Projects per year
Personal profile
Research interests
Dr. Thonhoff’s research focuses on the role of regulatory T cells (Tregs) in ALS. The loss of Treg function is associated with acceleration of disease progression in ALS. Dr. Thonhoff is exploring the mechanisms through which Treg function is lost in ALS and potential therapies aimed to enhance the neuroprotective function of Tregs. He is also investigating the use of autologous Treg infusions as a therapy for patients with ALS. In addition, he is involved in several clinical trials investigating novel treatments for patients with Myasthenia Gravis, Myotonic Dystrophy and CIDP.
Research Area Keywords
- Neurosciences
- Immunobiology & Inflammation
Free-text keywords
- Neuromuscular disorders
- Neurodegenerative diseases
- Amyotrophic Lateral Sclerosis (ALS)
- Myasthenia Gravis
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
- Muscular Dystrophy
- Cellular and genetic therapies
- Neuroinflammation
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Projects
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Phase 2a_AT-1501_ALS AT-1501-A201
Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.
10/30/20 → …
Project: Clinical Trial
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Alexion ALXN1210-ALS-308 Appel
Appel, S. H., Greene, E. P., Shroff, S. & Thonhoff, J. R.
8/19/20 → …
Project: Clinical Trial
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Dr. Appel_Biomarker Study_ALS and other Neurologic Diseases
Appel, S. H., Beers, D., Greene, E. P., Lai, E. C., Liao, B., Shroff, S., Thonhoff, J. R. & Zhao, W.
8/13/20 → …
Project: Clinical Trial
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Massachusetts General Hospital Healey Center for ALS - Healey ALS Platform Trial
Appel, S. H., Greene, E. P., Shroff, S. & Thonhoff, J. R.
7/24/20 → 12/31/22
Project: Non Profit
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HEALEY ALS Platform Trial - Regimen-Specific Appendix A - For 0.3mh/kg SC zilucoplan administered once daily and placebo
Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.
7/24/20 → 7/23/25
Project: Non Profit
Research output
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Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis
Beers, D. R., Zhao, W., Neal, D. W., Thonhoff, J. R., Thome, A. D., Faridar, A., Wen, S., Wang, J. & Appel, S. H., Sep 17 2020, In : Scientific Reports. 10, 1, p. 15295 15295.Research output: Contribution to journal › Article
Open Access -
Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls
Zhao, W., Beers, D. R., Thonhoff, J. R., Thome, A. D., Faridar, A., Wang, J., Wen, S., Ornelas, L., Sareen, D., Goodridge, H. S., Svendsen, C. N. & Appel, S. H., Jun 26 2020, In : iScience. 23, 6, 101192.Research output: Contribution to journal › Article
2 Scopus citations -
Increased activation ability of monocytes from ALS patients
Du, Y., Zhao, W., Thonhoff, J. R., Wang, J., Wen, S. & Appel, S. H., Jun 1 2020, In : Experimental Neurology. 328, 32105709.Research output: Contribution to journal › Article
3 Scopus citations -
Restoring regulatory T-cell dysfunction in Alzheimer's disease through ex vivo expansion
Faridar, A., Thome, A. D., Zhao, W., Thonhoff, J. R., Beers, D. R., Pascual, B., Masdeu, J. C. & Appel, S. H., 2020, In : Brain communications. 2, 2, p. fcaa112Research output: Contribution to journal › Article
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Expanded autologous regulatory T-lymphocyte infusions in ALS A phase I, first-in-human study
Thonhoff, J. R., Beers, D. R., Zhao, W., Pleitez, M., Simpson, E. P., Berry, J. D., Cudkowicz, M. E. & Appel, S. H., Jul 1 2018, In : Neurology: Neuroimmunology and NeuroInflammation. 5, 4, p. e465 e465.Research output: Contribution to journal › Article
47 Scopus citations