Research outputs

  1. 2019
  2. Update on ERbeta

    Gustafsson, J-A., Strom, A. & Warner, M., Jul 1 2019, In : Journal of Steroid Biochemistry and Molecular Biology. 191, 105312.

    Research output: Contribution to journalReview article

  3. Correction: Estrogen signalling and the metabolic syndrome: Targeting the hepatic estrogen receptor alpha action(PLoS ONE (2013) 8:2 (e57458) DOI: 10.1371/journal.pone.0057458)

    Matic, M., Bryzgalova, G., Gao, H., Antonson, P., Humire, P., Omoto, Y., Portwood, N., Pramfalk, C., Efendic, S., Berggren, P. O., Gustafsson, J-A. & Dahlman-Wright, K., Jun 1 2019, In : PloS one. 14, 6, e0217526.

    Research output: Contribution to journalComment/debate

  4. Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

    Griffiths, W. J., Abdel-Khalik, J., Yutuc, E., Roman, G. C., Warner, M., Gustafsson, J. Å. & Wang, Y., Apr 1 2019, In : Free Radical Biology and Medicine. 134, p. 42-52 11 p.

    Research output: Contribution to journalArticle

  5. Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse 11 Medical and Health Sciences 1103 Clinical Sciences

    González-Granillo, M., Helguero, L. A., Alves, E., Archer, A., Savva, C., Pedrelli, M., Ahmed, O., Li, X., Domingues, M. R., Parini, P., Gustafsson, J-A. & Korach-André, M., Feb 26 2019, In : Biology of Sex Differences. 10, 1, 11.

    Research output: Contribution to journalArticle

  6. Erratum: The genome landscape of ERα- and ERβ-binding DNA regions (Proceedings of the National Academy of Sciences of the United States of America (2008) 105 (2604–2609) DOI: 10.1073/pnas.0712085105)

    Liu, Y., Gao, H., Marstrand, T. T., Ström, A., Valen, E., Sandelin, A., Gustafsson, J-A. & Dahlman-Wright, K., Jan 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 4, p. 1460-1461 2 p.

    Research output: Contribution to journalComment/debate

  7. Colitis-induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity

    Ibrahim, A., Hugerth, L. W., Hases, L., Saxena, A., Seifert, M., Thomas, Q., Gustafsson, J-A., Engstrand, L. & Williams, C., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

    Research output: Contribution to journalArticle

  8. VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure

    Xu, H., Du, S., Fang, B., Li, C., Jia, X., Zheng, S., Wang, S., Li, Q., Su, W., Wang, N., Zheng, F., Chen, L., Zhang, X., Gustafsson, J-A. & Guan, Y., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 17, p. 8457-8462 6 p.

    Research output: Contribution to journalArticle

  9. 2018
  10. LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux

    Thomas, D. G., Doran, A. C., Fotakis, P., Westerterp, M., Antonson, P., Jiang, H., Jiang, X. C., Gustafsson, J-A., Tabas, I. & Tall, A. R., Dec 26 2018, In : Cell Reports. 25, 13, p. 3774-3785.e4

    Research output: Contribution to journalArticle

  11. Molecular and functional heterogeneity of IL-10-producing CD4 + T cells

    Brockmann, L., Soukou, S., Steglich, B., Czarnewski, P., Zhao, L., Wende, S., Bedke, T., Ergen, C., Manthey, C., Agalioti, T., Geffken, M., Seiz, O., Parigi, S. M., Sorini, C., Geginat, J., Fujio, K., Jacobs, T., Roesch, T., Izbicki, J. R., Lohse, A. W. & 8 othersFlavell, R. A., Krebs, C., Gustafsson, J-A., Antonson, P., Roncarolo, M. G., Villablanca, E. J., Gagliani, N. & Huber, S., Dec 1 2018, In : Nature Communications. 9, 1, 5457.

    Research output: Contribution to journalArticle

  12. The estrogen receptor variants β2 and β5 induce stem cell characteristics and chemotherapy resistance in prostate cancer through activation of hypoxic signaling

    Faria, M., Shepherd, P., Pan, Y., Chatterjee, S. S., Navone, N., Gustafsson, J-A. & Strom, A., Nov 1 2018, In : Oncotarget. 9, 91, p. 36273-36288 16 p.

