Martyn A. Sharpe, PhD

Links: Baskin Lab

Research outputs

  1. 2019
  2. Fibrinogen chains intrinsic to the brain

    Golanov, E. V., Sharpe, M. A., Regnier-Golanov, A. S., Del Zoppo, G. J., Baskin, D. S. & Britz, G. W., Jan 1 2019, In : Frontiers in Neuroscience. 13, MAY, 541.

    Research output: Contribution to journalArticle

  3. 2018
  4. Metabolism of fructose in B-cells: A 13C NMR spectroscopy based stable isotope tracer study

    Ijare, O. B., Baskin, D. S., Sharpe, M. A. & Pichumani, K., Jul 1 2018, In : Analytical Biochemistry. 552, p. 110-117 8 p.

    Research output: Contribution to journalArticle

  5. 2017
  6. Transfer of Dyes and Drugs into Cells Using EGFR-Targeted Nanosyringes

    Nilewski, L. G., Singh, M., Baskin, D. S., Tour, J. M. & Sharpe, M. A., Aug 14 2017, In : ACS Chemical Neuroscience.

    Research output: Contribution to journalArticle

  7. Metabolic sculpting of the mitochondria, cell signaling and the cancer phenotype

    Sharpe, M. A., Ismail, N. & Baskin, D. S., 2017, In : Translational Cancer Research. 6, p. S182-S188

    Research output: Contribution to journalArticle

  8. 2016
  9. Development of EGFR-targeted, drug/dye loaded nanosyringe for selective cellular imaging

    Sharpe, M. & Baskin, D., 2016, Society for Neuro-Oncology conference proceedings. suppl 6: Oxford University Press, Vol. 18. p. vi48 DDIS-07

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  10. 2015
  11. Successful Treatment of Intracranial Glioblastoma Xenografts With a Monoamine Oxidase B-Activated Pro-Drug

    Sharpe, M. A., Livingston, A. D., Gist, T. L., Ghosh, P., Han, J. & Baskin, D. S., Sep 1 2015, In : EBioMedicine. 2, 9, p. 1122-1132 11 p.

    Research output: Contribution to journalArticle

  12. Design and synthesis of a MAO-B-selectively activated prodrug based on MPTP: a mitochondria-targeting chemotherapeutic agent for treatment of human malignant gliomas

    Sharpe, M. A., Han, J., Baskin, A. M. & Baskin, D. S., Apr 2015, In : ChemMedChem. 10, 4, p. 621-628 8 p.

    Research output: Contribution to journalArticle

  13. 2014
  14. Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth

    Tsouko, E., Khan, A. S., White, M. A., Han, J. J., Shi, Y., Merchant, F. A., Sharpe, M. A., Xin, L. & Frigo, D., Jan 1 2014, In : Oncogenesis. 3, 5, e103.

    Research output: Contribution to journalArticle

  15. 2013
  16. COMPOUND COMPRISING A MAO TARGETING/SEEKER MOIETY FOR TREATING HUMAN GLIOMAS

    Baskin, David, S. & Sharpe, Martyn, A., Oct 10 2013, IPC No. A61K 31/ 4375 A I, Patent No. CA2887928, Priority date Oct 31 2012, Priority No. WO2012US62850

    Research output: Patent

  17. B-lymphocytes from a population of children with autism spectrum disorder and their unaffected siblings exhibit hypersensitivity to thimerosal

    Sharpe, M. A., Gist, T. L. & Baskin, D. S., Jul 19 2013, In : Journal of Toxicology. 2013, 801517.

    Research output: Contribution to journalArticle

  18. 2012
  19. Thimerosal-derived ethylmercury is a mitochondrial toxin in human astrocytes: Possible role of fenton chemistry in the oxidation and breakage of mtDNA

    Sharpe, M. A., Livingston, A. D. & Baskin, D. S., Aug 17 2012, In : Journal of Toxicology. 2012, 373678.

    Research output: Contribution to journalArticle

  20. Antibody-targeted nanovectors for the treatment of brain cancers

    Sharpe, M. A., Marcano, D. C., Berlin, J. M., Widmayer, M. A., Baskin, D. S. & Tour, J. M., Apr 24 2012, In : ACS Nano. 6, 4, p. 3114-3120 7 p.

