Projects per year
Personal profile
Personal profile
Jenny Chang, MD is the Ernest Cockrell, Jr. Presidential Distinguished Chair, President and CEO of the Houston Methodist Academic Institute, and Executive Vice President and Chief Academic Officer, Houston Methodist. She is a Professor of Medicine, Houston Methodist Academic Institute and Weill Cornell Medical College, and member of the Houston Methodist Research Institute.
Dr. Chang earned a medical degree at Cambridge University in England and completed fellowship training in medical oncology at the Royal Marsden Hospital/Institute for Cancer Research in the United Kingdom. She recieved a research doctorate from the University of London. Her recent work has focused on the intrinsic therapy resistance of cancer stem cells, and the role of targeting inflammatory pathways to change tumor immune microenvironment. Dr. Chang's clinical research aims to evaluate these novel biologic agents in breast cancer patients.
Research interests
Dr. Chang has worked in the field of tumor-initiating cells for more than ten years. After her discovery that tumor-initiating cells are chemo-resistant, and that targeting the EGFR/HER2 pathway can decrease this subpopulation, Dr. Chang has played a key role in demonstrating some of the limitations and mechanisms of tumor-initiating cells (Creighton et al., 2009; Li et al., 2008). Her work is now focused on the mechanisms that regulate TICs, as well as initiating and planning clinical trials that target this critical tumor initiating subpopulation. She is also interested in characterizing the cross-talk between these different pathways that may lead to mechanisms of resistance, and has identified some of the chief regulatory pathways involved in TIC self-renewal. She is a world-renown clinical investigator, credited as one of the first to describe intrinsic chemo-resistance of tumor-initiating cells.
Education/Academic qualification
MD, University of Cambridge
Aug 1 1986 → Dec 18 1990
Award Date: Dec 18 1990
Research Doctorate, University of London
External positions
Professor of Medicine, Weill Cornell Medical College
Research Area Keywords
- Cancer
- Systems Medicine & Bioinformatics
- Clinical Translation & Trials
Free-text keywords
- Cancer
- Stem cells
- Breast cancer
- High throughput
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Collaborations and top research areas from the last five years
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Novel potential drug targets for treatment of triple-negative breast cancer
Chang, J. C. (PI)
10/1/23 → 9/30/25
Project: Non Profit
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Dual targeting of PI3K and NOS pathways in Metaplastic Breast Cancer (MBC)
Chang, J. C. (PI)
7/8/23 → 6/30/28
Project: Federal Funding Agencies
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A phase II multi-center trial evaluating dual targeting of the PI3K/AKT and NOS pathways for treating metaplastic breast cancer (MpBC)
Chang, J. C. (PI)
6/10/22 → 5/31/27
Project: Federal Funding Agencies
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Spatiotemporal modeling of cancer-niche interactions in breast cancer bone metastasis
Wong, S. T. (PI), Chang, J. C. (Key Personnel) & Sheng, J. (Key Personnel)
9/15/20 → 8/31/25
Project: Federal Funding Agencies
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Sample and Data Collection for Houston Methodist Cancer Center Research
Chang, J. C. (PI), Bernicker, E. H. (Key Personnel), Darcourt, J. (Key Personnel), Heyne, K. (Key Personnel), Niravath, P. A. (Key Personnel) & Singh, M. (Key Personnel)
4/9/20 → …
Project: Clinical Trial
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HER2-positive breast cancer in patients with BRCA1/2 pathogenic variants: Case series and literature review
Munnangi, P., Niravath, P. A., Chang, J. C. & Sun, K., Mar 2025, In: Current Problems in Cancer: Case Reports. 17, 100335.Research output: Contribution to journal › Article › peer-review
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Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention in Women at High Risk of Cancer
Puri, A., Yin, Z., Granados-Principal, S., Ensor, J., Guzman, L., Rosato, R., Zhao, H., Wong, S., Wang, L., Patel, T. & Chang, J. C., 2025, In: International Journal of Breast Cancer. 2025, 1, 8831168.Research output: Contribution to journal › Article › peer-review
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Interplay Between Residential Nature Exposure and Walkability and Their Association with Cardiovascular Health
Makram, O. M., Nwana, N., Pan, A., Nicolas, J. C., Gullapelli, R., Bose, B., Sabharwal, A., Chang, J. C., Javed, Z., Kash, B. A., Maddock, J. E., Nasir, K. & Al-Kindi, S., Jan 2025, In: JACC: Advances. 4, 1, p. 101457 101457.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
MnSOD non-acetylation mimic knock-in mice exhibit dilated cardiomyopathy
Schell, J. R., Wei, S. J., Zhang, J., Trevino, R., Chen, W. H., Aguilar, L., Qian, W., Corbett, C. W., Jiang, H., Dong, F. F., Chocron, E. S., Nazarullah, A., Chang, J., Flanagan, M. E., Glatt, V., Dikalov, S., Munkácsy, E., Horikoshi, N. & Gius, D., Mar 1 2025, In: Free Radical Biology and Medicine. 229, p. 58-67 10 p.Research output: Contribution to journal › Article › peer-review
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Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome
Palczewski, M. B., Kuschman, H. P., Hoffman, B. M., Kathiresan, V., Yang, H., Glynn, S. A., Wilson, D. L., Kool, E. T., Montfort, W. R., Chang, J., Petenkaya, A., Chronis, C., Cundari, T. R., Sappa, S., Islam, K., McVicar, D. W., Fan, Y., Chen, Q., Meerzaman, D. & Sierk, M. & 1 others, , Dec 2025, In: Nature Communications. 16, 1, 1732.Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Prizes
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Presidential Award - Excellence in Education
Chang, J. C. (Recipient), 2023
Prize: Prize (including medals and awards)