Projects per year
Personal profile
Personal profile
Dr. Keith Chan received his PhD from the University of Texas Graduate School of Biomedical Sciences at MD Anderson Cancer Center in Houston, his BSc in Life Sciences from Queen’s University in Kingston, Ontario, Canada and was a postdoctoral fellow in cancer stem cells and immune evasion at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University in California. Dr. Chan most recently comes to Houston Methodist from Cedars-Sinai Medical Center where he was a professor of academic pathology and previously was a tenured associate professor of molecular and cellular biology at the Stem Cells and Regenerative Medicine (STaR) Center at the Baylor College of Medicine.
Research interests
With a focus on expediting the development of early-phase clinical trials and enhancing chemoimmunotherapy responses in bladder cancer, genitourinary cancer translational scientist Keith Syson Chan, PhD, is joining Houston Methodist thanks to a $6 million Established Investigator recruitment grant from the Cancer Prevention and Research Institute of Texas (CPRIT).
Research Area Keywords
- Cancer
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Projects
- 1 Active
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Cabozantinib plus Nivolumab Phase I Expansion Study in Patients with Metastatic Urothelial Carcinoma Refractory to Immune Checkpoint Inhibitor Therapy
Girardi, D. M., Niglio, S. A., Mortazavi, A., Nadal, R., Lara, P., Pal, S. K., Saraiya, B., Cordes, L., Ley, L., Ortiz, O. S., Cadena, J., Diaz, C., Bagheri, H., Redd, B., Steinberg, S. M., Costello, R., Chan, K. S., Lee, M. J., Lee, S., Yu, Y., & 15 others, Apr 1 2022, In: Clinical Cancer Research. 28, 7, p. 1353-1362 10 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors
Nikolos, F., Hayashi, K., Hoi, X. P., Alonzo, M. E., Mo, Q., Kasabyan, A., Furuya, H., Trepel, J., Di Vizio, D., Guarnerio, J., Theodorescu, D., Rosser, C., Apolo, A., Galsky, M. & Chan, K. S., Dec 2022, In: Nature Communications. 13, 1, 1487.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Characterizing molecular subtypes of high-risk non-muscle-invasive bladder cancer in African American patients
You, S., Kim, M., Widen, S., Yu, A., Galvan, G. C., Choi-Kuaea, Y., Eyzaguirre, E. J., Dyrskjøt, L., McConkey, D. J., Choi, W., Theodorescu, D., Chan, K. S., Shan, Y., Tyler, D. S., De Hoedt, A. M., Freedland, S. J. & Williams, S. B., Sep 2022, In: Urologic Oncology: Seminars and Original Investigations. 40, 9, p. 410.e19-410.e27Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment
Piras, R., Ko, E. Y., Barrett, C., De Simone, M., Lin, X., Broz, M. T., Tessaro, F. H. G., Castillo-Martin, M., Cordon-Cardo, C., Goodridge, H. S., Di Vizio, D., Batish, M., Lawrenson, K., Chen, Y. G., Chan, K. S. & Guarnerio, J., Dec 2022, In: Nature Communications. 13, 1, 7243.Research output: Contribution to journal › Article › peer-review
Open Access -
Discoidin Domain Receptor-Driven Gene Signatures as Markers of Patient Response to Anti-PD-L1 Immune Checkpoint Therapy
You, S., Kim, M., Hoi, X. P., Lee, Y. C., Wang, L., Spetzler, D., Abraham, J., Magee, D., Jain, P., Galsky, M. D., Chan, K. S. & Theodorescu, D., Oct 1 2022, In: Journal of the National Cancer Institute. 114, 10, p. 1380-1391 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations