Projects per year
Personal profile
Research interests
The Fang lab employ zebrafish and mouse models to studying the role of lipid metabolism in angiogenesis and lymphangiogenesis. During his postdoctoral studies at UC San Diego, Dr. Fang discovered that apolipoprotein (apoA-I) binding protein (AIBP) controls angiogenesis via regulation of cholesterol homeostasis.Based upon the findings, the Fang laboratory will be focusing on the role of AIBP-regulated lipid metabolism in angiogenesis and lymphangiogenesis. We will use a plethora of disease models such as heart hypertrophy, heart ischemia and reperfusion, peripheral artery ischemia and reperfusion, corneal angiogenesis, and tumorigenesis in mice as well as in zebrafish heart regeneration. Both zebrafish and mouse model will be used to study the role of AIBP in lymphangiogenesis.
Education/Academic qualification
Postdoctoral Associate, University of California, San Diego
Aug 1 2007 → Jun 30 2013
Award Date: Jun 1 2013
Biochemistry, PhD, CAS - Shanghai Institute of Biochemistry and Cell Biology
Sep 1 2000 → Apr 30 2007
Award Date: Apr 30 2007
Biotechnology, BS, Anhui Normal University
Aug 1 1996 → Jul 31 2000
Award Date: Jul 31 2000
Free-text keywords
- Angiogenesis
- Lymphangiogenesis
- hematopoiesis
- cholesterol metabolism
Research Area Keywords
- Heart & Vascular
Network
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Projects
Computational epigenetics modeling of cell identity genes
Chen, K., Cao, Q., Cooke, J. P. & Fang, L.
7/1/18 → 4/30/22
Project: Federal Funding Agencies
A novel treatment strategy to target the underlying causes of both the wet and dry forms of AMD
7/1/18 → 6/30/21
Project: Non Profit
AIBP Mediates a Novel Interplay between Cholesterol Metabolism and Lymphangiogenesis
Fang, L., Cooke, J. P. & Pownall, H. J.
National Heart Lung and Blood Institute
4/1/16 → 1/31/21
Project: Federal Funding Agencies
Research Output
Combination of apolipoprotein-A-I/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice
Zhu, L., Parker, M., Enemchukwu, N., Shen, M., Zhang, G., Yan, Q., Handa, J. T., Fang, L. & Fu, Y., Jul 16 2020, In : Communications Biology. 3, 1, 386.Research output: Contribution to journal › Article
Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: Connections with cardiovascular diseases
Morgan, P. K., Fang, L., Lancaster, G. I. & Murphy, A. J., May 1 2020, In : Journal of lipid research. 61, 5, p. 667-675 9 p.Research output: Contribution to journal › Review article
3
Scopus
citations
AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate
Gu, Q., Yang, X., Lv, J., Zhang, J., Xia, B., Kim, J. D., Wang, R., Xiong, F., Meng, S., Clements, T. P., Tandon, B., Wagner, D. S., Diaz, M. F., Wenzel, P. L., Miller, Y. I., Traver, D., Cooke, J. P., Li, W., Zon, L. I., Chen, K. & 2 others, , Mar 8 2019, In : Science. p. eaav1749Research output: Contribution to journal › Article
23
Scopus
citations
Regulation of lipid rafts, angiogenesis and inflammation by AIBP
Fang, L. & Miller, Y. I., Jun 1 2019, In : Current opinion in lipidology. 30, 3, p. 218-223 6 p.Research output: Contribution to journal › Review article
2
Scopus
citations
AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation
Choi, S. H., Wallace, A. M., Schneider, D. A., Burg, E., Kim, J., Alekseeva, E., Ubags, N. D., Cool, C. D., Fang, L., Suratt, B. T. & Miller, Y. I., Aug 23 2018, In : JCI insight. 3, 16Research output: Contribution to journal › Article
6
Scopus
citations