Maen Abdelrahim, MD, PhD, B Pharm

  • Source: Scopus
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Personal profile

Personal profile

Dr. Abdelrahim completed pharmacy training followed by graduate work in the field of pharmacology and toxicology. Upon completion of his graduate work, clinical training as a medical oncologist fueled his motivation and expertise in the field of anticancer drug discovery.

His translational research focus is on the discovery and development of new anticancer drugs. He has identified for the first time a new structural class of compounds that can target selective transcription factor called Sp proteins. Transcription factors are now recognized as targets for the development of new anticancer drugs. 

Research interests

  • Targeted therapy in GI cancer
  • Immunotherapy
  • T cell therapy 

Dr. Abdelrahim's research has pinpointed few compounds that inhibit tumor growth and angiogenesis in-part by inducing proteasome-dependent degradation of selected Sp proteins in cancer cells and tumors. The lead compound of this class (Tolfenamic acid) has reached Phase I Clinical Trial to treat patients with advanced and metastatic pancreatic cancer in combination with gemcitabine and radiation therapy. Dr. Abdelrahim has a patent application submitted for the new use of these compounds in GI cancers. In prior research, he was the first to find that Sp4 protein is over expressed in GI cancers including pancreatic cancer and that the role of Sp4 can be equally important as Sp1 in some type of GI cancers.

Researchers in cancer have the ultimate responsibility of taking their findings to the clinic which is described as translational research. By seeing GI cancer patients in his practice, collaborating with translational scientist in the lab and conducting and directing clinical trials, Dr. Abdelrahim hopes to continue to fuel the translational research cycle from lab to clinic and back to the lab.


Education/Academic qualification

Medicine, MD, Texas A&M Health Science Center College of Medicine

Jul 1 2008Jun 30 2012

Award Date: Aug 12 2018

Hematology, Fellow, Duke University Medical Center

Jul 1 2015Jun 30 2017

Award Date: Jun 30 2017

Internal Medicine, Residency

Jul 1 2013Jun 30 2015

Award Date: Jun 30 2015

Internal Medicine, Internship, Baylor College of Medicine

Jul 1 2012Jun 30 2013

Award Date: Jun 30 2013

PhD, Texas A&M University

Sep 1 2000May 31 2004

Award Date: May 31 2004

Pharmacy, B Pharm, Isra University

Sep 1 1994May 31 1999

Award Date: May 31 1999

External positions

Adjunct Assistant Professor, Texas A&M University

Jul 1 2012 → …

Research Area Keywords

  • Cancer
  • Clinical Translation & Trials
  • Clinical Care

Free-text keywords

  • Gastrointestinal cancer
  • Clinical research
  • Clinical trials
  • Translation research


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