Keith Syson Chan

2024

Chemotherapy, immunotherapy, or combination first-line treatment for metastatic urothelial carcinoma of the bladder: A large real-world experience

Ranganathan, S., Riveros, C., Xu, S., Hu, S., Geng, M., Huang, E., Melchiode, Z., Zhang, J., Efstathiou, E., Chan, K. S., Wallis, C. J. D., Sonpavde, G. & Satkunasivam, R., Sep 1 2024, In: Urologic Oncology: Seminars and Original Investigations. 42, 9, p. 291.e13-291.e25

Research output: Contribution to journal › Article › peer-review

Comparative real-world survival outcomes of muscle-invasive bladder cancer treated with bladder-only vs. whole-pelvis concurrent chemoradiation

Riveros, C., Ranganathan, S., Haque, W., Huang, E., Xu, J., Kulkarni, G. S., Geng, M., Anis, M., Muhammad, T., Chan, K. S., Farach, A., Teh, B. S., Miles, B. J., Klaassen, Z., Sonpavde, G. P., Wallis, C. J. D. & Satkunasivam, R., Feb 2024, In: Journal of the Canadian Urological Association. 18, 2, p. 17-24 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas

Broz, M. T., Ko, E. Y., Ishaya, K., Xiao, J., De Simone, M., Hoi, X. P., Piras, R., Gala, B., Tessaro, F. H. G., Karlstaedt, A., Orsulic, S., Lund, A. W., Chan, K. S. & Guarnerio, J., Dec 2024, In: Nature Communications. 15, 1, 2498.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

The Hallmarks of Precancer

Stangis, M. M., Chen, Z., Min, J., Glass, S. E., Jackson, J. O., Radyk, M. D., Hoi, X. P., Brennen, W. N., Yu, M., Dinh, H. Q., Coffey, R. J., Shrubsole, M. J., Chan, K. S., Grady, W. M., Yegnasubramanian, S., Lyssiotis, C. A., Maitra, A., Halberg, R. B., Dey, N. & Lau, K. S., Apr 4 2024, In: Cancer Discovery. 14, 4, p. 683-689 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2023

Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors

Heiser, C. N., Simmons, A. J., Revetta, F., McKinley, E. T., Ramirez-Solano, M. A., Wang, J., Kaur, H., Shao, J., Ayers, G. D., Wang, Y., Glass, S. E., Tasneem, N., Chen, Z., Qin, Y., Kim, W., Rolong, A., Chen, B., Vega, P. N., Drewes, J. L., Markham, N. O., & 13 othersSaleh, N., Nikolo, F., Vandekar, S., Jones, A. L., Washington, M. K., Roland, J. T., Chan, K. S., Schürpf, T., Sears, C. L., Liu, Q., Shrubsole, M. J., Coffey, R. J. & Lau, K. S., Dec 7 2023, In: Cell. 186, 25, p. 5620-5637.e16

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2022

Cabozantinib plus Nivolumab Phase I Expansion Study in Patients with Metastatic Urothelial Carcinoma Refractory to Immune Checkpoint Inhibitor Therapy

Girardi, D. M., Niglio, S. A., Mortazavi, A., Nadal, R., Lara, P., Pal, S. K., Saraiya, B., Cordes, L., Ley, L., Ortiz, O. S., Cadena, J., Diaz, C., Bagheri, H., Redd, B., Steinberg, S. M., Costello, R., Chan, K. S., Lee, M. J., Lee, S., Yu, Y., & 15 othersGurram, S., Chalfin, H. J., Valera, V., Figg, W. D., Merino, M., Toubaji, A., Streicher, H., Wright, J. J., Sharon, E., Parnes, H. L., Ning, Y. M., Bottaro, D. P., Cao, L., Trepel, J. B. & Apolo, A. B., Apr 1 2022, In: Clinical Cancer Research. 28, 7, p. 1353-1362 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors

Nikolos, F., Hayashi, K., Hoi, X. P., Alonzo, M. E., Mo, Q., Kasabyan, A., Furuya, H., Trepel, J., Di Vizio, D., Guarnerio, J., Theodorescu, D., Rosser, C., Apolo, A., Galsky, M. & Chan, K. S., Dec 2022, In: Nature Communications. 13, 1, 1487.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Characterizing molecular subtypes of high-risk non-muscle-invasive bladder cancer in African American patients

