Jason R. Thonhoff, MD, PhD

Assistant Professor of Neurology, Academic Institute
Assistant Member, Research Institute
Stanley H. Appel Department of Neurology
Neurological Institute
Houston Methodist Hospital
Houston Methodist

Source: Scopus
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Personal profile

Research interests

Dr. Thonhoff’s research focuses on the role of regulatory T cells (Tregs) in ALS. The loss of Treg function is associated with acceleration of disease progression in ALS. Dr. Thonhoff is exploring the mechanisms through which Treg function is lost in ALS and potential therapies aimed to enhance the neuroprotective function of Tregs. He is also investigating the use of autologous Treg infusions as a therapy for patients with ALS. In addition, he is involved in several clinical trials investigating novel treatments for patients with Myasthenia Gravis, Myotonic Dystrophy and CIDP.

Research Area Keywords

Neurosciences
Immunobiology & Inflammation

Free-text keywords

Neuromuscular disorders
Neurodegenerative diseases
Amyotrophic Lateral Sclerosis (ALS)
Myasthenia Gravis
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Muscular Dystrophy
Cellular and genetic therapies
Neuroinflammation

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24 Active

Phase 2a_AT-1501_ALS AT-1501-A201
Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.
10/30/20 → …
Project: Clinical Trial
Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS)
Shroff, S., Appel, S. H., Greene, E. P. & Thonhoff, J. R.
10/20/20 → …
Project: Clinical Trial
HEALEY ALS Platform Trial - Regimen A Zilucoplan
Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.
8/20/20 → …
Project: Clinical Trial
HEALEY ALS Platform Trial - Regimen B Verdiperstat
Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.
8/19/20 → …
Project: Clinical Trial
HEALEY ALS Platform Trial - Regimen C CNM-Au8
Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.
8/19/20 → …
Project: Clinical Trial

357 Citations
8 h-Index
13 Article
1 Review article

Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis
Beers, D. R., Zhao, W., Neal, D. W., Thonhoff, J. R., Thome, A. D., Faridar, A., Wen, S., Wang, J. & Appel, S. H., Sep 17 2020, In : Scientific Reports. 10, 1, p. 15295 15295.
Research output: Contribution to journal › Article

Open Access
Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls
Zhao, W., Beers, D. R., Thonhoff, J. R., Thome, A. D., Faridar, A., Wang, J., Wen, S., Ornelas, L., Sareen, D., Goodridge, H. S., Svendsen, C. N. & Appel, S. H., Jun 26 2020, In : iScience. 23, 6, 101192.
Research output: Contribution to journal › Article
2 Scopus citations
Increased activation ability of monocytes from ALS patients
Du, Y., Zhao, W., Thonhoff, J. R., Wang, J., Wen, S. & Appel, S. H., Jun 1 2020, In : Experimental Neurology. 328, 32105709.
Research output: Contribution to journal › Article
2 Scopus citations
Restoring regulatory T-cell dysfunction in Alzheimer's disease through ex vivo expansion
Faridar, A., Thome, A. D., Zhao, W., Thonhoff, J. R., Beers, D. R., Pascual, B., Masdeu, J. C. & Appel, S. H., 2020, In : Brain communications. 2, 2, p. fcaa112
Research output: Contribution to journal › Article
Expanded autologous regulatory T-lymphocyte infusions in ALS A phase I, first-in-human study
Thonhoff, J. R., Beers, D. R., Zhao, W., Pleitez, M., Simpson, E. P., Berry, J. D., Cudkowicz, M. E. & Appel, S. H., Jul 1 2018, In : Neurology: Neuroimmunology and NeuroInflammation. 5, 4, p. e465 e465.
Research output: Contribution to journal › Article
44 Scopus citations