Personal profile

Dr. John P. Cooke is the Chair of the Department of Cardiovascular Sciences at the Houston Methodist Research Institute, Director of the Center for Cardiovascular Regeneration, and Director of the RNA Therapeutics Program in the Houston Methodist DeBakey Heart and Vascular Center in Houston, Texas.

He trained in cardiovascular medicine and obtained a Ph.D. in physiology at the Mayo Clinic. He was recruited to Harvard Medical School as an assistant professor of medicine. In 1990, he was recruited to Stanford University to spearhead the program in vascular biology and medicine, and was appointed professor in the Division of Cardiovascular Medicine at Stanford University School of Medicine, and associate director of the Stanford Cardiovascular Institute until his recruitment to Houston Methodist in 2013.

Dr. Cooke has published over 500 research papers, position papers, reviews, book chapters and patents in the arena of vascular medicine and biology with over 20,000 citations. He serves on national and international committees that deal with cardiovascular diseases, including the American Heart Association, American College of Cardiology, Society for Vascular Medicine, and the National Heart, Lung and Blood Institute. He has served as president of the Society for Vascular Medicine, as a director of the American Board of Vascular Medicine, and as an associate editor of Vascular Medicine.

Research interests

Dr. Cooke’s research program is focused on vascular regeneration, vascular cell identity and nuclear reprogramming. The program is funded by grants from the National Institutes of Health, the American Heart Association, Cancer Prevention Research Institute, and industry.

The Cooke group aims to understand the mechanisms underlying epigenetic plasticity that are required for functional adaptation to cellular challenges.  Innate immune signaling causes global changes in the expression and activity of epigenetic modifiers with metabolic coupling that favors an open chromatin configuration.  The translational output of this work is vascular regeneration via therapeutic transdifferentiation using small molecules or mRNA. In his 25 years of translational vascular biology, Dr. Cooke first described and characterized the anti-atherogenic effects of endothelium-derived nitric oxide; the anti-angiogenic effect of the NO synthase inhibitor ADMA; the angiogenic pathway mediated by endothelial nicotinic acetylcholine receptors; the role for this pathway in states of pathological angiogenesis; and developed an antagonist of the pathway that is now in Phase II clinical trials. His clinical research group has explored the use of angiogenic agents and adult stem cells in the treatment of peripheral arterial disease. More recently, he has generated and characterized endothelial cells derived from human iPSCs, and explored their role in angiogenesis and vascular regeneration. Recent insights from the laboratory have clarified the role of innate immune signaling in nuclear reprogramming to pluripotency and therapeutic transdifferentiation for vascular disease.

Keywords

    Free-text keywords

  • Regenerative medicine, Stem cell, Vascular disease, Endothelium

    Research Area Keywords

  • Heart & Vascular
  • Regenerative Medicine

External positions

Professor of Cardiovascular Medicine in Cardiothoracic Surgery, Weill Cornell Medical College

Fingerprint

Nitric Oxide
Concept: Nitric Oxide
Weight: 100%
Domain: Medicine & Life Sciences
Blood Vessels
Concept: Blood Vessels
Weight: 98%
Domain: Medicine & Life Sciences
Peripheral Arterial Disease
Concept: Peripheral Arterial Disease
Weight: 84%
Domain: Medicine & Life Sciences
Endothelial Cells
Concept: Endothelial Cells
Weight: 72%
Domain: Medicine & Life Sciences
Nitric Oxide Synthase
Concept: Nitric Oxide Synthase
Weight: 65%
Domain: Medicine & Life Sciences
Endothelium
Concept: Endothelium
Weight: 58%
Domain: Medicine & Life Sciences
Atherosclerosis
Concept: Atherosclerosis
Weight: 58%
Domain: Medicine & Life Sciences
Vascular Diseases
Concept: Vascular Diseases
Weight: 42%
Domain: Medicine & Life Sciences
Cardiology
Concept: Cardiology
Weight: 30%
Domain: Medicine & Life Sciences
Induced Pluripotent Stem Cells
Concept: Induced Pluripotent Stem Cells
Weight: 28%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by John P. Cooke is tagged with the concept

Highlighted research outputs

Telomerase mRNA Reverses Senescence in Progeria Cells

Research output: Contribution to journalLetter

Proton Pump Inhibitors Accelerate Endothelial Senescence

Research output: Contribution to journalArticle

Activation of innate immunity is required for efficient nuclear reprogramming

Research output: Contribution to journalArticle

Endothelial cells derived from nuclear reprogramming

Research output: Contribution to journalArticle

Second hand smoke stimulates tumor angiogenesis and growth

Research output: Contribution to journalArticle

Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis

Research output: Contribution to journalArticle

Journals

Circulation

ISSNs: 0009-7322, 1524-4539

Lippincott Williams and Wilkins

Journal

68

Vascular Medicine (United Kingdom)

ISSNs: 1358-863X

Additional searchable ISSN (Electronic): 1477-0377

SAGE Publications Ltd

Journal

46

Circulation research

ISSNs: 0009-7330

Additional searchable ISSN (Electronic): 1524-4571

Lippincott Williams and Wilkins

Journal

21

Arteriosclerosis, thrombosis, and vascular biology

ISSNs: 1079-5642, 1524-4636

Lippincott Williams and Wilkins

Journal

19

Journal of the American College of Cardiology.

ISSNs: 0735-1097

Elsevier

Journal

18
has published Research OutputsResearch Output by John P. Cooke

Research Network

Visualization: Institutional Network

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John P. Cooke

Visualization: Co-author Network

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John P. Cooke

Shared Pub. Internal Organizations

Department of Cardiology

Organizational unit: Departments

5

Department of Orthopedic Surgery

Organizational unit: Departments

3

Regenerative Medicine Program

Organizational unit: Programs

3

Center for Bioenergetics

Organizational unit: Programs

3
3
has Research OutputsResearch Output by John P. Cooke

Shared Pub. External Organizations

Stanford University School of Medicine

External organization: Unknown

194

Stanford University

External organization: Unknown

57

Falk Cardiovascular Research Center, Stanford University

External organization: Unknown

27

Houston Methodist Research Institute

External organization: Unknown

27

Brigham and Women's Hospital

External organization: Unknown

25
has Research OutputsResearch Output by John P. Cooke

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with John P. Cooke

Shared Pub. External co-authors

P. S. Tsao

External person

61

Ngan F. Huang

External person

24

Bingyin Wang

External person

22

Jeffrey W. Olin

External person

19

V. J. Dzau

External person

18
has co-authored Research OutputsResearch Output with John P. Cooke

ID: 2286533