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Research interests
Dr. Thonhoff’s research focuses on the role of regulatory T cells (Tregs) in ALS. The loss of Treg function is associated with acceleration of disease progression in ALS. Dr. Thonhoff is exploring the mechanisms through which Treg function is lost in ALS and potential therapies aimed to enhance the neuroprotective function of Tregs. He is also investigating the use of autologous Treg infusions as a therapy for patients with ALS. In addition, he is involved in several clinical trials investigating novel treatments for patients with Myasthenia Gravis, Myotonic Dystrophy and CIDP.
Research Area Keywords
- Neurosciences
- Immunobiology & Inflammation
Free-text keywords
- Neuromuscular disorders
- Neurodegenerative diseases
- Amyotrophic Lateral Sclerosis (ALS)
- Myasthenia Gravis
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
- Muscular Dystrophy
- Cellular and genetic therapies
- Neuroinflammation
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Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development
for the Healey ALS Platform Trial Study Group, HEALEY ALS Platform Trial Study Group, Biostatisticians, Investigators, Clinical Operations Team & Medical Monitors, Feb 2022, In: Annals of Neurology. 91, 2, p. 165-175 11 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis
Thonhoff, J. R., Berry, J. D., Macklin, E. A., Beers, D. R., Mendoza, P. A., Zhao, W., Thome, A. D., Triolo, F., Moon, J. J., Paganoni, S., Cudkowicz, M. & Appel, S. H., Nov 1 2022, In: Neurology(R) neuroimmunology & neuroinflammation. 9, 6Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Extracellular Vesicles Derived From Ex Vivo Expanded Regulatory T Cells Modulate In Vitro and In Vivo Inflammation
Thome, A. D., Thonhoff, J. R., Zhao, W., Faridar, A., Wang, J., Beers, D. R. & Appel, S. H., Jun 22 2022, In: Frontiers in immunology. 13, 875825.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer’s disease
Faridar, A., Vasquez, M., Thome, A. D., Yin, Z., Xuan, H., Wang, J. H., Wen, S., Li, X., Thonhoff, J. R., Zhao, W., Zhao, H., Beers, D. R., Wong, S. T. C., Masdeu, J. C. & Appel, S. H., Sep 30 2022, In: Acta Neuropathologica Communications. 10, 1, 144.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Modulation of spontaneous motor unit potentials by a new motor cortical magnetic stimulation method in amyotrophic lateral sclerosis
Helekar, S. A., Thonhoff, J., John, B. S., Nguyen, L., Rosenfield, D. B. & Appel, S. H., Oct 2022, In: Journal of Neurology. 269, 10, p. 5487-5496 10 p.Research output: Contribution to journal › Article › peer-review