    Research output: Contribution to journalArticle

  13. Combining mouse embryonic stem cells and zebrafish embryos to evaluate developmental toxicity of chemical exposure

    Conde-Vancells, J., Vazquez-Chantada, M., McCollum, C. W., Bondesson, M., Kalasekar, S. M., Wlodarczyk, B. J., Gustafsson, J-A., Cabrera, R. M. & Finnell, R. H., Oct 1 2018, In : Reproductive Toxicology. 81, p. 220-228 9 p.

    Research output: Contribution to journalArticle

  14. ERα expression in T lymphocytes is dispensable for estrogenic effects in bone

    Gustafsson, K. L., Nilsson, K. H., Farman, H. H., Andersson, A., Lionikaite, V., Henning, P., Wu, J., Windahl, S. H., Islander, U., Movérare-Skrtic, S., Sjögren, K., Carlsten, H., Gustafsson, J-A., Ohlsson, C. & Lagerquist, M. K., Aug 1 2018, In : Journal of Endocrinology. 238, 2, p. 129-136 8 p.

    Research output: Contribution to journalArticle

  15. Human Proislet Peptide Promotes Pancreatic Progenitor Cells to Ameliorate Diabetes Through FOXO1/Menin-Mediated Epigenetic Regulation

    Jiang, Z., Shi, D., Tu, Y., Tian, J., Zhang, W., Xing, B., Wang, J., Liu, S., Lou, J., Gustafsson, J-A., Hua, X. & Ma, X., Jul 1 2018, In : Diabetes. 67, 7, p. 1345-1355 11 p.

    Research output: Contribution to journalArticle

  16. Estrogen receptor subtypes dictate the proliferative nature of the mammary gland

    Dall, G. V., Hawthorne, S., Seyed-Razavi, Y., Vieusseux, J., Wu, W., Gustafsson, J-A., Byrne, D., Murphy, L., Risbridger, G. P. & Britt, K. L., Jun 1 2018, In : Journal of Endocrinology. 237, 3, p. 323-336 14 p.

    Research output: Contribution to journalArticle

  17. Estrogen receptor β controls proliferation of enteric glia and differentiation of neurons in the myenteric plexus after damage

    D’Errico, F., Goverse, G., Dai, Y., Wu, W., Stakenborg, M., Labeeuw, E., De Simone, V., Verstockt, B., Gomez-Pinilla, P. J., Warner, M., Di Leo, A., Matteoli, G. & Gustafsson, J-A., May 29 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 22, p. 5798-5803 6 p.

    Research output: Contribution to journalArticle

  18. Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress

    Xu, S., Huang, S., Luan, Z., Chen, T., Wei, Y., Xing, M., Li, Y., Du, C., Wang, B., Zheng, F., Wang, N., Guan, Y., Gustafsson, J-A. & Zhang, X., May 22 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 21, p. 5600-5605 6 p.

    Research output: Contribution to journalArticle

  19. ERβ alters the chemosensitivity of luminal breast cancer cells by regulating p53 function

    Bado, I., Pham, E., Soibam, B., Nikolos, F., Gustafsson, J-A. & Thomas, C., Apr 27 2018, In : Oncotarget. 9, 32, p. 22509-22522 14 p.

    Research output: Contribution to journalArticle

  20. Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis

    Zhao, L., Huang, S., Mei, S., Yang, Z., Xu, L., Zhou, N., Yang, Q., Shen, Q., Wang, W., Le, X., Lau, W. B., Lau, B., Wang, X., Yi, T., Zhao, X., Wei, Y., Warner, M., Gustafsson, J-A. & Zhou, S., Apr 17 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 16, p. E3673-E3681

    Research output: Contribution to journalArticle

  21. ERb Sensitizes NSCLC to Chemotherapy by Regulating DNA Damage Response

    Nikolos, F., Thomas, C., Bado, I. & Gustafsson, J-A., Feb 1 2018, In : Molecular Cancer Research. 16, 2, p. 233-242 10 p.

    Research output: Contribution to journalArticle

  22. ERβ activation in obesity improves whole body metabolism via adipose tissue function and enhanced mitochondria biogenesis

    González-Granillo, M., Savva, C., Li, X., Fitch, M., Pedrelli, M., Hellerstein, M., Parini, P., Korach-André, M. & Gustafsson, J-A., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Endocrinology.

    Research output: Contribution to journalArticle

  23. Role of HSD17B13 in the liver physiology and pathophysiology

    Su, W., Mao, Z., Liu, Y., Zhang, X., Zhang, W., Gustafsson, J-A. & Guan, Y., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Endocrinology.

    Research output: Contribution to journalArticle

  24. The ERβ4 variant induces transformation of the normal breast mammary epithelial cell line MCF-10A; the ERβ variants ERβ2 and ERβ5 increase aggressiveness of TNBC by regulation of hypoxic signaling

    Faria, M., Karami, S., Granados-Principal, S., Dey, P., Verma, A., Choi, D. S., Elemento, O., Bawa-Khalfe, T., Chang, J. C., Strom, A. M. & Gustafsson, J-A., 2018, In : Oncotarget. 9, 15, p. 12201-12211 11 p.

    Research output: Contribution to journalArticle

  25. 2017
  26. Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on ca2+ entry in mouse pancreatic β-cells

    Villar-Pazos, S., Martinez-Pinna, J., Castellano-Muñoz, M., Alonso-Magdalena, P., Marroqui, L., Quesada, I., Gustafsson, J-A. & Nadal, A., Dec 1 2017, In : Scientific Reports. 7, 1, 11770.

    Research output: Contribution to journalArticle

  27. Role of estrogen receptor beta in neural differentiation of mouse embryonic stem cells

    Varshney, M. K., Inzunza, J., Lupu, D., Ganapathy, V., Antonson, P., Rüegg, J., Nalvarte, I. & Gustafsson, J-A., Nov 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 48, p. E10428-E10437

    Research output: Contribution to journalArticle

  28. Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis

    Bado, I., Nikolos, F., Rajapaksa, G., Wu, W., Castaneda, J., Krishnamurthy, S., Webb, P., Gustafsson, J-A. & Thomas, C., Jul 3 2017, In : Breast Cancer Research. 19, 1, 79.

    Research output: Contribution to journalArticle

  29. Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate

    Wu, W. F., Maneix, L., Insunza, J., Nalvarte, I., Antonson, P., Kere, J., Yu, N. Y. L., Tohonen, V., Katayama, S., Einarsdottir, E., Krjutskov, K., Dai, Y. B., Huang, B., Su, W., Warner, M. & Gustafsson, J. Å., May 9 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 19, p. E3816-E3822

    Research output: Contribution to journalArticle

  30. Liver X receptor α induces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c

    Su, W., Peng, J., Li, S., Dai, Y. B., Wang, C. J., Xu, H., Gao, M., Ruan, X. Z., Gustafsson, J-A., Guan, Y. F. & Zhang, X. Y., Apr 1 2017, In : American Journal of Physiology - Endocrinology and Metabolism. 312, 4, p. E357-E367

    Research output: Contribution to journalArticle

  31. Liver X receptor β increases aquaporin 2 protein level via a posttranscriptional mechanism in renal collecting ducts

    Su, W., Huang, S. Z., Gao, M., Kong, X. M., Gustafsson, J-A., Xu, S. J., Wang, B., Zheng, F., Chen, L. H., Wang, N. P., Guan, Y. F. & Zhang, X. Y., Apr 1 2017, In : American Journal of Physiology - Renal Physiology. 312, 4, p. F619-F628

    Research output: Contribution to journalArticle

  32. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis

    Zhang, X., Li, S., Zhou, Y., Su, W., Ruan, X., Wang, B., Zheng, F., Warner, M., Gustafsson, J-A. & Guan, Y., Mar 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 12, p. 3181-3185 5 p.

    Research output: Contribution to journalArticle

  33. High-Fat Diet Induces Unexpected Fatal Uterine Infections in Mice with aP2-Cre-mediated Deletion of Estrogen Receptor Alpha

    Ban, Z., Maurischat, P., Benz, V., Brix, S., Sonnenburg, A., Schuler, G., Klopfleisch, R., Rothe, M., Gustafsson, J-A., Foryst-Ludwig, A. & Kintscher, U., Feb 24 2017, In : Scientific Reports. 7, 43269.

