Projects per year
Personal profile
Research interests
The Fang lab employ zebrafish and mouse models to studying the role of lipid metabolism in angiogenesis and lymphangiogenesis. During his postdoctoral studies at UC San Diego, Dr. Fang discovered that apolipoprotein (apoA-I) binding protein (AIBP) controls angiogenesis via regulation of cholesterol homeostasis.Based upon the findings, the Fang laboratory will be focusing on the role of AIBP-regulated lipid metabolism in angiogenesis and lymphangiogenesis. We will use a plethora of disease models such as heart hypertrophy, heart ischemia and reperfusion, peripheral artery ischemia and reperfusion, corneal angiogenesis, and tumorigenesis in mice as well as in zebrafish heart regeneration. Both zebrafish and mouse model will be used to study the role of AIBP in lymphangiogenesis.
Education/Academic qualification
Postdoctoral Associate, University of California, San Diego
Aug 1 2007 → Jun 30 2013
Award Date: Jun 1 2013
Biochemistry, PhD, CAS - Shanghai Institute of Biochemistry and Cell Biology
Sep 1 2000 → Apr 30 2007
Award Date: Apr 30 2007
Biotechnology, BS, Anhui Normal University
Aug 1 1996 → Jul 31 2000
Award Date: Jul 31 2000
Research Area Keywords
- Heart & Vascular
Free-text keywords
- Angiogenesis
- Lymphangiogenesis
- hematopoiesis
- cholesterol metabolism
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Projects
- 9 Finished
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Computational epigenetics modeling of cell identity genes
Cao, Q., Cooke, J. P. & Fang, L.
7/1/18 → 11/1/20
Project: Federal Funding Agencies
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A novel treatment strategy to target the underlying causes of both the wet and dry forms of AMD
7/1/18 → 6/30/21
Project: Non Profit
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Cholesterol Metabolism, Hematopoiesis, and Cardiovascular Disease
7/1/18 → 6/30/21
Project: Non Profit
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AIBP-MEDIATED CHOLESTEROL METABOLISM REGULATES NOTCH SIGNALING AND ANGIOGENESIS
1/1/17 → 8/17/17
Project: Non Profit
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Free Cholesterol Bioavailability and Atherosclerosis
Abe, R. J., Abe, J. I., Nguyen, M. T. H., Olmsted-Davis, E. A., Mamun, A., Banerjee, P., Cooke, J. P., Fang, L., Pownall, H. & Le, N. T., May 2022, In: Current Atherosclerosis Reports. 24, 5, p. 323-336 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
AIBP, Angiogenesis, Hematopoiesis, and Atherogenesis
Qiu, X., Luo, J. & Fang, L., Jan 2021, In: Current Atherosclerosis Reports. 23, 1, 1.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Metabolic flexibility maintains proliferation and migration of FGFR signaling-deficient lymphatic endothelial cells
Song, H., Zhu, J., Han, F., Fang, L. & Yu, P., Aug 30 2021, In: J Biol Chem. 294, 4Research output: Contribution to journal › Article › peer-review
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Metabolic flexibility maintains proliferation and migration of FGFR signaling–deficient lymphatic endothelial cells
Song, H., Zhu, J., Li, P., Han, F., Fang, L. & Yu, P., Oct 1 2021, In: Journal of Biological Chemistry. 279, 4, 101149.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Systemic metabolite profiling reveals sexual dimorphism of AIBP control of metabolism in mice
Kim, J. D., Zhu, L., Sun, Q. & Fang, L., Apr 2021, In: PLoS ONE. 16, 4 April, e0248964.Research output: Contribution to journal › Article › peer-review
Open Access