Projects per year
Personal profile
Research interests
Dr. Thonhoff’s research focuses on the role of regulatory T cells (Tregs) in ALS. The loss of Treg function is associated with acceleration of disease progression in ALS. Dr. Thonhoff is exploring the mechanisms through which Treg function is lost in ALS and potential therapies aimed to enhance the neuroprotective function of Tregs. He is also investigating the use of autologous Treg infusions as a therapy for patients with ALS. In addition, he is involved in several clinical trials investigating novel treatments for patients with Myasthenia Gravis, Myotonic Dystrophy and CIDP.
Research Area Keywords
- Neurosciences
- Immunobiology & Inflammation
Free-text keywords
- Neuromuscular disorders
- Neurodegenerative diseases
- Amyotrophic Lateral Sclerosis (ALS)
- Myasthenia Gravis
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
- Muscular Dystrophy
- Cellular and genetic therapies
- Neuroinflammation
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Phase 2a_AT-1501_ALS AT-1501-A201
Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.
10/30/20 → …
Project: Clinical Trial
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Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development
for the Healey ALS Platform Trial Study Group, HEALEY ALS Platform Trial Study Group, Biostatisticians, Investigators, Clinical Operations Team & Medical Monitors, Feb 2022, In: Annals of Neurology. 91, 2, p. 165-175 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Tregs Attenuate Peripheral Oxidative Stress and Acute Phase Proteins in ALS
Beers, D. R., Thonhoff, J. R., Faridar, A., Thome, A. D., Zhao, W., Wen, S. & Appel, S. H., 2022, (Accepted/In press) In: Annals of Neurology.Research output: Contribution to journal › Article › peer-review
Open Access -
Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease
Thome, A. D., Atassi, F., Wang, J., Faridar, A., Zhao, W., Thonhoff, J. R., Beers, D. R., Lai, E. C. & Appel, S. H., Dec 2021, In: npj Parkinson's Disease. 7, 1, 41.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Multifocal Noninvasive Magnetic Stimulation of the Primary Motor Cortex in Type 1 Myotonic Dystrophy -A Proof of Concept Pilot Study
Greene, E., Thonhoff, J., John, B. S., Rosenfield, D. B. & Helekar, S. A., 2021, In: Journal of neuromuscular diseases. 8, 6, p. 963-972 10 p.Research output: Contribution to journal › Article › peer-review
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Serum programmed cell death proteins in amyotrophic lateral sclerosis
Beers, D. R., Zhao, W., Thonhoff, J. R., Faridar, A., Thome, A. D., Wen, S., Wang, J. & Appel, S. H., Mar 2021, In: Brain, behavior, & immunity - health. 12, p. 100209Research output: Contribution to journal › Article › peer-review