    Research output: Contribution to journalArticle

  21. 2010
  22. Quantification and calibration of images in fluorescence microscopy

    Baskin, D. S., Widmayer, M. A. & Sharpe, M. A., Sep 1 2010, In : Analytical Biochemistry. 404, 2, p. 118-126 9 p.

    Research output: Contribution to journalArticle

  23. Lipotoxicity in renal proximal tubular cells: Relationship between endoplasmic reticulum stress and oxidative stress pathways

    Katsoulieris, E., Mabley, J. G., Samai, M., Sharpe, M. A., Green, I. C. & Chatterjee, P. K., Jun 1 2010, In : Free Radical Biology and Medicine. 48, 12, p. 1654-1662 9 p.

    Research output: Contribution to journalArticle

  24. 2009
  25. Steady state redox levels in cytochrome oxidase: Relevance for in vivo near infrared spectroscopy (NIRS)

    Cooper, C. E., Sharpe, M. A., Mason, M. G. & Nicholls, P., Dec 1 2009, Advances in Experimental Medicine and Biology. Vol. 645. p. 123-128 6 p. (Advances in Experimental Medicine and Biology; vol. 645).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  26. EPR evidence of cyanide binding to the Mn(Mg) center of cytochrome c oxidase: Support for Cu a-Mg involvement in proton pumping

    Sharpe, M. A., Krzyaniak, M. D., Xu, S., McCracken, J. & Ferguson-Miller, S., Jan 20 2009, In : Biochemistry. 48, 2, p. 328-335 8 p.

    Research output: Contribution to journalArticle

  27. 2008
  28. Proton-dependent electron transfer from CuA to heme a and altered EPR spectra in mutants close to heme a of cytochrome oxidase

    Mills, D. A., Xu, S., Geren, L., Hiser, C., Qin, L., Sharpe, M. A., McCracken, J., Durham, B., Millett, F. & Ferguson-Miller, S., Nov 4 2008, In : Biochemistry. 47, 44, p. 11499-11509 11 p.

    Research output: Contribution to journalArticle

  29. A chemically explicit model for the mechanism of proton pumping in heme-copper oxidases

    Sharpe, M. A. & Ferguson-Miller, S., Oct 1 2008, In : Journal of Bioenergetics and Biomembranes. 40, 5, p. 541-549 9 p.

    Research output: Contribution to journalArticle

  30. 2007
  31. Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity

    Samai, M., Sharpe, M. A., Gard, P. R. & Chatterjee, P. K., Aug 15 2007, In : Free Radical Biology and Medicine. 43, 4, p. 528-534 7 p.

    Research output: Contribution to journalArticle

  32. Conserved lipid-binding sites in membrane proteins: a focus on cytochrome c oxidase

    Qin, L., Sharpe, M. A., Garavito, R. M. & Ferguson-Miller, S., Aug 1 2007, In : Current Opinion in Structural Biology. 17, 4, p. 444-450 7 p.

    Research output: Contribution to journalArticle

  33. Storage of an excess proton in the hydrogen-bonded network of the D-pathway of cytochrome c oxidase: Identification of a protonated water cluster

    Xu, J., Sharpe, M. A., Qin, L., Ferguson-Miller, S. & Voth, G. A., Mar 14 2007, In : Journal of the American Chemical Society. 129, 10, p. 2910-2913 4 p.

    Research output: Contribution to journalArticle

  34. 2006
  35. Fibrillar beta-amyloid peptide Aβ1-40 activates microglial proliferation via stimulating TNF-α release and H2O2 derived from NADPH oxidase: A cell culture study

    Jekabsone, A., Mander, P. K., Tickler, A., Sharpe, M. A. & Brown, G. C., Sep 7 2006, In : Journal of Neuroinflammation. 3, 24.

    Research output: Contribution to journalArticle

  36. 2005
  37. Cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: Implications for apoptosis and neurodegenerative disease

    Clayton, R., Clark, J. B. & Sharpe, M. A., Feb 1 2005, In : Journal of Neurochemistry. 92, 4, p. 840-849 10 p.

    Research output: Contribution to journalArticle

  38. 2004
  39. Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans

    Keaney, M., Matthijssens, F., Sharpe, M. A., Vanfleteren, J. & Gems, D., Jul 15 2004, In : Free Radical Biology and Medicine. 37, 2, p. 239-250 12 p.

