area Keywords

  • Cancer
  • Molecular Medicine
  • Neurosciences

Free-text keywords

  • Genome damage response
  • DNA repair
  • Neurodegenerative diseases
  • Alzheimer’s disease
  • Parkinson’s disease
  • Amyotrophic Lateral Sclerosis (ALS
  • Stroke

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Projects

Research Output

Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective

Kodavati, M., Wang, H. & Hegde, M., Apr 24 2020, In : Cells. 9, 4

Research output: Contribution to journalReview article

  • 3 Scopus citations

    A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson's disease: Emerging concepts and challenges

    Vasquez, V., Mitra, J., Wang, H., Hegde, P. M., Rao, K. S. & Hegde, M., Feb 1 2020, In : Progress in Neurobiology. 185, 101729.

    Research output: Contribution to journalReview article

  • 2 Scopus citations

    Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis

    Chakraborty, A., Tapryal, N., Venkova, T., Mitra, J., Vasquez, V., Sarker, A. H., Duarte-Silva, S., Huai, W., Ashizawa, T., Ghosh, G., MacIel, P., Sarkar, P. S., Hegde, M. L., Chen, X. & Hazra, T. K., Apr 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 8154-8165 12 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations
    Open Access
  • Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle

    Dharmalingam, P., Talakatta, G., Mitra, J., Wang, H., Derry, P. J., Nilewski, L. G., McHugh, E. A., Fabian, R. H., Mendoza, K., Vasquez, V., Hegde, P. M., Kakadiaris, E., Roy, T., Boldogh, I., Hegde, V. L., Mitra, S., Tour, J. M., Kent, T. A. & Hegde, M., Mar 24 2020, In : ACS Nano. 14, 3, p. 2827-2846 20 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Prizes

    ABAP Senior Scientist Award and Gold Medals

    Hegde, Muralidhar (Recipient), Dec 21 2019

    Prize: Prize (including medals and awards)

  • Award for Excellence in Peer-Reviewed Publication

    Hegde, Muralidhar (Recipient), Oct 31 2018

    Prize: Prize (including medals and awards)

  • Career Cornerstone Award

    Hegde, Muralidhar (Recipient), 2015

    Prize: Prize (including medals and awards)

    Distinguished Visiting Scientist award

    Hegde, Muralidhar (Recipient), 2016

    Prize: Prize (including medals and awards)

    Dr. Arturo Melo Outstanding Science Award-2018

    Hegde, Muralidhar (Recipient), 2018

    Prize: National/international honor