John P. Cooke, MD, PhD

  • 32883 Citations
  • 96 h-Index
1982 …2020

Research output per year

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Research Output

2020

AYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model

Chen, J., Ma, Q., King, J. S., Sun, Y., Xu, B., Zhang, X., Zohrabian, S., Guo, H., Cai, W., Li, G., Bruno, I. G., Cooke, J. P., Wang, C., Kontaridis, M., Wang, D. Z., Luo, H., Pu, W. T. & Lin, Z., 2020, In : Life Science Alliance. 3, 1, e201900424.

Research output: Contribution to journalArticle

1 Scopus citations

Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome

Mu, X., Tseng, C., Hambright, W. S., Matre, P., Lin, C. Y., Chanda, P., Chen, W., Gu, J., Ravuri, S., Cui, Y., Zhong, L., Cooke, J. P., Niedernhofer, L. J., Robbins, P. D. & Huard, J., Jul 25 2020, In : Aging Cell.

Research output: Contribution to journalArticle

Endotheliopathy of Obesity

Cooke, J. P., Jul 28 2020, In : Circulation. 142, 4, p. 380-383 4 p.

Research output: Contribution to journalEditorial

Machine learning uncovers cell identity regulator by histone code

Xia, B., Zhao, D., Wang, G., Zhang, M., Lv, J., Tomoiaga, A. S., Li, Y., Wang, X., Meng, S., Cooke, J. P., Cao, Q., Zhang, L. & Chen, K., Jun 1 2020, In : Nature Communications. 11, 1, 2696.

Research output: Contribution to journalArticle

Nanobiosensing with graphene and carbon quantum dots: Recent advances

Walther, B. K., Dinu, C. Z., Guldi, D. M., Sergeyev, V. G., Creager, S. E., Cooke, J. P. & Guiseppi-Elie, A., Jan 1 2020, In : Materials Today.

Research output: Contribution to journalReview article

1 Scopus citations

Rapamycin-Loaded Biomimetic Nanoparticles Reverse Vascular Inflammation

Boada, C., Zinger, A., Tsao, C., Zhao, P., Martinez, J. O., Hartman, K., Naoi, T., Sukhoveshin, R., Sushnitha, M., Molinaro, R., Trachtenberg, B. H., Cooke, J. P. & Tasciotti, E., Jan 3 2020, In : Circulation Research. 126, 1, p. 25-37 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription

Wang, G., Meng, Q., Xia, B., Zhang, S., Lv, J., Zhao, D., Li, Y., Wang, X., Zhang, L., Cooke, J. P., Cao, Q. & Chen, K., Apr 2 2020, In : Genome Biology. 21, 1, 84.

Research output: Contribution to journalArticle

Vascular Regeneration in Peripheral Artery Disease

Meng, S. & Cooke, J. P., Jan 1 2020, In : Arteriosclerosis, Thrombosis, and Vascular Biology. p. 1627-1634 8 p.

Research output: Contribution to journalReview article

2019

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate

Gu, Q., Yang, X., Lv, J., Zhang, J., Xia, B., Kim, J. D., Wang, R., Xiong, F., Meng, S., Clements, T. P., Tandon, B., Wagner, D. S., Diaz, M. F., Wenzel, P. L., Miller, Y. I., Traver, D., Cooke, J. P., Li, W., Zon, L. I., Chen, K. & 2 others, Bai, Y. & Fang, L., Mar 8 2019, In : Science. p. eaav1749

Research output: Contribution to journalArticle

23 Scopus citations

Asymmetric dimethylarginine predicts impaired epicardial coronary vasomotion in patients with angina in the absence of obstructive coronary artery disease

Parikh, R. V., Pargaonkar, V., Ball, R. L., Kobayashi, Y., Kimura, T., Yeung, A. C., Cooke, J. P. & Tremmel, J. A., Jan 1 2019, In : International Journal of Cardiology.

Research output: Contribution to journalArticle

1 Scopus citations

Cardiovascular Risk of Proton Pump Inhibitors

Ariel, H. & Cooke, J. P., Jul 1 2019, In : Methodist DeBakey cardiovascular journal. 15, 3, p. 214-219 6 p.

Research output: Contribution to journalReview article

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure

Berry, J. L., Zhu, W., Tang, Y. L., Krishnamurthy, P., Ge, Y., Cooke, J. P., Chen, Y., Garry, D. J., Yang, H. T., Rajasekaran, N. S., Koch, W. J., Li, S., Domae, K., Qin, G., Cheng, K., Kamp, T. J., Ye, L., Hu, S., Ogle, B. M., Rogers, J. M. & 13 others, Abel, E. D., Davis, M. E., Prabhu, S. D., Liao, R., Pu, W. T., Wang, Y., Ping, P., Bursac, N., Vunjak-Novakovic, G., Wu, J. C., Bolli, R., Menasché, P. & Zhang, J., Jan 4 2019, In : Circulation Research. 124, 1, p. 161-169 9 p.

Research output: Contribution to journalReview article

4 Scopus citations

Dietary Supplements: Facts and Fallacies

Raizner, A. E. & Cooke, J. P., Jul 1 2019, In : Methodist DeBakey cardiovascular journal. 15, 3, p. 169-170 2 p.

Research output: Contribution to journalEditorial

Dysfunction of iPSC-derived endothelial cells in human Hutchinson–Gilford progeria syndrome

Matrone, G., Thandavarayan, R. A., Walther, B. K., Meng, S., Mojiri, A. & Cooke, J. P., Oct 2 2019, In : Cell Cycle. 18, 19, p. 2495-2508 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase

Kotla, S., Le, N-T., Vu, H. T., Ko, K. A., Gi, Y. J., Thomas, T. N., Giancursio, C., Lusis, A. J., Cooke, J. P., Fujiwara, K. & Abe, J. I., Nov 1 2019, In : Metabolism: Clinical and Experimental. 100, 153962.

Research output: Contribution to journalArticle

1 Scopus citations

Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2–interacting protein

Kotla, S., Vu, H. T., Ko, K. A., Wang, Y., Imanishi, M., Heo, K. S., Fujii, Y., Thomas, T. N., Gi, Y. J., Mazhar, H., Paez-Mayorga, J., Shin, J. H., Tao, Y., Giancursio, C. J., Medina, J. L. M., Taunton, J., Lusis, A. J., Cooke, J. P., Fujiwara, K., Le, N-T. & 1 others, Abe, J. I., May 2 2019, In : JCI insight. 4, 9, e124867.

Research output: Contribution to journalArticle

5 Scopus citations

Glycolytic Switch Is Required for Transdifferentiation to Endothelial Lineage

Lai, L., Reineke, E. L., Hamilton, D. J. & Cooke, J. P., Jan 2 2019, In : Circulation. 139, 1, p. 119-133 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inflammation and Its Role in Regeneration and Repair

Cooke, J. P., Apr 12 2019, In : Circulation Research. 124, 8, p. 1166-1168 3 p.

Research output: Contribution to journalReview article

7 Scopus citations

MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis

Abe, J-I., Ko, K. A., Kotla, S., Wang, Y., Paez-Mayorga, J., Shin, I. J., Imanishi, M., Vu, H. T., Tao, Y., Leiva-Juarez, M. M., Thomas, T. N., Medina, J. L., Won, J. H., Fujii, Y., Giancursio, C. J., McBeath, E., Shin, J-H., Guzman, L., Abe, R. J., Taunton, J. & 6 others, Mochizuki, N., Faubion, W., Cooke, J. P., Fujiwara, K., Evans, S. E. & Le, N-T., Apr 4 2019, In : JCI insight. 4, 7

Research output: Contribution to journalArticle

5 Scopus citations

Nuclear S-nitrosylation defines an optimal zone for inducing pluripotency

Chanda, P. K., Meng, S., Lee, J., Leung, H. E., Chen, K. & Cooke, J. P., Sep 24 2019, In : Circulation. 140, 13, p. 1081-1099 19 p.

Research output: Contribution to journalArticle

2 Scopus citations

Rapamycin-Loaded Leukosomes Reverse Vascular Inflammation

Boada, C., Zinger, A., Tsao, C., Zhao, P., MARTINEZ JONATHAN, O., Hartman, K. A., Naoi, T., Sukhovershin, R., Sushnitha, M., Molinaro, R., Trachtenberg, B. H., Cooke, J. P. & Tasciotti, E., Oct 24 2019, In : Circulation Research.

Research output: Contribution to journalArticle

Transient introduction of human telomerase mRNA improves hallmarks of progeria cells

Li, Y., Zhou, G., Bruno, I. G., Zhang, N., Sho, S., Tedone, E., Lai, T. P., Cooke, J. P. & Shay, J. W., Aug 2019, In : Aging Cell. 18, 4, e12979.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Arachidonic acid as a target for treating hypertriglyceridemia reproduced by a causal network analysis and an intervention study

Yazdani, A., Yazdani, A., Bowman, T. A., Marotta, F., Cooke, J. P. & Samiei, A., Jun 1 2018, In : Metabolomics. 14, 6, 78.

Research output: Contribution to journalLetter

3 Scopus citations

Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery

Martinez, J. O., Molinaro, R., Hartman, K. A., Boada, C., Sukhovershin, R., De Rosa, E., Kirui, D., Zhang, S., Evangelopoulos, M., Carter, A. M., Bibb, J. A., Cooke, J. P. & Tasciotti, E., 2018, In : Theranostics. 8, 4, p. 1131-1145 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B

Hodgkinson, C. P., Pratt, R. E., Kirste, I., Dal-Pra, S., Cooke, J. P. & Dzau, V. J., Aug 2018, In : STEM CELLS. 36, 8, p. 1198-1209 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes

Mujoo, K., Hunt, C. R., Pandita, R. K., Ferrari, M., Krishnan, S., Cooke, J. P., Hahn, S. & Pandita, T. K., Aug 1 2018, In : Molecular Cancer Research. 16, 8, p. 1209-1214 6 p.

Research output: Contribution to journalReview article

3 Scopus citations

Induced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model

Clayton, Z. E., Tan, R. P., Miravet, M. M., Lennartsson, K., Cooke, J. P., Bursill, C. A., Wise, S. G. & Patel, S., Jul 31 2018, In : Bioscience Reports. 38, 4, BSR20180563.

Research output: Contribution to journalArticle

13 Scopus citations

Inflammation-targeted vascular nanomedicine

Cooke, J. P. & Ferrari, M., May 1 2018, In : Nature Biomedical Engineering. 2, 5, p. 269-270 2 p.

Research output: Contribution to journalShort survey

4 Scopus citations

Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis

Tan, R. P., Chan, A. H. P., Lennartsson, K., Miravet, M. M., Lee, B. S. L., Rnjak-Kovacina, J., Clayton, Z. E., Cooke, J. P., Ng, M. K. C., Patel, S. & Wise, S. G., Mar 21 2018, In : Stem Cell Research and Therapy. 9, 1, 70.

Research output: Contribution to journalArticle

12 Scopus citations

Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association

American Heart Association Council on Genomic and Precision Medicine; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Peripheral Vascular Disease; Council on Quality of Care and Outcomes Research; and Stroke Council, Jun 1 2018, In : Circulation. Genomic and precision medicine. 11, 6, p. e000046

Research output: Contribution to journalReview article

4 Scopus citations

Novel Markers for Adverse Events in Atrial Fibrillation

Cooke, J. P. & Sukhovershin, R. A., Aug 14 2018, In : Journal of the American College of Cardiology. 72, 7, p. 734-737 4 p.

Research output: Contribution to journalEditorial

1 Scopus citations

TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway

Meng, S., Gu, Q., Yang, X., Lv, J., Owusu, I., Matrone, G., Chen, K., Cooke, J. P. & Fang, L., Aug 28 2018, In : Circulation. 138, 9, p. 913-928 16 p.

Research output: Contribution to journalArticle

3 Scopus citations

Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming

Meng, S., Chanda, P., Thandavarayan, R. A. & Cooke, J. P., Jul 10 2018, In : Antioxidants and Redox Signaling. 29, 2, p. 205-218 14 p.

Research output: Contribution to journalReview article

5 Scopus citations
2017

A comparison of the pro-angiogenic potential of human induced pluripotent stem cell derived endothelial cells and induced endothelial cells in a murine model of peripheral arterial disease

Clayton, Z. E., Yuen, G. S. C., Sadeghipour, S., Hywood, J. D., Wong, J. W. T., Huang, N. F., Ng, M. K. C., Cooke, J. P. & Patel, S., May 1 2017, In : International Journal of Cardiology. 234, p. 81-89 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling

Mao, R., Meng, S., Gu, Q., Araujo-Gutierrez, R., Kumar, S., Yan, Q., Almazan, F., Youker, K. A., Fu, Y., Pownall, H. J., Cooke, J. P., Miller, Y. I. & Fang, L., May 26 2017, In : Circulation Research. 120, 11, p. 1727-1739 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

A Missing LNC in Vascular Diseases

Cooke, J. P. & Leeper, N. J., Aug 4 2017, In : Circulation Research. 121, 4, p. 320-322 3 p.

Research output: Contribution to journalEditorial

Discovery of novel determinants of endothelial lineage using chimeric heterokaryons

Wong, J., Matrone, G., Tian, X., Tomoiaga, S. A., Au, K. F., Meng, S., Yamazoe, S., Sieveking, D., Chen, K., Burns, D. M., Chen, J. K., Blau, H. M. & Cooke, J. P., Mar 21 2017, In : eLife. 6, e23588.

Research output: Contribution to journalArticle

2 Scopus citations

Identification of cardiovascular risk factors associated with bone marrow cell subsets in patients with STEMI: a biorepository evaluation from the CCTRN TIME and LateTIME clinical trials

Contreras, A., Orozco, A. F., Resende, M., Schutt, R. C., Traverse, J. H., Henry, T. D., Lai, D., Cooke, J. P., Bolli, R., Cohen, M. L., Moyé, L., Pepine, C. J., Yang, P. C., Perin, E. C., Willerson, J. T., Taylor, D. A. & For the Cardiovascular Cell Therapy Research Network (CCTRN), T. C. C. T. R. N. CCTRN., Jan 1 2017, In : Basic research in cardiology. 112, 1, 3.

