Projects per year
Personal profile
Personal profile
Luchang Zhu received his Ph.D. in Pathobiology in 2013 from the University of Illinois at Urbana-Champaign. He then joined Dr. James Musser’s group at the Houston Methodist Academic Institute as a postdoctoral researcher. In 2020, Dr. Zhu received faculty appointments as Assistant Research Professor of Pathology and Genomic Medicine at the Houston Methodist Academic Institute, Assistant Research Member at the Houston Methodist Research Institute, and Assistant Professor of Research in Pathology and Laboratory Medicine at Weill Cornell Medical College.
Research interests
Dr. Zhu’s research is focused on studying the molecular pathogenesis of Streptococcus pyogenes and Streptococcus agalactiae, the two major human pathogens causing a wide range of clinical infections. Current projects include (i) molecular mechanisms underpinning the reduced susceptibility of Streptococcus to beta-lactam antibiotics, (ii) genetic basis for Streptococcus colonization of human mucosal surfaces, and (iii) host-pathogen interactions during Streptococcal invasive infections.
Research Area Keywords
- Infectious Disease & Pathology
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Projects
- 3 Active
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Novel Determinants of Streptococcus Pyogenes Virulence and Protective Immunity in the Primate Oropharynx: A Genome-wide Strategy
Musser, J. M., Nagueh, S., Olsen, R. J. & Zhu, L.
6/1/21 → 5/31/22
Project: Federal Funding Agencies
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Determinants of Streptococcus pyogenes fitness in the female primate genital tract: A genome-wide analysis
Musser, J. M., Olsen, R. J. & Zhu, L.
6/1/19 → 5/31/22
Project: Federal Funding Agencies
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Determinants of Streptococcus pyogenes virulence in the primate oropharynx: A genome-wide analysis
Musser, J. M., Olsen, R. J. & Zhu, L.
2/15/19 → 1/31/22
Project: Federal Funding Agencies
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A Single Amino Acid Replacement in Penicillin-Binding Protein 2X in Streptococcus pyogenes Significantly Increases Fitness on Subtherapeutic Benzylpenicillin Treatment in a Mouse Model of Necrotizing Myositis
Olsen, R. J., Zhu, L. & Musser, J. M., Aug 2020, In: American Journal of Pathology. 190, 8, p. 1625-1631 7 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Genetic basis underlying the hyperhemolytic phenotype of streptococcus agalactiae strain CNCTC10/84
Zhu, L., Beres, S. B., Yerramilli, P., Pruitt, L., Cantu, C. C., Olsen, R. J. & Musser, J. M., Dec 2020, In: Journal of bacteriology. 202, 23, e00504-20.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Genome-wide assessment of streptococcus agalactiae genes required for survival in human whole blood and plasma
Zhu, L., Yerramilli, P., Pruitt, L., Saavedra, M. O., Cantu, C. C., Olsen, R. J., Beres, S. B., Waller, A. S. & Musser, J. M., Sep 18 2020, In: Infection and Immunity. 88, 10, e00357.Research output: Contribution to journal › Article › peer-review
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Genome-Wide Screens Identify Group A Streptococcus Surface Proteins Promoting Female Genital Tract Colonization and Virulence
Zhu, L., Olsen, R. J., Beres, S. B., Ojeda Saavedra, M., Kubiak, S. L., Cantu, C. C., Jenkins, L., Yerramilli, P., Pruitt, L., Charbonneau, A. R. L., Waller, A. S. & Musser, J. M., Apr 2020, In: American Journal of Pathology. 190, 4, p. 862-873 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
New pathogenesis mechanisms and translational leads identified by multidimensional analysis of necrotizing myositis in primates
Kachroo, P., Eraso, J. M., Olsen, R. J., Zhu, L., Kubiak, S. L., Pruitt, L., Yerramilli, P., Cantu, C. C., Saavedra, M. O., Pensar, J., Corander, J., Jenkins, L., Kao, L., Granillo, A., Porter, A. R., Deleo, F. R. & Musser, J. M., Feb 18 2020, In: mBio. 11, 1, e03363-19.Research output: Contribution to journal › Article › peer-review
9 Scopus citations
Prizes
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PISA 2020 George K. Michalopoulos Junior Faculty Scholar Award
Zhu, Luchang (Recipient), 2020
Prize: Prize (including medals and awards)