You, S., Kim, M., Widen, S., Yu, A., Galvan, G. C., Choi-Kuaea, Y., Eyzaguirre, E. J., Dyrskjøt, L., McConkey, D. J., Choi, W., Theodorescu, D., Chan, K. S., Shan, Y., Tyler, D. S., De Hoedt, A. M., Freedland, S. J. & Williams, S. B., Sep 2022, In: Urologic Oncology: Seminars and Original Investigations. 40, 9, p. 410.e19-410.e27

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment

Piras, R., Ko, E. Y., Barrett, C., De Simone, M., Lin, X., Broz, M. T., Tessaro, F. H. G., Castillo-Martin, M., Cordon-Cardo, C., Goodridge, H. S., Di Vizio, D., Batish, M., Lawrenson, K., Chen, Y. G., Chan, K. S. & Guarnerio, J., Dec 2022, In: Nature Communications. 13, 1, 7243.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Discoidin Domain Receptor-Driven Gene Signatures as Markers of Patient Response to Anti-PD-L1 Immune Checkpoint Therapy

You, S., Kim, M., Hoi, X. P., Lee, Y. C., Wang, L., Spetzler, D., Abraham, J., Magee, D., Jain, P., Galsky, M. D., Chan, K. S. & Theodorescu, D., Oct 1 2022, In: Journal of the National Cancer Institute. 114, 10, p. 1380-1391 12 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Dual Stromal Targeting Sensitizes Pancreatic Adenocarcinoma for Anti-Programmed Cell Death Protein 1 Therapy

Blair, A. B., Wang, J., Davelaar, J., Baker, A., Li, K., Niu, N., Wang, J., Shao, Y., Funes, V., Li, P., Pachter, J. A., Maneval, D. C., Dezem, F., Plummer, J., Chan, K. S., Gong, J., Hendifar, A. E., Pandol, S. J., Burkhart, R., Zhang, Y., & 2 othersZheng, L. & Osipov, A., Nov 2022, In: Gastroenterology. 163, 5, p. 1267-1280.e7

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

2021

An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

Gouin, K. H., Ing, N., Plummer, J. T., Rosser, C. J., Ben Cheikh, B., Oh, C., Chen, S. S., Chan, K. S., Furuya, H., Tourtellotte, W. G., Knott, S. R. V. & Theodorescu, D., Dec 1 2021, In: Nature Communications. 12, 1, 4906.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

MiR-1227 targets SEC23A to regulate the shedding of large extracellular vesicles

Chin, A., Mariscal, J., Kim, M., Guerra, G., Victor, B., Qian, C., Broseghini, E., Posadas, E., Freeman, M. R., Sharma, S., Gandellini, P., Zaffaroni, N., You, S., Chan, K. S., Guarnerio, J., Fabbri, M. & Di Vizio, D., Nov 1 2021, In: Cancers. 13, 22, 5850.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis

Ho, S. R., Lee, Y. C., Ittmann, M. M., Lin, F. T., Chan, K. S. & Lin, W. C., Nov 1 2021, In: Cancer Letters. 520, p. 344-360 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2020

A Consensus Molecular Classification of Muscle-invasive Bladder Cancer[Formula presented]

Kamoun, A., de Reyniès, A., Allory, Y., Sjödahl, G., Robertson, A. G., Seiler, R., Hoadley, K. A., Groeneveld, C. S., Al-Ahmadie, H., Choi, W., Castro, M. A. A., Fontugne, J., Eriksson, P., Mo, Q., Kardos, J., Zlotta, A., Hartmann, A., Dinney, C. P., Bellmunt, J., Powles, T., & 22 othersMalats, N., Chan, K. S., Kim, W. Y., McConkey, D. J., Black, P. C., Dyrskjøt, L., Höglund, M., Lerner, S. P., Real, F. X., Radvanyi, F., Aine, M., Bernard-Pierrot, I., Czerniak, B., Gibb, E. A., Kim, J., Kwiatkowski, D. J., Lebret, T., Liedberg, F., Siefker-Radtke, A., Sirab, N., Taber, A. & Weinstein, J., Apr 2020, In: European Urology. 77, 4, p. 420-433 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

756 Scopus citations

Integrative multi-omics analysis of muscle-invasive bladder cancer identifies prognostic biomarkers for frontline chemotherapy and immunotherapy

Mo, Q., Li, R., Adeegbe, D. O., Peng, G. & Chan, K. S., Dec 2020, In: Communications Biology. 3, 1, 784.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model

Furuya, H., Hayashi, K., Shimizu, Y., Kim, N., Tsukikawa, Y., Chen, R., Sun, Y., Chan, O. T. M., Pagano, I., Peres, R., Hokutan, K., Igari, F., Chan, K. S. & Rosser, C. J., Feb 5 2020, In: Journal of Translational Medicine. 18, 1, 57.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Prognostic significance of lymphocyte infiltration and a stromal immunostaining of a bladder cancer associated diagnostic panel in urothelial carcinoma

Furuya, H., Chan, O. T. M., Hokutan, K., Tsukikawa, Y., Chee, K., Kozai, L., Chan, K. S., Dai, Y., Wong, R. S. & Rosser, C. J., 2020, In: Diagnostics. 10, 1, 14.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death

Hayashi, K., Nikolos, F., Lee, Y. C., Jain, A., Tsouko, E., Gao, H., Kasabyan, A., Leung, H. E., Osipov, A., Jung, S. Y., Kurtova, A. V. & Chan, K. S., Dec 2020, In: Nature Communications. 11, 1, 6299.

Research output: Contribution to journal › Article › peer-review

Open Access

152 Scopus citations

2019

Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung

Lee, Y. C., Kurtova, A. V., Xiao, J., Nikolos, F., Hayashi, K., Tramel, Z., Jain, A., Chen, F., Chokshi, M., Lee, C., Bao, G., Zhang, X., Shen, J., Mo, Q., Jung, S. Y., Rowley, D. & Chan, K. S., Dec 1 2019, In: Nature Communications. 10, 1, 2131.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

2018

A fully Bayesian latent variable model for integrative clustering analysis of multi-type omics data

Mo, Q., Shen, R., Guo, C., Vannucci, M., Chan, K. S. & Hilsenbeck, S. G., Jan 1 2018, In: Biostatistics. 19, 1, p. 71-86 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

148 Scopus citations

Prognostic Power of a Tumor Differentiation Gene Signature for Bladder Urothelial Carcinomas

Mo, Q., Nikolos, F., Chen, F., Tramel, Z., Lee, Y. C., Hayashi, K., Xiao, J., Shen, J. & Chan, K. S., May 1 2018, In: Journal of the National Cancer Institute. 110, 5, p. 448-459 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

106 Scopus citations

2017

Cellular hierarchy as a determinant of tumor sensitivity to chemotherapy

Rodriguez-Brenes, I. A., Kurtova, A. V., Lin, C., Lee, Y. C., Xiao, J., Mims, M., Chan, K. S. & Wodarz, D., May 1 2017, In: Cancer research. 77, 9, p. 2231-2241 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2016

Bladder cancer molecular taxonomy: Summary from a consensus meeting

Lerner, S. P., McConkey, D. J., Hoadley, K. A., Chan, K. S., Kim, W. Y., Radvanyi, F., Höglund, M. & Real, F. X., 2016, In: Bladder Cancer. 2, 1, p. 37-47 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

173 Scopus citations

Molecular pathways: Targeting cancer stem cells awakened by chemotherapy to abrogate tumor repopulation

Chan, K. S., Feb 15 2016, In: Clinical Cancer Research. 22, 4, p. 802-806 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Positive association of collagen type I with non-muscle invasive bladder cancer progression

Brooks, M., Mo, Q., Krasnow, R., Ho, P. L., Lee, Y. C., Xiao, J., Kurtova, A., Lerner, S., Godoy, G., Jian, W., Castro, P., Chen, F., Rowley, D., Ittmann, M. & Chan, K. S., 2016, In: Oncotarget. 7, 50, p. 82609-82619 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

2015

Blocking PGE₂-induced tumour repopulation abrogates bladder cancer chemoresistance

Kurtova, A. V., Xiao, J., Mo, Q., Pazhanisamy, S., Krasnow, R., Lerner, S. P., Chen, F., Roh, T. T., Lay, E., Ho, P. L. & Chan, K. S., Jan 8 2015, In: Nature. 517, 7533, p. 209-213 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

468 Scopus citations

2014

RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation

Kim, W., Barron, D. A., Martin, R. S., Chan, K. S., Tran, L. L., Yang, F., Ressler, S. J. & Rowley, D. R., Nov 18 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 46, p. 13389-16394 3006 p.