    Research output: Contribution to journalArticle

  34. Sex differences and effects of oestrogen in rat gastric mucosal defence

    Shore, R., Björne, H., Omoto, Y., Siemiatkowska, A., Gustafsson, J-A., Lindblad, M. & Holm, L., Jan 21 2017, In : World Journal of Gastroenterology. 23, 3, p. 426-436 11 p.

    Research output: Contribution to journalArticle

  35. Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase i independent of Cdk2 activation

    Tu, Z., Bayazit, M. B., Liu, H., Zhang, J., Busayavalasa, K., Risal, S., Shao, J., Satyanarayana, A., Coppola, V., Tessarollo, L., Singh, M., Zheng, C., Han, C., Chen, Z., Kaldis, P., Gustafsson, J. Å. & Liu, K., Jan 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. 592-597 6 p.

    Research output: Contribution to journalArticle

  36. Body weight homeostat that regulates fat mass independently of leptin in rats and mice

    Jansson, J. O., Palsdottir, V., Hägg, D. A., Schéle, E., Dickson, S. L., Anesten, F., Bake, T., Montelius, M., Bellman, J., Johansson, M. E., Cone, R. D., Drucker, D. J., Wu, J., Aleksic, B., Törnqvist, A. E., Sjögren, K., Gustafsson, J-A., Windahl, S. H. & Ohlsson, C., Jan 9 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 2, p. 427-432 6 p.

    Research output: Contribution to journalArticle

  37. Estrogen Receptor β as a Pharmaceutical Target

    Warner, M., Huang, B. & Gustafsson, J. A., Jan 1 2017, In : Trends in Pharmacological Sciences. 38, 1, p. 92-99 8 p.

    Research output: Contribution to journalReview article

  38. Estrogen receptor ß2 induces proliferation and invasiveness of triple negative breast cancer cells; association with regulation of PHD3 and HIF-1α

    Bialesova, L., Xu, L., Gustafsson, J-A., Haldosen, L. A., Zhao, C. & Dahlman-Wright, K., 2017, In : Oncotarget. 8, 44, p. 76622-76633 12 p.

    Research output: Contribution to journalArticle

  39. Intratumor heterogeneity predicts metastasis of triplenegative breast cancer

    Yang, F., Wang, Y., Li, Q., Cao, L., Sun, Z., Jin, J., Fang, H., Zhu, A., Li, Y., Zhang, W., Wang, Y., Xie, H., Gustafsson, J-A., Wang, S. & Guan, X., 2017, In : Carcinogenesis. 38, 9, p. 900-909 10 p.

    Research output: Contribution to journalArticle

  40. 2016
  41. Genomics of sex hormone receptor signaling in hepatic sexual dimorphism

    Zheng, D., Wang, X., Antonson, P., Gustafsson, J-A. & Li, Z., Dec 16 2016, (Accepted/In press) In : Molecular and Cellular Endocrinology.

    Research output: Contribution to journalArticle

  42. An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice

    Miao, Y. F., Su, W., Dai, Y. B., Wu, W. F., Huang, B., Barros, R. P. A., Nguyen, H., Maneix, L., Guan, Y. F., Warner, M. & Gustafsson, J-A., Dec 6 2016, In : Scientific Reports. 6, 38579.

    Research output: Contribution to journalArticle

  43. Genetic and Epigenetic Mechanisms in Neural and Hormonal Controls over Female Reproductive Behaviors

    Kow, L. M., Lee, A. W., Klinge, C., Warner, M., Gustafsson, J-A. & Pfaff, D. W., Nov 9 2016, Molecular and Cellular Mechanisms. Elsevier, Vol. 3. p. 55-82 28 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  44. Defective cholesterol metabolism in amyotrophic lateral sclerosis

    Abdel-Khalik, J., Yutuc, E., Crick, P. J., Gustafsson, J-Å., Warner, M., Roman, G., Talbot, K., Gray, E., Griffiths, W. J., Turner, M. R. & Wang, Y., Nov 3 2016, In : Journal of Lipid Research. 58, 1, p. 267-278 12 p.

    Research output: Contribution to journalArticle

  45. Dysregulation of Notch and ERα signaling in AhR-/- male mice

    Huang, B., Butler, R., Miao, Y., Dai, Y., Wu, W., Su, W., Fujii-Kuriyama, Y., Warner, M. & Gustafsson, J-A., Oct 18 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. 11883-11888 6 p.

