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Personal profile
Personal profile
Jenny Chang, MD, is the Director of the Houston Methodist Dr. Mary and Ron Neal Cancer Center and holds the Emily Herrmann Presidential Distinguished Chair in Cancer Research. She is a Professor of Cancer with the Institute for Academic Medicine and a member of the Houston Methodist Research Institute and Professor at Weill Cornell Medical School. She obtained her medical degree at Cambridge University in England and completed fellowship training in medical oncology at the Royal Marsden Hospital/Institute for Cancer Research in the United Kingdom. She was also awarded a research doctorate from the University of London. Her recent work has focused on the intrinsic therapy resistance of cancer stem cells, and the role of targeting inflammatory pathways to change tumor immune microenvironment. Dr. Chang's clinical research aims to evaluate these novel biologic agents in breast cancer patients.
Research interests
Dr. Chang has worked in the field of tumor-initiating cells for more than ten years. After her discovery that tumor-initiating cells are chemo-resistant, and that targeting the EGFR/HER2 pathway can decrease this subpopulation, Dr. Chang has played a key role in demonstrating some of the limitations and mechanisms of tumor-initiating cells (Creighton et al., 2009; Li et al., 2008). Her work is now focused on the mechanisms that regulate TICs, as well as initiating and planning clinical trials that target this critical tumor initiating subpopulation. She is also interested in characterizing the cross-talk between these different pathways that may lead to mechanisms of resistance, and has identified some of the chief regulatory pathways involved in TIC self-renewal. She is a world-renown clinical investigator, credited as one of the first to describe intrinsic chemo-resistance of tumor-initiating cells.
Education/Academic qualification
MD, University of Cambridge
Aug 1 1986 → Dec 18 1990
Award Date: Dec 18 1990
Research Doctorate, University of London
External positions
Professor of Medicine, Weill Cornell Medical College
Research Area Keywords
- Cancer
- Systems Medicine & Bioinformatics
- Clinical Translation & Trials
Free-text keywords
- Cancer
- Stem cells
- Breast cancer
- High throughput
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Collaborations and top research areas from the last five years
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Breast Cancer Screening & Diagnostics for Black Individuals in the Houston Area (Susan G. Komen)
1/1/24 → 12/31/24
Project: Non Profit
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Novel potential drug targets for treatment of triple-negative breast cancer
10/1/23 → 9/30/24
Project: Non Profit
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Dual targeting of PI3K and NOS pathways in Metaplastic Breast Cancer (MBC)
7/8/23 → 6/30/28
Project: Federal Funding Agencies
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Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors
Ridnour, L. A., Cheng, R. Y. S., Kedei, N., Somasundaram, V., Bhattacharyya, D. D., Basudhar, D., Wink, A. L., Walke, A. J., Kim, C., Heinz, W. F., Edmondson, E. F., Butcher, D. O., Warner, A. C., Dorsey, T. H., Pore, M., Kinders, R. J., Lipkowitz, S., Bryant, R. J., Rittscher, J., Wong, S. T. C., & 10 others , Jun 24 2024, In: JCI insight. 9, 12, e165356.Research output: Contribution to journal › Article › peer-review
Open Access -
Correlation of HER2 Protein Level With mRNA Level Quantified by RNAscope in Breast Cancer
Li, X., Lee, J. H., Gao, Y., Zhang, J., Bates, K. M., Rimm, D. L., Zhang, H., Smith, G. H., Lawson, D., Meisel, J., Chang, J. & Huo, L., Feb 2024, In: Modern Pathology. 37, 2, 100408.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Ketogenic diet induces p53-dependent cellular senescence in multiple organs
Wei, S. J., Schell, J. R., Chocron, E. S., Varmazyad, M., Xu, G., Chen, W. H., Martinez, G. M., Dong, F. F., Sreenivas, P., Trevino, R., Jiang, H., Du, Y., Saliba, A., Qian, W., Lorenzana, B., Nazarullah, A., Chang, J., Sharma, K., Munkácsy, E., Horikoshi, N., & 1 others , May 2024, In: Science Advances. 10, 20, eado1463.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Neighborhood Walkability Is Associated With Lower Burden of Cardiovascular Risk Factors Among Cancer Patients
Nwana, N., Makram, O. M., Nicolas, J. C., Pan, A., Gullapelli, R., Parekh, T., Javed, Z., Titus, A., Al-Kindi, S., Guan, J., Sun, K., Jones, S. L., Maddock, J. E., Chang, J. & Nasir, K., Jun 2024, In: JACC: CardioOncology. 6, 3, p. 421-435 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The impact of nitric oxide on HER family post-translational modification and downstream signaling in cancer
O’Neill, C. E., Sun, K., Sundararaman, S., Chang, J. C. & Glynn, S. A., 2024, In: Frontiers in Physiology. 15, 1358850.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations