Personal profile
Personal profile
Dr. Masdeu trained in Psychiatry at the University of Valencia in Spain and in Neurology at Mt. Sinai Hospital in Chicago. He then served as a Fellow in Neuropathology at Peter Bent Brigham Hospital at Harvard Medical School. He was an Assistant and Associate Professor of Neurology at the Albert Einstein School of Medicine in New York, and has served as a Professor and Chair of Neurology at New York Medical College. Dr. Masdeu became a Professor and Chair of Neurology and Neuroscience at the University of Navarre Medical School in Pamplona, Spain. From 2008-2014, Dr. Masdeu was a senior staff physician and scientist in the Section of Integrative Neuroimaging of the Clinical Brain Disorders Branch at the National Institutes of Health. He is chairman of the Neuroimaging Research Group of the World Federation of Neurology. He has been a director of the American Academy of Neurology and president of the American Society of Neuroimaging. Since 2007, he has been Editor-in-Chief of the Journal of Neuroimaging. He is the author of 144 peer-reviewed papers, 62 book chapters, and seven books, including Localization in Clinical Neurology, a standard in the field, now in its 6th edition. Dr. Masdeu joined the Houston Methodist Research Institute in 2014.
Research interests
Dr. Masdeu’s main areas of research have been the following:
-Clarifying the neurobiology of Alzheimer’s disease and other neurodegenerative disorders
-Using spontaneous lesion models and/or imaging to map the localization of function in the human brain
-Developing novel neuroimaging signs and implementing neuroimaging as a biomarker of neurological disease
Education/Academic qualification
Neuropathology, Postdoctoral Fellowship, Brigham and Women’s Hospital
Neuroscience, PhD, Facultad de Medicina de la Universidad de Navarra, Pamplona
Research Area Keywords
- Neurosciences
Free-text keywords
- Alzheimer’s disease
- Brain lesions
- Neuroimaging
- Psychoses
- Beta-amyloid
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Collaborations and top research areas from the last five years
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ACR Appropriateness Criteria® Dementia: 2024 Update
Expert Panel on Neurological Imaging, May 2025, In: Journal of the American College of Radiology. 22, 5, p. S202-S233Research output: Contribution to journal › Article › peer-review
2 Link opens in a new tab Scopus citations -
Amyloid PET in Sporadic Early- Versus Late-Onset Alzheimer's Disease: Comparison of the LEADS and ADNI Cohorts
the LEADS Consortium for the Alzheimer's Disease Neuroimaging Initiative, Aug 2025, In: Annals of Neurology. 98, 2, p. 236-248 13 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Assessing Braak stage agreement between four Tau PET tracers
Rocha, A., Bellaver, B., Soares, C., Ferreira, P. C. L., Ruppert, E., Madeiros, M. S., Povala, G., Amaral, L., Bauer-Negrini, G., Lussier, F. Z., Rodrigues, M. S., Mroué, R., Masdeu, J. C., Tudorascu, D. L., Soleimani-Meigooni, D. N., Fortea, J., Lowe, V. J., Oh, H., Pascual, B. & Gordon, B. A. & 3 others, , Dec 1 2025, In: Alzheimer's & dementia : the journal of the Alzheimer's Association. 21, S2, e107635.Research output: Contribution to journal › Article › peer-review
Open Access -
Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease
Casaletto, K. B., Saloner, R., Kornak, J., Staffaroni, A. M., Villeda, S., Paolillo, E., VandeBunte, A. M., Cadwallader, C. J., Lario Lago, A., Webb, J., Chen, C., Rascovsky, K., Miyagawa, T., Ramos, E. M., Masdeu, J. C., Pantelyat, A., Tartaglia, M. C., Bozoki, A., Pressman, P. S. & Rademakers, R. & 25 others, , 2025, In: Brain Communications. 7, 1, fcae432.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Brain inflammation co-localizes highly with tau in mild cognitive impairment due to early-onset Alzheimer's disease
Appleton, J., Finn, Q., Zanotti-Fregonara, P., Yu, M., Faridar, A., Nakawah, M. O., Zarate, C., Carrillo, M. C., Dickerson, B. C., Rabinovici, G. D., Apostolova, L. G., Masdeu, J. C. & Pascual, B., Jan 1 2025, In: Brain. 148, 1, p. 119-132 14 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Link opens in a new tab Scopus citations