Projects per year
Personal profile
Personal profile
Dr. Kristopher Brannan is an Assistant Professor and CPRIT Scholar in the Center for RNA Therapeutics and Houston Methodist Cancer Center at the Houston Methodist Research Institute. He received his B.A. degree in molecular, cellular and developmental biology at the University of Colorado Boulder, and his Ph.D. in molecular biology at the University of Colorado School of Medicine. He was a postdoctoral fellow at the University of California San Diego and joined the faculty at the Houston Methodist Research Institute in 2021. His work is focused on RNA-protein interactions that regulate gene expression programs disrupted in cancer and neurological disease.
Research interests
We utilize innovative molecular and computational approaches to:
-Explore the functional RNA binding activity of the nucleocytoplasmic transport (NCT) machinery disrupted in neurodegeneration.
-Map the RNA-protein interaction networks that drive breast cancer progression and plasticity.
-Evaluate RNA-based therapeutics in cell-line models, animal models, and patient tissues.
External positions
Assistant Professor of Molecular Biology in Medicine, Weill Cornell Medical College
Jan 1 2023 → …
Research Area Keywords
- Heart & Vascular
- Cancer
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Collaborations and top research areas from the last five years
Projects
- 2 Active
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Exploring functional complexes and disease networks within human RNAbinding protein interactomes
7/1/22 → 6/30/25
Project: Federal Funding Agencies
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A relay velocity model infers cell-dependent RNA velocity
Li, S., Zhang, P., Chen, W., Ye, L., Brannan, K. W., Le, N. T., Abe, J. I., Cooke, J. P. & Wang, G., Apr 3 2023, In: Nature Biotechnology. 42, 1, p. 99-108 10 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Directed editing of cellular rna via nuclear delivery of crispr/cas9
Brannan, K. W., Marina, R., Yeo, E. & Nelles, D., Feb 23 2023, Patent No. US20230053915A1, Jul 11 2022, Priority date Jul 11 2022, Priority No. US17/811,626Research output: Patent
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HydRA: Deep-learning models for predicting RNA-binding capacity from protein interaction association context and protein sequence
Jin, W., Brannan, K. W., Kapeli, K., Park, S. S., Tan, H. Q., Gosztyla, M. L., Mujumdar, M., Ahdout, J., Henroid, B., Rothamel, K., Xiang, J. S., Wong, L. & Yeo, G. W., Jul 20 2023, In: Molecular Cell. 83, 14, p. 2595-2611.e11Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Methods and use of chimeric proteins
Brannan, K. W., Yeo, E., Marina, R., Lorenz, D. & Chaim, I., May 4 2023, Patent No. US20230138328A1, Mar 12 2021, Priority date Mar 12 2021, Priority No. US17/910,967Research output: Patent
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Directed editing of cellular RNA via nuclear delivery of CRISPR/CAS9
Brannan, K. W., Yeo, G. W., Marina, R. J. & Nelles, D., Sep 27 2022, IPC No. C12N9/78, Patent No. 11453891, May 9 2018, Priority date May 10 2017Research output: Patent