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Clinical Phase Ib/II Trial of L-NMMA Plus Docetaxel in the Treatment of Refractory Locally Advanced or Metastatic Triple Negative Breast Cancer Patients
Niravath, P. A. (PI), Beinart, G. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial
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Beamion BCGC-1: A Phase Ib dose escalation and Phase II dose optimization, randomized, open-label, multicenter trial of oral zongertinib (BI 1810631) in combination with intravenous trastuzumab deruxtecan (T-DXd) or in combination with intravenous trastuzumab emtansine (T-DM1) for treatment of patients with advanced HER2+ metastatic breast cancer (mBC) and metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma (mGEAC)
Niravath, P. A. (PI), Abdelrahim, M. (Key Personnel), Chang, J. C. (Key Personnel), Heyne, K. (Key Personnel), Mai, H. P. (Key Personnel), Singh, M. (Key Personnel) & Sun, K. (Key Personnel)
Project: Clinical Trial
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Phase Ib Trial of L-NMMA in Combination With Pembrolizumab in Patients With Melanoma, Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Classical Hodgkin Lymphoma, Urothelial Carcinoma, or Microsatellite Instability-High/Mismatch Repair
Zhang, J. (PI), Heyne, K. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial
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A Pilot Study of Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention In Women At High Risk Of Breast Cancer
Chang, J. C. (PI), Arentz, C. (Key Personnel), Niravath, P. A. (Key Personnel), Singh, M. (Key Personnel) & Templeton, S. (Key Personnel)
Project: Clinical Trial
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Neoadjuvant Combination Therapy of Lenvima® plus Transcatheter Arterial Chemoembolization (TACE) for Transplant-Eligible Patients with Large Hepatocellular Carcinoma
Abdelrahim, M. (PI), Connor, A. A. (Key Personnel), Ghobrial, R. M. (Key Personnel), Gibbs, J. M. (Key Personnel), Graviss, E. A. (Key Personnel), Gupta, N. (Key Personnel), Heyne, K. (Key Personnel), Kodali, S. (Key Personnel), Moore, L. W. (Key Personnel), Rizk, E. (Key Personnel), Saharia, A. (Key Personnel), Singh, M. (Key Personnel) & Victor, III, D. W. (Key Personnel)
Project: Clinical Trial
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A Prospective Registry Study to Evaluate the Effect of the DCISionRT Test on Treatment Decisions in Patients With DCIS Following Breast Conserving Therapy
Templeton, S. (PI), Arentz, C. (Key Personnel), Chang, J. C. (Key Personnel), Darcourt, J. (Key Personnel), Dubrovsky, E. (Key Personnel), Haque, W. M. (Key Personnel), Heyne, K. (Key Personnel), Morgan, P. B. (Key Personnel), Niravath, P. A. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial
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A Study to Assess the Antitumor Activity and Safety of IMAB362 in Combination With Nab-Paclitaxel and Gemcitabine (Nab-P + GEM) as First Line Treatment in Subjects With Claudin 18.2 (CLDN18.2) Positive, Metastatic Pancreatic Adenocarcinoma
Abdelrahim, M. (PI), Chang, J. C. (Key Personnel), Heyne, K. (Key Personnel), Niravath, P. A. (Key Personnel), Singh, M. (Key Personnel) & Zhang, J. (Key Personnel)
Project: Clinical Trial
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Durvalumab vs Placebo Following Stereotactic Body Radiation Therapy in Early Stage Non-small Cell Lung Cancer Patients
Zhang, J. (PI), Haque, W. M. (Key Personnel), Heyne, K. (Key Personnel), Shadle, K. M. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial
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GOG-0281
Kamat, A. A. (PI), Alaniz, A. (Key Personnel), Singh, M. (Key Personnel) & Suri, A. (Key Personnel)
Project: Clinical Trial
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PALbociclib CoLlaborative Adjuvant Study: A Randomized Phase III Trial of Palbociclib With Standard Adjuvant Endocrine Therapy Versus Standard Adjuvant Endocrine Therapy Alone for Hormone Receptor Positive (HR+) / Human Epidermal Growth Factor Receptor 2
Niravath, P. A. (PI), Chang, J. C. (Key Personnel), Heyne, K. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial
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GOG 213
Kamat, A. A. (PI), Alaniz, A. (Key Personnel), Beinart, G. (Key Personnel), Coffey, D. (Key Personnel), Singh, M. (Key Personnel), Suri, A. (Key Personnel) & Zaid, T. (Key Personnel)
Project: Clinical Trial
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Study of Sasanlimab (PF-06801591) in Combination With Bacillus Calmette-Guerin (BCG) in Participants With High-Risk Non-Muscle Invasive Bladder Cancer (CREST)
Satkunasivam, R. (PI), Singh, M. (Key Personnel) & Zhang, J. (Key Personnel)
Project: Clinical Trial
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GOG-0258
Kamat, A. A. (PI), Beinart, G. (Key Personnel), Butler, E. B. (Key Personnel), Singh, M. (Key Personnel) & Suri, A. (Key Personnel)
Project: Clinical Trial
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GOG0286B
Kamat, A. A. (PI), Alaniz, A. (Key Personnel), Singh, M. (Key Personnel), Suri, A. (Key Personnel) & Zaid, T. (Key Personnel)
Project: Clinical Trial
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GOG-0225
Kamat, A. A. (PI), Alaniz, A. (Key Personnel), Singh, M. (Key Personnel) & Suri, A. (Key Personnel)
Project: Clinical Trial
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A Randomized, Double-blind, Phase 3 Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer (ENGOT-0V44 The FIRST)
Suri, A. (PI), Alaniz, A. (Key Personnel), Singh, M. (Key Personnel) & Zaid, T. (Key Personnel)
Project: Clinical Trial
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A Phase 3, Randomized, Open-label Study to Evaluate Perioperative Enfortumab Vedotin Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Gemcitabine and Cisplatin in Cisplatin-eligible Participants With Muscle-invasive Bladder Cancer (KEYNOTE-B15 / EV-304)
Satkunasivam, R. (PI), Singh, M. (Key Personnel) & Zhang, J. (Key Personnel)
Project: Clinical Trial
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MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005)
Zaid, T. (PI), Alaniz, A. (Key Personnel), Beinart, G. (Key Personnel), Coffey, D. (Key Personnel), Ramirez, P. T. (Key Personnel), Singh, M. (Key Personnel) & Suri, A. (Key Personnel)
Project: Clinical Trial
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Phase I Trial of Atezolizumab and Interleukin-12 Gene Therapy in Metastatic Non-Small Cell Lung Cancer With Progression on First-Line Immunotherapy With or Without Chemotherapy
Zhang, J. (PI), Chan, E. Y. (Key Personnel), Gibbs, J. M. (Key Personnel), Heyne, K. (Key Personnel), Kim, M. P. (Key Personnel), Rudkovskaia, A. A. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial
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Phase III Trial of Docetaxel vs. Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Heyne, K. (Key Personnel), Singh, M. (Key Personnel) & Zhang, J. (Key Personnel)
Project: Clinical Trial
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Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy With or Without Adjuvant Chemotherapy in High-Risk Patients With Early-Stage Cervical Carcinoma Following Radical Hysterectomy (RTOG 0724/GOG-0724 )
Kamat, A. A. (PI), Butler, E. B. (Key Personnel), Farach, A. M. (Key Personnel), Morgan, P. B. (Key Personnel), Singh, M. (Key Personnel) & Suri, A. (Key Personnel)
Project: Clinical Trial
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A Randomized Phase III Trial of Radiation Therapy and Cisplatin Alone or in Combination With Intravenous Triapine in Women With Newly Diagnosed Bulky Stage IB2, Stage II, IIIB, or IVA Cancer of the Uterine Cervix or Stage II-IVA Vaginal Cancer (NRG-GY006)
Zaid, T. (PI), Alaniz, A. (Key Personnel), Butler, E. B. (Key Personnel), Farach, A. M. (Key Personnel), Haque, W. M. (Key Personnel), Kamat, A. A. (Key Personnel), Morgan, P. B. (Key Personnel), Shadle, K. M. (Key Personnel), Shkedy, C. (Key Personnel), Singh, M. (Key Personnel) & Suri, A. (Key Personnel)
Project: Clinical Trial
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Pivotal, Randomized, Open-label Study of Tumor Treating Fields (TTFields, 150kHz) Concomitant With Gemcitabine and Nab-paclitaxel for Front-line Treatment of Locally-advanced Pancreatic Adenocarcinoma