Research output: Contribution to journalArticle

10 Scopus citations

Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration

Matrone, G., Meng, S., Gu, Q., Lv, J., Fang, L., Chen, K. & Cooke, J. P., Oct 1 2017, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 10, p. 1860-1868 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Peripheral Blood Cytokine Levels After Acute Myocardial Infarction: IL-1β and IL-6 Related Impairment of Bone Marrow Function

Shahrivari, M., Wise, E., Resende, M., Shuster, J. J., Zhang, J., Bolli, R., Cooke, J. P., Hare, J. M., Henry, T. D., Khan, A., Taylor, D. A., Traverse, J. H., Yang, P. C., Pepine, C. J. & Cogle, C. R., May 10 2017, In : Circulation Research.

Research output: Contribution to journalArticle

16 Scopus citations

Retinoic Acid Inducible Gene 1 Protein (RIG1)-Like Receptor Pathway Is Required for Efficient Nuclear Reprogramming

Sayed, N., Ospino, F., Himmati, F., Lee, J., Chanda, P., Mocarski, E. S. & Cooke, J. P., May 2017, In : STEM CELLS. 35, 5, p. 1197-1207 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis

Suh, J. H., Lai, L., Nam, D., Kim, J., Jo, J., Taffet, G. E., Kim, E., Kaelber, J. T., Lee, H. K., Entman, M. L., Cooke, J. P. & Reineke, E. L., 2017, In : Journal of Biological Chemistry. 292, 52, p. 21643-21652 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Telomerase mRNA Reverses Senescence in Progeria Cells

Li, Y., Zhou, G., Bruno, I. G. & Cooke, J. P., Aug 8 2017, In : Journal of the American College of Cardiology. 70, 6, p. 804-805 2 p.

Research output: Contribution to journalLetter

2 Scopus citations

The nicotinic cholinergic pathway contributes to retinal neovascularization in a mouse model of retinopathy of prematurity

Hackett, S. F., Seidel, C., Abraham, S., Chadha, R., Fortmann, S. D., Campochiaro, P. A. & Cooke, J. P., Feb 2017, In : Investigative Ophthalmology and Visual Science. 58, 2, p. 1296-1303 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging

Karuppagounder, V., Arumugam, S., Babu, S. S., Palaniyandi, S. S., Watanabe, K., Cooke, J. P. & Amirthalingam Thandavarayan, R., May 1 2017, In : Ageing Research Reviews. 35, p. 291-296 6 p.

Research output: Contribution to journalReview article

15 Scopus citations

Transflammation: Innate immune signaling in nuclear reprogramming

Meng, S., Chanda, P., Thandavarayan, R. A. & Cooke, J. P., Oct 1 2017, In : Advanced Drug Delivery Reviews. 120, p. 133-141 9 p.

Research output: Contribution to journalReview article

5 Scopus citations
2016

Aligned nanofibrillar collagen scaffolds – Guiding lymphangiogenesis for treatment of acquired lymphedema

Hadamitzky, C., Zaitseva, T. S., Bazalova-Carter, M., Paukshto, M. V., Hou, L., Strassberg, Z., Ferguson, J., Matsuura, Y., Dash, R., Yang, P. C., Kretchetov, S., Vogt, P. M., Rockson, S. G., Cooke, J. P. & Huang, N. F., Sep 1 2016, In : Biomaterials. 102, p. 259-267 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
21 Scopus citations

Bone marrow cell characteristics associated with patient profile and cardiac performance outcomes in the LateTIME-Cardiovascular Cell Therapy Research Network (CCTRN) trial

Bhatnagar, A., Bolli, R., Johnstone, B. H., Traverse, J. H., Henry, T. D., Pepine, C. J., Willerson, J. T., Perin, E. C., Ellis, S. G., Zhao, D. X. M., Yang, P. C., Cooke, J. P., Schutt, R. C., Trachtenberg, B. H., Orozco, A., Resende, M., Ebert, R. F., Sayre, S. L., Simari, R. D., Moyé, L. & 2 others, Cogle, C. R. & Taylor, D. A., Sep 1 2016, In : American Heart Journal. 179, p. 142-150 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Enhancing Stent Effectiveness with Nanofeatures

Bassous, N., Cooke, J. P. & Webster, T. J., Sep 2016, In : Methodist DeBakey cardiovascular journal. 12, 3, p. 163-168 6 p.

Research output: Contribution to journalArticle

5 Scopus citations