Masahiro Fujita, MD, PhD

  • 6444 Citations
  • 42 h-Index
1989 …2020

Research output per year

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Personal profile

Personal profile

Dr. Masahiro Fujita is PET Core Director for the Translational Imaging Center and Chair of the Radiation Safety Committee at Houston Methodist Research Institute. Dr. Fujita is a world-renowned expert on brain molecular imaging using positron emission tomography (PET) with expertise in the evaluation of PET tracers and kinetic analysis of brain PET. Using PET, Dr. Fujita aims to guide the development of novel therapies by bridging expertise in basic and clinical sciences. 

Dr. Fujita earned MD and PhD from Osaka University, Japan, in 1987 and 1992, respectively. In Japan, he earned board certification in nuclear medicine and diagnostic radiology and also obtained qualification as Type-1 Radiation Protection Supervisor. Prior to joining HMRI, Dr. Fujita held positions of Staff Scientist at National Institute of Mental Health, National Institutes of Health from 2002 to 2018 and Assistant Professor at Department of Psychiatry, Yale University School of Medicine from 1999 to 2002.

Research interests

Dr. Fujita has made significant contributions to advance knowledge on brain disorders by imaging and discovering pathological changes in brain molecules. Increasing number of basic studies have shown that neuroinflammation is a key player in many brain diseases such as Alzheimer’s disease, amyotrophic lateral sclerosis, and major depressive disorder. Dr. Fujita has done pioneering research studies to detect neuroinflammation by imaging translocator protein using PET. Dr. Fujita has also discovered abnormalities in signal transduction inside of cells and its correction by antidepressant in major depressive disorder. By collaborating with clinical and basic scientists within and outside of Houston Methodist, Dr. Fujita visualizes molecules, which is used as a novel marker of disease status and therapeutic effect or as a target for novel therapy.

Education/Academic qualification

MD, Faculty of Medicine, Osaka University

PhD, Osaka University Graduate School of Medicine

Research Area Keywords

  • Imaging & Radiology
  • Neurosciences

Free-text keywords

  • Molecular imaging
  • Positron emission tomography
  • Brain imaging
  • Image quantification

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Projects

Research Output

Discovery, Radiolabeling, and Evaluation of Subtype-Selective Inhibitors for Positron Emission Tomography Imaging of Brain Phosphodiesterase-4D

Wakabayashi, Y., Telu, S., Dick, R. M., Fujita, M., Ooms, M., Morse, C. L., Liow, J. S., Hong, J. S., Gladding, R. L., Manly, L. S., Zoghbi, S. S., Mo, X., D'Amato, E. C., Sindac, J. A., Nugent, R. A., Marron, B. E., Gurney, M. E., Innis, R. B. & Pike, V. W., May 6 2020, In : ACS Chemical Neuroscience. 11, 9, p. 1311-1323 13 p.

Research output: Contribution to journalArticle

  • First-in-human evaluation of [11C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain

    Kim, M. J., Lee, J. H., Juarez Anaya, F., Hong, J., Miller, W., Telu, S., Singh, P., Cortes, M. Y., Henry, K., Tye, G. L., Frankland, M. P., Montero Santamaria, J. A., Liow, J. S., Zoghbi, S. S., Fujita, M., Pike, V. W. & Innis, R. B., Jan 1 2020, In : European Journal of Nuclear Medicine and Molecular Imaging.

    Research output: Contribution to journalArticle

  • PET measurement of cyclooxygenase-2 using a novel radioligand: Upregulation in primate neuroinflammation and first-in-human study

    Shrestha, S., Kim, M. J., Eldridge, M., Lehmann, M. L., Frankland, M., Liow, J. S., Yu, Z. X., Cortes-Salva, M., Telu, S., Henter, I. D., Gallagher, E., Lee, J. H., Fredericks, J. M., Poffenberger, C., Tye, G., Ruiz-Perdomo, Y., Anaya, F. J., Montero Santamaria, J. A., Gladding, R. L., Zoghbi, S. S. & 4 others, Fujita, M., Katz, J. D., Pike, V. W. & Innis, R. B., May 2 2020, In : Journal of Neuroinflammation. 17, 1, 140.

    Research output: Contribution to journalArticle

  • [11C](R)-Rolipram positron emission tomography detects DISC1 inhibition of phosphodiesterase type 4 in live Disc1 locus-impaired mice

    Ooms, M., Tsujikawa, T., Lohith, T. G., Mabins, S. N., Zoghbi, S. S., Sumitomo, A., Jaaro-Peled, H., Kimura, Y., Telu, S., Pike, V. W., Tomoda, T., Innis, R. B., Sawa, A. & Fujita, M., Jul 1 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 7, p. 1306-1313 8 p.

    Research output: Contribution to journalArticle

  • Building a database for brain 18 kDa translocator protein imaged using [11C]PBR28 in healthy subjects

    Paul, S., Gallagher, E., Liow, J. S., Mabins, S., Henry, K., Zoghbi, S. S., Gunn, R. N., Kreisl, W. C., Richards, E. M., Zanotti-Fregonara, P., Morse, C. L., Hong, J., Kowalski, A., Pike, V. W., Innis, R. B. & Fujita, M., Jun 1 2019, In : Journal of Cerebral Blood Flow and Metabolism. 39, 6, p. 1138-1147 10 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations