Projects per year
Personal profile
Personal profile
Dr. Jun Li serves as Chairman of the Stanley H. Appel Department of Neurology at the Houston Methodist Neurological Institute, effective June 1, 2022. Dr. Li most recently served as the Chairman of the Department of Neurology, the Scientific Director of Translational Neuroscience Initiatives at Wayne State University, and the Specialist-in-Chief of Neurology at the Detroit Medical Center. Dr. Li spent nine years of his junior faculty career at WSU and another nine years at Vanderbilt University before taking on the chairman position at WSU.
Dr. Li received his medical degree from Anhui Medical University in the People’s Republic of China in 1985. He received his doctoral degree in Neurosciences in 1995 from the Drexel University College of Medicine (formerly Hahnemann University). He completed a Neurology residency in 1999 at the Ohio State University; and an EMG/Neuromuscular Fellowship in 2000 in the Department of Neurology at the University of Utah.
Research interests
As a physician-scientist, Dr. Li subspecializes in peripheral nerve diseases and myelin biology. His laboratory has been continuously funded by NIH since 2004. He has published more than 90 articles in peer-reviewed journals and book chapters. These contributions earned him a Wolfe Research Prize from American Neurological Association in 2014. He is a current member of the ANA Board of Directors and has also served as a member of the Scientific Advisory Board for the Muscular Dystrophy Association, Charcot-Marie-Tooth Association, and the scientific committee of the Peripheral Nerve Society. He has been a member of NIH study sections for more than a decade.
Dr. Jun Li's research has two arms – basic science studies in laboratory and clinical research. The basic science research focuses on a better understanding of how myelinating Schwann cells interact with axons and how various genetic mutations in inherited peripheral nerve diseases (or Charcot-Marie-Tooth diseases) alter the molecular signaling between the two types of cells. These studies aim to identify molecular targets for developing therapeutic interventions.
His clinical studies examine a group of inherited peripheral nerve diseases that typically result in limb muscle weakness, sensory loss, and foot deformities in these patients. Dr. Li directs a CMT clinic that is specifically designated for patients with inherited peripheral nerve diseases. This multi-disciplinary clinic occurs weekly and sees patients from throughout the United States. His research team is interested in the genotype/phenotype of these diseases, the identification of novel genetic mutations causing the diseases, translating the laboratory findings to bedside practice, and developing biomarkers to monitor disease progression.
External positions
Professor of Neurology, Weill Cornell Medicine
Nov 1 2022 → …
Research Area Keywords
- Neurosciences
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Collaborations and top research areas from the last five years
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Myelin Junction Therapy in Peripheral Neuropathies
Li, J. (PI)
1/1/23 → 12/31/25
Project: Federal Funding Agencies
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Biomarker development in patients with HNPP
Li, J. (PI)
6/1/22 → 12/31/24
Project: Federal Funding Agencies
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MRI Biomarkers of Disease Progression in Inherited Neuropathies
Li, J. (PI)
1/31/23 → 3/31/24
Project: Federal Funding Agencies
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Charcot-Marie-Tooth Disease
Benitez, S., Hu, B. & Li, J., Feb 12 2024, Reference Module in Neuroscience and Biobehavioral Psychology. Elsevier, p. 676-686 11 p. ISBN 9780122268700Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Multiparametric Quantitative MRI of Peripheral Nerves in the Leg: A Reliability Study
Chen, Y., Baraz, J., Xuan, S. Y., Yang, X., Castoro, R., Xuan, Y., Roth, A. R., Dortch, R. D. & Li, J., Feb 2024, In: Journal of Magnetic Resonance Imaging. 59, 2, p. 563-574 12 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
PAK2 is necessary for myelination in the peripheral nervous system
Hu, B., Moiseev, D., Schena, I., Faezov, B., Dunbrack, R., Chernoff, J. & Li, J., May 3 2024, In: Brain. 147, 5, p. 1809-1821 13 p.Research output: Contribution to journal › Article › peer-review
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Disease Progression in Charcot–Marie–Tooth Disease Related to MPZ Mutations: A Longitudinal Study
the Inherited Neuropathies Consortium–Rare Diseases Clinical Research Network, Mar 2023, In: Annals of Neurology. 93, 3, p. 563-576 14 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Genetic analysis and natural history of Charcot-Marie-Tooth disease CMTX1 due to GJB1 variants
Inherited Neuropathies Consortium-Rare Disease Clinical Research Network, Oct 1 2023, In: Brain. 146, 10, p. 4336-4349 14 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations