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Johnny Xiao, PhD

  • 1202 Citations
  • 19 h-Index
20072020

Research output per year

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Personal profile

Research interests

Dr. Xiao’s research interests are related to how the immune system responds to allotransplants, with specific emphasis on the fundamental mechanisms that control various T cell programs involved in transplant rejection and tolerance. One of the key aspects of his recent research focuses on the role of costimulatory molecules in T helper cells differentiation, functions, and fate decisions.

Personal profile

Dr. Xiang Xiao earned his Ph.D. in cell biology from University of Science and Technology of China in Heifei, China in 2005. He completed his postdoctoral fellowship training at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston in 2013. After that, he joined Houston Methodist Research Institute as a research scientist. Dr. Xiao is now an assistant research professor of transplant immunology in surgery. Dr. Xiao studies the cellular and molecular mechanisms T cell functions relevant to transplant tolerance. He has published more than 20 original papers and review articles in high-impact scientific journals.

Education/Academic qualification

Cell Biology, PhD, University of Science and Technology of China

Sep 1 2002 → May 8 2005

Award Date: May 8 2005

Transplantation Immunology, Postdoctoral Fellowship, Harvard Medical School

Jul 5 2011 → Mar 4 2013

Transplantation Immunology, Postdoctoral Fellowship, Beth Israel Deaconess Medical Center

Nov 6 2006 → Jul 4 2011

Research Area Keywords

  • Immunobiology & Inflammation
  • Transplantation

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Projects

Studies of a new checkpoint regulator in controlling lung inflammation

Zhang, Z. & Xiao, J.

9/1/20 → 8/31/21

Project: Federal Funding Agencies

T cell fate decisions and transplant outcomes

Li, X. C. & Xiao, J.

1/10/18 → 12/31/22

Project: Federal Funding Agencies

Development of T Regulatory Cells and Their Association With Outcomes Following Liver Transplantation

Ghobrial, R. M., Graviss, E. A., Hobeika, M. J., Li, X. C., Moore, L. W., Saharia, A. & Xiao, J.

9/24/14 → …

Project: Clinical Trial

T cell fate decisions and transplant outcomes

Li, X. C. & Xiao, J.

8/18/17 → 1/9/18

Project: Federal Funding Agencies

Control of Treg exhaustion by OX40

Li, X. C. & Xiao, J.

Natl Inst of AllergyandInfectious Disease

9/1/13 → 1/31/14

Project: Federal Funding Agencies

Research Output

  • 1202 Citations
  • 19 h-Index
  • 31 Article
  • 3 Review article

Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics

Chen, S., Zhang, L., Ying, Y., Wang, Y., Arnold, P. R., Wang, G., Li, J., Ghobrial, R. M., Chen, W., Xiao, X. & Li, X. C., Sep 1 2020, In : American Journal of Transplantation. 20, 9, p. 2366-2379 14 p.

Research output: Contribution to journal › Article

    • T cell exhaustion is associated with antigen abundance and promotes transplant acceptance

    Zou, D., Dai, Y., Zhang, X., Wang, G., Xiao, X., Jia, P., Li, X. C., Guo, Z. & Chen, W., Mar 17 2020, In : American Journal of Transplantation. 20, 9, p. 2540-2550 11 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    T follicular helper and memory cell responses and the mTOR pathway in murine heart transplantation

    Xie, A., Yan, H., Fu, J., He, A., Xiao, X., Li, X. C. & Chen, W., Feb 2020, In : Journal of Heart and Lung Transplantation. 39, 2, p. 134-144 11 p.

    Research output: Contribution to journal › Article

    • The transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo

    Zhang, L., Ying, Y., Chen, S., Arnold, P. R., Tian, F., Minze, L. J., Xiao, X. & Li, X. C., Jan 1 2020, In : Cellular and Molecular Immunology.

    Research output: Contribution to journal › Article

    • Ablation of interferon regulatory factor 4 in T cells induces “memory” of transplant tolerance that is irreversible by immune checkpoint blockade

    Zhang, H., Wu, J., Zou, D., Xiao, X., Yan, H., Li, X. C. & Chen, W., Mar 2019, In : American Journal of Transplantation. 19, 3, p. 884-893 10 p.

    Research output: Contribution to journal › Article

    • 4 Scopus citations

    Prizes

    the 2016 Moran Foundation Award

    Xiao, Johnny (Recipient), Oct 24 2016

    Prize: Prize (including medals and awards)