    Research output: Contribution to journalArticle

  40. EUK-134 reduces renal dysfunction and injury caused by oxidative and nitrosative stress of the kidney

    Chatterjee, P. K., Patel, N. S. A., Kvale, E. O., Brown, P. A. J., Stewart, K. N., Mota-Filipe, H., Sharpe, M. A., Di Paola, R., Cuzzocrea, S. & Thiemermann, C., Apr 21 2004, In : American Journal of Nephrology. 24, 2, p. 165-177 13 p.

    Research output: Contribution to journalArticle

  41. Cerebrospinal fluid nitrite/nitrate correlated with oxyhemoglobin and outcome in patients with subarachnoid hemorrhage

    Rejdak, K., Petzold, A., Sharpe, M. A., Kay, A. D., Kerr, M., Keir, G., Thompson, E. J. & Giovannoni, G., Apr 15 2004, In : Journal of the neurological sciences. 219, 1-2, p. 71-76 6 p.

    Research output: Contribution to journalArticle

  42. 2003
  43. Nitric oxide and peroxynitrite cause irreversible increases in the K m for oxygen of mitochondrial cytochrome oxidase: In vitro and in vivo studies

    Cooper, C. E., Davies, N. A., Psychoulis, M., Canevari, L., Bates, T. E., Dobbie, M. S., Casley, C. S. & Sharpe, M. A., Oct 17 2003, In : Biochimica et Biophysica Acta - Bioenergetics. 1607, 1, p. 27-34 8 p.

    Research output: Contribution to journalArticle

  44. Nitric oxide and Fenton/Haber-Weiss chemistry: Nitric oxide is a potent antioxidant at physiological concentrations

    Sharpe, M. A., Robb, S. J. & Clark, J. B., Oct 1 2003, In : Journal of Neurochemistry. 87, 2, p. 386-394 9 p.

    Research output: Contribution to journalArticle

  45. Serum and urine nitrate and nitrite are not reliable indicators of intrathecal nitric oxide production in acute brain injury

    Rejdak, K., Petzold, A., Sharpe, M. A., Smith, M., Keir, G., Stelmasiak, Z., Thompson, E. J. & Giovannoni, G., Apr 15 2003, In : Journal of the neurological sciences. 208, 1-2, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  46. A superoxide dismutase mimetic with catalase activity (EUK-8) reduces the organ injury in endotoxic shock

    McDonald, M. C., Di Villa Bianca, R. D. E., Wayman, N. S., Pinto, A., Sharpe, M. A., Cuzzocrea, S., Chatterjee, P. K. & Thiemermann, C., Apr 11 2003, In : European Journal of Pharmacology. 466, 1-2, p. 181-189 9 p.

    Research output: Contribution to journalArticle

  47. 2002
  48. β-Amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons

    Casley, C. S., Land, J. M., Sharpe, M. A., Clark, J. B., Duchen, M. R. & Canevari, L., Nov 6 2002, In : Neurobiology of Disease. 10, 3, p. 258-267 10 p.

    Research output: Contribution to journalArticle

  49. Presyervation of extracellular glutathione by an astrocyte derived factor with properties comparable to extracellular superoxide dismutase

    Stewart, V. C., Stone, R., Gegg, M. E., Sharpe, M. A., Hurst, R. D., Clark, J. B. & Heales, S. J. R., Nov 1 2002, In : Journal of Neurochemistry. 83, 4, p. 984-991 8 p.

    Research output: Contribution to journalArticle

  50. Superoxide dismutase mimetics with catalase activity reduce the organ injury in hemorrhagic shock

    Izumi, M., McDonald, M. C., Sharpe, M. A., Chatterjee, P. K. & Thiemermann, C., Sep 1 2002, In : Shock. 18, 3, p. 230-235 6 p.

    Research output: Contribution to journalArticle

  51. Oxidation of nitric oxide by oxomanganese-salen complexes: A new mechanism for cellular protection by superoxide dismutase/catalase mimetics

    Sharpe, M. A., Ollosson, R., Stewart, V. C. & Clark, J. B., Aug 15 2002, In : Biochemical Journal. 366, 1, p. 97-107 11 p.

    Research output: Contribution to journalArticle

  52. Toxicity of myoglobin and haemoglobin: Oxidative stress in patients with rhabdomyolysis and subarachnoid haemorrhage

    Reeder, B. J., Sharpe, M. A., Kay, A. D., Kerr, M., Moore, K. & Wilson, M. T., Aug 1 2002, In : Biochemical Society Transactions. 30, 4, p. 745-748 4 p.

    Research output: Contribution to journalArticle

  53. β-Amyloid inhibits integrated mitochondrial respiration and key enzyme activities

    Casley, C. S., Canevari, L., Land, J. M., Clark, J. B. & Sharpe, M. A., Jun 20 2002, In : Journal of Neurochemistry. 80, 1, p. 91-100 10 p.

    Research output: Contribution to journalArticle

  54. Superoxide dismutase mimetic with catalase activity, EUK-134, attenuates the multiple organ injury and dysfunction caused by endotoxin in the rat

    Bianca, R. D. E., Wayman, N. S., McDonald, M. C., Pinto, A., Sharpe, M. A., Chatterjee, P. K. & Thiemermann, C., Feb 20 2002, In : Medical Science Monitor. 8, 1

    Research output: Contribution to journalArticle

  55. Characteristics and mechanism of formation of peroxide-induced heme to protein cross-linking in myoglobin

    Reeder, B. J., Svistunenko, D. A., Sharpe, M. A. & Wilson, M. T., Jan 8 2002, In : Biochemistry. 41, 1, p. 367-375 9 p.

    Research output: Contribution to journalArticle

  56. 2000
  57. The pH dependence of naturally occurring low-spin forms of methaemoglobin and metmyoglobin: An EPR study

    Svistunenko, D. A., Sharpe, M. A., Nicholls, P., Blenkinsop, C., Davies, N. A., Dunne, J., Wilson, M. T. & Cooper, C. E., Nov 1 2000, In : Biochemical Journal. 351, 3, p. 595-605 11 p.

    Research output: Contribution to journalArticle

  58. Astrocyte-derived nitric oxide causes both reversible and irreversible damage to the neuronal mitochondrial respiratory chain

    Stewart, V. C., Sharpe, M. A., Clark, J. B. & Heales, S. J. R., Aug 7 2000, In : Journal of Neurochemistry. 75, 2, p. 694-700 7 p.

    Research output: Contribution to journalArticle

  59. Cytochrome c oxidase rapidly metabolises nitric oxide to nitrite

    Torres, J., Sharpe, M. A., Rosquist, A., Cooper, C. E. & Wilson, M. T., Jun 23 2000, In : FEBS Letters. 475, 3, p. 263-266 4 p.

    Research output: Contribution to journalArticle

  60. A New Method for Quantitation of Spin Concentration by EPR Spectroscopy: Application to Methemoglobin and Metmyoglobin

    Svistunenko, D. A., Sharpe, M. A., Nicholls, P., Wilson, M. T. & Cooper, C. E., Feb 1 2000, In : Journal of Magnetic Resonance. 142, 2, p. 266-275 10 p.

    Research output: Contribution to journalArticle

  61. 1998
  62. Nitric oxide as an effector and a substrate for cytochrome c oxidase

    Nicholls, P., Sharpe, M. A., Torres, J., Wilson, M. T. & Cooper, C. E., Dec 1 1998, In : Biochemical Society Transactions. 26, 4

    Research output: Contribution to journalArticle

  63. Peroxynitrite reacts with methemoglobin to generate globin-bound free radical species. Implications for vascular injury

    Cooper, C. E., Torres, J., Sharpe, M. A., Wilson, M. T. & Svistunenko, D. A., Dec 1 1998, In : Advances in Experimental Medicine and Biology. 454, p. 195-202 8 p.

    Research output: Contribution to journalArticle

  64. Interaction of peroxynitrite with mitochondrial cytochrome oxidase. Catalytic production of nitric oxide and irreversible inhibition of enzyme activity

    Sharpe, M. A. & Cooper, C. E., Nov 20 1998, In : Journal of Biological Chemistry. 273, 47, p. 30961-30972 12 p.

    Research output: Contribution to journalArticle

  65. Reactivity of nitric oxide with cytochrome c oxidase: Interactions with the binuclear centre and mechanism of inhibition

    Torres, J., Cooper, C. E., Sharpe, M. A. & Wilson, M. T., Jun 18 1998, In : Journal of Bioenergetics and Biomembranes. 30, 1, p. 63-69 7 p.

    Research output: Contribution to journalArticle

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