John P. Cooke, MD, PhD

  • 32883 Citations
  • 96 h-Index
1982 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

AYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model

Chen, J., Ma, Q., King, J. S., Sun, Y., Xu, B., Zhang, X., Zohrabian, S., Guo, H., Cai, W., Li, G., Bruno, I. G., Cooke, J. P., Wang, C., Kontaridis, M., Wang, D. Z., Luo, H., Pu, W. T. & Lin, Z., 2020, In : Life Science Alliance. 3, 1, e201900424.

Research output: Contribution to journalArticle

1 Scopus citations

Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome

Mu, X., Tseng, C., Hambright, W. S., Matre, P., Lin, C. Y., Chanda, P., Chen, W., Gu, J., Ravuri, S., Cui, Y., Zhong, L., Cooke, J. P., Niedernhofer, L. J., Robbins, P. D. & Huard, J., Jul 25 2020, In : Aging Cell.

Research output: Contribution to journalArticle

Machine learning uncovers cell identity regulator by histone code

Xia, B., Zhao, D., Wang, G., Zhang, M., Lv, J., Tomoiaga, A. S., Li, Y., Wang, X., Meng, S., Cooke, J. P., Cao, Q., Zhang, L. & Chen, K., Jun 1 2020, In : Nature Communications. 11, 1, 2696.

Research output: Contribution to journalArticle

Rapamycin-Loaded Biomimetic Nanoparticles Reverse Vascular Inflammation

Boada, C., Zinger, A., Tsao, C., Zhao, P., Martinez, J. O., Hartman, K., Naoi, T., Sukhoveshin, R., Sushnitha, M., Molinaro, R., Trachtenberg, B. H., Cooke, J. P. & Tasciotti, E., Jan 3 2020, In : Circulation Research. 126, 1, p. 25-37 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription

Wang, G., Meng, Q., Xia, B., Zhang, S., Lv, J., Zhao, D., Li, Y., Wang, X., Zhang, L., Cooke, J. P., Cao, Q. & Chen, K., Apr 2 2020, In : Genome Biology. 21, 1, 84.

Research output: Contribution to journalArticle

2019

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate

Gu, Q., Yang, X., Lv, J., Zhang, J., Xia, B., Kim, J. D., Wang, R., Xiong, F., Meng, S., Clements, T. P., Tandon, B., Wagner, D. S., Diaz, M. F., Wenzel, P. L., Miller, Y. I., Traver, D., Cooke, J. P., Li, W., Zon, L. I., Chen, K. & 2 others, Bai, Y. & Fang, L., Mar 8 2019, In : Science. p. eaav1749

Research output: Contribution to journalArticle

23 Scopus citations

Asymmetric dimethylarginine predicts impaired epicardial coronary vasomotion in patients with angina in the absence of obstructive coronary artery disease

Parikh, R. V., Pargaonkar, V., Ball, R. L., Kobayashi, Y., Kimura, T., Yeung, A. C., Cooke, J. P. & Tremmel, J. A., Jan 1 2019, In : International Journal of Cardiology.

Research output: Contribution to journalArticle

1 Scopus citations

Dysfunction of iPSC-derived endothelial cells in human Hutchinson–Gilford progeria syndrome

Matrone, G., Thandavarayan, R. A., Walther, B. K., Meng, S., Mojiri, A. & Cooke, J. P., Oct 2 2019, In : Cell Cycle. 18, 19, p. 2495-2508 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase

Kotla, S., Le, N-T., Vu, H. T., Ko, K. A., Gi, Y. J., Thomas, T. N., Giancursio, C., Lusis, A. J., Cooke, J. P., Fujiwara, K. & Abe, J. I., Nov 1 2019, In : Metabolism: Clinical and Experimental. 100, 153962.

Research output: Contribution to journalArticle

1 Scopus citations

Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2–interacting protein

Kotla, S., Vu, H. T., Ko, K. A., Wang, Y., Imanishi, M., Heo, K. S., Fujii, Y., Thomas, T. N., Gi, Y. J., Mazhar, H., Paez-Mayorga, J., Shin, J. H., Tao, Y., Giancursio, C. J., Medina, J. L. M., Taunton, J., Lusis, A. J., Cooke, J. P., Fujiwara, K., Le, N-T. & 1 others, Abe, J. I., May 2 2019, In : JCI insight. 4, 9, e124867.

Research output: Contribution to journalArticle

5 Scopus citations

Glycolytic Switch Is Required for Transdifferentiation to Endothelial Lineage

Lai, L., Reineke, E. L., Hamilton, D. J. & Cooke, J. P., Jan 2 2019, In : Circulation. 139, 1, p. 119-133 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis

Abe, J-I., Ko, K. A., Kotla, S., Wang, Y., Paez-Mayorga, J., Shin, I. J., Imanishi, M., Vu, H. T., Tao, Y., Leiva-Juarez, M. M., Thomas, T. N., Medina, J. L., Won, J. H., Fujii, Y., Giancursio, C. J., McBeath, E., Shin, J-H., Guzman, L., Abe, R. J., Taunton, J. & 6 others, Mochizuki, N., Faubion, W., Cooke, J. P., Fujiwara, K., Evans, S. E. & Le, N-T., Apr 4 2019, In : JCI insight. 4, 7

Research output: Contribution to journalArticle

5 Scopus citations

Nuclear S-nitrosylation defines an optimal zone for inducing pluripotency

Chanda, P. K., Meng, S., Lee, J., Leung, H. E., Chen, K. & Cooke, J. P., Sep 24 2019, In : Circulation. 140, 13, p. 1081-1099 19 p.

Research output: Contribution to journalArticle

2 Scopus citations

Rapamycin-Loaded Leukosomes Reverse Vascular Inflammation

Boada, C., Zinger, A., Tsao, C., Zhao, P., MARTINEZ JONATHAN, O., Hartman, K. A., Naoi, T., Sukhovershin, R., Sushnitha, M., Molinaro, R., Trachtenberg, B. H., Cooke, J. P. & Tasciotti, E., Oct 24 2019, In : Circulation Research.

Research output: Contribution to journalArticle

Transient introduction of human telomerase mRNA improves hallmarks of progeria cells

Li, Y., Zhou, G., Bruno, I. G., Zhang, N., Sho, S., Tedone, E., Lai, T. P., Cooke, J. P. & Shay, J. W., Aug 2019, In : Aging Cell. 18, 4, e12979.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery

Martinez, J. O., Molinaro, R., Hartman, K. A., Boada, C., Sukhovershin, R., De Rosa, E., Kirui, D., Zhang, S., Evangelopoulos, M., Carter, A. M., Bibb, J. A., Cooke, J. P. & Tasciotti, E., 2018, In : Theranostics. 8, 4, p. 1131-1145 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B

Hodgkinson, C. P., Pratt, R. E., Kirste, I., Dal-Pra, S., Cooke, J. P. & Dzau, V. J., Aug 2018, In : STEM CELLS. 36, 8, p. 1198-1209 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Induced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model

Clayton, Z. E., Tan, R. P., Miravet, M. M., Lennartsson, K., Cooke, J. P., Bursill, C. A., Wise, S. G. & Patel, S., Jul 31 2018, In : Bioscience Reports. 38, 4, BSR20180563.

Research output: Contribution to journalArticle

13 Scopus citations

Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis

Tan, R. P., Chan, A. H. P., Lennartsson, K., Miravet, M. M., Lee, B. S. L., Rnjak-Kovacina, J., Clayton, Z. E., Cooke, J. P., Ng, M. K. C., Patel, S. & Wise, S. G., Mar 21 2018, In : Stem Cell Research and Therapy. 9, 1, 70.

Research output: Contribution to journalArticle

12 Scopus citations

TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway

Meng, S., Gu, Q., Yang, X., Lv, J., Owusu, I., Matrone, G., Chen, K., Cooke, J. P. & Fang, L., Aug 28 2018, In : Circulation. 138, 9, p. 913-928 16 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

A comparison of the pro-angiogenic potential of human induced pluripotent stem cell derived endothelial cells and induced endothelial cells in a murine model of peripheral arterial disease

Clayton, Z. E., Yuen, G. S. C., Sadeghipour, S., Hywood, J. D., Wong, J. W. T., Huang, N. F., Ng, M. K. C., Cooke, J. P. & Patel, S., May 1 2017, In : International Journal of Cardiology. 234, p. 81-89 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling

Mao, R., Meng, S., Gu, Q., Araujo-Gutierrez, R., Kumar, S., Yan, Q., Almazan, F., Youker, K. A., Fu, Y., Pownall, H. J., Cooke, J. P., Miller, Y. I. & Fang, L., May 26 2017, In : Circulation Research. 120, 11, p. 1727-1739 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Discovery of novel determinants of endothelial lineage using chimeric heterokaryons

Wong, J., Matrone, G., Tian, X., Tomoiaga, S. A., Au, K. F., Meng, S., Yamazoe, S., Sieveking, D., Chen, K., Burns, D. M., Chen, J. K., Blau, H. M. & Cooke, J. P., Mar 21 2017, In : eLife. 6, e23588.

Research output: Contribution to journalArticle

2 Scopus citations

Identification of cardiovascular risk factors associated with bone marrow cell subsets in patients with STEMI: a biorepository evaluation from the CCTRN TIME and LateTIME clinical trials

Contreras, A., Orozco, A. F., Resende, M., Schutt, R. C., Traverse, J. H., Henry, T. D., Lai, D., Cooke, J. P., Bolli, R., Cohen, M. L., Moyé, L., Pepine, C. J., Yang, P. C., Perin, E. C., Willerson, J. T., Taylor, D. A. & For the Cardiovascular Cell Therapy Research Network (CCTRN), T. C. C. T. R. N. CCTRN., Jan 1 2017, In : Basic research in cardiology. 112, 1, 3.

Research output: Contribution to journalArticle

10 Scopus citations

Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration

Matrone, G., Meng, S., Gu, Q., Lv, J., Fang, L., Chen, K. & Cooke, J. P., Oct 1 2017, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 10, p. 1860-1868 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Peripheral Blood Cytokine Levels After Acute Myocardial Infarction: IL-1β and IL-6 Related Impairment of Bone Marrow Function

Shahrivari, M., Wise, E., Resende, M., Shuster, J. J., Zhang, J., Bolli, R., Cooke, J. P., Hare, J. M., Henry, T. D., Khan, A., Taylor, D. A., Traverse, J. H., Yang, P. C., Pepine, C. J. & Cogle, C. R., May 10 2017, In : Circulation Research.

Research output: Contribution to journalArticle

16 Scopus citations

Retinoic Acid Inducible Gene 1 Protein (RIG1)-Like Receptor Pathway Is Required for Efficient Nuclear Reprogramming

Sayed, N., Ospino, F., Himmati, F., Lee, J., Chanda, P., Mocarski, E. S. & Cooke, J. P., May 2017, In : STEM CELLS. 35, 5, p. 1197-1207 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis

Suh, J. H., Lai, L., Nam, D., Kim, J., Jo, J., Taffet, G. E., Kim, E., Kaelber, J. T., Lee, H. K., Entman, M. L., Cooke, J. P. & Reineke, E. L., 2017, In : Journal of Biological Chemistry. 292, 52, p. 21643-21652 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

The nicotinic cholinergic pathway contributes to retinal neovascularization in a mouse model of retinopathy of prematurity

Hackett, S. F., Seidel, C., Abraham, S., Chadha, R., Fortmann, S. D., Campochiaro, P. A. & Cooke, J. P., Feb 2017, In : Investigative Ophthalmology and Visual Science. 58, 2, p. 1296-1303 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Aligned nanofibrillar collagen scaffolds – Guiding lymphangiogenesis for treatment of acquired lymphedema

Hadamitzky, C., Zaitseva, T. S., Bazalova-Carter, M., Paukshto, M. V., Hou, L., Strassberg, Z., Ferguson, J., Matsuura, Y., Dash, R., Yang, P. C., Kretchetov, S., Vogt, P. M., Rockson, S. G., Cooke, J. P. & Huang, N. F., Sep 1 2016, In : Biomaterials. 102, p. 259-267 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
21 Scopus citations

Bone marrow cell characteristics associated with patient profile and cardiac performance outcomes in the LateTIME-Cardiovascular Cell Therapy Research Network (CCTRN) trial

Bhatnagar, A., Bolli, R., Johnstone, B. H., Traverse, J. H., Henry, T. D., Pepine, C. J., Willerson, J. T., Perin, E. C., Ellis, S. G., Zhao, D. X. M., Yang, P. C., Cooke, J. P., Schutt, R. C., Trachtenberg, B. H., Orozco, A., Resende, M., Ebert, R. F., Sayre, S. L., Simari, R. D., Moyé, L. & 2 others, Cogle, C. R. & Taylor, D. A., Sep 1 2016, In : American Heart Journal. 179, p. 142-150 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Enhancing Stent Effectiveness with Nanofeatures

Bassous, N., Cooke, J. P. & Webster, T. J., Sep 2016, In : Methodist DeBakey cardiovascular journal. 12, 3, p. 163-168 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Erratum: Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA

Bai, Y., Kan, S., Zhou, S., Wang, Y., Xu, J., Cooke, J. P., Wen, J. & Deng, H., 2016, In : Cell Discovery. 2, p. 16032

Research output: Contribution to journalArticle

Identification of bone marrow cell subpopulations associated with improved functional outcomes in patients with chronic left ventricular dysfunction: An embedded cohort evaluation of the FOCUS-CCTRN trial

Taylor, D. A., Perin, E. C., Willerson, J. T., Zierold, C., Resende, M., Carlson, M., Nestor, B., Wise, E., Orozco, A., Pepine, C. J., Henry, T. D., Ellis, S. G., Zhao, D. X. M., Traverse, J. H., Cooke, J. P., Schutt, R. C., Bhatnagar, A., Grant, M. B., Lai, D., Johnstone, B. H. & 6 others, Sayre, S. L., Moyé, L., Ebert, R. F., Bolli, R., Simari, R. D. & Cogle, C. R., Sep 2 2016, In : Cell Transplantation. 25, 9, p. 1675-1687 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

LIM domain only 2 regulates endothelial proliferation, angiogenesis, and tissue regeneration

Meng, S., Matrone, G., Lv, J., Chen, K., Wong, J. W. T. & Cooke, J. P., Oct 6 2016, In : Journal of the American Heart Association. 5, 10, e004117.

Research output: Contribution to journalArticle

5 Scopus citations

Nanotherapeutic Solutions for Cardiovascular Disease

Cooke, J. P. & Atkins, J., Sep 2016, In : Methodist DeBakey cardiovascular journal. 12, 3, p. 132-133 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Optimal ROS Signaling Is Critical for Nuclear Reprogramming

Zhou, G., Meng, S., Li, Y., Ghebre, Y. T. & Cooke, J. P., May 3 2016, In : Cell Reports. 15, 5, p. 919-925 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Polymer-DNA nanoparticle-induced CXCR4 overexpression improves stem cell engraftment and tissue regeneration in a mouse hindlimb ischemia model

Deveza, L., Choi, J., Lee, J., Huang, N., Cooke, J. & Yang, F., 2016, In : Theranostics. 6, 8, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Proton Pump Inhibitors Accelerate Endothelial Senescence

Yepuri, G., Sukhovershin, R., Nazari-Shafti, T. Z., Petrascheck, M., Ghebre, Y. T. & Cooke, J. P., Jun 10 2016, In : Circulation Research. 118, 12, p. e36-e42

Research output: Contribution to journalArticle

58 Scopus citations

Reply

Shah, N. H., Cooke, J. P. & Leeper, N. J., Feb 1 2016, In : Gastroenterology. 150, 2, p. 528 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeted delivery of human iPS-ECs overexpressing IL-8 receptors inhibits neointimal and inflammatory responses to vascular injury in the rat

Giordano, S., Zhao, X., Xing, D., Hage, F., Oparil, S., Cooke, J. P., Lee, J., Nakayama, K. H., Huang, N. F. & Chen, Y. F., Mar 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 6, p. H705-H715

Research output: Contribution to journalArticle

11 Scopus citations
13 Scopus citations

The use of machine learning for the identification of peripheral artery disease and future mortality risk

Ross, E. G., Shah, N. H., Dalman, R. L., Nead, K. T., Cooke, J. P. & Leeper, N. J., Nov 1 2016, In : Journal of Vascular Surgery. 64, 5, p. 1515-1522.e3

Research output: Contribution to journalArticle

28 Scopus citations

Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation

Meng, S., Zhou, G., Gu, Q., Chanda, P. K., Ospino, F. & Cooke, J. P., Oct 14 2016, In : Circulation Research. 119, 9, p. e129-e138

Research output: Contribution to journalArticle

12 Scopus citations
2015

Aligned-Braided Nanofibrillar Scaffold with Endothelial Cells Enhances Arteriogenesis

Nakayama, K. H., Hong, G., Lee, J. C., Patel, J., Edwards, B., Zaitseva, T. S., Paukshto, M. V., Dai, H., Cooke, J. P., Woo, Y. J. & Huang, N. F., Jul 28 2015, In : ACS Nano. 9, 7, p. 6900-6908 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Bone marrow characteristics associated with changes in infarct size after STEMI: A biorepository evaluation from the CCTRN TIME trial

Schutt, R. C., Trachtenberg, B. H., Cooke, J. P., Traverse, J. H., Henry, T. D., Pepine, C. J., Willerson, J. T., Perin, E. C., Ellis, S. G., Zhao, D. X. M., Bhatnagar, A., Johnstone, B. H., Lai, D., Resende, M., Ebert, R. F., Wu, J. C., Sayre, S. L., Orozco, A., Zierold, C., Simari, R. D. & 3 others, Moyé, L., Cogle, C. R. & Taylor, D. A., Jan 2 2015, In : Circulation Research. 116, 1, p. 99-107 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrillation: Data from ROCKET AF

ROCKET AF Steering Committee and Investigators, 2015, In : Journal of the American Heart Association. 5, 3, e002197.

Research output: Contribution to journalArticle

64 Scopus citations

Effect of Physical Activity Assessment on Prognostication for Peripheral Artery Disease and Mortality

Chang, P., Nead, K. T., Olin, J. W., Myers, J., Cooke, J. P. & Leeper, N. J., Mar 2015, In : Mayo Clinic Proceedings. 90, 3, p. 339-345 7 p.

Research output: Contribution to journalArticle

12 Scopus citations