Abdelrahim, M. (PI), Chang, J. C. (Key Personnel), Heyne, K. (Key Personnel), Niravath, P. A. (Key Personnel), Singh, M. (Key Personnel) & Templeton, S. (Key Personnel)
Project: Clinical Trial
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A Phase II Trial of Ribociclib (LEE011) Plus Letrozole in Women With Recurrent Low-Grade Serous Carcinoma of the Ovary, Fallopian Tube or Peritoneum (GOG-3026)
Kamat, A. A. (PI), Alaniz, A. (Key Personnel), Singh, M. (Key Personnel), Suri, A. (Key Personnel) & Zaid, T. (Key Personnel)
Project: Clinical Trial
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Randomized Study of Erlotinib vs Observation in Patients With Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC)
Zhang, J. (PI), Chang, J. C. (Key Personnel), Heyne, K. (Key Personnel), Niravath, P. A. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial
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Phase II Open Label, Study of IMMU-132 in Metastatic Urothelial Cancer After Failure of Platinum-Based Regimen or Anti-PD-1/ PD-L1 Based Immunotherapy
Abdelrahim, M. (Key Personnel), Chang, J. C. (Key Personnel), Heyne, K. (Key Personnel), Niravath, P. A. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial
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(PENELOPE-B) GBG-78 - BIG 1-13 - NSABP-B-54-I A Study of Palbociclib in Addition to Standard Endocrine Treatment in Hormone Receptor Positive Her2 Normal Patients With Residual Disease After Neoadjuvant Chemotherapy and Surgery
Chang, J. C. (PI), Niravath, P. A. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial
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A Phase 1/2 Study of BMS-986340 as Monotherapy and in Combination with Nivolumab in Participants with Advanced Solid Tumors
Abdelrahim, M. (PI), Heyne, K. (Key Personnel), Singh, M. (Key Personnel), Sun, K. (Key Personnel) & Zhang, J. (Key Personnel)
Project: Clinical Trial
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A151216 - Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery ALCHEMIST
Zhang, J. (PI), Heyne, K. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial
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NRG-GY018. Also PRO00022968
Zaid, T. (PI), Alaniz, A. (Key Personnel), Singh, M. (Key Personnel) & Suri, A. (Key Personnel)
Project: Clinical Trial
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GOG0274The OUTBACK Trial
Kamat, A. A. (PI), Alaniz, A. (Key Personnel), Butler, E. B. (Key Personnel), Farach, A. M. (Key Personnel), Morgan, P. B. (Key Personnel), Singh, M. (Key Personnel) & Suri, A. (Key Personnel)
Project: Clinical Trial
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A Randomized, Double-blind, Phase III Study, Comparing NIS793 in Combination With Gemcitabine and Nab-paclitaxel Versus (vs.) Placebo Combined With Gemcitabine and Nab-paclitaxel for First Line Treatment of Metastatic Pancreatic Ductal Adenocarcinoma
Abdelrahim, M. (PI) & Singh, M. (Key Personnel)
Project: Clinical Trial
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A Randomized, Double-Blind, Phase III Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed by Adjuvant Continuation of Atezolizumab or Placebo
Niravath, P. A. (PI), Abdelrahim, M. (Key Personnel), Arentz, C. (Key Personnel), Chang, J. C. (Key Personnel), Heyne, K. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial
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Acupuncture Trial
Niravath, P. A. (PI), Chang, J. C. (Key Personnel), Heyne, K. (Key Personnel), Mai, H. P. (Key Personnel), Singh, M. (Key Personnel) & Sun, K. (Key Personnel)
Project: Clinical Trial
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A Phase II Randomized, Open-label, Multi-center Study of the Safety and Efficacy of IMCgp100 Compared With Investigator Choice in HLA-A*0201 Positive Patients With Previously Untreated Advanced Uveal Melanoma
Abdelrahim, M. (Key Personnel), Heyne, K. (Key Personnel), Niravath, P. A. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial
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Katherine, B50, for Treatment of Adjuvant HER2 Positive Breast Cancer
Chang, J. C. (PI), Niravath, P. A. (Key Personnel) & Singh, M. (Key Personnel)
Project: Clinical Trial