Research interests

Dr. Thonhoff’s research focuses on the role of regulatory T cells (Tregs) in ALS. The loss of Treg function is associated with acceleration of disease progression in ALS.  Dr. Thonhoff is exploring the mechanisms through which Treg function is lost in ALS and potential therapies aimed to enhance the neuroprotective function of Tregs. He is also investigating the use of autologous Treg infusions as a therapy for patients with ALS. In addition, he is involved in several clinical trials investigating novel treatments for patients with Myasthenia Gravis, Myotonic Dystrophy and CIDP.

Keywords

    Research Area Keywords

  • Neurosciences
  • Immunobiology & Inflammation

    Free-text keywords

  • Neuromuscular disorders, Neurodegenerative diseases, Amyotrophic Lateral Sclerosis (ALS), Myasthenia Gravis, Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Muscular Dystrophy, Cellular and genetic therapies, Neuroinflammation

Fingerprint

Neural Stem Cells
Concept: Neural Stem Cells
Weight: 100%
Domain: Medicine & Life Sciences
Amyotrophic Lateral Sclerosis
Concept: Amyotrophic Lateral Sclerosis
Weight: 86%
Domain: Medicine & Life Sciences
Motor Neurons
Concept: Motor Neurons
Weight: 81%
Domain: Medicine & Life Sciences
Fetal Stem Cells
Concept: Fetal Stem Cells
Weight: 41%
Domain: Medicine & Life Sciences
Fibroblast Growth Factor 2
Concept: Fibroblast Growth Factor 2
Weight: 37%
Domain: Medicine & Life Sciences
Disease Progression
Concept: Disease Progression
Weight: 37%
Domain: Medicine & Life Sciences
Microglia
Concept: Microglia
Weight: 36%
Domain: Medicine & Life Sciences
Regulatory T-Lymphocytes
Concept: Regulatory T-Lymphocytes
Weight: 27%
Domain: Medicine & Life Sciences
Stem Cells
Concept: Stem Cells
Weight: 23%
Domain: Medicine & Life Sciences
Stem Cell Transplantation
Concept: Stem Cell Transplantation
Weight: 22%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Jason R. Thonhoff is tagged with the concept

Journals

PLoS ONE

Additional searchable ISSN (Electronic): 1932-6203

Public Library of Science

Journal

1

Neuroscience Letters

ISSNs: 0304-3940

Elsevier Ireland Ltd

Journal

1

Molecular Neurodegeneration

ISSNs: 1750-1326

BioMed Central

Journal

1

Brain Research

ISSNs: 0006-8993

Elsevier

Journal

1

Cell Transplantation

ISSNs: 0963-6897

Cognizant Communication Corporation

Journal

1
has published Research OutputsResearch Output by Jason R. Thonhoff

Research Network

Visualization: Institutional Network

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Jason R. Thonhoff

Visualization: Co-author Network

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Jason R. Thonhoff

Shared Pub. Internal Organizations

Department of Pathology & Genomic Medicine

Organizational unit: Departments

6

Neurosciences Research Program

Organizational unit: Programs

3

Weill Cornell Medical College

Organizational unit: Schools & Hospitals

3

Nantz National Alzheimer Center

Organizational unit: Programs

1
has Research OutputsResearch Output by Jason R. Thonhoff

Shared Pub. External Organizations

University of Texas Medical Branch at Galveston

External organization: Academic

7

Dept. of Neurosci. and Cell Biology

External organization: Unknown

6

Houston Methodist Research Institute

External organization: Unknown

2

University of Texas Medical Branch at Galveston

External organization: Unknown

1

University of Florida

External organization: Academic

1
has Research OutputsResearch Output by Jason R. Thonhoff

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Jason R. Thonhoff

Shared Pub. External co-authors

Lin Ping Wu

External person

7

Luis Ojeda

External person

4

Junling Gao

External person

4

Paivi M. Jordan

External person

3

Tiffany J. Dunn

External person

3
has co-authored Research OutputsResearch Output with Jason R. Thonhoff

ID: 45934651