Max Yu, PhD

  • 1693 Citations
  • 18 h-Index
19972020

Research output per year

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Personal profile

Personal profile

Dr. Yu graduated with a Ph.D. from Peking University in 1996. He completed his postdoctoral training in Nuclear Medicine and Pharmacolgy at Kupio University Hospital in Finland before taking a position as a Research Scientist at the Turku PET Center in Finland. In 2001, he joined the Harvard Medical School Radiology Department at Massachusetts General Hospital as a Research Scientist and Instructor before being appointed Associate Professor and Chief Radiochemist at the University of Tennessee in 2005. He was also the Senior Radiochemist at Banner Alxheimer's Institute in Phoenix, AZ from 2007 to 2009 before joining Houston Methodist in 2009. At the Research Institute, Dr. Yu oversees the design and operation of the cyclotron facility, which produces PET radiopharmaceuticals for clinical use in compliance with FDA cGMP (current good manufacture practice) regulations.

Research interests

Dr. Yu's research focuses on molecular imaging biomarker development for translational medicine applications. Functional parameters from in vivo imaging include biodistribution, metabolism, receptor and transporter occupancy, as well as blood flow will be important in diseases diagnosis, stages and response evaluation. For these purposes, his team is developing PET and SPECT imaging tracers of pharmacological affects on glutamate receptors, dopamine transporters and receptors, and serotonin transporters and receptors, which are important in neurodegeneration diseases and psychiatry. In addition, as the Ccyclotron Operation/Radiochemistry Director, Dr. Yu supervises the Research Institute cyclotron facility design, including the installation and operation of the cyclotron, hot cells, radiochemistry synthetic modules, quality control instruments, and radiation safety monitoring. He also oversees the development of standard operation procedures for cyclotron operation, PET radiopharmaceutical production, quality control, and radiation safety.

Education/Academic qualification

Radiochemistry, MS, ChinA Institute of Atomic Energy

Postdoctoral Fellowship, Department of Nuclear Medicine and Physiology, Kuopio University Hospital, Finland

Biological Radiochemistry, PhD, Peking University

Research Area Keywords

  • Imaging & Radiology

Free-text keywords

  • PET tracer development and production
  • Cyclotron operation
  • Radiochemistry
  • FDA cGMP regulation
  • Radiopharmaceutical production

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Projects

Research Output

  • 1693 Citations
  • 18 h-Index
  • 40 Article
  • 1 Conference contribution
  • 1 Review article

Multimodal 18F-AV-1451 and MRI findings in nonfluent variant of primary progressive aphasia: Possible insights on nodal propagation of tau protein across the syntactic network

Pascual, B., Funk, Q., Zanotti-Fregonara, P., Pal, N., Rockers, E., Yu, M. M., Spann, B., Román, G. C., Schulz, P. E., Karmonik, C., Appel, S. H. & Masdeu, J. C., Feb 1 2020, In : Journal of Nuclear Medicine. 61, 2, p. 263-269 7 p.

Research output: Contribution to journalArticle

  • A novel approach to medical radioisotope production using inverse kinematics: A successful production test of the theranostic radionuclide 67 Cu

    Souliotis, G. A., Rodrigues, M. R. D., Wang, K., Iacob, V. E., Nica, N., Roeder, B., Tabacaru, G., Yu, M., Zanotti-Fregonara, P. & Bonasera, A., Jul 2019, In : Applied Radiation and Isotopes. 149, p. 89-95 7 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Head-to-head comparison of 11C-PBR28 and 18F-GE180 for quantification of the translocator protein in the human brain

    Zanotti Fregonara, P., Pascual, M. B., Rizzo, G., Yu, M. M., Pal, N., Beers, D., Carter, R., Appel, S. H., Atassi, N. & Masdeu, J. C., Aug 1 2018, In : Journal of Nuclear Medicine. 59, 8, p. 1260-1266 7 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Cu2+-labeled dansyl compounds as fluorescent and PET probes for imaging apoptosis

    Han, J., Wang, X. & Yu, M. M., Jan 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5594-5596 3 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations