Martyn A. Sharpe, PhD

Links: Baskin Lab

Personal profile

Martyn A. Sharpe is a classically trained biochemist and bioenergeticist with a strong background in chemistry and the reactions of both reactive oxygen and nitrogen species. He has had more than a decade’s worth of experience in examining the cell proliferation/death mechanisms, and has examined the growth and characteristics of many different cell types including astrocytes, neurons and neuronal/astrocyte co-cultures.

Dr. Sharpe enjoys a large number of collaborations/friendships with scientists worldwide and has published papers with 85 co-authors over the last 15 years. He is often asked to participate in projects where there is an overlap of chemistry/cell physiology; especially in the areas of reactive oxygen/nitrogen species.

Dr. Sharpe switched from classical biochemistry/bioenergetics into related pathologies, especially of the brain, a decade ago following the death of his uncle from glioblastoma multiforme, soon after diagnosis. He has used the knowledge he acquired to develop drugs and drug delivery systems to target gliomas.
In addition to nanosyringes Sharpe & Baskin have been developing prodrugs to target gliomas that are based on their maturation by monoamine oxidase B (MAOB).

Martyn is deeply committed to neuro-oncology and is determined to develop a therapy to treat the 220,000 people, worldwide, who develop gliomas each year.

Research interests

Dr Sharpe main areas of research have been the following:
-Design, synthesis and testing in vitro and in vivo MAOB activated pro-drugs and retention dyes for the treatment of glioma.
-Development of targeted nanosyringes for chemotherapy
-Examination of the sensitivity of human brain cells, astrocytes and neuron’s, toward organomercury
-Development of assays for identifying specific lesions in DNA

Keywords

    Research Area Keywords

  • Neurosciences

    Free-text keywords

  • Drug design, Nanotechnology

Fingerprint

Electron Transport Complex IV
Concept: Electron Transport Complex IV
Weight: 100%
Domain: Medicine & Life Sciences
Nitric Oxide
Concept: Nitric Oxide
Weight: 49%
Domain: Medicine & Life Sciences
Heme
Concept: Heme
Weight: 36%
Domain: Medicine & Life Sciences
Mitochondria
Concept: Mitochondria
Weight: 34%
Domain: Chemical Compounds
Superoxide Dismutase
Concept: Superoxide Dismutase
Weight: 29%
Domain: Medicine & Life Sciences
Protons
Concept: Protons
Weight: 27%
Domain: Medicine & Life Sciences
Astrocytes
Concept: Astrocytes
Weight: 27%
Domain: Medicine & Life Sciences
Peroxynitrous Acid
Concept: Peroxynitrous Acid
Weight: 23%
Domain: Medicine & Life Sciences
Glioma
Concept: Glioma
Weight: 23%
Domain: Medicine & Life Sciences
Oleic Acid
Concept: Oleic Acid
Weight: 22%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Martyn A. Sharpe is tagged with the concept

Journals

Biochemical Society Transactions

ISSNs: 0300-5127

Portland Press Ltd.

Journal

9

Biochemical Journal

ISSNs: 0264-6021

Portland Press Ltd.

Journal

5

Journal of Neurochemistry

ISSNs: 0022-3042

Wiley

Journal

5

FEBS Letters

ISSNs: 0014-5793

Elsevier

Journal

4

Biochemistry

ISSNs: 0006-2960

American Chemical Society

Journal

3
has published Research OutputsResearch Output by Martyn A. Sharpe

Research Network

Visualization: Institutional Network

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Martyn A. Sharpe

Visualization: Co-author Network

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Martyn A. Sharpe

Shared Pub. Internal Organizations

Neurosciences Research Program

Organizational unit: Programs

16

Weill Cornell Medical College

Organizational unit: Schools & Hospitals

16

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

15

Center for Neuroregeneration

Organizational unit: Programs

1
has Research OutputsResearch Output by Martyn A. Sharpe

Shared Pub. External Organizations

University of Essex

External organization: Unknown

17

Institute of Neurology

External organization: Unknown

9

UCL

External organization: Unknown

8

Houston Methodist Research Institute

External organization: Unknown

8

Brock University

External organization: Academic

7
has Research OutputsResearch Output by Martyn A. Sharpe

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Martyn A. Sharpe

Shared Pub. External co-authors

Chris E. Cooper

External person

19

P. Nicholls

External person

12

J. Clark

External person

7

Jaume Torres

External person

7

Shelagh Ferguson-Miller

External person

6
has co-authored Research OutputsResearch Output with Martyn A. Sharpe

ID: 2284208