Projects per year
Personal profile
Research interests
Dr. Xiao’s research interests are related to how the immune system responds to allotransplants, with specific emphasis on the fundamental mechanisms that control various T cell programs involved in transplant rejection and tolerance. One of the key aspects of his recent research focuses on the role of costimulatory molecules in T helper cells differentiation, functions, and fate decisions.
Personal profile
Dr. Xiang Xiao earned his Ph.D. in cell biology from University of Science and Technology of China in Heifei, China in 2005. He completed his postdoctoral fellowship training at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston in 2013. After that, he joined Houston Methodist Research Institute as a research scientist. Dr. Xiao is now an assistant research professor of transplant immunology in surgery. Dr. Xiao studies the cellular and molecular mechanisms T cell functions relevant to transplant tolerance. He has published more than 20 original papers and review articles in high-impact scientific journals.
Education/Academic qualification
Cell Biology, PhD, University of Science and Technology of China
Sep 1 2002 → May 8 2005
Award Date: May 8 2005
Transplantation Immunology, Postdoctoral Fellowship, Harvard Medical School
Jul 5 2011 → Mar 4 2013
Transplantation Immunology, Postdoctoral Fellowship, Beth Israel Deaconess Medical Center
Nov 6 2006 → Jul 4 2011
Research Area Keywords
- Immunobiology & Inflammation
- Transplantation
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Projects
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Studies of a new checkpoint regulator in controlling lung inflammation
9/1/20 → 8/31/21
Project: Federal Funding Agencies
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Development of T Regulatory Cells and Their Association With Outcomes Following Liver Transplantation
Ghobrial, R. M., Graviss, E. A., Hobeika, M. J., Li, X. C., Moore, L. W., Saharia, A. & Xiao, J.
9/24/14 → …
Project: Clinical Trial
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Research Output
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The transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo
Zhang, L., Ying, Y., Chen, S., Arnold, P. R., Tian, F., Minze, L. J., Xiao, X. & Li, X. C., Jan 2021, In : Cellular and Molecular Immunology. 18, 1, p. 230-242 13 p.Research output: Contribution to journal › Article
1 Scopus citations -
Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics
Chen, S., Zhang, L., Ying, Y., Wang, Y., Arnold, P. R., Wang, G., Li, J., Ghobrial, R. M., Chen, W., Xiao, X. & Li, X. C., Sep 1 2020, In : American Journal of Transplantation. 20, 9, p. 2366-2379 14 p.Research output: Contribution to journal › Article
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T cell exhaustion is associated with antigen abundance and promotes transplant acceptance
Zou, D., Dai, Y., Zhang, X., Wang, G., Xiao, X., Jia, P., Li, X. C., Guo, Z. & Chen, W., Mar 17 2020, In : American Journal of Transplantation. 20, 9, p. 2540-2550 11 p.Research output: Contribution to journal › Article
3 Scopus citations -
T follicular helper and memory cell responses and the mTOR pathway in murine heart transplantation
Xie, A., Yan, H., Fu, J., He, A., Xiao, X., Li, X. C. & Chen, W., Feb 2020, In : Journal of Heart and Lung Transplantation. 39, 2, p. 134-144 11 p.Research output: Contribution to journal › Article
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Ablation of interferon regulatory factor 4 in T cells induces “memory” of transplant tolerance that is irreversible by immune checkpoint blockade
Zhang, H., Wu, J., Zou, D., Xiao, X., Yan, H., Li, X. C. & Chen, W., Mar 2019, In : American Journal of Transplantation. 19, 3, p. 884-893 10 p.Research output: Contribution to journal › Article
5 Scopus citations
Prizes
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the 2016 Moran Foundation Award
Xiao, Johnny (Recipient), Oct 24 2016
Prize: Prize (including medals and awards)