Projects per year
Personal profile
Personal profile
Joan E. Nichols, MA, PhD directs and collaborates in research projects examining wound and tissue repair mechanisms, and alterations in immune response of the lung and other respiratory tissues after exposure to pollutants and/or respiratory pathogens. She has expertise in the areas of tissue engineering, stem cell therapies, immunology of wound healing and foreign body response, inflammation, disease pathogenesis, stem cell characterization/differentiation and host response to microbial pathogens.
Dr. Nichols has collaborated with Houston Methodist Research Institute since 2011, and in 2021 joined HMRI as Professor of Immunology in Surgery. Prior to 2019, she was at University of Texas Medical Branch at Galveston (UTMB) for 27 years.
Her research group has combined adult and embryonic stem cells with tissue engineering techniques to construct human bioengineered microphysiologic tissue models systems (MPS) to study wound healing as well as disease pathogenesis and the response to human pathogens such as avian-influenza, NIPAH virus, SARS-CoV-2 and other BSL-2, -3 and -4 agents. Modeling tissue development using small MPS tissue engineered constructs has led to development of methods to support whole organ engineering and to a preclinical pilot focused on transplantation of whole tissue engineered lung into a large animal model. Publication highlights include manuscripts demonstrating production of whole human acellular scaffolds, production of bioengineered pediatric lungs from adult lung cells, systems to support vascular engineering and production and transplantation of bioengineered lung.
Research Area Keywords
- Regenerative Medicine
- Infectious Disease & Pathology
- Transplantation
- Nanomedicine
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Collaborations and top research areas from the last five years
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Advancing Human Lung Microphysiological Systems to Model Coronavirus Infection and Test Candidate Countermeasures
10/14/22 → 3/22/24
Project: Federal Funding Agencies
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Lung Microphysiological Systems to Model Select Agent Bacteria and Viral Infection and Test Candidate Countermeasures
5/13/21 → 4/4/22
Project: Federal Funding Agencies
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Using a Human Lung Microphysiologic System to Model SARS-CoV-2 Infection and Test Candidate Countermeasures
2/4/21 → 2/28/23
Project: Federal Funding Agencies
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Changes in local tissue microenvironment in response to subcutaneous long-acting delivery of tenofovir alafenamide in rats and non-human primates
Pons-Faudoa, F. P., Di Trani, N., Capuani, S., Hernandez, N., Wood, A. M., Nehete, B., Niles, J., Shelton, K. A., Kezar, S., Bushman, L. R., Chua, C. Y. X., Ittmann, M. M., Anderson, P. L., Nehete, P. N., Arduino, R. C., Nichols, J. E. & Grattoni, A., Jun 2023, In: Journal of Controlled Release. 358, p. 116-127 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Long-acting refillable nanofluidic implant confers protection against SHIV infection in nonhuman primates
Pons-Faudoa, F. P., Trani, N. D., Capuani, S., Campa-Carranza, J. N., Nehete, B., Sharma, S., Shelton, K. A., Bushman, L. R., Abdelmawla, F., Williams, M., Roon, L., Nerguizian, D., Chua, C. Y. X., Ittmann, M. M., Nichols, J. E., Kimata, J. T., Anderson, P. L., Nehete, P. N., Arduino, R. C. & Grattoni, A., Jun 28 2023, In: Science translational medicine. 15, 702, p. eadg2887 eadg2887.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Emerging local immunomodulatory strategies to circumvent systemic immunosuppression in cell transplantation
Campa-Carranza, J. N., Paez-Mayorga, J., Chua, C. Y. X., Nichols, J. E. & Grattoni, A., May 29 2022, (E-pub ahead of print) In: Expert Opinion on Drug Delivery. 19, 5, p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats
Paez-Mayorga, J., Campa-Carranza, J. N., Capuani, S., Hernandez, N., Liu, H-C., Chua, C. Y. X., Pons-Faudoa, F. P., Malgir, G., Alvarez, B., Niles, J. A., Argueta, L. B., Shelton, K. A., Kezar, S., Nehete, P. N., Berman, D. M., Willman, M. A., Li, X. C., Ricordi, C., Nichols, J. E., Gaber, A. O., & 2 others , Dec 26 2022, In: Nature Communications. 13, 1, 7951.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Localization of drug biodistribution in a 3D-bioengineered subcutaneous neovascularized microenvironment
Capuani, S., Hernandez, N., Paez-Mayorga, J., Dogra, P., Wang, Z., Cristini, V., Chua, C. Y. X., Nichols, J. E. & Grattoni, A., Dec 2022, In: Materials Today Bio. 16, 100390.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations