Projects per year
Personal profile
Research interests
Dr. Xiao’s research interests are related to how the immune system responds to allotransplants, with specific emphasis on the fundamental mechanisms that control various T cell programs involved in transplant rejection and tolerance. One of the key aspects of his recent research focuses on the role of costimulatory molecules in T helper cells differentiation, functions, and fate decisions.
Personal profile
Dr. Xiang Xiao earned his Ph.D. in cell biology from University of Science and Technology of China in Heifei, China in 2005. He completed his postdoctoral fellowship training at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston in 2013. After that, he joined Houston Methodist Research Institute as a research scientist. Dr. Xiao is now an assistant research professor of transplant immunology in surgery. Dr. Xiao studies the cellular and molecular mechanisms T cell functions relevant to transplant tolerance. He has published more than 20 original papers and review articles in high-impact scientific journals.
Education/Academic qualification
Cell Biology, PhD, University of Science and Technology of China
Sep 1 2002 → May 8 2005
Award Date: May 8 2005
Transplantation Immunology, Postdoctoral Fellowship, Harvard Medical School
Jul 5 2011 → Mar 4 2013
Transplantation Immunology, Postdoctoral Fellowship, Beth Israel Deaconess Medical Center
Nov 6 2006 → Jul 4 2011
Research Area Keywords
- Immunobiology & Inflammation
- Transplantation
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Development of T Regulatory Cells and Their Association With Outcomes Following Liver Transplantation
Ghobrial, R. M., Graviss, E. A., Hobeika, M. J., Li, X. C., Moore, L. W., Saharia, A. & Xiao, J.
12/3/13 → …
Project: Clinical Trial
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Studies of a new checkpoint regulator in controlling lung inflammation
9/1/20 → 8/31/21
Project: Federal Funding Agencies
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Genetically targeting the BATF family transcription factors BATF and BATF3 in the mouse abrogates effector T cell activities and enables long-term heart allograft survival
Wang, Y., Xiao, X., Kong, G., Wen, M., Wang, G., Ghobrial, R. M., Dong, N., Chen, W. & Li, X. C., Feb 2022, In: American Journal of Transplantation. 22, 2, p. 414-426 13 p.Research output: Contribution to journal › Article › peer-review
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The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions
Wang, G., Xiao, X., Wang, Y., Chu, X., Dou, Y., Minze, L. J., Ghobrial, R. M., Zhang, Z. & Li, X. C., Jun 2022, In: Cellular and Molecular Immunology. 19, 6, p. 687-701 15 p.Research output: Contribution to journal › Article › peer-review
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The transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo
Zhang, L., Ying, Y., Chen, S., Arnold, P. R., Tian, F., Minze, L. J., Xiao, X. & Li, X. C., Jan 2021, In: Cellular and Molecular Immunology. 18, 1, p. 230-242 13 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Transgenic Expression of a Mutant Ribonuclease Regnase-1 in T Cells Disturbs T Cell Development and Functions
Kong, G., Dou, Y., Xiao, X., Wang, Y., Ming, Y. & Li, X. C., Jul 8 2021, In: Frontiers in immunology. 12, 682220.Research output: Contribution to journal › Article › peer-review
Open Access -
Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics
Chen, S., Zhang, L., Ying, Y., Wang, Y., Arnold, P. R., Wang, G., Li, J., Ghobrial, R. M., Chen, W., Xiao, X. & Li, X. C., Sep 1 2020, In: American Journal of Transplantation. 20, 9, p. 2366-2379 14 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations
Prizes
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the 2016 Moran Foundation Award
Xiao, Johnny (Recipient), Oct 24 2016
Prize: Prize (including medals and awards)