Research output per year
Research output per year
Personal profile
Personal profile
Luchang Zhu received his Ph.D. in Pathobiology in 2013 from the University of Illinois at Urbana-Champaign. He then joined Dr. James Musser’s group at the Houston Methodist Academic Institute as a postdoctoral researcher. In 2020, Dr. Zhu received faculty appointments as Assistant Research Professor of Pathology and Genomic Medicine at the Houston Methodist Academic Institute, Assistant Research Member at the Houston Methodist Research Institute, and Assistant Professor of Research in Pathology and Laboratory Medicine at Weill Cornell Medical College.
Research interests
Dr. Zhu’s research is focused on studying the molecular pathogenesis of Streptococcus pyogenes and Streptococcus agalactiae, the two major human pathogens causing a wide range of clinical infections. Current projects include (i) molecular mechanisms underpinning the reduced susceptibility of Streptococcus to beta-lactam antibiotics, (ii) genetic basis for Streptococcus colonization of human mucosal surfaces, and (iii) host-pathogen interactions during Streptococcal invasive infections.
Research Area Keywords
- Infectious Disease & Pathology
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Integrative Reverse Genetic Analysis Identifies Polymorphisms Contributing to Decreased Antimicrobial Agent Susceptibility in Streptococcus pyogenes
Beres, S. B., Zhu, L., Pruitt, L., Olsen, R. J., Faili, A., Kayal, S. & Musser, J. M., Feb 1 2022, In: mBio. 13, 1, e03618.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Functional insights into the high-molecular-mass penicillin- binding proteins of streptococcus agalactiae revealed by gene deletion and transposon mutagenesis analysis
Zhu, L., Yerramilli, P., Pruitt, L., Mishra, A., Olsen, R. J., Beres, S. B., Waller, A. S. & Musser, J. M., Sep 2021, In: Journal of bacteriology. 203, 17, e00234-21.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
A Single Amino Acid Replacement in Penicillin-Binding Protein 2X in Streptococcus pyogenes Significantly Increases Fitness on Subtherapeutic Benzylpenicillin Treatment in a Mouse Model of Necrotizing Myositis
Olsen, R. J., Zhu, L. & Musser, J. M., Aug 2020, In: American Journal of Pathology. 190, 8, p. 1625-1631 7 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Genetic basis underlying the hyperhemolytic phenotype of streptococcus agalactiae strain CNCTC10/84
Zhu, L., Beres, S. B., Yerramilli, P., Pruitt, L., Cantu, C. C., Olsen, R. J. & Musser, J. M., Dec 2020, In: Journal of bacteriology. 202, 23, e00504-20.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Genome-wide assessment of streptococcus agalactiae genes required for survival in human whole blood and plasma
Zhu, L., Yerramilli, P., Pruitt, L., Saavedra, M. O., Cantu, C. C., Olsen, R. J., Beres, S. B., Waller, A. S. & Musser, J. M., Sep 18 2020, In: Infection and Immunity. 88, 10, e00357.Research output: Contribution to journal › Article › peer-review
5 Scopus citations
Prizes
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PISA 2020 George K. Michalopoulos Junior Faculty Scholar Award
Zhu, Luchang (Recipient), 2020
Prize: Prize (including medals and awards)