Projects per year
Personal profile
Research interests
Dr. Xiao’s research interests are related to how the immune system responds to allotransplants, with specific emphasis on the fundamental mechanisms that control various T cell programs involved in transplant rejection and tolerance. One of the key aspects of his recent research focuses on the role of costimulatory molecules in T helper cells differentiation, functions, and fate decisions.
Personal profile
Dr. Xiang Xiao earned his Ph.D. in cell biology from University of Science and Technology of China in Heifei, China in 2005. He completed his postdoctoral fellowship training at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston in 2013. After that, he joined Houston Methodist Research Institute as a research scientist. Dr. Xiao is now an assistant research professor of transplant immunology in surgery. Dr. Xiao studies the cellular and molecular mechanisms T cell functions relevant to transplant tolerance. He has published more than 20 original papers and review articles in high-impact scientific journals.
Education/Academic qualification
Cell Biology, PhD, University of Science and Technology of China
Sep 1 2002 → May 8 2005
Award Date: May 8 2005
Transplantation Immunology, Postdoctoral Fellowship, Harvard University
Jul 5 2011 → Mar 4 2013
Transplantation Immunology, Postdoctoral Fellowship, Beth Israel Deaconess Medical Center
Nov 6 2006 → Jul 4 2011
Research Area Keywords
- Immunobiology & Inflammation
- Transplantation
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Control of dysfunctional Tregs
Li, X. C. (PI) & Xiao, J. (Key Personnel)
2/1/14 → 1/31/26
Project: Federal Funding Agencies
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Development of T Regulatory Cells and Their Association With Outcomes Following Liver Transplantation
Ghobrial, R. M. (PI), Connor, A. A. (Key Personnel), Graviss, E. A. (Key Personnel), Li, X. C. (Key Personnel), Mobley, C. M. (Key Personnel), Moore, L. W. (Key Personnel), Rizk, E. (Key Personnel), Saharia, A. (Key Personnel), Uosef, A. (Key Personnel) & Xiao, J. (Key Personnel)
12/3/13 → …
Project: Clinical Trial
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Studies of a new checkpoint regulator in controlling lung inflammation
Zhang, Z. (PI) & Xiao, J. (Key Personnel)
9/1/20 → 8/31/21
Project: Federal Funding Agencies
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T cell fate decisions and transplant outcomes
Li, X. C. (PI) & Xiao, J. (Key Personnel)
1/10/18 → 12/31/23
Project: Federal Funding Agencies
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T cell fate decisions and transplant outcomes
Li, X. C. (PI) & Xiao, J. (Key Personnel)
8/18/17 → 1/9/18
Project: Federal Funding Agencies
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Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease models
Xiao, X., Du, Y., Sun, S., Su, X., Xing, J., Wang, G., Elzein, S. M., Zou, D., Minze, L. J., Mao, Z., Ghobrial, R. M., Connor, A. A., Chen, W., Zhang, Z. & Li, X. C., Dec 31 2024, In: The Journal of clinical investigation. 135, 4, e183671.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
CD4+ T cell immunity is dependent on an intrinsic stem-like program
Zou, D., Yin, Z., Yi, S. G., Wang, G., Guo, Y., Xiao, X., Li, S., Zhang, X., Gonzalez, N. M., Minze, L. J., Wang, L., Wong, S. T. C., Osama Gaber, A., Ghobrial, R. M., Li, X. C. & Chen, W., Jan 2024, In: Nature immunology. 25, 1, p. 66-76 11 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8+ T Cell Immunity against Tumor
Yu, A., Fu, J., Yin, Z., Yan, H., Xiao, X., Zou, D., Zhang, X., Zu, X., Li, X. C. & Chen, W., Nov 2023, In: Research. 6, 0271.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Gasdermin D-mediated pyroptosis is regulated by AMPK-mediated phosphorylation in tumor cells
Chu, X., Xiao, X., Wang, G., Uosef, A., Lou, X., Arnold, P., Wang, Y., Kong, G., Wen, M., Minze, L. J. & Li, X. C., Jul 2023, In: Cell Death and Disease. 14, 7, 469.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
The transcription factor IRF4 determines the anti-tumor immunity of CD8+ T cells
Yan, H., Dai, Y., Zhang, X., Zhang, H., Xiao, X., Fu, J., Zou, D., Yu, A., Jiang, T., Li, X. C., Zhao, Z. & Chen, W., Nov 17 2023, In: iScience. 26, 11, 108087.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations
Prizes
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the 2016 Moran Foundation Award
Xiao, X. (Recipient), Oct 24 2016
Prize: Prize (including medals and awards)