    Research output: Contribution to journalArticle

  46. 24-hydroxycholesterol participates in pancreatic neuroendocrine tumor development

    Soncini, M., Corna, G., Moresco, M., Coltella, N., Restuccia, U., Maggioni, D., Raccosta, L., Lin, C. Y., Invernizzi, F., Crocchiolo, R., Doglioni, C., Traversari, C., Bachi, A., Bernardi, R., Bordignon, C., Gustafsson, J-A. & Russo, V., Oct 11 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 41, p. E6219-E6227

    Research output: Contribution to journalArticle

  47. Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells

    McCollum, C. W., Conde-Vancells, J., Hans, C., Vazquez-Chantada, M., Kleinstreuer, N., Tal, T., Knudsen, T., Shah, S. S., Merchant, F. A., Finnell, R. H., Gustafsson, J-A., Cabrera, R. & Bondesson, M., Aug 16 2016, (Accepted/In press) In : Reproductive Toxicology.

    Research output: Contribution to journalArticle

  48. The role of membrane ERα signaling in bone and other major estrogen responsive tissues

    Gustafsson, K. L., Farman, H., Henning, P., Lionikaite, V., Moverare-Skrtic, S., Wu, J., Ryberg, H., Koskela, A., Gustafsson, J-A., Tuukkanen, J., Levin, E. R., Ohlsson, C. & Lagerquist, M. K., Jul 8 2016, In : Scientific Reports. 6, 29473.

    Research output: Contribution to journalArticle

  49. Ablation of Liver X receptors α and β leads to spontaneous peripheral squamous cell lung cancer in mice

    Dai, Y. B., Miao, Y. F., Wu, W. F., Li, Y., D'Errico, F., Su, W., Burns, A. R., Huang, B., Maneix, L., Warner, M. & Gustafsson, J. Å., Jul 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 27, p. 7614-7619 6 p.

    Research output: Contribution to journalArticle

  50. Estrogen receptor beta reduces colon cancer metastasis through a novel miR-205 - PROX1 mechanism

    Nguyen-Vu, T., Wang, J., Mesmar, F., Mukhopadhyay, S., Saxena, A., McCollum, C. W., Gustafsson, J-A., Bondesson, M. & Williams, C., Jul 5 2016, In : Oncotarget. 7, 27, p. 42159-42171 13 p.

    Research output: Contribution to journalArticle

  51. Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma

    Sareddy, G. R., Li, X., Liu, J., Viswanadhapalli, S., Garcia, L., Gruslova, A., Cavazos, D., Garcia, M., Strom, A. M., Gustafsson, J-A., Tekmal, R. R., Brenner, A. & Vadlamudi, R. K., Apr 29 2016, In : Scientific Reports. 6, 24185.

    Research output: Contribution to journalArticle

  52. Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

    Zimmer, S., Grebe, A., Bakke, S. S., Bode, N., Halvorsen, B., Ulas, T., Skjelland, M., De Nardo, D., Labzin, L. I., Kerksiek, A., Hempel, C., Heneka, M. T., Hawxhurst, V., Fitzgerald, M. L., Trebicka, J., Björkhem, I., Gustafsson, J-A., Westerterp, M., Tall, A. R., Wright, S. D. & 5 othersEspevik, T., Schultze, J. L., Nickenig, G., Lütjohann, D. & Latz, E., Apr 6 2016, In : Science Translational Medicine. 8, 333, ra50.

    Research output: Contribution to journalArticle

  53. Liver X receptor β: new player in the regulatory network of thyroid hormone and ‘browning’ of white fat

    Miao, Y., Warner, M. & Gustafsson, J-A., Apr 2 2016, In : Adipocyte. 5, 2, p. 238-242 5 p.

    Research output: Contribution to journalComment/debate

  54. Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor

    Lu, X., Wang, F., Xu, C., Soodvilai, S., Peng, K., Su, J., Zhao, L., Yang, K. T., Feng, Y., Zhou, S. F., Gustafsson, J. Å. & Yang, T., Mar 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. E1898-E1906

    Research output: Contribution to journalArticle

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