Personal profile

Dr. Jenny C. Chang is the Director of Houston Methodist Cancer Center and Emily Herrmann Chair in Cancer Research in Houston, Texas. She obtained her medical degree at Cambridge University in England, and then completed fellowship training in medical oncology at the Royal Marsden Hospital/Institute for Cancer Research in the United Kingdom. She was also awarded a research doctorate from the University of London. Her recent work has focused on the intrinsic therapy resistance of cancer stem cells, which has led to several publications and international presentations. Dr. Chang’s clinical research aims to evaluate novel biologic agents in breast cancer patients.

Research interests

Dr. Chang has worked in the field of tumor-initiating cells for more than ten years. After her discovery that tumor-initiating cells are chemo-resistant, and that targeting the EGFR/HER2 pathway can decrease this subpopulation, Dr. Chang has played a key role in demonstrating some of the limitations and mechanisms of tumor-initiating cells (Creighton et al., 2009; Li et al., 2008). Her work is now focused on the mechanisms that regulate TICs, as well as initiating and planning clinical trials that target this critical tumor initiating subpopulation. She is also interested in characterizing the cross-talk between these different pathways that may lead to mechanisms of resistance, and has identified some of the chief regulatory pathways involved in TIC self-renewal. She is a world-renown clinical investigator, credited as one of the first to describe intrinsic chemo-resistance of tumor-initiating cells.

Keywords

    Research Area Keywords

  • Cancer
  • Systems Medicine & Bioinformatics
  • Clinical Translation & Trials

    Free-text keywords

  • Cancer, Stem cells, Breast cancer, High throughput

External positions

Professor of Medicine, Weill Cornell Medical College, Cornell University

Fingerprint

Breast Neoplasms
Concept: Breast Neoplasms
Weight: 100%
Domain: Medicine & Life Sciences
Triple Negative Breast Neoplasms
Concept: Triple Negative Breast Neoplasms
Weight: 49%
Domain: Medicine & Life Sciences
Neoplastic Stem Cells
Concept: Neoplastic Stem Cells
Weight: 34%
Domain: Medicine & Life Sciences
docetaxel
Concept: docetaxel
Weight: 31%
Domain: Medicine & Life Sciences
Neoplasms
Concept: Neoplasms
Weight: 30%
Domain: Medicine & Life Sciences
Therapeutics
Concept: Therapeutics
Weight: 20%
Domain: Medicine & Life Sciences
Estrogen Receptors
Concept: Estrogen Receptors
Weight: 15%
Domain: Medicine & Life Sciences
Drug Therapy
Concept: Drug Therapy
Weight: 14%
Domain: Medicine & Life Sciences
Breast
Concept: Breast
Weight: 14%
Domain: Medicine & Life Sciences
Epithelial-Mesenchymal Transition
Concept: Epithelial-Mesenchymal Transition
Weight: 13%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Jenny C. Chang is tagged with the concept

Journals

Breast Cancer Research and Treatment

ISSNs: 0167-6806

Springer New York

Journal

17

Clinical Cancer Research

ISSNs: 1078-0432

American Association for Cancer Research Inc.

Journal

13

Breast Cancer Research

ISSNs: 1465-5411

Additional searchable ISSN (Electronic): 1465-542X

BioMed Central

Journal

11

Journal of Clinical Oncology

ISSNs: 0732-183X

Additional searchable ISSN (Electronic): 1527-7755

Journal

9

Annals of Oncology

ISSNs: 0923-7534

Additional searchable ISSN (Electronic): 1569-8041

Oxford University Press

Journal

8
has published Research OutputsResearch Output by Jenny C. Chang

Research Network

Visualization: Institutional Network

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Jenny C. Chang

Visualization: Co-author Network

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Jenny C. Chang

Shared Pub. Internal Organizations

Department of Medicine

Organizational unit: Departments

16

Department of Nanomedicine

Organizational unit: Departments

7

Department of Urology

Organizational unit: Departments

6

Cores, Biostatistics and Bioinformatics

Organizational unit: Programs

6

Department of Radiation Oncology

Organizational unit: Departments

5
has Research OutputsResearch Output by Jenny C. Chang

Shared Pub. External Organizations

Baylor College of Medicine

External organization: Unknown

50

Houston Methodist Research Institute

External organization: Unknown

35

University of Texas M. D. Anderson Cancer Center

External organization: Unknown

18

Royal Marsden Hospital, Sutton

External organization: Unknown

15

Weill Medical College of Cornell University

External organization: Unknown

12
has Research OutputsResearch Output by Jenny C. Chang

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Jenny C. Chang

Shared Pub. External co-authors

Susan G. Hilsenbeck

External person

32

Melissa D. Landis

External person

20

T. J. Powles

External person

18

Helen Wong

External person

16

Richard Elledge

External person

15
has co-authored Research OutputsResearch Output with Jenny C. Chang

ID: 2286342