Research output per year
Research output per year
Personal profile
Personal profile
Dr. Mahinur Mattohti is an Assistant Professor of Cancer Epigenomics at Houston Methodist Research Institute (HMRI), Weill Cornell Medical College. Prior to joining HMRI as faculty in September 2022, she completed her postdoctoral fellowship and held an instructor position at the University of Texas MD Anderson Cancer Center. Dr. Mattohti’s work focuses on understanding how epigenetic changes drive tumorigenesis, disease progression, and the development of therapy resistance, with the goal of leveraging these insights to design innovative therapeutic strategies.
Research interests
Dr. Mattohti’s laboratory combines experimental, computational, and high-throughput technologies to study and modulate epigenetic changes in cancer. The overarching goals of the lab are to: (1) identify the epigenetic drivers of cancer development and progression, (2) uncover the epigenetic alterations and mechanisms underlying resistance to targeted and immunotherapies, and (3) exploit novel epigenetic targets to develop innovative therapeutic strategies.
Education/Academic qualification
Research Doctorate, Cancer Genomics, Beth Israel Deaconess Medical Center
Postdoctoral Fellowship, Cancer Epigenomics, MD Anderson Cancer Center
Postdoctoral Associate, Epigenetics, Massachusetts General Cancer Center
External positions
Assistant Professor of Cancer Biology in Surgery, Weill Cornell Medicine
Jun 1 2023 → …
Research Area Keywords
- Cancer
Free-text keywords
- Epigenomics
- Transcriptional regulation
- Immunotherapy
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Collaborations and top research areas from the last five years
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Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer
Orouji, E., Raman, A. T., Singh, A. K., Sorokin, A., Arslan, E., Ghosh, A. K., Schulz, J., Terranova, C., Jiang, S., Tang, M., Maitituoheti, M., Callahan, S. C., Barrodia, P., Tomczak, K., Jiang, Y., Jiang, Z., Davis, J. S., Ghosh, S., Lee, H. M. & Reyes-Uribe, L. & 9 others, , May 1 2022, In: Gut. 71, 5, p. 938-949 12 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma
Lamhamedi-Cherradi, S. E., Maitituoheti, M., Menegaz, B. A., Krishnan, S., Vetter, A. M., Camacho, P., Wu, C. C., Beird, H. C., Porter, R. W., Ingram, D. R., Ramamoorthy, V., Mohiuddin, S., McCall, D., Truong, D. D., Cuglievan, B., Futreal, P. A., Velasco, A. R., Anvar, N. E., Utama, B. & Titus, M. & 10 others, , Dec 2022, In: Nature Communications. 13, 1, 3057.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
KMT2D deficiency confers a therapeutic vulnerability to glycolytic and IGFR inhibitors in melanoma
Murugesan, N. & Maitituoheti, M., 2021, In: Molecular and Cellular Oncology. 8, 5, 1984827.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
Terranova, C. J., Tang, M., Maitituoheti, M., Raman, A. T., Ghosh, A. K., Schulz, J., Amin, S. B., Orouji, E., Tomczak, K., Sarkar, S., Oba, J., Creasy, C., Wu, C. J., Khan, S., Lazcano, R., Wani, K., Singh, A., Barrodia, P., Zhao, D. & Chen, K. & 6 others, , Jul 20 2021, In: Cell Reports. 36, 3, 109410.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma
Maitituoheti, M., Keung, E. Z., Tang, M., Yan, L., Alam, H., Han, G., Singh, A. K., Raman, A. T., Terranova, C., Sarkar, S., Orouji, E., Amin, S. B., Sharma, S., Williams, M., Samant, N. S., Dhamdhere, M., Zheng, N., Shah, T., Shah, A. & Axelrad, J. B. & 12 others, , Oct 20 2020, In: Cell Reports. 33, 3, 108293.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations