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Personal profile

Research interests

The Fang lab employ zebrafish and mouse models to studying the role of lipid metabolism in angiogenesis and lymphangiogenesis. During his postdoctoral studies at UC San Diego, Dr. Fang discovered that apolipoprotein (apoA-I) binding protein (AIBP) controls angiogenesis via regulation of cholesterol homeostasis.Based upon the findings, the Fang laboratory will be focusing on the role of AIBP-regulated lipid metabolism in angiogenesis and lymphangiogenesis. We will use a plethora of disease models such as heart hypertrophy, heart ischemia and reperfusion, peripheral artery ischemia and reperfusion, corneal angiogenesis, and tumorigenesis in mice as well as in zebrafish heart regeneration. Both zebrafish and mouse model will be used to study the role of AIBP in lymphangiogenesis.

Education/Academic qualification

Postdoctoral Associate, University of California, San Diego

Aug 1 2007Jun 30 2013

Award Date: Jun 1 2013

Biochemistry, PhD, CAS - Shanghai Institute of Biochemistry and Cell Biology

Sep 1 2000Apr 30 2007

Award Date: Apr 30 2007

Biotechnology, BS, Anhui Normal University

Aug 1 1996Jul 31 2000

Award Date: Jul 31 2000

Free-text keywords

  • Angiogenesis
  • Lymphangiogenesis
  • hematopoiesis
  • cholesterol metabolism

Research Area Keywords

  • Heart & Vascular

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Projects

Research Output

  • 1246 Citations
  • 16 h-Index
  • 23 Article
  • 6 Review article
  • 1 Comment/debate

Combination of apolipoprotein-A-I/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice

Zhu, L., Parker, M., Enemchukwu, N., Shen, M., Zhang, G., Yan, Q., Handa, J. T., Fang, L. & Fu, Y., Jul 16 2020, In : Communications Biology. 3, 1, 386.

Research output: Contribution to journalArticle

  • Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: Connections with cardiovascular diseases

    Morgan, P. K., Fang, L., Lancaster, G. I. & Murphy, A. J., May 1 2020, In : Journal of lipid research. 61, 5, p. 667-675 9 p.

    Research output: Contribution to journalReview article

  • 3 Scopus citations

    AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate

    Gu, Q., Yang, X., Lv, J., Zhang, J., Xia, B., Kim, J. D., Wang, R., Xiong, F., Meng, S., Clements, T. P., Tandon, B., Wagner, D. S., Diaz, M. F., Wenzel, P. L., Miller, Y. I., Traver, D., Cooke, J. P., Li, W., Zon, L. I., Chen, K. & 2 others, Bai, Y. & Fang, L., Mar 8 2019, In : Science. p. eaav1749

    Research output: Contribution to journalArticle

  • 23 Scopus citations

    Regulation of lipid rafts, angiogenesis and inflammation by AIBP

    Fang, L. & Miller, Y. I., Jun 1 2019, In : Current opinion in lipidology. 30, 3, p. 218-223 6 p.

    Research output: Contribution to journalReview article

  • 2 Scopus citations

    AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation

    Choi, S. H., Wallace, A. M., Schneider, D. A., Burg, E., Kim, J., Alekseeva, E., Ubags, N. D., Cool, C. D., Fang, L., Suratt, B. T. & Miller, Y. I., Aug 23 2018, In : JCI insight. 3, 16

    Research output: Contribution to journalArticle

  • 6 Scopus citations