Research output: Contribution to journal › Article › peer-review

Open Access

107 Scopus citations

2012

Stat3 activation in urothelial stem cells leads to direct progression to invasive bladder cancer

Ho, P. L., Lay, E. J., Jian, W., Parra, D. & Chan, K. S., Jul 1 2012, In: Cancer research. 72, 13, p. 3135-3142 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

116 Scopus citations

Three differentiation states risk-stratify bladder cancer into distinct subtypes

Volkmer, J. P., Sahoo, D., Chin, R. K., Ho, P. L., Tang, C., Kurtova, A. V., Willingham, S. B., Pazhanisamy, S. K., Contreras-Trujillo, H., Storm, T. A., Lotan, Y., Beck, A. H., Chung, B. I., Alizadeh, A. A., Godoy, G., Lerner, S. P., Van De Rijn, M., Shortliffe, L. D., Weissman, I. L. & Chan, K. S., Feb 7 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 2078-2083 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

200 Scopus citations

2009

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

Chan, K. S., Espinosa, I., Chao, M., Wong, D., Ailles, L., Diehn, M., Gill, H., Presti, J., Chang, H. Y., Van De Rijn, M., Shortliffe, L. & Weissman, I. L., Aug 18 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 33, p. 14016-14021 6 p.

Research output: Contribution to journal › Article › peer-review

542 Scopus citations

Imaging of STAT3 signaling pathway during mouse embryonic stem cell differentiation

Xie, X., Chan, K. S., Cao, F., Huang, M., Li, Z., Lee, A., Weissman, I. L. & Wu, J. C., Mar 1 2009, In: Stem Cells and Development. 18, 2, p. 205-214 10 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

2008

Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis

Chan, K. S., Sano, S., Kataoka, K., Abel, E., Carbajal, S., Beltran, L., Clifford, J., Peavey, M., Shen, J. & DiGiovanni, J., Feb 14 2008, In: Oncogene. 27, 8, p. 1087-1094 8 p.

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

2007

Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis

Dae, J. K., Chan, K. S., Sano, S. & DiGiovanni, J., Aug 2007, In: Molecular Carcinogenesis. 46, 8, p. 725-731 7 p.

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

2006

Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions

Yin, W., Cheepala, S., Roberts, J. N., Syson-Chan, K., DiGiovanni, J. & Clifford, J. L., Apr 7 2006, In: Molecular Cancer. 5, 15.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

2005

Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation

Sano, S., Chan, K. S., Kira, M., Kataoka, K., Takagi, S., Tarutani, M., Itami, S., Kiguchi, K., Yokoi, M., Sugasawa, K., Mori, T., Hanaoka, F., Takeda, J. & DiGiovanni, J., Jul 1 2005, In: Cancer research. 65, 13, p. 5720-5729 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

88 Scopus citations

Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model

Sano, S., Chan, K. S., Carbajal, S., Clifford, J., Peavey, M., Kiguchi, K., Itami, S., Nickoloff, B. J. & DiGiovanni, J., Jan 2005, In: Nature Medicine. 11, 1, p. 43-49 7 p.

Research output: Contribution to journal › Article › peer-review

640 Scopus citations

2004

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

Chan, K. S., Sano, S., Kiguchi, K., Anders, J., Komazawa, N., Takeda, J. & DiGiovanni, J., Sep 2004, In: Journal of Clinical Investigation. 114, 5, p. 720-728 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

318 Scopus citations

Epidermal Growth Factor Receptor-Mediated Activation of Stat3 during Multistage Skin Carcinogenesis

Chan, K. S., Carbajal, S., Kiguchi, K., Clifford, J., Sano, S. & DiGiovanni, J., Apr 1 2004, In: Cancer research. 64, 7, p. 2382-2389 8 p.

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

2001

Constitutive expression of ErbB-2 in gallbladder epithelium results in development of adenocarcinoma

Kiguchi, K., Carbajal, S., Chan, K., Beltrán, L., Ruffino, L., Shen, J., Matsumoto, T., Yoshimi, N. & DiGiovanni, J., Oct 1 2001, In: Cancer research. 61, 19, p. 6971-6976 6 p.

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

2000

Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development

Kiguchi, K., Bol, D., Carbajal, S., Beltrán, L., Moats, S., Chan, K., Jorcano, J. & DiGiovanni, J., Aug 31 2000, In: Oncogene. 19, 37, p. 4243-4254 12 p.

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Keith Syson Chan, PhD

Research output

Search results