Personal profile

Dr. Brenner completed his postdoctoral training in 1981 and joined the Clinical Research Centre of Northwick Park Hospital in London, England as a MRC Clinical Scientist and Honorary Senior Registrar. He also began lecturing in Haematology at the Royal Free Hospital and Hospital for Sick Children, also in London.

Dr. Brenner joined the faculty at the University of Tennessee in Memphis as a Professor in the Departments of Pediatrics and Medicine in 1990. He also became the Director of the Bone Marrow Transplant Division of the St. Jude Children's Research Hospital that same year. He later directed the Cell and Gene Therapy Program at St. Jude's from 1994 until 1997, when he assumed his current positions at the Baylor College of Medicine.

Research interests

Dr. Brenner's research focuses on gene transfer to stem cells and to effector cells of the immune system. His research group was one of the first to use gene transfer in human subjects, establishing the feasibility of tracking human stem cells and their progeny in subjects with cancer. Dr. Brenner also develops tumor vaccines for pediatric and hematological malignancies, using genetic modification with retroviral and adenoviral vectors.

Keywords

    Free-text keywords

  • Cell therapy, Gene therapy, Stem cells, Vectors

Fingerprint

T-Lymphocytes
Concept: T-Lymphocytes
Weight: 100%
Domain: Medicine & Life Sciences
T-cells
Concept: T-cells
Weight: 59%
Domain: Chemical Compounds
Bone Marrow Transplantation
Concept: Bone Marrow Transplantation
Weight: 58%
Domain: Medicine & Life Sciences
Human Herpesvirus 4
Concept: Human Herpesvirus 4
Weight: 58%
Domain: Medicine & Life Sciences
Cytotoxic T-Lymphocytes
Concept: Cytotoxic T-Lymphocytes
Weight: 54%
Domain: Medicine & Life Sciences
Neoplasms
Concept: Neoplasms
Weight: 49%
Domain: Medicine & Life Sciences
Bone Marrow
Concept: Bone Marrow
Weight: 39%
Domain: Medicine & Life Sciences
Genes
Concept: Genes
Weight: 35%
Domain: Medicine & Life Sciences
Interleukin-2
Concept: Interleukin-2
Weight: 34%
Domain: Medicine & Life Sciences
Genetic Therapy
Concept: Genetic Therapy
Weight: 32%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Malcolm Brenner is tagged with the concept

Journals

Blood

ISSNs: 0006-4971

American Society of Hematology

Journal

72

Molecular therapy : the journal of the American Society of Gene Therapy

ISSNs: 1525-0016

Additional searchable ISSN (Electronic): 1525-0024

Nature Publishing Group

Journal

50

Bone Marrow Transplantation

ISSNs: 0268-3369

Nature Publishing Group

Journal

26

Human gene therapy

ISSNs: 1043-0342

Mary Ann Liebert Inc.

Journal

26

British Journal of Haematology

ISSNs: 0007-1048

Wiley

Journal

14
has published Research OutputsResearch Output by Malcolm Brenner

Research Network

Visualization: Institutional Network

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Malcolm Brenner

Visualization: Co-author Network

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Malcolm Brenner

Shared Pub. Internal Organizations

Institute for Academic Medicine

Organizational unit: Institutes

203

Department of Medicine

Organizational unit: Departments

202

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

7

Weill Cornell Medical College

Organizational unit: Schools & Hospitals

7

Department of Pathology & Genomic Medicine

Organizational unit: Departments

3
has Research OutputsResearch Output by Malcolm Brenner

Shared Pub. External Organizations

Baylor College of Medicine

External organization: Unknown

117

Baylor College of Medicine

External organization: Unknown

84

Texas Children's Hospital Houston

External organization: Unknown

74

St. Jude Children's Research Hospital

External organization: Unknown

65

UCL

External organization: Unknown

56
has Research OutputsResearch Output by Malcolm Brenner

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Malcolm Brenner

Shared Pub. External co-authors

Cliona M. Rooney

External person

124

R. A. Krance

External person

63

Gianpietro Dotti

External person

58

H. G. Prentice

External person

55

Barbara Savoldo

External person

47
has co-authored Research OutputsResearch Output with Malcolm Brenner

ID: 2285754