Maen Abdelrahim, MD, PhD, B Pharm

Professional Information

Dr. Abdelrahim completed pharmacy training followed by graduate work in the field of pharmacology and toxicology. Upon completion of his graduate work, clinical training as a medical oncologist fueled his motivation and expertise in the field of anticancer drug discovery.

His translational research is focusing on the discovery and development of new anticancer drugs. He has identified for the first time a new structural class of compounds that can target selective transcription factor called Sp proteins. Transcription factors are now recognized as targets for the development of new anticancer drugs. 

Research interests

  • Targeted therapy in GI cancer
  • Immunotherapy
  • T cell therapy 

Dr. Abdelrahim's research has pinpointed few compounds that inhibit tumor growth and angiogenesis in-part by inducing proteasome-dependent degradation of selected Sp proteins in cancer cells and tumors. The lead compound of this class (Tolfenamic acid) has reached Phase I Clinical Trial to treat patients with advanced and metastatic pancreatic cancer in combination with gemcitabine and radiation therapy. Dr. Abdelrahim has a patent application submitted for the new use of these compounds in GI cancers. In prior research, he was the first to find that Sp4 protein is over expressed in GI cancers including pancreatic cancer and that the role of Sp4 can be equally important as Sp1 in some type of GI cancers.

Researchers in cancer have the ultimate responsibility of taking their findings to the clinic which is described as translational research. By seeing GI cancer patients in his practice, collaborating with translational scientist in the lab and conducting and directing clinical trials, Dr. Abdelrahim hopes to continue to fuel the translational research cycle from lab to clinic and back to the lab.

 

Keywords

    Research Area Keywords

  • Cancer
  • Clinical Translation & Trials
  • Clinical Care

    Free-text keywords

  • Gastrointestinal cancer, Clinical research, Clinical trials, Translation research

External positions

Adjunct Assistant Professor, Texas A&M University

Jul 1 2012 → …

Fingerprint

Neoplasms
Concept: Neoplasms
Weight: 100%
Domain: Medicine & Life Sciences
Pancreatic Neoplasms
Concept: Pancreatic Neoplasms
Weight: 80%
Domain: Medicine & Life Sciences
Sp Transcription Factors
Concept: Sp Transcription Factors
Weight: 76%
Domain: Medicine & Life Sciences
Growth
Concept: Growth
Weight: 70%
Domain: Medicine & Life Sciences
Methane
Concept: Methane
Weight: 64%
Domain: Medicine & Life Sciences
Breast Neoplasms
Concept: Breast Neoplasms
Weight: 55%
Domain: Medicine & Life Sciences
Estrogen Receptor alpha
Concept: Estrogen Receptor alpha
Weight: 55%
Domain: Medicine & Life Sciences
Proteins
Concept: Proteins
Weight: 52%
Domain: Medicine & Life Sciences
Apoptosis
Concept: Apoptosis
Weight: 47%
Domain: Medicine & Life Sciences
PPAR gamma
Concept: PPAR gamma
Weight: 46%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Maen Abdelrahim is tagged with the concept

Journals

Molecular Cancer Therapeutics

ISSNs: 1535-7163

American Association for Cancer Research Inc.

Journal

8

Cancer Research

ISSNs: 0008-5472

American Association for Cancer Research Inc.

Journal

8

Molecular Pharmacology

ISSNs: 0026-895X

American Society for Pharmacology and Experimental Therapeutics

Journal

5

Carcinogenesis

ISSNs: 0143-3334

Oxford University Press

Journal

4

Endocrinology

ISSNs: 0013-7227

The Endocrine Society

Journal

3
has published Research OutputsResearch Output by Maen Abdelrahim

Research Network

Visualization: Institutional Network

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Maen Abdelrahim

Visualization: Co-author Network

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Maen Abdelrahim

Shared Pub. Internal Organizations

Immunobiology & Transplant Science Center

Organizational unit: Programs

7

J.C. Walter Jr. Transplant Center

Organizational unit: Centers of Excellence

5

Department of Surgery

Organizational unit: Departments

4
4

Department of Pathology & Genomic Medicine

Organizational unit: Departments

2
has Research OutputsResearch Output by Maen Abdelrahim

Shared Pub. External Organizations

Texas A and M University

External organization: Unknown

38

University of Texas M. D. Anderson Cancer Center

External organization: Unknown

19

Orlando Regional Medical Center

External organization: Medical

14

Texas A and M Health Science Center

External organization: Unknown

10

University of Texas MD Anderson Cancer Center

External organization: Academic

9
has Research OutputsResearch Output by Maen Abdelrahim

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Maen Abdelrahim

Shared Pub. External co-authors

Stephen H. Safe

External person

48

A. Abudayyeh

External person

12

Sudhakar Chintharlapalli

External person

11

Shengxi Liu

External person

11

Ala Abudayyeh

External person

9
has co-authored Research OutputsResearch Output with Maen Abdelrahim

ID: 33110468