Projects per year
Personal profile
Personal profile
Dr. Masayuki Nigo holds an M.D. and a Master of Science in Biomedical Informatics. He began his career in medicine after graduating from Fukui University, Japan, in 2005. Dr. Nigo honed his medical skills through a residency in Japan, followed by an internal medicine residency at Beth Israel Medical Center in New York, completed in 2013.
His expertise in infectious diseases was further cultivated at UTHealth McGovern Medical School, where he completed a fellowship in infectious diseases, and an advanced fellowship focusing on Transplant Infectious Diseases. Dr. Nigo's academic career took a significant stride forward at UTHealth McGovern Medical School, where he was appointed as an Assistant Professor in the Division of Infectious Diseases in 2016 and later elevated to Associate Professor in 2022.
In addition to his clinical and teaching roles, Dr. Nigo expanded his academic horizon by obtaining a Master of Science from the McWilliams School of Biomedical Informatics at UTHealth Houston.
In January 2023, Dr. Nigo embarked on a new chapter in his career by joining the Division of Infectious Diseases, Department of Medicine at Houston Methodist. Here, he continues his journey as an Associate Professor of Clinical Medicine, contributing his extensive knowledge and experience to the field of infectious diseases.
Research interests
Dr. Nigo’s primary research interest lies in harnessing the vast potential of electronic health record (EHR) datasets to address critical clinical questions encountered at the patient's bedside. Through advanced coding and data analysis techniques, Dr. Nigo's lab explores a broad spectrum of research queries, employing both local and de-identified EHR datasets.
A key focus of his research is in the realm of precision medicine, applying artificial intelligence—particularly deep-learning models—to optimize antimicrobial therapy. His work aims to tailor treatment for high-risk patient populations, focusing on antimicrobial pharmacokinetics and the prediction of drug-resistant bacteria. This is achieved by integrating a wide range of patient-specific features extracted from electronic health records. Dr. Nigo's cutting-edge research is supported by NIH funding.
The Nigo Lab is a collaborative environment, boasting a diverse team of informaticians, fellows, residents, and students from both medical and bioinformatics disciplines. Dr. Nigo places a high value on mentorship and collaboration, fostering a rich learning atmosphere. This has led to successful projects, culminating in publications in peer-reviewed journals.
External positions
Associate Professor of Clinical Medicine, Weill Cornell Medicine
May 1 2024 → …
Adjunct Associate Professor, UT Health
Jul 1 2016 → …
Divisions
- Infectious Disease
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Collaborations and top research areas from the last five years
Projects
- 3 Active
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Cardiovascular Disease Health System Registry
Nasir, K. (PI), Al Rifai, M. S. (Key Personnel), Al-Kindi, S. G. (Key Personnel), Avenatti, E. (Key Personnel), Bhimaraj, A. (Key Personnel), Guha, A. (Key Personnel), Javed, Z. (Key Personnel), Jones, S. L. (Key Personnel), Lador, A. (Key Personnel), Malahfji, M. (Key Personnel), Nigo, M. (Key Personnel) & Patel, K. V. (Key Personnel)
3/31/25 → …
Project: Clinical Trial
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A Phase III, adjudicator-blinded, randomised study to evaluate the efficacy and safety of treatment with olorofim versus treatment with AmBisome® followed by standard of care (SOC) in patients with invasive fungal disease (IFD) caused by Aspergillus species
Grimes, K. A. (PI), Lin, J. (Key Personnel), Malik, A. I. (Key Personnel) & Nigo, M. (Key Personnel)
11/16/23 → …
Project: Clinical Trial
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PK-RNN-V - Deep-Learning Based Pharmacokinetic Model for Vancomycin
Nigo, M. (PI)
9/21/23 → 7/31/28
Project: Federal Funding Agencies
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Artificial Intelligence Assessment of Chest Radiographs for COVID-19
Sasaki, K., Garcia-Manero, G., Nigo, M., Jabbour, E., Ravandi, F., Wierda, W. G., Jain, N., Takahashi, K., Montalban-Bravo, G., Daver, N. G., Thompson, P. A., Pemmaraju, N., Kontoyiannis, D. P., Sato, J., Karimaghaei, S., Soltysiak, K. A., Raad, I. I., Kantarjian, H. M., Carter, B. W. & D3CODE Research Team, May 2025, In: Clinical Lymphoma, Myeloma and Leukemia. 25, 5, p. 319-327 9 p.Research output: Contribution to journal › Article › peer-review
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Cefepime-zidebactam therapy for extensively drug-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae infection as a bridge to liver transplantation.
Tsai, S., Nigo, M., Kang, D., Baptista, R. P., Tamma, P. D., Jacobs, E., Bergman, Y., Victor, D. W., Connor, A. A., Saharia, A., Ghobrial, R. M., Arias, C. A. & Miller, W. R., Aug 1 2025, In: JAC-Antimicrobial Resistance. 7, 4, p. dlaf129 dlaf129.Research output: Contribution to journal › Article › peer-review
Open Access -
Exploration of zileuton protective mechanisms against vancomycin-associated nephrotoxicity
Hudson, C. S., Smith, J. E., Sun, R., Vuong, L. T., Truong, L. D., Sheikh-Hamad, D., Nigo, M., Hu, M. & Tam, V. H., Dec 2025, In: Toxicology and Applied Pharmacology. 505, 117543.Research output: Contribution to journal › Article › peer-review
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Letermovir Conversion for Cytomegalovirus Prophylaxis in Solid Organ Transplant
Amin, S. J., Rogers, A. W., Yun, A. N., Nigo, M., Ghobrial, R. M. & Gaber, A. O., Nov 2025, In: Clinical Transplantation. 39, 11, e70366.Research output: Contribution to journal › Article › peer-review
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Platelets and mortality in bloodstream infection: author's response
Adelman, M. W., Casarin, S., Arias, C. A. & Nigo, M., Sep 12 2025, (E-pub ahead of print) In: Clinical Microbiology and Infection.Research output: Contribution to journal › Article › peer-review
Prizes
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Presidential Award - Career Cornerstone
Nigo, M. (Recipient), 2023
Prize: Prize (including medals and awards)
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Presidential Award - Peer Reviewed Publication
Nigo, M. (Recipient), 2024
Prize: Prize (including medals and awards)